Abstract: A method for treating cancer including administering to a patient in need thereof an effective amount of a compound having the formula: wherein R1, R2 , Ya, Xa, and J? are as defined herein, and may be where R1 and R2 are independently selected from methyl, ethyl, n-propyl, or i-propyl; Xa is N or CH; Ya is hydrogen or independently selected from halogen, cyano, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, heteroaryl of 6 members and aryl; n is 1 or 2; wherein J? is fluoride, chloride, bromide, iodide, acetate, sulfate or sulfonate such as tosylate, mesylate, besylate.
Abstract: Herein presented is a new, versatile fusion protein tool (tag) to improve the solubility and purification of proteins. Particularly, the fusion tag is the substantially full-length (about 23 kD) Recoverin molecule (TagR) that is used for protein purification in a single step, even in the presence of detergents.
Abstract: A cross tube for a helicopter skid landing gear, including a monolithic metallic tube having a central portion extending transversely between two end portions with longitudinal central axes of the central portion and of the end portions being located in a plane, where the central portion has inner and outer heights, the end portions each have inner and outer heights, and the inner and outer heights of one of the central portion and the end portion are respectively greater than the inner and outer heights of the other of the central portion and the end portion. A skid tube with two portions with cross-sections having one or both of different orientations with respect to one another and different dimensions with respect to one another, and a method of forming a structural tube for a helicopter skid landing gear are also provided.
Type:
Grant
Filed:
December 19, 2013
Date of Patent:
June 12, 2018
Assignees:
Bell Helicopter Textron Inc., Université Laval
Inventors:
Simon Bernier, Robert Clive Fews, Michel Guillot, Augustin Gakwaya, Jocelyn Blanchet, Xavier Jean-Gilles Elie-Dit-Cosaque, Julie Levesque, Giuseppe Aquino
Abstract: A method for treating cancer comprising administering to a patient in need thereof an effective amount of a compound having the formula: wherein R1 and R2 are independently alkyl of 1 to 6 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, Xa is CH or N, Ya is hydrogen or a substituent, each of which is independently selected; n is an integer from 1 to 5, J is a counter ion.
Abstract: The present disclosure highlights the relationship between extracellular mitochondrial components, optionally in combination with the secreted phospholipase A2-IIA and/or an auto-antibody, and in vivo as well as in vitro and inflammatory reactions/conditions, especially those released as a result of the degradation of a platelet. The present disclosure provides methods for determining the presence of inflammatory mediators, for limiting inflammatory reactions/conditions, for the diagnosis inflammatory reactions/conditions, for screening therapeutics for the treatment and/or the alleviation of symptoms of inflammatory reactions/conditions based on the detection or modulation of the level of these extracellular mitochondrial components.
Type:
Grant
Filed:
October 10, 2014
Date of Patent:
April 17, 2018
Assignees:
Université Laval, Hérma-Québec, University of Washington
Inventors:
Eric Boilard, Luc Boudreau, Louis Thibault, Michael Herman Gelb
Abstract: The present disclosure relates to a novel active compound having the formula Ia: solid preparations, uses and methods for the treatment or prevention of respiratory diseases comprising said compound as well as process of preparation thereof.
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
April 17, 2018
Assignee:
UNIVERSITÉ LAVAL
Inventors:
Evelyne Israel-Assayag, Pierre Lavallee, Yvon Cormier, Bildad Nyambura
Abstract: A catalytic process for the metal-free functionalization of sp2-carbons is described herein. The catalytic process is suitable for forming borylated alkenes, arenes and heteroarenes and comprises the use of catalysts comprising a Frustrated Lewis Pair (FLP).
Abstract: An electromechanical system operates through physical interaction with an operator, and includes a plurality of joints providing multiple degrees of freedom (DOF), including actuated joints and unactuated joints. The unactuated joints are distal with respect to the actuated joints and are in redundant DOF to the actuated joints. The system includes a plurality of actuators each configured to actuate one or more of the actuated joints, and a plurality of sensors each positioned with respect to a respective one of the actuated and unactuated joints. Each sensor is configured to measure corresponding joint data indicative of a position or angle of the respective actuated or unactuated joints. A controller in communication with the sensors receives the measured joint data as feedback signals, generates control signals using the feedback signals, and transmits the control signals to the actuators to thereby control an actuation state of the actuators.
Type:
Application
Filed:
November 3, 2017
Publication date:
March 22, 2018
Applicants:
GM Global Technology Operations LLC, Université Laval
Inventors:
Muhammad E. Abdallah, Clement Gosselin, Thierry Laliberte, Simon Foucault, Pascal Labrecque, James W. Wells, Jerome Landure
Abstract: There is provided a method for preparing microporous hollow fiber membranes comprising melt-extruding a polymer-salt blend followed by salt leaching. Microporous hollow fiber membranes are also disclosed.
Abstract: The optical device coupleable to a waveguide to receive an optical signal from the waveguide generally has at least two diffraction grating devices optically coupled to one another and having corresponding spectral responses, the spectral response of at least one of said diffraction grating devices being tunable to adjust an amount of overlapping between
Abstract: Catalysts for the reduction of CO2 are described herein. More specifically, catalysts of Formula I and Formula II: wherein LB is a Lewis base; LA is a Lewis acid; R1 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; and R9 and R10 are independently selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; are described. A process for the production of methanol from CO2 using such catalysts is also described.
Abstract: An electrochemical ion sensor and a method for sensing a presence of at least one ion species in a solution are provided. The electrochemical sensor includes a solid-state electrolyte medium doped with an organometallic material, having an electrochemical affinity with the ion species, and a pair of electrodes electrically contacting the solid-state electrolyte. The electrochemical sensor also includes an electrical circuit configured to drive the pair of electrodes with an AC electrical excitation and to measure at least one parameter related to a complex electrical impedance of the doped solid-state electrolyte medium in response to the AC electrical excitation. The parameter may be an electrical resistance, an inductance or a combination of both, and represents the presence of the ion species in the solution when the solid-state electrolyte medium is exposed to the solution.
Abstract: The method includes receiving a value of a quantity of heat applied to at least a portion of a structure, said structure having a sensor surface exposed to the environment, receiving a temperature measurement of the sensor surface, receiving a wind speed measurement of the environment, receiving an ambient temperature measurement of the environment, determining a heat transfer projection of the sensor area using at least the wind speed measurement, the ambient temperature measurement, and one of the value of a quantity of heat and a target temperature of the sensor surface; comparing the heat transfer projection to an associated heat transfer value, and generating a signal indicating the icing condition status based on the comparison.
Type:
Grant
Filed:
May 17, 2013
Date of Patent:
December 19, 2017
Assignee:
UNIVERSITÉ LAVAL
Inventors:
André Bégin-Drolet, Jean Ruel, Jean Lemay
Abstract: There is provided an imaging system for producing an image of a scene, the image having at least one distorted zone, the imaging system comprising image producing means for producing an image of the scene; optical means for orienting light from the scene towards the image producing means, the optical means having a base optical power, the optical means being configurable to form at least one modified portion, each one of the at least one modified portion having a modified optical power different from the base optical power to thereby create at least one distorted zone on the image; and control means operatively connected to the optical means for changing the configuration of the optical means for forming the at least one modified portion. The imaging system may be reversible and provided instead as a scanning system.
Abstract: An optogenetic probe, an optogenetic system, and a method for fabricating an optogenetic probe are provided. The optogenetic probe has a proximal and a distal end, and includes an elongated body made of a body glass material and extending longitudinally between the proximal and distal ends. The optogenetic probe also includes at least one optical channel, each including an optical channel glass material having a refractive index larger than a refractive index of the body glass material, so as to guide light therealong. The optogenetic probes also includes at least one electrical channel, each including an electrical channel structure having an electrical conductivity larger than the electrical conductivity of the body glass material, so as to conduct electricity therealong. The optogenetic probe further includes at least one fluidic channel, each adapted for transporting fluid therealong. Each optical, electrical and fluidic channel extends longitudinally within the elongated body.
Abstract: The present invention relates to uses and methods comprising one or more RANK/RANKL antagonists or of a pharmaceutical composition comprising one or more RANK/RANKL antagonists and a pharmaceutically acceptable carrier for treating neuromuscular disorders, non-genetic myopathies, or genetic myopathies; maintaining and/or preserving the excitation:contraction:relaxation coupling; reducing loss of muscle strength associated with neuromuscular disorders, non-genetic myopathies or genetic myopathies; reducing the loss of muscular strength associated with skeletal or cardiac muscle disuse, diseases and aging; or regulating skeletal or cardiac muscle disuse, diseases and/or aging in a patient in need thereof. The present invention also relates to combinations and compositions comprising one or more RANK/RANKL antagonists and to methods for identifying candidate compounds.
Abstract: The present relates to the use of miRNA-132/212 mimics or activators comprising a doubled stranded ribonucleic acid molecule comprising a seed region sequence of miRNA-132 or miRNA-212, a spacer, a stabilizing sequence, and a carrier for the treatment of neurodegenerative disorders, including Alzheimer's disease, Tauopathies, Amyotrophic lateral sclerosis, Parkinson's disease, frontotemporal dementia, prion's disease, mild cognitive impairment and Huntington's disease.
Abstract: A method and a system for obtaining a high-resolution image of a volume of a sample using laser imaging are provided. The method includes a step of probing the volume of the sample with a first excitation beam having an intensity profile of maximum intensity at a center thereof, thereby obtaining a positive image of the volume. The method also includes a step of probing the volume of the sample with a second excitation beam having an intensity profile of minimum intensity at a center thereof and defining a peripheral region of maximum intensity around the center, thereby obtaining a negative image of the volume. The method finally includes a step of subtracting the negative image from the positive image, thereby obtaining the high-resolution image of the volume of the sample. Advantageously, embodiments of the invention can be probe- and fluorescence-independent, and be conveniently retrofitted into existing laser imaging systems.
Type:
Grant
Filed:
November 8, 2012
Date of Patent:
August 1, 2017
Assignee:
UNIVERSITÉ LAVAL
Inventors:
Michel Piché, Harold Dehez, Yves De Koninck
Abstract: Provided are compounds of general formula A and A?, wherein X1 and X2 are each C, CH or N; R3 and R4 are each H, optionally substituted C1-C30 saturated or unsaturated chemical group, or together form an optionally substituted C5-C8 cycle; Z1; Z2 and Z3 are each N or CH; V is C?O, C?S or CH2; n is from 1 to 12; W1 and W2 are each H, CH2, O or S; and R1 and R2 are each H, Cr1C6 alkyl, C1C6 aryl, C1C12 alkylaryl, optionally substituted phenyl, C1C6 alkoxy, C1C6 thioalkoxy, F, Cl, Br or I. These compounds inhibit steroid sulfatase (STS), act as selective estrogen receptor modulators (SERMs), increase alkaline phosphatase (ALP) activity, and are useful in the treatment of medical conditions involving hormones such as breast cancer, prostate cancer, endometriosis, osteoporosis, benign prostatic hyperplasia and endometrial cancer.
Abstract: Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
Type:
Grant
Filed:
November 16, 2012
Date of Patent:
July 18, 2017
Assignee:
UNIVERSITÉ LAVAL
Inventors:
Jacques P. Tremblay, Joel Rousseau, Pierre Chapdelaine, Zoe Coulombe