Patents Assigned to UNIVERSITÉ DE LILLE
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Patent number: 10842635Abstract: A temporo-mandibular prosthesis including a glenoid part and a condylar part intended to be articulated relative to the glenoid part. The glenoid part including a glenoid support made in a metallic material; and a glenoid insert made in a non-metal lie material, and defining a seat for a head of said condylar part to define said articulation, wherein the glenoid support defines a housing having an opening through which said glenoid insert is insertable into said housing, said opening opening on an external side (E) of said glenoid support, the glenoid support comprising a tab configurable in a passive position and in an active position in which said tab allows and forbids, respectively, the insertion and the extraction, respectively, of said glenoid insert into and out of said housing, respectively.Type: GrantFiled: February 14, 2018Date of Patent: November 24, 2020Assignees: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre Hospitalier Regional Universitaire De Lille, Universite De LilleInventor: Joel Ferri
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Patent number: 10807958Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.Type: GrantFiled: June 15, 2018Date of Patent: October 20, 2020Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE DE LILLE 2 DROIT ET SANTEInventors: Nicolas Sergeant, Luc Buee, Patricia Melnyk, Marion Gay, Nicolas Le Fur
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Patent number: 10772884Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.Type: GrantFiled: August 27, 2019Date of Patent: September 15, 2020Assignees: Alzprotect, Universite De Lille 2 Droit Et Sante, INSERM (Institut National De La Sante Et De La Recherche)Inventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
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Patent number: 10736937Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial superinfections post-influenza. In particular, the present invention relates to a method of treating a bacterial superinfection post-influenza in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide optionally in combination with at least one antibiotic.Type: GrantFiled: December 22, 2015Date of Patent: August 11, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE LILLE, INSTITUT PASTEUR DE LILLEInventors: Jean-Claude Sirard, Christophe Carnoy, François Trottein, Rémi Porte
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Patent number: 10712865Abstract: A computerized device having a man-machine input interface, a controller and a display. The controller being arranged to control the display according to a control value measured on the man-machine input interface at a first measuring frequency.Type: GrantFiled: September 19, 2017Date of Patent: July 14, 2020Assignees: Université De Lille, Inria Institut National De Recherche En Informatique Et En AutomatiqueInventors: Géry Casiez, Denis Efimov, Rosane Ushirobira, Stanislav Aranovskiy, Nicolas Roussel
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Publication number: 20200179247Abstract: An oil-in-water microemulsion including, in weight percentages: between 70% and 94% of water; between 1% and 15% of at least one perfumed hydrophobic substance; between 4% and 20% of at least one preferably volatile solvo-surfactant, which is a monoalkylated glycerol derivative of formula (I); and between 0.1% and 15% of at least one anionic surfactant and at least one alkyl glucoside as a hydrotropic agent. The microemulsion can therefore be used to produce a fine fragrance composition or a cosmetic or personal hygiene composition.Type: ApplicationFiled: May 31, 2018Publication date: June 11, 2020Applicants: CHANEL PARFUMS BEAUTE, UNIVERSITE DE LILLEInventors: Oriana BOUCENNA VERDIER, Véronique RATAJ-NARDELLO, Jean-Marie AUBRY, Grégory DOUYERE, Corentine MAINGUY
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Patent number: 10584383Abstract: The present invention relates to a method for predicting mortality of a test patient with chronic heart failure comprising based on detecting the expression level of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 1 to 8. The present invention also relates to a method for predicting cardiac remodeling after myocardial infarction in a test patient based on detecting the expression level of one or more lncRNAs selected from SEQ ID NOs 1 to 8.Type: GrantFiled: March 18, 2015Date of Patent: March 10, 2020Assignees: MEDIZINISCHE HOCHSCHULE HANNOVER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITÉ DE LILLE 2 (LILLE 2)—UNIVERSITY OF LAW AND HEALTH, CENTRE HOSPITALIER UNIVERSITAIRE LILLE (CHU), INSTITUT PASTEUR DE LILLE (IPL)Inventors: Thomas Thum, Regalla Kumarswamy, Florence Pinet, Christophe Bauters, Pascal De Groote
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Patent number: 10561856Abstract: The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).Type: GrantFiled: November 25, 2014Date of Patent: February 18, 2020Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Lille 2 Droit et Santé, Centre Hospitalier Regional et Universitaire de Lille (CHRU)Inventors: Serge Mordon, Nacim Betrouni, Laurent Mortier
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Patent number: 10537569Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.Type: GrantFiled: December 22, 2016Date of Patent: January 21, 2020Assignees: ALZPROTECT, Universite de Lille 2 Droit et Saute, Inserm (Institut National De La Saute et de la Recherche MedicaleInventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
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Patent number: 10519945Abstract: A method for generating a flow of fluid, implemented in a device including a membrane (2) provided with at least one hole (20) and elements (4) generating back-and-forth movements, wherein a flow is generated through the membrane by actuating the membrane, at least in the region of the at least one hole (20), according to a mode of deformation of the at least one hole, causing the at least one hole to open and close and disturbing the fluid in order to generate the flow. The device suitable for implementing the method is also described.Type: GrantFiled: October 24, 2014Date of Patent: December 31, 2019Assignees: UNIVERSITÉ DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, ECOLE CENTRALE DE LILLEInventors: Alain Merlen, Farzam Zoueshtiagh, Abdelkrim Talbi, Philippe Pernod, Christophe Frankiewicz
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Publication number: 20190382361Abstract: A method is for the preparation of furoic acid or of one of its derivatives of formula (I): in which R1, R2, R3 and R4 represent, independently of each other, a hydrogen atom, a linear or branched C1-C6 alkyl group, a —C(?O)—H group or a —COOH group, by heterogeneous catalytic oxidation of furfural or a derivative thereof of formula (II). The oxidation is carried out in the presence of a supported catalyst based on gold nanoparticles, and in a non-alkaline aqueous medium. A composition useful in the method includes at least furfural and supported gold nanoparticles.Type: ApplicationFiled: March 16, 2017Publication date: December 19, 2019Applicants: Université de Lille, Ecole Centrale de Lille, Centre national de la recherche scientifique, Alma Mater Studiorum - Universita' di BolognaInventors: Sébastien PAUL, Francesco SANTARELLI, Robert WOJCIESZAK, Franck DUMEIGNIL, Fabrizio CAVANI
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Publication number: 20190374119Abstract: The present invention provides a method (30) of determining mechanical properties of the pelvic cavity of a person or an animal, the pelvic cavity including a plurality of organs and the method comprising a step (34) during which pressure is measured at one or more points of the surface of one of the organs of said pelvic cavity, and during which, simultaneously, movements of a plurality of organs of said pelvic cavity are also measured. The present invention also provides a measuring device for measuring pressure in an organ of the pelvic cavity in order to perform the above method (30). The measuring device comprises an optical fiber pressure sensor mounted in a non-metallic housing, and a closed flexible reservoir mounted in said non-metallic housing and having a surface, in particular a flexible surface, that constitutes a pressure measuring surface.Type: ApplicationFiled: February 20, 2018Publication date: December 12, 2019Applicants: UNIVERSITE DE LILLE, ECOLE CENTRALE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE, ECOLE NATIONALE SUPERIEURE D?ARTS ET METIERSInventors: Mathias BRIEU, Michel COSSON, Chrystèle RUBOD DIT GUILLET, Pauline LECOMTE, Jean-François WITZ, Laurent PATROUIX
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Patent number: 10435450Abstract: Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.Type: GrantFiled: January 21, 2016Date of Patent: October 8, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DE LILLE, UNIVERSITA' DEGLI STUDI DI PAVIA, UNIVERSITÉ DE LILLEInventors: Jerome Vicogne, Oleg Melnyk, Nathalie Ollivier, Eric Adriaenssens, Berenice Leclercq, Claire Simonneau, Giovanni De Nola, Ermanno Gherardi, Hugo De Jonge
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Publication number: 20190271613Abstract: This device comprises an immobilizing device of a first portion (4A) of the shaft, the shaft (4) extending along a first axis (A1), and a movement device of a second portion (4B) of the shaft so as to load the shaft (4) in bending. The moving device comprises a first cylinder (10), a second cylinder (12), and a connecting device (14) configured to form, between the shaft (4) and one end of the first cylinder (10), a first connection (16) prohibiting a translation perpendicular to the first axis (A1) and allowing a rotation around the first axis (A1), and to form, between the shaft (4) and one end of the second cylinder (12) or between the end of the first cylinder (10) connected to the shaft (4) and one end of the second cylinder (12), a second connection (18) prohibiting a translation perpendicular to the first axis (A1) and allowing a rotation around a second axis (A2) parallel to the first axis (A1).Type: ApplicationFiled: October 23, 2017Publication date: September 5, 2019Applicants: MG-VALDUNES, UNIVERSITE DE LILLEInventors: Florent BRUNEL, Philippe DUFRÉNOY, François DEMILLY
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Patent number: 10401567Abstract: An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the ?X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the ?X and ?Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.Type: GrantFiled: February 3, 2017Date of Patent: September 3, 2019Assignees: INSERM ( INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ DE LILLE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)Inventors: Serge Mordon, Pascal Delepôrte, Nacim Betrouni
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Patent number: 10393582Abstract: A method refocuses on an optical assembly target surface, using at least one beam originating from a short-pulse optical source, having at least one optical system for focusing the beam on the surface. Refocusing occurs after learning reference conditions for which the assembly is considered as focused. A focusing signal is detected representing a time overlap of pulses between a beam reflected and a reference beam not reflected by the surface, one of the beams delayed by a delay line. The optical path on which the delay line is placed is varied, on the basis of the reference conditions, to cause the focusing signal to reach or exceed a predetermined threshold. The focus is adjusted on the basis of the path variation between the reference conditions and the conditions for which the focusing signal reaches or exceeds the threshold.Type: GrantFiled: December 22, 2015Date of Patent: August 27, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE 1, ISENInventor: Arnaud Devos
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Patent number: 10369551Abstract: The present invention relates to the use of haloapatites as catalysts of the dehydration reaction of ?-hydroxylated carboxylic acids or acid esters, in particular of lactic acid or of methyl lactate, and also to a process for producing unsaturated carboxylic acids or acid esters, in particular acrylic acid or methyl acrylate, in the gas phase in a stainless steel reactor, in the presence of such a catalyst.Type: GrantFiled: December 8, 2015Date of Patent: August 6, 2019Assignees: ECOLE CENTRALE DE LILLE, UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Sébastien Paul, Benjamin Katryniok, Franck Dumeignil, Thomas Bonnotte
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Patent number: 10333267Abstract: A terahertz laser suitable for emitting at least one first electromagnetic radiation, a first emission frequency of which is between 700 and 1200 GHz. The laser comprises an infrared laser source and a resonant cavity arranged to be optically pumped by the infrared laser source, the resonant cavity containing ammonia gas as an amplifier medium and having at least one configuration in which the resonant cavity is a resonant cavity at the first emission frequency. The infrared laser source is a continuous semiconductor laser source capable of exciting molecules of the amplifier medium from an initial energy level to at least one first excited energy level, the molecules of the amplifier medium placed in the first energy level being able to relax through a pure inversion transition for which the relaxation energy corresponds to the first emission frequency.Type: GrantFiled: August 18, 2016Date of Patent: June 25, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLEInventors: Jean-François Lampin, Antoine Pagies
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Patent number: 10323016Abstract: The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.Type: GrantFiled: June 11, 2015Date of Patent: June 18, 2019Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Manuel Lassalle, Barbara Dubanchet
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Publication number: 20190130258Abstract: An artificial neuron including: a membrane capacitor; an input of an external synaptic excitation in current, the membrane capacitor integrating the input current; a negative-feedback impulse circuit, supplied by a power supply at a negative voltage between ?200 mV and 0 mV and at a positive voltage between 0 mV and +200 mV, including: a bridge based on pMOS and nMOS transistors in series and linked by a midpoint to the membrane capacitor, the midpoint defining the output of the artificial neuron, at least one delay capacitor between the gate and the source of one of the transistors of the bridge, at least two CMOS inverters between the membrane capacitor and the gates of the transistors of the bridge.Type: ApplicationFiled: April 7, 2017Publication date: May 2, 2019Applicants: UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Alain CAPPY, Francois DANNEVILLE, Virginie HOEL, Christophe LOYEZ