Patents Assigned to United Therapeutic Corporation
  • SOLID FORMS OF TREPROSTINIL
    Publication number: 20180072649
    Abstract: There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same.
    Type: Application
    Filed: October 25, 2017
    Publication date: March 15, 2018
    Applicant: United Therapeutics Corporation
    Inventors: Kenneth Phares, Michael SCANNELL
  • INHALATION FORMULATIONS OF TREPROSTINIL
    Publication number: 20180042876
    Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 24, 2017
    Publication date: February 15, 2018
    Applicant: United Therapeutics Corporation
    Inventor: Michael Wade
  • PROCESS FOR MAKING BERAPROST
    Publication number: 20180037563
    Abstract: A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
    Type: Application
    Filed: September 18, 2017
    Publication date: February 8, 2018
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 9878972
    Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: January 30, 2018
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola
  • CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS
    Publication number: 20170369416
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Applicant: United Therapeutics Corporation
    Inventor: Peter Laing
  • EXTRACELLULAR VESICLES WITH ENHANCED POTENCY
    Publication number: 20170360840
    Abstract: Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
    Type: Application
    Filed: June 16, 2017
    Publication date: December 21, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Sarah HOGAN, Roger Marquez ILAGAN, Maria Pia RODRIGUEZ, Carolina MEDRANO, John CHEADLE
  • Solid forms of treprostinil
    Patent number: 9822057
    Abstract: There is provided individual polymorphic forms of treprostinil and pharmaceutical formulations comprising the same, methods of making and using the same.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 21, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, Michael Scannell
  • SALTS OF TREPROSTINIL
    Publication number: 20170267619
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: June 6, 2017
    Publication date: September 21, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay SHARMA, Sanmin YANG, Yi ZHANG
  • Process for making beraprost
    Patent number: 9765047
    Abstract: A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer steps than the known methods for making these compounds and can be used to scale up the reaction more easily to produce commercial quantities.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: September 19, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Liang Guo
  • Controlled release pharmaceutical formulations
    Patent number: 9758465
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: September 12, 2017
    Assignee: United Therapeutics Corporation
    Inventor: Peter Laing
  • Parenteral formulations of treprostinil
    Patent number: 9713599
    Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: July 25, 2017
    Assignee: United Therapeutics Corporation
    Inventor: Michael Wade
  • SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION
    Publication number: 20170197898
    Abstract: The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound.
    Type: Application
    Filed: February 23, 2017
    Publication date: July 13, 2017
    Applicant: United Therapeutics Corporation
    Inventor: Vijay Sharma
  • Salts of treprostinil
    Patent number: 9701611
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: July 11, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20170181990
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: March 10, 2017
    Publication date: June 29, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
    Publication number: 20170158602
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Application
    Filed: February 22, 2017
    Publication date: June 8, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20170144958
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®
    Publication number: 20170144957
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
  • Compounds and methods for delivery of prostacyclin analogs
    Patent number: 9624156
    Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: April 18, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Ken Phares, David Mottola, Roger Jeffs
  • TREPROSTINIL FORMULATIONS
    Publication number: 20170095432
    Abstract: Provided are ion complexes comprising treprostinil and an ion-exchange resin, pharmaceutical formulations based on such complexes, and methods of treating diseases and conditions using the ion complexes and pharmaceutical formulations.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 6, 2017
    Applicant: United Therapeutics Corporation
    Inventors: Ken PHARES, Courtney CHANG
  • Synthesis of intermediate for treprostinil production
    Patent number: 9611206
    Abstract: The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: April 4, 2017
    Assignee: United Therapeutics Corporation
    Inventor: Vijay Sharma