Abstract: According to one aspect, a fluence monitoring detector for use with a multileaf collimator on a radiotherapy machine having an x-ray radiation source. The fluence monitoring detector includes a plurality of scintillating optical fibers, each scintillating optical fiber configured to generate a light output at each end thereof in response to incident radiation pattern thereon from the radiation source and multileaf collimator, a plurality of collection optical fibers coupled to the opposing ends of the scintillating optical fibers and operable to collect the light output coming from both ends of each scintillating optical fiber, and a photo-detector coupled to the collection optical fibers and operable to converts optical energy transmitted by the collection optical fibers to electric signals for determining actual radiation pattern information.

Abstract: A cell surface molecule designated DCIR (for dendritic cells ImmunoReceptor), a member of a recently described family of DC-expressing C-type lectin receptors, has been shown to participate to the capture of human immunodeficiency virus (HIV) and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DC. The contribution of DCIR to these processes was revealed using DCIR-specific siRNAs and a polyclonal antibody specific for the carbohydrate recognition domain of DCIR. Therapeutic agents for HIV infection are therefore provided herein. These therapeutic agents are useful for impairing the interaction between DCIR and HIV and as such may be useful for treatment or prevention of HIV infection. Also provided are assays for identifying additional therapeutics agents for treatment or prevention HIV infection.

Abstract: The present invention relates to a method and apparatus for limiting the contact force between a moving device and another object, using a parallel mechanism and torque limiters where the threshold force to activate the force limiting mechanism is not related to the configuration of the moving device or the location of the contact force relative to the activation point of the force limiting mechanism, and where the mechanism may be configured for one, two or three degrees of freedom. A counterbalance mechanism is also provided to counteract gravity load when the force limiting mechanism is configured for three degrees of freedom and responsive to contact forces including a vertical element. In particular, the invention relates to a method and apparatus for limiting the contact force between a moving robotic device and a contactable object.

Abstract: AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH2 into PGF2?. AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF2? are also provided.

Abstract: According to one aspect, methods for validating plastic scintillating detectors (PSD) for photon dosimetry and applications of same. In some embodiments, the method includes using at least one PSD to obtain at least one dose measurement, determining at least one PSD correction factor suitable for compensation for variations in energy response of the at least one PSD over the energy range of interest, and determining at least one corrected dose measurement based on the at least one PSD correction factor. In some embodiments, the PSD may be incorporated into a wearable article, such as gloves, eyewear and the like, or used for skin surface measurements.

Abstract: The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation. Reduction of inflammation manifestations and reactions occurs by using an anti-S100 polynucleotide or polypeptide inhibitor or antagonist, which is essentially targeted against S100A8, S100A9 or S100A12, alone or in combination with other inhibitors of chemokines or immune modulating products.

Abstract: Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defined herein are also provided.

Abstract: The invention is concerned with methods, compounds and pharmaceutical compositions for interfering dendritic cell immunoreceptor (DCIR) activity and signalling events. Described herein are compounds useful in targeting one or more of intracellular modulators and the uses thereof for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus (HIV) binding, entry and/or replication in human cells. Exemplary compounds include peptides and antisense molecules.

Abstract: Reagents, methods and kits for screening for compounds that modulate the activity of voltage-gated sodium channels (NaV), such as human NaV1.5/SC-N5A/hH1 are described. The reagents, methods and kits are based on mutated NaV alpha subunit polyptides of SEQ ID NO:5 with mutations at positions 372, 898, 1419 and 1711 (the DEKA motif) and at positions 11485, 1486 and 1487 (the IFM motif) resulting in increased permeability for a group IIA divalent cation (Ca++) and decreased inactivation rate. The mutant polypeptide is used in a method and kit for determining whether a test compound modulates the channel activity, preferably using a chimeric polypeptide (chameleon polypeptide) comprising calmodulin, a calmodulin binding protein (M13), and two fluorescent agents.

Abstract: A variable optical device for controlling the propagation of light has a liquid crystal layer (1), electrodes (4) arranged to generate an electric field acting on the liquid crystal layer, and an electric field modulation layer (3,71) arranged between the electrodes and adjacent the liquid crystal layer for spatially modulating said electric field in a manner to control the propagation of light passing through said optical device. The electric field modulation layer has either an optical index of refraction that is essentially spatially uniform, or a polar liquid or gel, or a very high low frequency dielectric constant material having a dielectric constant greater than 20, and preferably greater than 1000.

Abstract: Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defined herein are also provided.

Abstract: Methods, uses, kits and products are described for the prognosis, diagnosis, prevention and treatment of myotronic dystrophy type 1 (DM1), and more particularly for the prognosis, diagnosis, prevention and treatment of the congenital form of myotronic dystrophy type 1 (cDM1), based on changes in/modulation of prostaglandin E2 (PGE2).

Abstract: A method of inferring intentions of an operator to move a robotic system includes monitoring the intention of the operator, with a controller. The intention of the operator is inferred to be one of a desired acceleration and a desired deceleration. The intention of the operator is also as a desired velocity. Admittance parameters are modified as a function of at least one of the inferred acceleration, deceleration, and velocity.

Abstract: A liquid crystal display or other light modulator is provide with an alignment layer with a pretilt that is better than is currently available with rubbing technology. The liquid crystal cell consumes less electrical power to operate. The pretilt can be programmed using suitable field and recorded in the alignment layer.

Abstract: Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.

Abstract: A GPS system for obtaining data from a GPS signal received at a plurality of antenna stations, each antenna station being connected to a common receiver station through an optical fiber link. The system includes a light generating module at the receiver station generating an optical reference signal, and an antenna station module at each antenna station. The antenna station modules modulate the optical reference signal according to the GPS signal received, obtaining a twice modulated optical signal, and sending this signal to the receiver station. Finally, an output module is provided at the receiver station, this module being used for extracting the GPS signal and the oscillating reference signal, calibrating in real time the optical fiber links based on a phase comparison, and processing the GPS signal from the antenna stations, taking into account the real time calibration of the optical fiber links.

Abstract: A method for writing a Bragg grating in a rare-earth doped glass optical waveguide is provided. Ultrafast optical pulses are generated, preferably in the femtosecond range and having a writing wavelength in the range of 300 nm to 700 nm and an intensity sufficient to induce a change of refractive index in the rare-earth doped glass waveguide through densification. The optical pulses are diffracted using a phase mask, to generate an interference pattern having a pitch providing a fundamental Bragg resonance corresponding to the target wavelength to be reflected by the grating. The interference pattern is impinged on a region of the rare-earth doped glass waveguide, which is heated to a temperature above a threshold of about 350° C., for a predetermined heating period. Advantageously, the heating step allows the elimination of photodarkening effects which would otherwise be present in the waveguiding properties of the waveguide.

Abstract: System and method for converting kinetic energy from a fluid flow into mechanical energy, the method comprising the steps of: a) providing a turbine including first and second hydrofoils, each of the hydrofoils being able to move lin-early in a heaving motion, and being able to oscillate about a spanwise axis in a pitching motion, said heaving and pitching motions being quasi-si-nusoidal, b) coupling the heaving motions of the first and second hydrofoils to the pitching motions of the second and first hydrofoils respectively, with the pitch-heave motion phase being substantially equal to the inter-hydrofoil phase, the heaving motion of one of the hydrofoils thereby driving the pitching motion of the other hydrofoil; and c) transforming the heaving motions of the hydrofoils into a rotational movement of a rotatable shaft, with linear-to-rotary transmission means.

Abstract: The present invention relates to a method for isolating microorganisms and/or microorganisms nucleic acids from a bodily fluid that may comprise or may be suspected to comprise microorganisms and/or host cells and/or host cells debris. Microorganisms nucleic acids may further be isolated by lysing the isolated microorganisms. The present invention also relates to a method for detecting microorganisms in a bodily fluid. The present invention further relates to a saponin formulation and its use.

Abstract: There is provided a method for referencing and correcting the beating spectrum generated by the interference of the components of a frequency comb source. The proposed method allows monitoring of variations of a mapping between the source and the beating replica. This can then be used to compensate small variations of the source in Fourier transform spectroscopy or in any other interferometry application in order to overcome the accuracy and measurement time limitations of the prior art. Constraints on source stability are consequently reduced.