Patents Assigned to United Therapeutic Corporation
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20150299091
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Dosage inhaler
    Patent number: 9155846
    Abstract: A dosage inhaler includes an active liquid container, which contains a liquid having an active ingredient dissolved therein, and an atomizer by which the liquid is transformed into an aerosol and can be introduced into an aerosol dome, in which there is a baffle plate and to which an inlet tube and an outlet tube are attached, and an electronic control. The atomizer can be intermittently operated by a user and the user command readout is visible to the user. The generation of the amount of aerosol inside, and below, the aerosol dome is able to be separated in time from its eventual inhalation by the user.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: October 13, 2015
    Assignee: United Therapeutics Corporation
    Inventor: Joachim Kern
  • Process to prepare treprostinil, the active ingredient in remodulin®
    Patent number: 9156786
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: October 13, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • SALTS OF TREPROSTINIL
    Publication number: 20150266801
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: February 27, 2015
    Publication date: September 24, 2015
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS
    Publication number: 20150259274
    Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
    Type: Application
    Filed: May 13, 2015
    Publication date: September 17, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Ken PHARES, David MOTTOLA
  • TREATMENT OF PULMONARY ARTERIAL HYPERTENSION WITH MESENCHYMAL STEM CELLS
    Publication number: 20150246078
    Abstract: The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
    Type: Application
    Filed: July 30, 2013
    Publication date: September 3, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • IMINOSUGARS AND METHODS OF TREATING VIRAL DISEASES
    Publication number: 20150224128
    Abstract: Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
    Type: Application
    Filed: April 27, 2015
    Publication date: August 13, 2015
    Applicants: United Therapeutics Corporation, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Urban Ramstedt, Brennan Klose, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • TREATMENT OF PULMONARY ARTERIAL HYPERTENSION WITH PROSTACYCLIN-TREATED ENDOTHELIAL PROGENITOR CELLS
    Publication number: 20150216909
    Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a by perproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
    Type: Application
    Filed: July 30, 2013
    Publication date: August 6, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • Long chain N-alkyl compounds and oxa-derivatives thereof
    Patent number: 9089515
    Abstract: Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: July 28, 2015
    Assignees: Thomas Jefferson University, The Chancellor, Masters and Scholars of the University of Oxford, United Therapeutics Corporation
    Inventors: Nicole Zitzmann, Terry D. Butters, Frances M. Platt, Gary S. Jacob, Donald H. Picker, Sandra Carrouee, George W. J. Fleet, Raymond A. Dwek, David Durantel, Anand Mehta, Timothy M. Block
  • INHALATION FORMULATIONS OF TREPROSTINIL
    Publication number: 20150164834
    Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 24, 2015
    Publication date: June 18, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 9050311
    Abstract: This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: June 9, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola, Hitesh Batra
  • Iminosugars and methods of treating viral diseases
    Patent number: 9044470
    Abstract: Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: June 2, 2015
    Assignees: United Therapeutics Corporation, The Chancellor, Masters and Scholars of The University of Oxford
    Inventors: Urban Ramstedt, Brennan Klose, Nicole Zitzmann, Raymond A. Dwek, Terry D. Butters
  • TREPROSTINIL PRODUCTION
    Publication number: 20150105582
    Abstract: The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
  • Treatment for pulmonary hypertension
    Patent number: 8969409
    Abstract: One embodiment relates to a method of treating pulmonary hypertension based upon co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension. The benefit of the co-administration of these agents is to eliminate or reduce one or more side effects associated with mono-therapy of either agent, as well as one or more side effects associated with other administration routes such as subcutaneous or intravenous administration.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: March 3, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Martine A. Rothblatt, Lewis J. Rubin
  • Treprostinil production
    Patent number: 8940930
    Abstract: The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 27, 2015
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
  • COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS
    Publication number: 20150005374
    Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
    Type: Application
    Filed: September 18, 2014
    Publication date: January 1, 2015
    Applicant: United Therapeutics Corporation
    Inventors: Ken Phares, David MOTTOLA, Roger Jeffs
  • CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS
    Publication number: 20140323567
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicant: United Therapeutics Corporation
    Inventor: Peter Laing
  • PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS
    Publication number: 20140288314
    Abstract: A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 25, 2014
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • SALTS OF TREPROSTINIL
    Publication number: 20140275616
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang
  • SOLID FORMS OF TREPROSTINIL
    Publication number: 20140275262
    Abstract: There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: United Therapeutics Corporation
    Inventors: Ken Phares, Michael Scannell