Patents Assigned to United Therapeutic Corporation
  • METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION
    Publication number: 20200222412
    Abstract: The present disclosure provides compositions and methods for treating pulmonary hypertension. The compositions and methods are based on administering a NO-releasing compound, such as nitrite, to a subject in need thereof in an amount sufficient to increase the level of circulating nitric oxide (NO), a potent vasodilator, thereby reducing the subject's blood pressure and increasing blood flow.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Applicant: United Therapeutics Corporation
    Inventor: Martine A. Rothblatt
  • Inhalation formulations of treprostinil
    Patent number: 10695308
    Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: June 30, 2020
    Assignee: United Therapeutics Corporation
    Inventor: Michael Wade
  • COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS
    Publication number: 20200181057
    Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 11, 2020
    Applicant: United Therapeutics Corporation
    Inventor: Ken Phares
  • TREPROSTINIL ADMINISTRATION BY INHALATION
    Publication number: 20200171044
    Abstract: Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
    Type: Application
    Filed: January 31, 2020
    Publication date: June 4, 2020
    Applicant: United Therapeutics Corporation
    Inventors: Horst OLSCHEWSKI, Robert ROSCIGNO, Lewis J. RUBIN, Thomas Schmehl, Werner SEEGER, Carl STERRITT, Robert VOSWINCKEL
  • CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS
    Publication number: 20200062691
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Application
    Filed: October 29, 2019
    Publication date: February 27, 2020
    Applicant: United Therapeutics Corporation
    Inventor: Peter Laing
  • Process to prepare treprostinil, the active ingredient in Remodulin®
    Patent number: 10548863
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 4, 2020
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20200030271
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: October 7, 2019
    Publication date: January 30, 2020
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • TREPROSTINIL ADMINISTRATION BY INHALATION
    Publication number: 20190365778
    Abstract: Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
    Type: Application
    Filed: August 9, 2019
    Publication date: December 5, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Horst OLSCHEWSKI, Robert ROSCIGNO, Lewis J. RUBIN, Thomas SCHMEHL, Werner SEEGER, Carl STERRITT, Robert VOSWINCKEL
  • Controlled release pharmaceutical formulations
    Patent number: 10494327
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: December 3, 2019
    Assignee: United Therapeutics Corporation
    Inventor: Peter Laing
  • Process to prepare treprostinil, the active ingredient in Remodulin®
    Patent number: 10478410
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: November 19, 2019
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS
    Publication number: 20190345091
    Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
    Type: Application
    Filed: July 23, 2019
    Publication date: November 14, 2019
    Applicant: United Therapeutics Corporation
    Inventor: Ken Phares
  • APPARATUS AND METHOD FOR CONTROLLING FLUID FLOW
    Publication number: 20190331145
    Abstract: Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.
    Type: Application
    Filed: April 29, 2019
    Publication date: October 31, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Anna GALEA, Joseph Beuford Parse, Kylie Stengel, Kristen LeRoy, Minh Duong, Samuel Harrington Warner, Andrew Evan Kamholz, Brandon Johnson
  • SALTS OF TREPROSTINIL
    Publication number: 20190256449
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang
  • Treprostinil administration by inhalation
    Patent number: 10376525
    Abstract: Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: August 13, 2019
    Assignee: United Therapeutics Corporation
    Inventors: Horst Olschewski, Robert Roscigno, Lewis J. Rubin, Thomas Schmehl, Werner Seeger, Carl Sterritt, Robert Voswinckel
  • INHALATION FORMULATIONS OF TREPROSTINIL
    Publication number: 20190231722
    Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 14, 2018
    Publication date: August 1, 2019
    Applicant: United Therapeutics Corporation
    Inventor: Michael Wade
  • SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
    Publication number: 20190233362
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Method for purifying antibodies using PBS
    Patent number: 10329323
    Abstract: Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition. The method disclosed here can be particularly useful for removing one or more impurities from the biologic composition, such as bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane (Bis-tris).
    Type: Grant
    Filed: July 25, 2015
    Date of Patent: June 25, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, United Therapeutics Corporation
    Inventors: Samir H. Shaban, Mary P. Koleck, David A. Meh, Gerald M. Farquharson, Timothy O. Atolagbe, George Mitra
  • Process to prepare treprostinil, the active ingredient in remodulin®
    Patent number: 10322099
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: June 18, 2019
    Assignee: UNITED THERAPEUTICS CORPORATION
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • TREATMENT OF VASCULOPATHY WITH PROSTACYCLIN AND MESENCHYMAL STEM CELLS
    Publication number: 20190160032
    Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
    Type: Application
    Filed: September 21, 2018
    Publication date: May 30, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • SALTS OF TREPROSTINIL
    Publication number: 20190127307
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: June 1, 2018
    Publication date: May 2, 2019
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay SHARMA, Sanmin YANG, Yi ZHANG