Patents Assigned to Université Laval
  • Patent number: 11409140
    Abstract: There is described an optical phase modulator generally having a substrate; a waveguide mounted to the substrate and extending along a path of the substrate, the waveguide having a first series of phase shift units distributed along the waveguide, each phase shift unit having two Bragg gratings being spaced apart from one another along the path and a cavity between the two spaced-apart Bragg gratings; and a modulation circuit configured for driving a length of the series of phase shift units of the waveguide in accordance with a modulation signal thereby modulating a refractive index of the waveguide to induce a phase shift to an optical signal propagating along the waveguide.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 9, 2022
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Wei Shi, Larochelle Sophie, Omid Jafari
  • Patent number: 11390878
    Abstract: A method of increasing the yield, stability, or both of an acid sensitive protein in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant. The first nucleic acid comprises a first regulatory region active in the plant and operatively linked to a nucleotide sequence encoding the acid sensitive protein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a channel protein, for example but not limited to a proton channel protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby increasing the yield of the acid sensitive protein when compared to the yield of the acid sensitive protein produced in the plant or portion of the plant produced under the same conditions, and in the absence of the proton channel protein.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: July 19, 2022
    Assignees: MEDICAGO INC., UNIVERSITE LAVAL
    Inventors: Marc-Andre D'Aoust, Manon Couture, Louis-Philippe Vezina, Dominique Michaud, Philippe Varennes-Jutras, Frank Sainsbury
  • Patent number: 11366977
    Abstract: A method for determining a threshold for spike detection in a noisy signal in real-time is provided. The method includes estimating a current variability of noise in the noisy signal according to a measured instantaneous value and a window of previous instantaneous values using a sigma-delta control loop, determining the threshold based on the estimated variability of the noise; and repeating the steps to update the estimate of the variability of the noise and adjust the threshold in real-time as the noisy signal changes. A non-transitory computer-readable storage medium for executing the method on a processing unit, and a low-power digital system implementing the method are also provided.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: June 21, 2022
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Gabriel Gagnon-Turcotte, Benoit Gosselin
  • Patent number: 11365386
    Abstract: There is described a cellular behaviour monitoring device for monitoring changes in behaviour of cells contained in a sample. The device generally has a well plate with a sample receiving well recessed therein. A filter membrane extends across the well plate and hermetically covers the sample receiving well. The filter membrane has nutrient-permeable and cell-impermeable pores extending through the filter membrane. The device has an electrode layer extending across the filter membrane. The electrode layer has a substrate and behaviour monitoring electrodes spaced-apart from one another in a region of the substrate, with the region being aligned with the sample receiving well. The electrode layer has nutrient-permeable apertures distributed across the region, with at least some of pores are aligned with at least some of the apertures to allow fluid communication therebetween, and nutrient exchange between the sample receiving well and a surrounding environment.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: June 21, 2022
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Benoit Gosselin, Younès Messaddeq, Jacques Corbeil, Eric Bharucha
  • Patent number: 11359010
    Abstract: It is provided an inhibitor of Toll-like Receptor 2 (TLR2) that specifically blocks an interaction between S1009A and Toll-like Receptor 2 (TLR2), and more particularly a humanized antibody against S100A9 protein for inhibiting and treating inflammatory conditions in a human patient. Particularly, this humanized antibody is specific for blocking the interaction between the S100A9 protein and the TLR-2 receptor.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 14, 2022
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Philippe Tessier, Mélanie Tardif, Traian Sulea
  • Patent number: 11351180
    Abstract: The present invention relates to a pharmaceutical or veterinary composition for the use thereof in preventing and/or treating infection by the influenza viruses. Said composition is characterized in that it contains, in an appropriate pharmaceutical carrier, at least one compound selected from among Etilefrine and Diltiazem.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: June 7, 2022
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), HOSPICES CIVILS DE LYON, UNIVERSITE LAVAL
    Inventors: Manuel Rosa-Calatrava, Olivier Terrier, Julien Textoris, Guy Boivin, Mario Pizzorno
  • Patent number: 11294076
    Abstract: A radiation dosimeter for measuring radiation dose within a region includes a structure having a scintillating material that emits light when exposed to radiation. Deformable radio-luminescent elements are located within the structure and configured to generate optical energy in response to irradiation.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 5, 2022
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Louis Archambault, Luc Beaulieu, Émily Cloutier
  • Patent number: 11285643
    Abstract: There is provided herein thermoset porous polymer composites a methods for producing such composites. The method comprises: preparing a mixture comprising a resin, optionally a curing agent, and dry ice; optionally casting the mixture; curing the mixture to obtain the porous composite; and optionally controlling at least one of a reaction rate and an expansion rate of the mixture during the curing.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: March 29, 2022
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Gholamali Sharifishourabi, Denis Rodrigue
  • Patent number: 11266705
    Abstract: The invention concerns a nutritional or therapeutic agent comprising a molecule mix obtained from Vitis vinifera and Vaccinium angustifolium, comprising: at least 1% of catechins and epicatechins, the percentage being given by weight in relation to the total weight of the mix, preferably at least 5%, at least 5 ppm (parts per million in the mix) of ferulic acid, preferably at least 10 ppm. The invention also relates to the use of this agent due to its effects on cognitive functions in particular.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: March 8, 2022
    Assignees: SPECIALITES PET FOOD, ACTIV'INSIDE, INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE LAVAL
    Inventors: David Gaudout, Stephane Rey, Benoit Lemaire, Julien Bensalem, Anne Lepoudere, Delphine Lethuillier, Marie-Eve Paradis, Stephanie Dudonne, Yves Desjardins, Frederic Calon, Alexandre Dal-Pan, Charles Ramassamy
  • Patent number: 11259738
    Abstract: Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: March 1, 2022
    Assignee: Université Laval
    Inventors: Marc Hébert, Michel Maziade, Chantal Mérette
  • Patent number: 11247332
    Abstract: A jointed mechanism includes a passive pendulum system attached to and suspended from the multi-axis robot. The system includes one or more position sensors configured to measure a joint angle on the pendulum system, at least one arm, and an end-effector attached to a distal end of the pendulum system. A controller implements a method to selectively control motion of the robot in a plurality of control modes. The control modes include a Cooperative Mode and an Autonomous Mode. The controller is configured to detect contact with the end-effector when operating in the Autonomous Mode, and to automatically initiate a control action in response to the contact. The pendulum system may be a parallelogram arrangement.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: February 15, 2022
    Assignees: GM Global Technology Operations LLC, Universite Laval
    Inventors: Muhammad E. Abdallah, James W. Wells, Pascal Labrecque, Clement Gosselin, Thierry Laliberte
  • Publication number: 20210379796
    Abstract: A shotcrete nozzle assembly comprising: a tubular body operatively connectable to a concrete source, the tubular body including a stream controlling section for controlling a stream of fresh concrete projected from an outlet body end, the stream controlling section including at least one helicoidal conduit defined within the body sidewall, each helicoidal conduit extending helicoidally around a central conduit between an air inlet end operatively connectable to a pressurized air source and an air outlet end located towards the outlet body end, each helicoidal conduit being twisted around the central passageway to guide pressurized air exiting through the air outlet end along an helicoidal path extending away from the outlet body end and around the stream of fresh concrete exiting the outlet body end.
    Type: Application
    Filed: August 20, 2021
    Publication date: December 9, 2021
    Applicant: Université Laval
    Inventors: Pierre SICCARDI, Marc JOLIN, Thomas JACOB-VAILLANCOURT, Antoine GAGNON
  • Publication number: 20210379795
    Abstract: A shotcrete nozzle assembly comprising: a tubular body including a body sidewall defining a central passageway extending along a central longitudinal passageway axis, and water dispensing bores extending through the body sidewall and including: first and second sets of water dispensing bores positioned such that outlet openings thereof defined in an inner face of the body sidewall are disposed in a respective one of longitudinally spaced-apart first and second transversal planes extending perpendicularly to the passageway axis, at least some of the water dispensing bores being oriented such that the central bore axes thereof extend in a non-radial direction relative to the passageway axis, and such that an orthogonal projection of the central bore axes of the first and second sets of water dispensing bores onto one of the transversal planes forms first and second projected central bore axes which intersect each other at a first non-zero angle.
    Type: Application
    Filed: August 20, 2021
    Publication date: December 9, 2021
    Applicant: Universite Laval
    Inventors: Pierre Siccardi, Marc Jolin, Thomas Jacob-Vaillancourt, Antoine Gagnon
  • Publication number: 20210362383
    Abstract: There is provided herein thermoset porous polymer composites a methods for producing such composites. The method comprises: preparing a mixture comprising a resin, optionally a curing agent, and dry ice; optionally casting the mixture; curing the mixture to obtain the porous composite; and optionally controlling at least one of a reaction rate and an expansion rate of the mixture during the curing.
    Type: Application
    Filed: October 23, 2019
    Publication date: November 25, 2021
    Applicant: UNIVERSITÉ LAVAL
    Inventors: Gholamali SHARIFISHOURABI, Denis RODRIGUE
  • Patent number: 11174282
    Abstract: Estrane-based and androstane-based aminosteroid derivatives are described herein. More specifically, the following piperazinyl-steroid compounds of Formula I, Formula II, Formula III, and Formula IV are described. The compounds display cytotoxicity on a variety of cancer cell lines. A process for producing the compounds and their use in the manufacture of pharmaceutical formulations and/or combinations is also disclosed.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: November 16, 2021
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Donald Poirier, René Maltais, Martin Perreault
  • Publication number: 20210308839
    Abstract: An insertion system includes an insertion device including a body defining a longitudinal axis, the body including a wall having an outer surface and an inner surface defining a cylindrical opening through the body, the body having a first body portion and a second body portion formed by separating the body along the longitudinal axis, an effector configured to interface with the insertion device, the effector having an effector body, a first mechanism coupled to the effector body and coupled to the first body portion of the insertion device, and a second mechanism coupled to the effector body and coupled to the second body portion of the insertion device, and an insertion mechanism coupled with the effector body. The insertion mechanism enables a force application at a position offset from the insertion device.
    Type: Application
    Filed: April 6, 2020
    Publication date: October 7, 2021
    Applicants: GM GLOBAL TECHNOLOGY OPERATIONS LLC, Université Laval
    Inventors: Muhammad E. Abdallah, James W. Wells, Clement Gosselin, Thierry Laliberte, Jerome Landure
  • Patent number: 11123730
    Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-Tillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: September 21, 2021
    Assignees: Universite Laval, Meridian Bioscience Canada Inc.
    Inventors: Régis Peytavi, Sébastien Chapdelaine
  • Publication number: 20210283092
    Abstract: Colchicine derivative(s), method(s) and use(s) thereof for treatment of inflammation.
    Type: Application
    Filed: June 28, 2019
    Publication date: September 16, 2021
    Applicants: Alberta Health Services, Université Laval
    Inventors: Jack TUSZYNSKI, Maria FERNANDES
  • Publication number: 20210277101
    Abstract: It is provided an inhibitor of Toll-like Receptor 2 (TLR2) that specifically blocks an interaction between S1009A and Toll-like Receptor 2 (TLR2), and more particularly a humanized antibody against S100A9 protein for inhibiting and treating inflammatory conditions in a human patient. Particularly, this humanized antibody is specific for blocking the interaction between the S100A9 protein and the TLR-2 receptor.
    Type: Application
    Filed: July 11, 2016
    Publication date: September 9, 2021
    Applicant: UNIVERSITÉ LAVAL
    Inventors: Philippe TESSIER, Mélanie TARDIF, Traian SULEA
  • Publication number: 20210261634
    Abstract: A light-inducible intracellular protein aggregation system is described herein, which provides invaluable tools to study the role of protein aggregates in proteinopathies and to screen for novel therapeutic compounds. The system generally comprises a cell expressing an alpha-synuclein polypeptide or another proteopathic polypeptide that self-aggregates under pathogenic conditions, operably linked to a photoactivatable polypeptide. Illumination of the photoactivatable polypeptide with light having a wavelength sufficient for photoactivation triggers irreversible accumulation of intracellular protein aggregates comprising the alpha-synuclein polypeptide or proteopathic polypeptide. The intracellular protein aggregates can be made to accumulate in real-time during the illumination, thereby enabling spatiotemporal control of protein aggregation.
    Type: Application
    Filed: July 3, 2019
    Publication date: August 26, 2021
    Applicant: UNIVERSITÉ LAVAL
    Inventor: Abid Oueslati