Abstract: Methods and systems for writing a Bragg grating along a grating region of an optical fiber through a polymer coating of the optical fiber are provided. A light beam of ultrafast optical pulses is impinged on the grating region, the ultrafast optical pulses being characterized by writing wavelength at the grating region to which the polymer coating is substantially transparent The light beam is diffracted through a phase mask so as to form an interference pattern defining the Bragg grating at the grating region of the optical fiber. The light beam is also focussed such that the intensity of the optical pulses is below a damage threshold within the polymer coating, and above an FBG inscription threshold within the grating region of the fiber. Optical fiber having Bragg gratings and improved mechanical are also provided.

Abstract: An interrogation device for detecting luminescent light produced by analytes in a sample excited by multiple excitation light beams each having individual spectral contents, comprising a plurality of light sources each generating an excitation light beam; at least one detector for detecting the luminescent light produced by the sample; and an optical assembly defining distinct and fixed excitation light paths for each of the excitation light beams from the light sources to a common excitation site on the sample and defining a shared luminescence light path for the luminescent light from the excitation site on sample to the at least one detector, the excitation light paths and the luminescence light path being on a same side of the sample, the optical assembly including sample-side optics projecting the excitation light towards the sample and collecting luminescent light from the sample.

Abstract: A patterned capillary device comprising a pattern on an inner surface is described herein. More specifically, the patterned capillary device comprises a wall having an outer surface and an inner surface, the wall defining a fluidic channel. A substantially opaque film covers the inner surface of the wall, the opaque film comprising a plurality of substantially transparent segments defining a pattern. A process for fabricating a pattern formed of opaque and transparent portions on an inner surface of a capillary device is also described herein.

Abstract: The optical device coupleable to a waveguide to receive an optical signal from the waveguide generally has at least two diffraction grating devices optically coupled to one another and having corresponding spectral responses, the spectral response of at least one of said diffraction grating devices being tunable to adjust an amount of overlapping between the spectral responses of the at least two diffraction grating devices.

Abstract: The mid-infrared laser system has an amplifier including at least one pump laser adapted to generate a pump laser beam and a length of fiber made of a low phonon energy glass and having at least one laser-active doped region between a first end and a second end, and a seed laser to generate a seed laser beam having a seed optical spectrum in the mid-infrared. The seed laser beam is launched into the first end to generate a mid-infrared laser beam outputted from the second end via stimulated emission upon pumping of the at least one laser-active doped region with the pump laser beam. When the power of the pump laser exceeds a spectrum modification threshold, the mid-infrared laser beam has an output optical spectrum being broadened relative to the seed optical spectrum.

Abstract: The present description relates to an anti-S1008 protein for treating leukemia. More specifically, is disclosed anti-S100A8 antibody that specifically binds to a portion of S100A8 protein and/or a S100A8/S100A9 heterodimer for treating leukemia.

Abstract: Disclosed methods and systems allow provision of zone-based services to users. Both zones and users have their own profiles. A detection system allows determining when users enter or leave a zone. A pairing is calculated between compatible elements of zone profiles, or between compatible elements of the user profiles. Delivery of zone-based services may conditionally be granted according to a level of the pairing. Pairings may also be established between users or between zones. A server may manage profiles for the zones and for the users.

Abstract: The present invention provides methods and uses for the diagnostic of a subject predisposed or suspected of developing a neurodegenerative disease or suffering from a neurodegenerative disease. The present invention also relates to methods and uses for identifying candidate compounds and to compounds for treating neurodegenerative disease. The present invention also relates to an animal model for neurodegenerative disease.

Abstract: A method for treating cancer including administering to a patient in need thereof an effective amount of a compound having the formula: wherein R1, R2 , Ya, Xa, and J? are as defined herein, and may be where R1 and R2 are independently selected from methyl, ethyl, n-propyl, or i-propyl; Xa is N or CH; Ya is hydrogen or independently selected from halogen, cyano, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, heteroaryl of 6 members and aryl; n is 1 or 2; wherein J? is fluoride, chloride, bromide, iodide, acetate, sulfate or sulfonate such as tosylate, mesylate, besylate.

Abstract: Herein presented is a new, versatile fusion protein tool (tag) to improve the solubility and purification of proteins. Particularly, the fusion tag is the substantially full-length (about 23 kD) Recoverin molecule (TagR) that is used for protein purification in a single step, even in the presence of detergents.

Abstract: A cross tube for a helicopter skid landing gear, including a monolithic metallic tube having a central portion extending transversely between two end portions with longitudinal central axes of the central portion and of the end portions being located in a plane, where the central portion has inner and outer heights, the end portions each have inner and outer heights, and the inner and outer heights of one of the central portion and the end portion are respectively greater than the inner and outer heights of the other of the central portion and the end portion. A skid tube with two portions with cross-sections having one or both of different orientations with respect to one another and different dimensions with respect to one another, and a method of forming a structural tube for a helicopter skid landing gear are also provided.

Abstract: A method for treating cancer comprising administering to a patient in need thereof an effective amount of a compound having the formula: wherein R1 and R2 are independently alkyl of 1 to 6 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, Xa is CH or N, Ya is hydrogen or a substituent, each of which is independently selected; n is an integer from 1 to 5, J is a counter ion.

Abstract: The present disclosure relates to a novel active compound having the formula Ia: solid preparations, uses and methods for the treatment or prevention of respiratory diseases comprising said compound as well as process of preparation thereof.

Abstract: The present disclosure highlights the relationship between extracellular mitochondrial components, optionally in combination with the secreted phospholipase A2-IIA and/or an auto-antibody, and in vivo as well as in vitro and inflammatory reactions/conditions, especially those released as a result of the degradation of a platelet. The present disclosure provides methods for determining the presence of inflammatory mediators, for limiting inflammatory reactions/conditions, for the diagnosis inflammatory reactions/conditions, for screening therapeutics for the treatment and/or the alleviation of symptoms of inflammatory reactions/conditions based on the detection or modulation of the level of these extracellular mitochondrial components.

Abstract: A catalytic process for the metal-free functionalization of sp2-carbons is described herein. The catalytic process is suitable for forming borylated alkenes, arenes and heteroarenes and comprises the use of catalysts comprising a Frustrated Lewis Pair (FLP).

Abstract: An electromechanical system operates through physical interaction with an operator, and includes a plurality of joints providing multiple degrees of freedom (DOF), including actuated joints and unactuated joints. The unactuated joints are distal with respect to the actuated joints and are in redundant DOF to the actuated joints. The system includes a plurality of actuators each configured to actuate one or more of the actuated joints, and a plurality of sensors each positioned with respect to a respective one of the actuated and unactuated joints. Each sensor is configured to measure corresponding joint data indicative of a position or angle of the respective actuated or unactuated joints. A controller in communication with the sensors receives the measured joint data as feedback signals, generates control signals using the feedback signals, and transmits the control signals to the actuators to thereby control an actuation state of the actuators.

Abstract: There is provided a method for preparing microporous hollow fiber membranes comprising melt-extruding a polymer-salt blend followed by salt leaching. Microporous hollow fiber membranes are also disclosed.

Abstract: The optical device coupleable to a waveguide to receive an optical signal from the waveguide generally has at least two diffraction grating devices optically coupled to one another and having corresponding spectral responses, the spectral response of at least one of said diffraction grating devices being tunable to adjust an amount of overlapping between

Abstract: Catalysts for the reduction of CO2 are described herein. More specifically, catalysts of Formula I and Formula II: wherein LB is a Lewis base; LA is a Lewis acid; R1 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; and R9 and R10 are independently selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; are described. A process for the production of methanol from CO2 using such catalysts is also described.

Abstract: A movement device is moved along an X axis and a Y axis by providing a sensor configured to measure angle of rotation of at least one of a first and a second kinematic link about a respective axis of rotation. A force is imparted on the first and second kinematic links such that an angular displacement of the first and second kinematic links about the respective axis of rotation is achieved. The angular displacement of the first and second kinematic links about the respective axis of rotation is determined. The movement device is moved along the X axis and/or the Y axis in response to the determination of the angle of rotation of the first and second kinematic links about the respective axis of rotation until first and second kinematic links are vertical.