Abstract: Compounds of formula (I) wherein R1, R4, R8, X and Y as defined herein are provided as useful for the inhibition of certain types of cancer cells, amongst others, breast cancer cells, or for the manufacture of anti-cancer agents.

Abstract: A method for preparing polymers by direct heteroarylation or arylation polycondensation is described herein. The method includes preparing a reaction mixture including at least a monomer to be polymerized, a catalyst and a ligand; heating the reaction mixture; and, optionally, end-capping the reaction mixture.

Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. A bottom-fillable chamber is coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber. A container is wholly provided in a retention chamber and contains a liquid diluent, until it releases it upon application of an external force, restoring the fluidic connection between the liquid diluent and the fluid in the retention chamber. The retention chamber can have a flow decoupling receptacle for receiving the fluid, located at the outer side of the retention chamber and interrupting a fluidic connection between the entry and exit of the retention chamber. A test apparatus and a testing method using a fluidic centripetal device for testing components of a biological material in a fluid are also provided.

Abstract: A method for preparing polymers by direct heteroarylation or arylation polycondensation is described herein. The method includes preparing a reaction mixture including at least a monomer to be polymerized, a catalyst and a ligand; heating the reaction mixture, and, optionally, end-capping the reaction mixture.

Abstract: The present disclosure provides novel formulations suitable for the intravaginal delivery of tinidazole, as well as methods of using the same.

Abstract: Compounds of formula (I) wherein R1, R4, R8, X and Y as defined herein are provided as useful for the inhibition of certain types of cancer cells, amongst others, breast cancer cells, or for the manufacture of anti-cancer agents.

Abstract: A power surface or chamber having nearly constant electromagnetic field distribution in 3D comprising at least one primary coil and one primary resonance array made of several coils connected in parallel for generating the electromagnetic field distribution; a single power driver circuit for activating the coils; and a secondary coil and an optional secondary resonance coil to recover the generated electromagnetic field and power up an electric device.

Abstract: A method for administering a gas containing oxygen to a patient. The method includes: measuring an oxygen-dependent physiological parameter in the patient; determining an optimal gas delivery parameter based on the oxygen-dependent physiological parameter; and administering the gas to the patient in accordance with the optimal gas delivery parameter. In some embodiment of the invention, the method also includes monitoring the oxygen-dependent physiological parameter.

Abstract: The present invention relates to a method and apparatus for limiting the contact force between a moving device and another object, using a parallel mechanism and torque limiters where the threshold force to activate the force limiting mechanism is not related to the configuration of the moving device or the location of the contact force relative to the activation point of the force limiting mechanism, and where the mechanism may be configured for one, two or three degrees of freedom. A counterbalance mechanism is also provided to counteract gravity load when the force limiting mechanism is configured for three degrees of freedom and responsive to contact forces including a vertical element. In particular, the invention relates to a method and apparatus for limiting the contact force between a moving robotic device and a contactable object.

Abstract: The invention is concerned with methods, compounds and pharmaceutical compositions for interfering dendritic cell immunoreceptor (DCIR) activity and signalling events. Described herein are compounds useful in targeting one or more of intracellular modulators and the uses thereof for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus (HIV) binding, entry and/or replication in human cells. Exemplary compounds include peptides and antisense molecules.

Abstract: The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

Abstract: An apparatus and method for measuring three-dimensional radiation dose distributions with high spatial and temporal resolution using a large-volume scintillator. The scintillator converts the radiation dose distribution into a visible light distribution. The visible light is transported to one or more photo-detectors, which measure the light intensity. The light signals are processed to correct for optical artifacts, and the three-dimensional light distribution is reconstructed. The reconstructed light distribution is post-processed to convert light amplitudes to measured radiation doses. The high temporal resolution of the detector makes it possible to observe the evolution of a dynamic dose distribution as it changes over time. Integral dose distributions can be measured by summing the dose over time.

Abstract: A method of inferring intentions of an operator to move a robotic system includes monitoring the intention of the operator, with a controller. The intention of the operator is inferred to be one of a desired acceleration and a desired deceleration. The intention of the operator is also as a desired velocity. Admittance parameters are modified as a function of at least one of the inferred acceleration, deceleration, and velocity.

Abstract: Applicants have discovered a multi-layer quality control/quality assurance system that provides higher quality data, without human intervention, by rejecting images that do not achieve a pre-determined quality threshold. In some embodiments of the present invention, there is provided a new method of processing an image from a data set through a pipeline wherein quality control/assurance allows to determine a quality of the image processing, the method comprising; receiving a test image; pre-processing the test image; registering the test image to a reference image; calculating a test image quality using a correlation of image intensity values between corresponding locations of the test image and the reference image; providing a plurality of training images and calculating training image quality distribution statistics for the training images with respect to the reference image; and relating the test image quality to the training image quality distribution.

Abstract: Compounds of formula (I) wherein R1, R4, R8, X and Y as defined herein are provided as useful for the inhibition of certain types of cancer cells, amongst others, breast cancer cells, or for the manufacture of anti-cancer agents.

Abstract: The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on Aug. 29, 2006 under accession numbers ADI-290806-01, ADI-290806-02 and ADS-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human.

Abstract: A robotic charging station for charging a battery of an electric vehicle includes a base plate, a riser coupled with the base plate and extending substantially transverse to the base plate, and a robotic arm. The robotic arm extends from the riser and supports an end effector. The end effector includes a plurality of electrical contacts configured to couple with a receptacle disposed on the electric vehicle. The robotic arm is configured to move the end effector in three degrees of motion.

Abstract: The present disclosure relates to a novel active compound having the formula Ia: solid preparations, uses and methods for the treatment or prevention of respiratory diseases comprising said compound as well as process of preparation thereof.

Abstract: A system for assisting an operator in a manual assembly task includes a base assembly, end-effector, and controller. The base assembly has joint actuators providing three or more degrees of freedom (DOF). The end-effector is in series with the base assembly and has additional joints providing one or more additional DOFs. The base assembly and end-effector support a task load, including a weight and/or a reaction torque of an object. Sensors measure joint positions. The controller receives the measured positions, controls the joint actuators to support the task load, and extends a range of motion of the object. A method includes receiving the position signals as the operator manipulates the object, generating an output signal using the measured positions, and transmitting the output signal to the joint actuators to control the joint actuators, support the task load, and extending a range of motion of the object.

Abstract: A laser scanning imaging system and method for obtaining an extended-depth-of-field image of a volume of a sample are provided. The system includes a laser module generating an input laser beam, a beam shaping module including an axicon and a Fourier-transform lens, and an imaging module including an objective lens and a detecting assembly. The axicon, Fourier-transform lens and objective lens are formed and disposed to successively convert the input laser beam into an intermediate non-diffracting beam, an intermediate annular beam, and an excitation non-diffracting beam. The excitation beam is projected onto the sample and has a depth of field and transverse resolution together defining a three-dimensional excitation region. The detecting assembly collects electromagnetic radiation from the excitation region to obtain one pixel of the extended-depth-of-field image.