Patents Assigned to United States Government as Represented by the Department of Veterans Affairs
  • Devices, and systems for remotely monitoring and treating wounds or wound infections
    Patent number: 11395918
    Abstract: Devices and methods for remotely monitoring and treating wounds or wound infections are disclosed. A device can include a multi-layered, flexible substrate having a dressing layer positioned on a wound side of the substrate, and a flexible printed circuit board layer positioned on an electronics side of the substrate that is opposite the wound side of the dressing layer. A plurality of electrodes can be electrically coupled to the flexible printed circuit board. A plurality of temperature sensors can be electrically coupled to the flexible printed circuit board. Systems including the described devices are also disclosed.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: July 26, 2022
    Assignees: United States Government as Represented by the Department of Veterans Affairs, Case Western Reserve University
    Inventors: Kath M. Bogie, Christian A. Zorman
  • Devices, systems, and methods for socket fit management
    Patent number: 11395748
    Abstract: Disclosed herein are devices, systems, and methods for measuring socket fit in lower limb prostheses and detecting motion of a residual limb relative to a prosthetic socket. Also disclosed herein are methods for developing a socket-fit detection system for sock management that can be applied to adjustable socket systems.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: July 26, 2022
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventors: John Ferguson, Gregory Owen Voss, Stuart Richard Fairhurst, Andrew Hansen
  • NON-INVASIVE ESTIMATION OF THE MECHANICAL PROPERTIES OF THE HEART
    Publication number: 20220211351
    Abstract: Methods and systems for utilizing myocardial strain imaging in an inverse framework to identify mechanical properties of the heart and to determine structural and functional milestones for the development and progression to heart failure.
    Type: Application
    Filed: March 23, 2022
    Publication date: July 7, 2022
    Applicants: University of South Carolina, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: William M. Torres, Francis G. Spinale, Tarek M. Shazly
  • CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBXO7 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA
    Publication number: 20220204484
    Abstract: A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 30, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Rama K. Mallampalli, Beibei Chen, Charleen T. Chu, Yuan Liu
  • CCL21 AND CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20220177534
    Abstract: The present disclosure relates, in general, to methods for treating cancer comprising administering to a subject in need thereof an effective amount of dendritic cells comprising the human CCL21 gene in combination with an anti-PD-1 antibody. In one aspect, the treatment is amenable to patients with tumors having a high mutational burden.
    Type: Application
    Filed: May 10, 2019
    Publication date: June 9, 2022
    Applicants: The Regents of the University of California, The United States Government Represented by the Department of Veterans Affairs
    Inventors: Steven M. DUBINETT, Jay Moon LEE, Bin LIU, Ramin SALEHI-RAD, Sharvendra SHARMA
  • Cellular seeding and co-culture of a three dimensional fibroblast construct
    Patent number: 11345894
    Abstract: The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: May 31, 2022
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jordan Lancaster, Steve Goldman
  • COMBINATION IMMUNOTHERAPY
    Publication number: 20220162279
    Abstract: The invention is based on the disclosure provided herein that secondary lymphoid organ chemokine (SLC) inhibits the growth of syngeneic tumors in vivo. Thus, the invention provides a method of treating cancer in a mammal subject by administering a therapeutically effective amount of an SLC to the mammal in combination with a checkpoint inhibitor, including monoclonal antibodies and small molecule inhibitors. Exemplary checkpoint molecules include CTLA-4, a CTLA-4 receptor, PD-1, PD1-L1, PD1-L2, 4-1BB, OX40, LAG-3, TIM-3 or a combination thereof. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 26, 2022
    Applicants: The Regents of the University of California, United States Government represented by the Department of Veterans Affairs
    Inventors: Steven M. DUBINETT, Sherven SHARMA, Jay M. LEE
  • SYSTEM AND MEDICATION BOX FOR IMPROVING MEDICATION ADHERENCE
    Publication number: 20220160587
    Abstract: A medication adherence system and corresponding medication box for improving medication adherence. The system includes the medication box, which is transparent and has a machine-readable marker, such as a QR code, on or beneath the floor thereof. The marker is capable of being scanned and read through the transparent bottoms of individual chambers. Data embedded in the marker includes, but is not limited to, the user's medication plan, the date and time when the medication is to be ingested, and instructions for recording the date and time when the marker is scanned and read. The underlying software program/application processes this information and provides an indication as to the user's compliance with the medication plan.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Applicants: University of South Florida, The United States Government as represented by the Department of Veterans Affairs
    Inventors: William Diehl Kearns, Kimberly Ann Crosland, Jeffrey D. Craighead, James Leonard Fozard
  • Wireless iontophoresis patch and controller
    Patent number: 11331478
    Abstract: An iontophoresis system for positioning against skin of a subject is disclosed. The iontophoresis system can comprise at least one vessel having a solvent therein. An anode apparatus can couple to the at least one vessel. The anode apparatus can comprise a first reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir. A cathode apparatus can couple to the at least one vessel. The cathode apparatus can comprise a second reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: May 17, 2022
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventors: Anton Sabiev, William Bauman, Mark Korsten
  • Brain stimulation treatment in depression
    Patent number: 11324963
    Abstract: Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: May 10, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Amit Etkin, Corey Keller, Wei Wu
  • Breathable residual-limb socket system
    Patent number: 11324612
    Abstract: A liner defines a pouch, an opening, a cup, and a first ring positioned on the pouch distal to the opening. The pouch is air-permeable and defines an internal volume for receiving a residual limb. The opening defined by the pouch provides access to the internal volume. The cup is air-impermeable and is positioned on the pouch distal to the opening. The liner is combined with an adapter for connecting a residual limb to a prosthetic limb. The adapter has a socket for receiving the cup, at least one hole positioned within the socket for drainage therefrom and sleeve extending from the socket and surrounding a central space. The adapter also has at least one vent positioned in the sleeve and overlies the air permeable material.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: May 10, 2022
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventors: Andrew H. Hansen, Eric A. Nickel, Billie Caris Savvas Slater, Stuart R. Fairhurst, Jennifer Leestma
  • Methods and compositions for treating liver disease
    Patent number: 11318190
    Abstract: Disclosed is a method of modulating the Sct/SR axis in a mammalian subject in need thereof, including in a subject suffering from a liver disease, such as but not limited to, Early Stage PBC, Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, Biliary Altresia, NASH, NAFLD, or Alcohol induced liver injury. A method of treating Late Stage PBC in a mammalian subject in need thereof is also disclosed; further disclosed is a method of ameliorating PBC-induced biliary damage in a mammalian subject in need thereof. Pharmaceutical compositions for modulating the Sct/SR axis, comprising a SR antagonist or a SR agonist, and a pharmaceutically acceptable carrier or excipient are also disclosed.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 3, 2022
    Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Gianfranco Alpini, Shannon Glaser, Fanyin Meng
  • Compositions and methods of inhibiting the binding of plasma IgG autoantibodies to serotonin 2A receptor
    Patent number: 11306122
    Abstract: Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: April 19, 2022
    Assignee: The United States Government As Represented By The Department of Veterans Affairs
    Inventor: Mark B. Zimering
  • Bacterial protein compositions and uses thereof
    Patent number: 11291712
    Abstract: Disclosed herein is an attenuated Acinetobacter baumannii comprising an expression vector comprising a nucleic acid encoding the ABUW_1645 protein or a variant thereof. Disclosed herein are methods of treating or preventing colonization, infection, or disease by an Acinetobacter baumannii microbe, the method comprising administering a clinically effective dose of the attenuated Acinetobacter baumannii to a subject in need thereof, wherein the attenuated Acinetobacter baumannii comprises an expression vector expressing the ABUW_1645 protein or variants thereof.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: April 5, 2022
    Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Philip Rather, David Weiss, Chui-Yoke Chin, Kyle Tipton
  • Methods and compositions for treating cancer
    Patent number: 11285154
    Abstract: Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: March 29, 2022
    Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Amyn Aziz Habib
  • Gene expression signatures useful to predict or diagnose sepsis and methods of using the same
    Patent number: 11286525
    Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: March 29, 2022
    Assignees: Duke University, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Ephraim L. Tsalik, Geoffrey S. Ginsburg, Christopher W. Woods, Ricardo Henao Giraldo, Rachel A. Myers
  • GAS5 binding compounds, formulations, and uses thereof
    Patent number: 11278521
    Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 22, 2022
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL—PSG IV (024)
    Inventors: Niketa A. Patel, Jianfeng Cai
  • Compositions and methods for in vivo excision of HIV-1 proviral DNA
    Patent number: 11274305
    Abstract: Methods and kits for excising HIV-1 DNA in vivo are provided, which employ Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-Associated (cas) proteins. Vectors harboring nucleic acids encoding one or more guide RNA, wherein said guide RNA hybridizes with a target HIV-1 DNA are also provided.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: March 15, 2022
    Assignees: TRUSTEES OF DARTMOUTH COLLEGE, United States Government as Represented by The Department of Veterans Affairs
    Inventors: Alexandra L. Howell, Susan K. Eszterhas
  • Toilet seat wrap
    Patent number: D946722
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: March 22, 2022
    Assignees: United States Government as Represented by the Department of Veterans Affairs, University of Pittsburgh—Of The Commonwealth System Of Higher Education
    Inventors: Rory A. Cooper, Rosemarie Cooper
  • Toilet seat wrap
    Patent number: D950690
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: May 3, 2022
    Assignees: United States Government as Represented by the Department of Veterans Affairs, University of Pittsburgh - Of The Commonwealth System Of Higher Education
    Inventors: Rory A. Cooper, Rosemarie Cooper