Patents Assigned to United States Government as Represented by the Department of Veterans Affairs
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Publication number: 20210315895Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.Type: ApplicationFiled: November 19, 2020Publication date: October 14, 2021Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans AffairsInventors: Beibei Chen, Rama K. Mallampalli
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Patent number: 11141398Abstract: The present disclosures provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.Type: GrantFiled: January 5, 2018Date of Patent: October 12, 2021Assignee: The United States Government as Represented by the Department of Veterans AffairsInventor: Guy Weinberg
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Patent number: 11110207Abstract: Tissue scaffolds for neural tissue growth have a plurality of microchannels disposed within a sheath. Each microchannel comprises a porous wall having a thickness of ?about 100 ?m that is formed from a biocompatible and biodegradable material comprising a polyester polymer. The polyester polymer may be polycaprolactone, poly(lactic-co-glycolic acid) polymer, and combinations thereof. The tissue scaffolds have high open volume % enabling superior (linear and high fidelity) neural tissue growth, while minimizing inflammation near the site of implantation in vivo. In other aspects, methods of making such tissue scaffolds are provided. Such a method may include mixing a reduced particle size porogen with a polymeric precursor solution. The material is cast onto a template and then can be processed, including assembly in a sheath and removal of the porogen, to form a tissue scaffold having a plurality of porous microchannels.Type: GrantFiled: August 20, 2019Date of Patent: September 7, 2021Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The United States Government as represented by the Department of Veterans AffairsInventors: Jeffrey S. Sakamoto, Dena Shahriari, Mark H. Tuszynski, Wendy Campana, Yacov Koffler
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Patent number: 11110183Abstract: A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.Type: GrantFiled: August 5, 2019Date of Patent: September 7, 2021Assignees: University of South Florida, The United States Government as Represented by the Department of Veterans AffairsInventors: Shyam S. Mohapatra, Subhra Mohapatra, Eleni Markousta
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Patent number: 11098302Abstract: Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest.Type: GrantFiled: April 27, 2012Date of Patent: August 24, 2021Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as Represented by the Department of Veterans AffairInventors: William H. Robinson, Yann Chong Tan, Jeremy Sokolove
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Patent number: 11090313Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).Type: GrantFiled: October 23, 2019Date of Patent: August 17, 2021Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
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Patent number: 11083652Abstract: Disclosed herein is a footplate assembly for monitoring foot position in real time, as a wheelchair is driven. Optionally, the footplate assembly can use an array of force-sensing resistors and infrared distance sensors to detect the pressure and location of the foot within the immediate confines of the footplate. The footplate assembly can be provided as an overlay to an existing wheelchair footplate structure, or the footplate assembly can be integrated into or replace an existing wheelchair footplate structure.Type: GrantFiled: April 3, 2018Date of Patent: August 10, 2021Assignees: United States Government as Represented by the Department of Veterans Affairs, Case Western Reserve UniversityInventors: Katherine M. Bogie, Mary Kristina Henzel, Steven Majerus, Steven J. Mitchell
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Patent number: 11077178Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.Type: GrantFiled: September 20, 2017Date of Patent: August 3, 2021Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The United States Government as represented by the Department of Veterans AffairsInventors: Liyanage Parakrama Perera, Thomas Alexander Waldmann, Kevin Charles Conlon, Pin-Yu Perera
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Patent number: 11072606Abstract: A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s—NH—(CH2)t, (CH2)s—O—(CH2)t, or (CH2)s—C(NH2)—(CH2)v—NH—(CH2)t, where s, t and v are each, independently an integer from 1 to 5; A and B are each, independently, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; C and D are each, independently, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-C1-6 alkyl, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; each Rg is, independently, halogen, C1-6 alkyl, C1-6 haloalkyl, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6alkylamino, or di-C1-6alkylamino; and n1 and p1 are each, independently, integers from 1 to 10.Type: GrantFiled: October 11, 2019Date of Patent: July 27, 2021Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans AffairsInventors: Beibei Chen, Rama K. Mallampalli
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Patent number: 11065254Abstract: Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV in an infected patient.Type: GrantFiled: March 11, 2020Date of Patent: July 20, 2021Assignees: The United States Government As Represented By The Department of Veterans Affairs, Emory UniversityInventors: Christina Gavegnano, Raymond F. Schinazi
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Patent number: 11067583Abstract: The present invention provides a method of making an antibody by identifying a circulating antibody with activity from a subject comprising i) subjecting biological fluid selected from the group consisting of blood, plasma and serum and combinations thereof from the subject to one or more rounds of affinity chromatography to purify the circulating antibody; ii) optionally further subjecting the circulating antibody to isoelectric focusing to purify the circulating antibody based on charge; iii) testing the purified circulating antibody for activity; iv) digesting the purified circulating antibody from parts i) or ii) to create an antibody fragment; v) subjecting the antibody fragment to mass spectrometry to generate a mass assignment and a deduced amino acid sequence of the antibody fragment; vi) comparing the deduced amino acid sequence with an amino acid sequence of an antibody generated from the subject's B-cells to identify an antibody sequence that matches the deduced amino acid sequence; vii) generatingType: GrantFiled: May 25, 2017Date of Patent: July 20, 2021Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Mohammad Sajadi, Anthony DeVico, George Lewis
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Patent number: 11060060Abstract: Provided herein are methods of producing trabecular bone material, such as trabecular bone or trabecular bone matrix and cells useful in preparing the trabecular bone material.Type: GrantFiled: September 16, 2016Date of Patent: July 13, 2021Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans Affairs, University of Chicago, Washington UniversityInventors: Harry Colbert Blair, Quitterie Larrouture, Irina L. Tourkova, Deborah J. Nelson, Paul Schlesinger
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Patent number: 11053290Abstract: Embodiments of the present disclosure provide polypeptides, related materials and compositions, and methods for their use. In certain embodiments, the present disclosure provides a monomeric Tamm-Horsfall Protein polypeptide, or a biologically active truncation thereof. Other embodiments provide polynucleotides encoding a polypeptide described herein, nucleic acid expression vectors including the polynucleotides, and recombinant host cells including the expression vector. Yet other embodiments provide pharmaceutical compositions including a polypeptide described herein. Also provided are methods for treating a renal disease, disorder, or condition in a subject and/or modulating an immune response in a subject.Type: GrantFiled: October 28, 2016Date of Patent: July 6, 2021Assignees: Indiana University Research and Technology Corporation, The United States Government as Represented by the Department of Veterans AffairInventors: Tarek Maurice Ashkar, Radmila Micanovic
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Publication number: 20210198221Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.Type: ApplicationFiled: December 15, 2016Publication date: July 1, 2021Applicants: University of South Florida, The United States Government as Represented by the Department of Veterans Affairs Office of GeneralInventors: Niketa A. Patel, Jianfeng Cai
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Patent number: 11040082Abstract: The present invention relates to methods of treating a patient who has colorectal cancer and to methods of reducing the likelihood that a patient will develop or experience a recurrence of colorectal cancer. The methods comprise a step of introducing, to the patient, an effective amount of an agent that targets an intestinal H+-coupled di/tripeptide transporter (PepT1). Useful compositions including, for example, the tripeptide KPV, vectors encoding such peptides, and cells (e.g., bacterial cells) including them, are also within the scope of the present invention, as are kits including such compositions.Type: GrantFiled: August 6, 2015Date of Patent: June 22, 2021Assignees: Georgia State University Research Foundation, Inc., The United States Government as Represented by The Department of Veterans AffairsInventor: Didier Merlin
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Patent number: 11043143Abstract: A method and system are presented for performing virtual surgery simulations. The computer system includes a processor and a memory. The method includes receiving user input from a user via a user interface. The user input includes input representing surgical operations or non-surgical invasive procedures. The method also includes processing the user input and utilizing the input to generate or modify a computational model. The method also includes running simulations using the computational model in accordance with the user input. After running the simulations, the method further includes determining results from the simulations. The results correspond to probable effects or outcomes of performing real life surgical operations or non-surgical invasive procedures corresponding to the user input. Last, the method includes presenting the results to the user via the user interface.Type: GrantFiled: February 3, 2017Date of Patent: June 22, 2021Assignee: United States Government as Represented by the Department of Veterans AffairsInventors: Mark B. Ratcliffe, Liang Ge, Alan Bao-Chan Dang
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Patent number: 11033554Abstract: Disclosed herein are methods of treating disorders of the retina (e.g., macular degeneration, retinitis pigmentosa, etc.) comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound (for example, an antipsychotic drug) that blocks or diminishes agonist-mediated responses upon binding to either dopamine D2-like receptors or serotonin 5-HT2 receptors.Type: GrantFiled: July 25, 2016Date of Patent: June 15, 2021Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventor: Ralph Jensen
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Patent number: 11029113Abstract: A device for pulling the trigger of a firearm includes an actuator, a controller in signal communication with the actuator and a switch in communication with the controller. The actuator mounts on the firearm adjacent to the trigger. The actuator has a body movable into engagement with the trigger for pulling the trigger. The body is movable out of engagement with the trigger permitting the trigger to reset. The controller is adapted to transmit first and second commands to the actuator. The first command directs moving the body into engagement with the trigger, and the second command directs moving the body out of engagement with the trigger. The switch is adapted to transmit a first signal to the controller causing the controller to transmit the first command to the actuator, and a second signal to the controller for causing the controller to transmit the second command to the actuator.Type: GrantFiled: February 12, 2020Date of Patent: June 8, 2021Assignee: The United States Government as represented by the Department of Veterans AffairsInventor: Seth R. Hills
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Patent number: 11020510Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.Type: GrantFiled: December 20, 2018Date of Patent: June 1, 2021Assignees: Arizona Board of Regents on Behalf of the University of Arizona, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Jordan J. Lancaster, Steven Goldman
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Patent number: 11014892Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.Type: GrantFiled: November 2, 2017Date of Patent: May 25, 2021Assignees: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRSInventors: Christopher C. Lindsey, Craig C. Beeson, Yuri Karl Peterson, Rick G. Schnellmann