Patents Assigned to UNIVERSITÉ DE LILLE
  • Patent number: 11364219
    Abstract: The present invention relates to the treatment of microbiome dysregulations. Said dysregulations may subsequently contribute to the development of several chronic diseases. Thus characterization of new post-biotic compounds inducing beneficial changes on host-microbiota interactions may be highly desirable. The inventors showed that Nlrp6 diurnally coordinates cyclical adaptation of the gut microbiota diversity to epithelial plasticity in response to a treatment with a Csnk2 inhibitor. The invention therefore relates to an inhibitor of Csnk2, for use in the treatment of microbiome dysregulations notably associated with circadian clock disruption. Said inhibitor may be selected among chemically synthesized or natural selective Csnk2 inhibitors such as flavones.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: June 21, 2022
    Assignees: INSERM (INSTITUT NATION DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE LILLE, INSTITUT PASTEUR DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CRNS—
    Inventor: Mathias Chamaillard
  • Publication number: 20220137706
    Abstract: A system includes sensor-actuator units fixed onto a plate to be actuated according to at least one predetermined vibratory mode, each sensor-actuator unit having an electromechanical actuator and a deformation or vibratory speed sensor, wherein the electromechanical actuator and the sensor are colocated on the surface, that is to say that the measurement by the sensor is performed in immediate proximity to the electromechanical actuator, this proximity being such that the actuator and the sensor can respectively actuate and measure the same predetermined vibratory mode.
    Type: Application
    Filed: February 27, 2020
    Publication date: May 5, 2022
    Applicants: HAP2U, Université de Lille
    Inventors: Frederic GIRAUD, Christophe GIRAUD-AUDINE, Michel AMBERG, Betty LEMAIRE-SEMAIL, Bruno CHALLIOL
  • Publication number: 20220042926
    Abstract: A microstrip-type microwave sensor for the measurement of the dielectric properties of a solid or liquid material, constituted by a main line and two connected transmission lines integral at one of their extremities to the main line, the main line and two connected transmission lines being spaced from one another by a slot and being made integral with a substrate. The main line is connected to an electrical circuit by each of its two extremities to inject a sinusoidal signal, and wherein said main line has a width giving it an impedance in the range 50 Ohm, the two connected transmission lines being of the same width and of a length equal to one quarter of the wavelength guided in the substrate, the substrate having a height or thickness giving it flexibility or rigidity, the substrate being applied to a metallic support formed of a layer of metallic material.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 10, 2022
    Applicants: UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ASSOCIATION YNCRÉA HAUTS-DE-FRANCE, ECOLE CENTRALE DE LILLE, UNIVERSITÉ POLYTECHNIQUE HAUTS-DE-FRANCE
    Inventors: Etienne HERTH, Christophe LOYEZ, Laurie CALVET
  • Publication number: 20220026381
    Abstract: This invention concerns a method for analysing the ageing stability of a bituminous binder, in particular by reference to its susceptibility to oxidation, by analysing a sample of the bituminous binder by means of electron spin resonance and measuring the integral of the signal of the carbon-centred stable radicals; accelerated ageing of the bituminous binder, comprising: i) heating the bituminous binder, followed by ii) heating the bituminous binder resulting from step i) under pressure; analysing a sample of the aged bituminous binder obtained from step b) by means of electron spin resonance and measuring the integral of the signal of the carbon-centred stable radicals; and comparing the integral of the signal of the carbon-centred stable radicals of the bituminous binder obtained from the first step and that obtained from the previous step.
    Type: Application
    Filed: November 26, 2019
    Publication date: January 27, 2022
    Applicants: TOTAL MARKETING SERVICES, Centre national de la recherche scientifique, Université de Lille
    Inventors: Manuel MERCE, Simon PONDAVEN, Philippe MARCHAND, Hervé VEZIN, Karima BEN TAYEB MEZIANE
  • Patent number: 11226343
    Abstract: The present invention relates to methods and kits for diagnosing a postoperative pulmonary infection in a patient who underwent surgery. More particularly, the present invention relates to a method for diagnosing a postoperative pulmonary infection in a patient who underwent surgery, comprising a step consisting of measuring the concentration of endocan in a blood sample obtained from said patient, at a time point comprised between 3 h and 30 h after surgery.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: January 18, 2022
    Assignees: BIOTHELIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LE RECHERCHE MEDICAL), INSTITUT PASTEUR DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE DE LILLE
    Inventors: Philippe Lasalle, Sidney Chocron, Nathalie De Freitas Caires
  • Patent number: 11226262
    Abstract: This device comprises an immobilizing device of a first portion of the shaft, the shaft extending along a first axis, and a movement device of a second portion of the shaft so as to load the shaft in bending. The moving device comprises a first cylinder, a second cylinder, and a connecting device configured to form, between the shaft and one end of the first cylinder, a first connection prohibiting a translation perpendicular to the first axis and allowing a rotation around the first axis, and to form, between the shaft and one end of the second cylinder or between the end of the first cylinder connected to the shaft and one end of the second cylinder, a second connection prohibiting a translation perpendicular to the first axis and allowing a rotation around a second axis parallel to the first axis.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: January 18, 2022
    Assignees: MG-VALDUNES, Université de Lille
    Inventors: Florent Brunel, Philippe Dufrénoy, François Demilly
  • Publication number: 20210382290
    Abstract: According to one aspect, the invention relates to a device (200) for transporting and controlling light beams comprising a light guide (40) comprising a bundle (50) of uncoupled single-mode optical fibers (Fi), each single-mode optical fiber (Fi) being intended to receive an elementary light beam (B1i) at a proximal end and to emit a light beam (B2i) at a distal end, said bundle of single-mode optical fibers comprising, in operation, a minimum radius of curvature corresponding to a maximum curvature of the bundle of fibers.
    Type: Application
    Filed: September 10, 2019
    Publication date: December 9, 2021
    Applicants: Centre National de la Recherche Scientifique, Université d'Aix-Marseille, Université de Lille, Ecole Centrale de Marseille
    Inventors: Hervé Rigneault, Géraud Bouwmans, Esben Andresen, Siddarth Sivankutty, Viktor Tsvirkun, Olivier Vanvincq
  • Patent number: 11168183
    Abstract: The present invention concerns a method for producing a hydrogel comprising the following steps in succession: a first step (i) of providing at least one powder of an anionic polymer (A) and at least one chitosan powder (B) comprising amine functions (—NH2); a second step (ii) consisting in dry mixing at least the powders (A) and (B) from the first step in order to form a mixture of powders; a third step (iii) of suspending the mixture of powders obtained from the second step in an aqueous medium having a pH that can enable the anionic polymer (A) to be dissolved without dissolving the chitosan (B); a fourth step (iv) of adding an acid to the suspension obtained from the third step in order to form the hydrogel; or the third (iii) and fourth (iv) steps are replaced by a mixing fifth step (v), comprising mixing an acidified aqueous medium including at least one compound (C) comprising at least one unit of a hexose or a unit derived from a hexose, and/or at least one phosphate of said compound (C), with said
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: November 9, 2021
    Assignees: UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
    Inventors: Nicolas Blanchemain, Bernard Martel, Claudia Flores, Frédéric Cazaux, Feng Chai, Nicolas Tabary, Marco Lopez Heredia
  • Patent number: 11135443
    Abstract: System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: October 5, 2021
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Lille, Centre Hospitalier Regional et Universitaire de Lille (CHRU)
    Inventors: Maximilien Vermandel, Clement Dupont, Nicolas Reyns, Pascal Deleporte, Serge Mordon, Nacim Betrouni
  • Publication number: 20210262868
    Abstract: An optical fibre, for use in the field of distributed measurement of temperature or deformation by optical reflectometry in the frequency domain using the Rayleigh backscattered signal in the fibre, includes a core doped with nanoparticles for example formed from gold particles covered with zirconium oxide, and can be subjected to high temperatures during the measurement. A method for producing the optical fibre includes a step of heat treatment during which the optical fibre is subjected, for a duration of at least one hour, to a heat treatment temperature higher than a maximum temperature to which it will be subjected during a measurement.
    Type: Application
    Filed: June 21, 2019
    Publication date: August 26, 2021
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE
    Inventors: Patrick BULOT, Remy BERNARD, Odile CRISTINI, Monika BOUET, Guillaume LAFFONT, Marc DOUAY
  • Patent number: 11099205
    Abstract: A device for measuring an acceleration includes a vibrating accelerometer including: a semiconductor substrate forming a fixed frame of the accelerometer; a test weight of the same material as the substrate and connected to the fixed frame, movable translationally along at least one sensing axis of the vibrating accelerometer; a guide of the same material as the substrate, connected to the fixed frame and test weight, guiding the test weight in the direction of the sensing axis; a layer made of a piezoelectric semiconductor deposited on the substrate, the layer being tensilely prestrained; a resonator in the layer connected to the fixed frame, the resonator subjected to tension or compression in the direction of the sensing axis; and at least one transducer connected to the resonator, able to actuate the resonator, to keep the resonator oscillating and/or to detect an electrical signal generated by the resonator.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: August 24, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE
    Inventors: Marc Faucher, Christophe Morelle
  • Publication number: 20210257908
    Abstract: A continuous time digital signal processing (CT DSP) token includes a first signal indicating a change has occurred and a second signal indicating a direction of the change. An amplitude generation circuit operates to generate an amplitude value x in response to the token. A power estimation circuit processes the amplitude value x to generate a digital power signal in accordance with the formula: x2±2x+1.
    Type: Application
    Filed: February 13, 2020
    Publication date: August 19, 2021
    Applicants: Universite de Lille, Centre National De La Recherche Scientifique, ISEN Yncrea Hauts-de-France, STMicroelectronics SA
    Inventors: Angel de Dios GONZALEZ SANTOS, Andreas KAISER, Antoine FRAPPE, Philippe CATHELIN, Benoit LARRAS
  • Patent number: 11090698
    Abstract: Method for increasing the ability of at least one droplet to slide over a medium. An ultrasonic surface wave is generated in the medium with a sufficient amplitude to cause the droplet to deform in an inertio-capillary eigen-vibration mode, thus decreasing the attachment of the droplet to the medium, so as to make it easier for the droplet to move under the effect of an external force, the amplitude of the ultrasonic surface wave being insufficient to cause the droplet to deform asymmetrically to the point that it moves in the absence of the external force in the direction of propagation of the ultrasonic surface wave.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 17, 2021
    Assignees: UNIVERSITÉ DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE CENTRALE DE LILLE
    Inventors: Adrien Bussonniere, Olivier Bou Matar-Lacaze, Michaël Baudoin, Philippe Brunet
  • Publication number: 20210214215
    Abstract: A nanostructure transfer method is provided. The method includes providing a first substrate (10) having thereon a plurality of nanostructures (12), the nanostructures (12) extending away from the first substrate (10). A solder material (14) is deposited on distal ends of the nanostructures (12). A second substrate (18) having thereon a first metal layer (20) is provided. The solder material (14) is bonded to the first metal layer (20), thereby attaching the nanostructures (12) to the second substrate (18). The attached nanostructures (12) are then released from the first substrate (10).
    Type: Application
    Filed: August 29, 2019
    Publication date: July 15, 2021
    Applicants: THALES SOLUTIONS ASIA PTE LTD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, NANYANG TECHNOLOGICAL UNIVERSITY, UNIVERSITÉ DE LILLE
    Inventors: Jianxiong Wang, Philippe Coquet, Beng Kang Tay
  • Patent number: 11052025
    Abstract: Disclosed is a microemulsion of oil-in-water type including, preferably consisting of, by weight relative to the total weight of microemulsion: •70% to 94% of water, •1% to 15% of at least one hydrophobic fragrancing substance, •4% to 20% of at least one preferably volatile solvo-surfactant, and •0.1% to 15%, preferably 1% to 13%, of at least one hydrotropic agent or at least one surfactant selected from anionic surfactants, cationic surfactants, amphoteric surfactants and non-ionic surfactants. The solvo-surfactant is selected from monoalkylated glycerol derivatives of following formula (I): wherein the “alkyl” group is a linear or branched alkyl group including from 1 to 8 carbon atoms, and R and R? are each independently H or a linear or branched alkyl group including from 1 to 5 carbon atoms, with the proviso that R is different from R?, and mixtures thereof.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: July 6, 2021
    Assignees: CHANEL PARFUMS BEAUTE, UNIVERSITE DE LILLE
    Inventors: Oriana Boucenna Verdier, Christian Mahe, Véronique Rataj-Nardello, Jean-Marie Aubry, Maxime Nollet, Raphaël Lebeuf
  • Patent number: 11008217
    Abstract: The invention relates to an installation and a method for treating hydrogen sulphide. In particular, the invention relates to an installation and a method comprising at least one system for oxidizing hydrogen sulfide to sulfur (S) and water (H2O) with a solid reagent and at least one oxidizing system with an agent for oxidizing the solid reagent present in the reduced state, wherein the system of oxidizing the hydrogen sulfide to sulfur and the system for oxidizing the solid reagent, are so arranged that the hydrogen sulfide is not brought into contact with the agent oxidizing the solid reagent.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 18, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE
    Inventors: Axel Lofberg, Jesus Guerrero
  • Publication number: 20210107984
    Abstract: The disclosure relates to an antibody which is directed against galectin-9 and is an inhibitor of the suppressor activity of regulatory T lymphocytes, and also to the use of this antibody for the treatment of diseases associated with the suppressor activity of regulatory T lymphocytes, in particular the treatment of cancer.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 15, 2021
    Applicants: Universite de Lille, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Cellvax, Universite Paris Saclay
    Inventors: Nadira Delhem, Pierre Busson, Olivier Morales, Clement Barjon, Dhafer Mrizak, Claire Lhuillier, Rami Mustapha
  • Patent number: 10961212
    Abstract: A method is for the preparation of furoic acid or of one of its derivatives of formula (I): in which R1, R2, R3 and R4 represent, independently of each other, a hydrogen atom, a linear or branched C1-C6 alkyl group, a —C(?O)—H group or a —COOH group, by heterogeneous catalytic oxidation of furfural or a derivative thereof of formula (II). The oxidation is carried out in the presence of a supported catalyst based on gold nanoparticles, and in a non-alkaline aqueous medium. A composition useful in the method includes at least furfural and supported gold nanoparticles.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: March 30, 2021
    Assignees: UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ALMA MATER STUDIORUM—UNIVERSITA' DI BOLOGNA
    Inventors: Sébastien Paul, Francesco Santarelli, Robert Wojcieszak, Franck Dumeignil, Fabrizio Cavani
  • Patent number: 10899838
    Abstract: The invention relates to an antibody which is directed against galectin-9 and is an inhibitor of the suppressor activity of regulatory T lymphocytes, and also to the use of this antibody for the treatment of diseases associated with the suppressor activity of regulatory T lymphocytes, in particular the treatment of cancer.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: January 26, 2021
    Assignees: Universite de Lille, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Cellvax, Universite Paris-Saclay
    Inventors: Nadira Delhem, Pierre Busson, Olivier Morales, Clement Barjon, Dhafer Mrizak, Claire Lhuillier, Rami Mustapha
  • Patent number: 10844008
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 24, 2020
    Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)
    Inventors: Patricia Melnyk, Patrick Vermersch, Pascal Carato, Bénédicte Oxombre-Vanteghem, Héléne Zephir, Marion Donnier-Marechal