Abstract: Mid-infrared-transparent optical fiber products with enhanced resistance to OH diffusion are disclosed, which may be used fiber laser oscillator and amplifiers systems. In one embodiment, an optical fiber product may include optical fiber configured for propagation of mid-infrared radiation toward a light-radiating endface of or coupled to the optical fiber, and a diffusion barrier disposed on the light-radiating endface and configured for allowing the mid-infrared radiation emanating from the light-radiating endface to pass therethrough and for preventing OH diffusion therethrough toward the light-radiating endface.

Abstract: The present description relates to the use of a SRSF3 agent for regulating the function of a myeloid cell, such as a microglial cell and/or monocyte, for treating neurological conditions, cancers, bacterial infections and viral infections wherein the SRSF3 agent inhibits expression or function of SRSF3.

Abstract: A catalytic process for the metal-free functionalization of sp2-carbons is described herein. The catalytic process is suitable for forming borylated alkenes, arenes and heteroarenes and comprises the use of catalysts comprising a Frustrated Lewis Pair (FLP).

Abstract: The present description relates to methods for clinically assessing Parkinson's disease in a subject using erythrocyte-derived extracellular vesicles (EEV) as a biomarker.

Abstract: An optical fiber comprises a core having an elliptical cross section and a cladding having a circular cross section. The core has an ellipticity between 2 and 40. The core and the cladding have a common central axis with the core being enclosed by the cladding. The difference of a refractive index of the cladding to a refractive index of the core is between 1×10?2 and 1.5×10?1. A trench is located between the core and the cladding. The trench has a uniform width and encircles the core. The refractive index of the trench is lower than the refractive index of the cladding.

Abstract: A method of increasing expression of an heterologous protein of interest in a plant or portion of the plant is provided. The method comprises treating the plant or portion of the plant with a jasmonate-pathway activator, and introducing a nucleotide sequence operably linked to a regulatory region derived from a DNA plant virus and encoding the heterologous protein of interest into the plant or portion of the plant. Alternatively, the plant or plant portion may comprise the nucleic acid and encoding the heterologous protein of interest, and the plant or portion of the plant is treated with the jasmonate pathway activator. The treated plant is incubated under conditions to permit expression of the nucleotide sequence encoding the heterologous protein of interest.

Abstract: The present description relates to an anti-S1008 protein for treating leukemia. More specifically, is disclosed anti-S100A8 antibody that specifically binds to a portion of S100A8 protein and/or a S100A8/S100A9 heterodimer for treating leukemia.

Abstract: An optical fiber having a Bragg grating along a non-photosensitized grating region thereof and a pristine polymer coating around the grating region with the Bragg grating having been written through the polymer coating has a mechanical resistance that is greater than 20% of the mechanical resistance of an identical grating-free optical fiber.

Abstract: Precatalysts and catalytic processes for the functionalization of sp2-carbons using the precatalysts are described herein. The precatalysts comprise an intramolecular Frustrated Lewis Pair (FLP) that is generated in situ from the corresponding precatalyst fluoroborate salts. The precatalyst fluoroborate salts are deprotected in situ to generate catalysts including intramolecular FLPs for the dehydrogenative borylation of alkenes, arenes and heteroarenes. The catalytic process comprises contacting a precatalyst, a functionalization reagent; and a substrate comprising a sp2-H carbon, under conditions to provide a substrate comprising a functionalized sp2 carbon.

Abstract: A fiber-optic thermometer probe has an optical fiber with a sensing portion, namely a region of reduced cladding thickness coated with a temperature-dependent refractive index material to provide variations in propagated light power upon changes in temperature in a vicinity of the sensing portion. A reflective interface optically coupled to a core of the optical fiber reflects light propagated therein. The sensing portion can be the tip and prepared by etching using a dipping process.

Abstract: Fluorescent nanosensors for extracellular ion concentration measurements are disclosed herein. More specifically, a fluorescent nanosensor for extracellular ion measurements comprising a photoluminescent nanostructure disposed on a substrate surface is disclosed. The photoluminescent nanostructure comprises a fluorescent metallic core-silica shell containing nanoparticle, wherein the fluorescent silica shell comprises a fluorophore dispersed therein. The nanosensor emits a fluorescence emission in function of the extracellular ion concentration.

Abstract: An electromechanical system operates through physical interaction with an operator, and includes a plurality of joints providing multiple degrees of freedom (DOF), including actuated joints and unactuated joints. The unactuated joints are distal with respect to the actuated joints and are in redundant DOF to the actuated joints. The system includes a plurality of actuators each configured to actuate one or more of the actuated joints, and a plurality of sensors each positioned with respect to a respective one of the actuated and unactuated joints. Each sensor is configured to measure corresponding joint data indicative of a position or angle of the respective actuated or unactuated joints. A controller in communication with the sensors receives the measured joint data as feedback signals, generates control signals using the feedback signals, and transmits the control signals to the actuators to thereby control an actuation state of the actuators.

Abstract: Methods of performing dual-comb interferometry using a dual-comb interferometer and methods of characterizing a volume using dual-comb interferogram data are described.

Abstract: Liquid crystal modulator optical devices and more specifically shutters and smart windows are presented. The liquid crystal modulator devices are characterized by a reduced polymer content which is eliminated from the material composition of the liquid crystal layer and characterized by non-uniform electrode structures in the liquid crystal structure configured to generate spatially non-uniform electric fields and therefore non-uniform molecular reorientation of liquid crystal molecules. This arrangement advantageously makes light scattering electrically controllable.

Abstract: Methods and systems are described herein which allow to determine an icing condition without requiring a wind speed measurement. The methods and systems use two sensing members both being exposed to conditions in an environment. The determination is made based on a capacity of the sensing members to react differently to the conditions to which they are exposed. The conditions can be environmental or controlled. The determination includes measuring a variable indicative of the thermal state of each individual sensing member, and processing the measured values to generate the signal indicative of icing condition. The icing condition can be instrumental or meteorological.

Abstract: A method and system for detecting and ranging targets within a scene are provided. The method can include emitting an emission signal onto the scene and receiving a return signal including echoes produced by reflection of the emission signal from the targets. The method can also include digitizing the return signal into a digital signal waveform including N real-valued samples representing the return signal at N sequential sampling times. The method can further include creating, from the digital signal waveform, an N×N second-order signal matrix having a main diagonal whose nth element is expressed in terms of the square of the nth sample of the digital signal waveform. The method can also include deriving, based on the signal matrix, time-of-flight information associated with the echoes and indicative of range information associated with the targets. The method and system can be used, for example, in lidar-based remote sensing applications.

Abstract: This disclosure relates to methods, non-transitory computer readable media, and systems that use a local-lighting-estimation-neural network to render a virtual object in a digital scene by using a local-lighting-estimation-neural network to analyze both global and local features of the digital scene and generate location-specific-lighting parameters for a designated position within the digital scene. For example, the disclosed systems extract and combine such global and local features from a digital scene using global network layers and local network layers of the local-lighting-estimation-neural network. In certain implementations, the disclosed systems can generate location-specific-lighting parameters using a neural-network architecture that combines global and local feature vectors to spatially vary lighting for different positions within a digital scene.

Abstract: A method and system for improving lateral resolution in optical microscopy are provided. The method includes generating a source optical beam and passing the source optical beam successively through an axicon, a Fourier-transform lens and an objective to convert the source optical beam into an excitation Bessel-type beam having a central lobe and at least one side lobe. The method also includes focusing the excitation beam onto a focal plane of the objective within or on a sample to generate a sample light signal, and spatially filtering the sample light signal. The spatial filtering includes rejecting light originating from outside of the focal plane and light generated by the at least one side lobe of the excitation beam. The spatial filtering also includes permitting passage, as a filtered light signal, of light generated by the central lobe of the excitation beam. The method further includes detecting the filtered light signal.

Abstract: There is disclosed an imaging system for use in imaging a sample. The imaging system comprising a light source and a light detector. A probe optically coupled to the imaging assembly. The probe being configured to, during use, direct light from the light source to a focal point to illuminate the sample, and from the focal point to the light detector. The probe having a tunable liquid crystal lens (TLCL) assembly comprising at least one pair of TLCLs, the TLCLs of the pair being superposed to one another, a gradient-index (GRIN) lens assembly having a base being optically connected to the TLCL assembly, and a tip opposite to the base. The focal point being at a working distance from the tip. The working distance being adjustable relative to the tip by tuning each TLCL of the TLCL assembly during use.