Abstract: There is provided herein high tensile strength cementitious matrices for use with a fabric-reinforced cementitious matrix (FRCM) system for repairing a concrete substrate. The FRCM systems include a high tensile strength cementitious matrix according to the present disclosure and a fabric mesh. The high tensile strength cementitious matrices can have an ultimate strength that is at least 1/600th of the ultimate strength of the fabric mesh or at least 2.5 MPa. The high tensile strength cementitious matrices can have a compression strength of at least 70 MPa. The FRCM system can have an ultimate strength that is at least 50% of the ultimate strength of the fabric mesh. The high tensile strength cementitious matrix can exhibit microcracks having a width of less than 100 ?m at a service load of the concrete substrate. The high tensile strength cementitious matrix can include 0.3% wt to 8% wt fibers.

Abstract: A method of selective deposition that includes disposing in a deposition chamber a patterned substrate of side-by-side areas of metal and dielectric. The deposition chamber is connected to a bubbler that contains an N-heterocyclic carbenes (NHC) precursor. By heating the bubbler, gaseous free NHC is generated which is pulsed into the deposition chamber, where the NHC selectively chemisorbs onto the metal surface. Annealing after deposition of NHC improves surface patterning by removing stray metal from the dielectric section.

Abstract: There is described a fiber laser system generally having a pump laser generating a pump laser beam; and a length of optical fiber optically coupled to the pump laser, the length of optical fiber having: a laser cavity having a cavity path, a first fiber Bragg grating having a first reflectivity profile, a second filter having a second filter profile, and an optical gain region between the first fiber Bragg grating and the second filter along the cavity path, the first reflectivity profile being spectrally detuned from the second filter profile, the first fiber Bragg grating having a first refractive index profile comprising a full width at half maximum bandwidth of at least 0.2 nm and a Gaussian-like apodization, wherein, upon pumping of the optical gain region with the pump laser beam and mode locking of the laser cavity, optical pulses are circulated along the cavity path; and an output.

Abstract: The invention relates to a method of treatment for early onset preeclampsia in a pregnant subject, including determining a level of soluble fms-like tyrosine kinase-1 (sFlt-1) or fragment(s) thereof in a sample that has been isolated from said pregnant subject. The invention further relates to the combined measurement of sFlt-1 and PlGF, The invention relates further to a kit for carrying out the method of the invention, including detection reagents for determining the level sFlt-1 or fragment(s) thereof, and optionally for determining the level of at least one additional biomarker, in a sample from a subject.

Abstract: The present document relates to amphiphilic poly(monoglycerol acrylate) (PMGA) polymers, comprising an hydrophilic repeating unit of monoglycerol acrylate and one or more biodegradable hydrophobic group and their use and methods of use in the delivery of bioactive agents. Additionally, the invention provides a method for preparing monoglycerol acrylate-based polymers.

Abstract: Lymphocytes having a suppressed autophagy gene useful in immunotherapy are disclosed. The lymphocytes can express an antigen targeting receptor such as a chimeric antigen receptor (CAR) or endogenous or engineered T-cell receptor to target cells expressing a tumor-specific antigen. Methods of making and using such lymphocytes are disclosed. Some such lymphocytes are useful in conducting CAR-T or TCR-T therapy.

Abstract: A method and system for determining a radiation dose is provided. The method can include receiving at least one polarized signal from a radio-luminescent element and determining a degree of linear polarization and an angle of linear polarization of the at least one polarized signal based on at least one predetermined polarization transmission axis. The system can include a polarization sensitive sensor for capturing at least one polarized signal from a radio-luminescent element; and a processor. The processor can be configured to: receive the at least one polarized signal; and determine a degree of linear polarization and an angle of linear polarization of the at least one polarized signal based on at least one predetermined polarization transmission axis.

Abstract: A spatial parallel mechanism comprises a platform. Three or more legs configured for extending from a base or ground to the platform, each leg has a distal link, one or more distal joint providing one rotational degree of freedom (DOF) about a distal rotational axis, the distal joint connecting a distal end of the distal link to the platform. A proximal joint provides at least two rotational DOFs at the proximal end of the distal link. Assemblies of joints and links provide DOFs to each said leg between the proximal joint and the base or ground. The distal rotational axes of the three legs are parallel to one another.

Abstract: The present invention relates to clinical diagnostics including diagnosis, prognosis, prediction, risk assessment and/or risk stratification of preterm birth (PTB) and subsequent treatment in a pregnant subject, and corresponding methods and products. The invention provides decision tools to help clinicians choosing the most appropriate management for the pregnant women. In particular, the present invention relates to a method for the diagnosis, prognosis, prediction, risk assessment and/or risk stratification of preterm birth (PTB) in a pregnant subject, the method comprising determining a level of one or more biomarkers in a sample that has been isolated from said pregnant subject, wherein the one or more biomarkers comprise at least one of matrix metallopeptidase 9 (MMP9) or fragment(s) thereof and Pappalysin-2 (PAPP-A2) or fragment(s) thereof, wherein the level of the one or more biomarkers in the sample is indicative of the presence or absence of a subsequent PTB.

Abstract: The present description relates to methods for clinically assessing Parkinson's disease in a subject using protein biomarkers of erythrocyte-derived extracellular vesicles (EEV).

Abstract: Methods and products are described herein for the modification of nucleic acids using a CRISPR/Cas9 system. Also described herein are uses of such methods and products for the modification of a target nucleic acid in a cell, in vitro or in vivo. Such methods and products may also be used for prevention or treatment of a condition associated with a target polynucleotide.

Abstract: Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.

Abstract: Colchicine derivative(s), method(s) and use(s) thereof for treatment of inflammation.

Abstract: The present application provides a synthetic method for production of 3-azido-3-deoxy-D-galactopyranose. Also provided are methods of using the 3-azido-3-deoxy-D-galactopyranose in the manufacture of galactoside galectin antagonists, such as TD139 (GB0139), GB1107, GB2064, and GB1211.

Abstract: Fiber amplifiers for extending their gain bandwidth through an optimization of the host matrix using phosphorus/aluminum (P/Al) as glass modifier are provided. In one aspect, an optical glass fiber comprising an Erbium doped silicate is provided, where the optical glass fiber comprises P2O5 of greater than 6 mol %; and Al2O3 of between 1.5 and 6 mol %, where a molar percent ratio of the P2O5 and the Al2O3 is between 2 and 4. Further, in some cases, use of yttrium as an alternative co-dopant to ytterbium may be used.

Abstract: A process for the total synthesis of selenoneine, iso-selenoneine, and isomers thereof is disclosed herein. Regarding the synthesis of selenoneine, the process comprises reacting an alkylated L-histidine methyl ester with a stable, acid-labile alkylating agent followed by reaction with elemental selenium under mildly basic conditions; and an acidic hydrolysis step. Regarding the synthesis of iso-selenoneine, the process comprises reacting hercynine with an electrophilic R—Se—X species, wherein the R—Se—X species is obtained by reaction of an alkyl diselenide with X2, and wherein X is F, Cl, Br or I; and a deprotection reaction.

Abstract: There is provided a process for manufacturing a carbonaceous anode for an electrolysis cell for the production of aluminium. The process comprises contacting coke particles with a boron-containing solution to obtain boron-impregnated coke particles, mixing the boron-impregnated coke particles with coal tar pitch to form an anode paste, and forming a green anode with the anode paste. A carbonaceous anode for an electrolysis cell for the production of aluminium is also provided, which comprises at least a first fraction of coke particle, a second fraction of coke particles and coal tar pitch, wherein at least the first faction of coke particles comprises boron-impregnated coke particles, the boron-impregnated coke particles being distributed throughout the carbonaceous anode. The carbonaceous anode presents good resistivity towards air and CO2 oxidation, which translates into less dusting of the anode, thus improving its integrity throughout its lifetime.

Abstract: There is described a method for determining a refractive index of a medium. The method generally has providing a substrate having a surface, the surface having a first surface portion and a second surface portion spaced-apart from the first surface portion and recessed of a depth relative to the first surface portion; receiving the medium at least on the second surface portion; propagating a first optical beam towards the first surface portion and a second optical beam towards the second surface portion; collecting the first and second optical beams after said propagating and generating first and second signals being indicative of a phase of a respective one of the first and second collected optical beams; and determining a refractive index of said medium based on the first and second signals, the depth, a wavelength associated to the first and second optical beams and a refractive index of the substrate.

Abstract: Mid-infrared-transparent optical fiber products with enhanced resistance to OH diffusion are disclosed, which may be used fiber laser oscillator and amplifiers systems. In one embodiment, an optical fiber product may include optical fiber configured for propagation of mid-infrared radiation toward a light-radiating endface of or coupled to the optical fiber, and a diffusion barrier disposed on the light-radiating endface and configured for allowing the mid-infrared radiation emanating from the light-radiating endface to pass therethrough and for preventing OH diffusion therethrough toward the light-radiating endface.

Abstract: A method for treating a subject to reduce the risk of early onset preeclampsia in a pregnant subject determining a level of soluble fms-like tyrosine kinase-1 (sFlt-1) or fragment(s) thereof in a sample that has been isolated from said pregnant subject. The the sample is isolated from a subject before the end of the 12th week of gestation, where the level of sFlt-1 or fragment(s) thereof is indicative of early onset preeclampsia occurring before the end of the 33rd week of gestation. The subject is then treated to decrease the risk of developing, delay the time point of the onset and/or reduce the severity of preeclampsia.