Abstract: Variant guinea pig L-asparaginases which are truncated and humanized are described as are fusion proteins containing the L-asparaginase and use of the L-asparaginases in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.

Abstract: The present invention provides benzamide compounds, compositions containing the benzamides, and use of the benzamides for inhibiting androgen receptor (AR) and/or aldo-keto reductase family 1 member C3 (AKR1C3). Also described herein methods for the treatment of hormone-mediated diseases and conditions, including hormone-related cancers such as castration resistant prostate cancer.

Abstract: The described invention provides methods for treating an inflammatory brain disease, disorder or condition and for treating a traumatic brain injury having an inflammatory component in a subject in need thereof using isolated erythropoietin (EPO)-derived oligopeptides.

Abstract: The present invention provides a method of predicting whether a pulmonary nodule in a subject is benign or non-small cell lung cancer, comprising obtaining the results of an assay that measures an expression level of miR205-5p in a plasma sample from the subject; obtaining the results of an assay that measures an expression level of miR126 in a plasma sample from the subject; obtaining the results of an assay that provides a size of the pulmonary nodule in the subject; and calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule, wherein if the probability value exceeds a specified threshold, the pulmonary nodule is predicted as non-small cell lung cancer.

Abstract: Disclosed are novel compounds for treating and preventing schizophrenia, and more generally psychosis, by bioinformatics drug repurposing using novel genes expression biomarkers involved in psychotic symptoms (delusions, hallucinations); methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for psychosis in a subject; and method of using repurposed drugs and natural compounds to prevent and to treat psychosis. Methods are disclosed using a universal approach, in everybody, as well as personalized approaches by gender. The discovery describes compounds for use in everybody (universal), as well as personalized by gender (males, females). Methods for identifying which subjects should be receiving which treatment, using genes expression biomarkers for patient stratification and measuring response to treatment. The disclosure also relates to algorithms.

Abstract: A method may include applying, to a corpus of data, a first machine learning technique to identify candidate domains of an ontology mapping brain structure to mental function. The corpus of data may include textual data describing a plurality of mental functions and spatial data corresponding to a plurality of brain structures. A second machine technique may be applied to optimize a quantity of domains included in the ontology and/or a quantity of mental function terms included in each domain. The ontology may be applied to phenotype an electronic medical record and predict a clinical outcome for a patient associated with the electronic medical record. Related systems and articles of manufacture, including computer program products, are also provided.

Abstract: Methods for disinfecting a surface are provided which include contacting a surface with a solution comprising Fe(VI)O42?, thereby disinfecting the surfaces. In some cases, the surface to be contacted with the solution is in a space suitable for human occupancy and the surface is arranged in the ambient of the space. In addition, solutions comprising Fe(VI)O42? are provided. The solutions may additionally include a hypohalite salt and a surfactant.

Abstract: A genus of dihydropyridine chemical modulators of synaptojanin is disclosed. These modulators are selective inhibitors of synaptojanin 1 and may be used to treat cognitive impairment or traumatic brain injury, including promoting regeneration in cases of traumatic brain injury, or for treating neurodegenerative disorders.

Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.

Abstract: The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.

Abstract: A personal mobility device includes a frame, a plurality of wheels attached to the frame and one or more pneumatic motors. Each of the one or more pneumatic motors has a drive shaft in operative connection with at least one of the plurality of wheels. The personal mobility device further includes at least one tank (that is, a storage container) for storage of a pressurized gas in operative connection with the one or more pneumatic motors to supply pressurized gas to the one or more pneumatic motors and a control system in operative connection with the at least one tank and with the one or more pneumatic motors.

Abstract: The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of A? peptide in neural tissue. The subject invention also concerns materials and methods for treating and/or preventing stress disorders, such as post-traumatic stress disorder (PTSD). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of cotinine, or a pharmaceutically acceptable salt thereof, to a person or animal in need of treatment. The methods of the invention can be used to prevent and/or treat Alzheimer's disease, Parkinson's disease, and/or Down's syndrome. The subject invention also concerns compositions that comprise cotinine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or adjuvant.

Abstract: The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.

Abstract: Syringe pump controllers which memorialize the process of hydrodynamic isotonic saline delivery (HIFD) to reverse acute kidney injury are disclosed. In some embodiments, the syringe pump controllers are constructed to control syringe pump(s) to deliver a defined volume of saline at a prescribed perfusion rate while monitoring renal vein pressures during the infusion. In some embodiments, the syringe pump controllers have safety features designed to shut off the infusion if the renal vein pressure goes above set safety limits.

Abstract: A training manikin can have a front, a longitudinal axis, and a sagittal axis perpendicular to the longitudinal axis. The training manikin can comprise a head portion having an oral aperture. A simulated esophagus can be in communication with the oral aperture of the head portion. The simulated esophagus can be configured to receive a gastrointestinal tube. A simulated larynx can be positioned between the simulated esophagus and the front of the manikin relative to the sagittal axis. A reservoir can be configured to receive a liquid. A conduit in communication with the reservoir, can have an outlet end that is positioned proximate to the oral aperture of the head portion. A pump can be positioned between, and in communication with, the reservoir and the conduit and configured to begin pumping the liquid from the reservoir to the outlet end of the conduit upon a first condition.

Abstract: Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.

Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one or more objects of interest from the classified pixels.

Abstract: Provided are devices and methods for providing a flexible implantable tissue stimulator. A flexible implantable tissue stimulator can be use in a variety of medical/surgical procedures, and therapeutic interventions, such as musculoskeletal stimulation therapy. The flexible implantable tissue stimulator can be implanted via a minimally invasive procedure and comprises a biocompatible flexible construction that enables it to conform to a variety of implantation orientations and biological conditions. The flexible implantable tissue can provide programmable biphasic electrical stimulation to impaired tissue, such as a gluteal muscle.

Abstract: The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.