Patents Assigned to United Therapeutic Corporation
  • Iminosugars and methods of treating viral diseases
    Patent number: 8450345
    Abstract: Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: May 28, 2013
    Assignees: The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics Corporation
    Inventors: Urban Ramstedt, Brennan Klose, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • Combinatorial library approach to iminocyclitols with biological activity
    Patent number: 8445670
    Abstract: A method of synthesizing stereochemically defined iminocyclitol comprises replacing an intraring oxygen in a cyclic sugar by an intraring imine to form an iminocyclitol, wherein said iminocyclitol has a defined stereochemical configuration different from a stereochemical configuration of the cyclic sugar. The invention also provides combinatorial libraries of iminocyclitol compounds, allowing for diverse C1 and N-substitution. In addition, provided are methods of treating viral infections with iminocyclitols compounds.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: May 21, 2013
    Assignee: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Carmen Mitan, Kenneth R. Phares
  • Iminosugars and methods of treating bunyaviral and togaviral diseases
    Patent number: 8426445
    Abstract: Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: April 23, 2013
    Assignees: United Therapeutics Corporation, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Urban Ramstedt, Brennan Klose, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • TREPROSTINIL TREATMENT FOR INTERSTITIAL LUNG DISEASE AND ASTHMA
    Publication number: 20130096200
    Abstract: The present invention describes methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of interstitial lung disease or asthma, or a condition, such as pulmonary fibrosis, associated with interstitial lung disease or a condition associated with asthma. The invention also relates to kits for treatment and/or prevention of such condition that include an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 10, 2012
    Publication date: April 18, 2013
    Applicant: United Therapeutics Corporation
    Inventor: United Therapeutics Corporation
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 8410169
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: April 2, 2013
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola
  • Iminosugars and methods of treating bunyaviral and togaviral diseases
    Patent number: 8367705
    Abstract: Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: February 5, 2013
    Assignees: United Therapeutics Corporation, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Urban Ramstedt, Brennan Klose, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • Treprostinil formulation
    Patent number: 8350079
    Abstract: There is provided a stable monohydrate form of treprostinil and pharmaceutical formulation comprising the same, method of making and using the same.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: January 8, 2013
    Assignee: United Therapeutics Corporation
    Inventor: David A. Walsh
  • Solid formulations of prostacyclin analogs
    Patent number: 8349892
    Abstract: Moderate moisture levels, such as greater than 3% but no greater than 7%, may be beneficial for solid formulations of certain prostacyclin analogs. Accordingly, a solid formulation containing a prostacyclin analog may be packaged inside a pharmaceutical packaging with such amount of a desiccant or a drying agent that after the storage the solid formulation may have a moderate level of moisture in it.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: January 8, 2013
    Assignee: United Therapeutics Corporation
    Inventor: Kenneth R. Phares
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 8252839
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: August 28, 2012
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola
  • Process to prepare treprostinil, the active ingredient in remodulin
    Patent number: 8242305
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: August 14, 2012
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 8232316
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: July 31, 2012
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola
  • Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
    Patent number: 7999007
    Abstract: Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: August 16, 2011
    Assignee: United Therapeutics Corporation
    Inventors: Roger Jeffs, David Zaccardelli
  • Use of Treprostinil to treat neuropathic diabetic foot ulcers
    Patent number: 7879909
    Abstract: The present invention describes novel methods for using 9-deoxy-2?,9-?-methano-3-oxa-4,5,6-trinor-3,7-(1?,3?-interphenylene)-13,14-dihydro-prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: February 1, 2011
    Assignee: United Therapeutics Corporation
    Inventors: Michael Wade, Roger Andrew Jeffs, Deborah Strootman
  • Long chain n-alkyl compounds and oxa-derivatives thereof
    Patent number: 7816560
    Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: October 19, 2010
    Assignees: Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics Corporation
    Inventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
  • Cooperative processing with mobile monitoring device and computer system
    Patent number: 7715905
    Abstract: An arrangement includes a mobile device executing a process to detect an episode in electrical signals representative of a beating heart. The mobile device determines that the detected episode is a notable finding and sends data corresponding to the notable finding to a second system. The second system analyzes the data corresponding to the notable finding using one or more additional computing resources.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: May 11, 2010
    Assignee: United Therapeutics Corporation
    Inventors: Raymond C. Kurzweil, Paul Albrecht, Lucy Gibson
  • Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy
    Patent number: 7612093
    Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: November 3, 2009
    Assignee: United Therapeutics Corporation
    Inventors: Gary S. Jacob, Timothy M. Block, Raymond A. Dwek
  • Atrial fibrillation detection
    Patent number: 7596405
    Abstract: Atrial fibrillation is detected in an electrical signal representative of a beating heart by measuring atrial activity over a time window of three or more beats, measuring beat interval variation over the time window and combining the measures of atrial activity and beat interval variation to produce an indication of an atrial fibrillation condition in the electrical signal.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: September 29, 2009
    Assignee: United Therapeutics Corporation
    Inventors: Raymond C. Kurzweil, Lucy Gibson, Paul Albrecht, Paul Grimshaw
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 7544713
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: June 9, 2009
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 7417070
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: August 26, 2008
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 7384978
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: June 10, 2008
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola