Patents Assigned to United Therapeutic Corporation
  • Use of treprostinil to improve kidney functions
    Patent number: 7199157
    Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for improving kidney functions, such as urine output, and treating symptoms associated with kidney malfunction or failure. The invention also relates to kits for the improvement of kidney functions and the treatment of symptoms associated with kidney malfunction or failure, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: April 3, 2007
    Assignee: United Therapeutics Corporation
    Inventors: Michael Wade, Roger Andrew Jeffs, Kathryn Bronstein, Deborah Strootman
  • Process for stereoselective synthesis of prostacyclin derivatives
    Patent number: 6809223
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. “Also described are novel intermediate compounds used in the process described for making 9-deoxy-PGF1-type compounds.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: October 26, 2004
    Assignee: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Hitesh Bhatra
  • Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
    Patent number: 6803386
    Abstract: The present invention is directed to a pharmaceutical composition containing a cancer-treating effective amount of a class of prostacyclin derivatives, and a pharmaceutically acceptable carrier, and to kits and methods of employing the same for the treatment of cancer.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: October 12, 2004
    Assignee: United Therapeutics Corporation
    Inventors: Robert Shorr, Martine Rothblatt
  • Process for stereoselective synthesis of prostacyclin derivatives
    Publication number: 20040176645
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: August 27, 2003
    Publication date: September 9, 2004
    Applicant: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Hitesh Bxatra
  • Process for stereoselective synthesis of prostacyclin derivatives
    Patent number: 6765117
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF1-type compounds.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: July 20, 2004
    Assignee: United Therapeutic Corporation
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Method for delivering benzindene prostaglandins by inhalation
    Patent number: 6756033
    Abstract: A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: June 29, 2004
    Assignee: United Therapeutics Corporation
    Inventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
  • Process for stereoselective synthesis of prostacyclin derivatives
    Patent number: 6700025
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: March 2, 2004
    Assignee: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Hitesh Batra
  • Reversible infertility in male mice following oral administration of alkylated imino sugars: a non-hormonal approach to male contraception
    Publication number: 20040019082
    Abstract: The present invention provides a method by which to reversibly render male mammals infertile. Thus, the disclosed N-substituted imino compounds, and pharmaceutical compositions thereof, completely impair the fertility of male mammals, but exhibit no effect on that of female mammals, and are thus useful as male contraceptives.
    Type: Application
    Filed: March 13, 2003
    Publication date: January 29, 2004
    Applicant: United Therapeutics Corporation
    Inventors: Aarnoud C. van der Spoel, Mylvaganam Jeyakumar, Terry D. Butters, Raymond A. Dwek, Frances M. Platt
  • Inhibitors of endothelin-1 synthesis
    Publication number: 20030109480
    Abstract: Sequences in human preproendothelin-1 mRNA are described against which antisense oligonucleotides can be used to inhibit the synthesis of endothelin-1. This inhibition of endothelin-1 synthesis may be used to treat diseases where excess production of endothelin-1 is an underlying cause of the symptoms.
    Type: Application
    Filed: November 18, 2002
    Publication date: June 12, 2003
    Applicant: United Therapeutics Corporation
    Inventors: Roger Corder, Adrian P.L. Smith, Timothy W. Higenbottam, Martine Rothblatt, Sir John Vane, Delphine Dominique Marthe Lees
  • Method for delivering benzidine prostaglandins by inhalation
    Publication number: 20030053958
    Abstract: A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.
    Type: Application
    Filed: August 6, 2002
    Publication date: March 20, 2003
    Applicant: United Therapeutics Corporation
    Inventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
  • Prostacyclin derivatives
    Patent number: 6528688
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: March 4, 2003
    Assignee: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
    Patent number: 6521212
    Abstract: A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: February 18, 2003
    Assignee: United Therapeutics Corporation
    Inventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
  • Process for stereoselective synthesis of prostacyclin derivatives
    Publication number: 20020173672
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: July 1, 2002
    Publication date: November 21, 2002
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Process for stereoselective synthesis of prostacyclin derivatives
    Patent number: 6441245
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: August 27, 2002
    Assignee: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Process for stereoselective synthesis of prostacyclin derivatives
    Publication number: 20020087025
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: February 15, 2002
    Publication date: July 4, 2002
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
    Patent number: 6242482
    Abstract: Prostaglandin and analogs thereof which include protective groups attached to at least one site which are pharmaceutically acceptable and which are capable of slowing the metabolic rate of the active groups for administration to a warm blooded animal for the treatment of congestive heart failure.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: June 5, 2001
    Assignee: United Therapeutics Corporation
    Inventors: Robert Shorr, Martine Rothblatt, Michael D. Bentley, Xuan Zhao