Patents Assigned to UNIVERSITÉ PIERRE ET MARIE CURIE
  • Patent number: 11110252
    Abstract: Device (100) for holding in position a probe for placing the inside of a patient's body in communication with the outside, characterized in that it comprises, arranged along a longitudinal axis (X-X?) of the device: at its distal end, a means (110) of supporting the device on the patient's body and that extends radially, comprising an axial opening (114) for the passage of said probe and comprising a first radial opening (111) communicating with the said axial opening, at its proximal end, a means (120) of guiding said probe comprising a second radial opening (121), a means (130) of spacing said bearing means and said guide means apart longitudinally.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: September 7, 2021
    Assignees: MMG, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Thomas Similowski, Serge Renaux
  • Patent number: 11103615
    Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: August 31, 2021
    Assignees: Centre National De La Recherche Scientifique CNRS, Hemarina, Universite Pierre Et Marie Curie
    Inventors: Franck Zal, Morgane Rousselot
  • Publication number: 20210190726
    Abstract: An electromagnetic sensing device comprising: a reference microfluidic reservoir to receive a reference substance with magnetic nanoparticles; an analyte microfluidic reservoir to receive an analyte and magnetic nanoparticles; a first excitation magnetic coil to subject the reference microfluidic reservoir to an alternating magnetic field at a first frequency; a second excitation magnetic coil to subject the analyte microfluidic reservoir to an alternating magnetic field at the first frequency; a third excitation magnetic coil to subject the reference microfluidic reservoir to an alternating magnetic field at a second frequency distinct from the first frequency; a fourth excitation magnetic coil to subject the analyte microfluidic reservoir to an alternating magnetic field at the second frequency; a first detection magnetic coil to detect a response magnetic field of the magnetic nanoparticles in the reference microfluidic reservoir; a second detection magnetic coil to detect a response magnetic field of the
    Type: Application
    Filed: October 5, 2018
    Publication date: June 24, 2021
    Applicants: Université Pierre et Marie Curie, Centre National de la Recherche Scientifique, Forschungszentrum Jülich GmbH
    Inventors: Hamid Kokabi, Hans-Joachim Krause, Kieu An Ngo, Amine Rabehi
  • Patent number: 10981021
    Abstract: The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 20, 2021
    Assignees: Carthera, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie (Paris 6)
    Inventors: Alexandre Carpentier, Michael Canney, Alexandre Vignot
  • Patent number: 10952701
    Abstract: The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising: —a holder comprising: —a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves, —a removable imaging device comprising: —a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18), —a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder, —an ultrasound probe (32), and —a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 23, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE RECHERCHE MEDICAL (INSERM), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thomas Deffieux, Jean-Luc Gennisson, Mickaël Tanter, Ivan Cohen, Mathieu Pernot
  • Patent number: 10947152
    Abstract: The invention relates to a process for permanently electrostatically doping a layer of a conductive or non-conductive material that is deposited on a solid substrate, to the doped material obtained according to this process, and to the use of such a material.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: March 16, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIC, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Abhay Shukla, Johan Biscaras, Andrea Paradisi
  • Patent number: 10939838
    Abstract: The invention relates to a method for detecting a physiological state of a patient deviating from a reference physiological state, in which, after having determined, in each of Q frequency bands, R reference matrices PRq,r with qe[1 . . . Q] and r?[1 . . . R] which correspond to the reference physiological state, the following steps are repeated in a loop: carrying out measurements, in M time segments, of an electroencephalographic signal; filtering and centering the measurements in Q frequency bands to obtain and determine M×Q scaled matrices of spatial covariance; for each time segment m, calculating a deviation from the reference physiological state, and comparing each of the deviations from the reference physiological state to a predefined threshold. The invention also relates to a monitoring device applying said method.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: March 9, 2021
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FONDATION ICM—INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Thomas Similowski, Mathieu Raux, Mario Chavez, Jacques Martinerie, Pierre Pouget
  • Patent number: 10881380
    Abstract: The present invention concerns a method for obtaining a functional parameter of a muscle having a part, the method comprising the steps of: a) applying ultrasound waves to the muscle, b) collecting the ultrasound waves retrodiffused by the muscle at a plurality of times, to obtain collected ultrasound waves, c) determining a first plurality of values representative of stiffness values of one part at a first plurality of times by using the collected ultrasound waves, d) determining a second plurality of values representative of deformation values of said part at a second plurality of times by using the collected ultrasound waves, and e) deducing at least one functional parameter based on the first plurality of values and the second plurality of values. The invention also concerns a corresponding device.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: January 5, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Mickael Tanter, Mathieu Pernot
  • Patent number: 10869705
    Abstract: An implant and guide are described, together with methods for configuring the same. The implant and guide are for maxillofacial osteosynthesis and may be provided as a kit. Three-dimensional models of the pre- and post-operative anatomy are used to define attachment points. These attachment points are used to define a structure for the implant and the guide.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: December 22, 2020
    Assignees: OBL S.A., Université Pierre et Marie Curie (Paris 6), Assistance Publique—Hôpitaux de Paris (Paris)
    Inventors: Guillaume Dubois, Patrick Goudot, Thomas Schouman
  • Patent number: 10857239
    Abstract: The invention relates to the use of HNRNPC-expressing vectors for preventing and/or treating a tauopathy, such as Alzheimer's disease. The invention relates to methods for detecting a risk of developing a tauopathy such Alzheimer's disease in a patient, comprising the step of detecting the level of HNRNPC in a biological sample obtained from said patient.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 8, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Thierry Leveillard, Jose-Alain Sahel, Hawa Camara
  • Patent number: 10844367
    Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: November 24, 2020
    Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE NICE SOPHIA ANTIPOLIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Alain Nicolas, Gianni Liti
  • Patent number: 10780435
    Abstract: Disclosed is a minifluidic device including a matrix, an elongated guiding duct embedded at least in part in the matrix, with at least one port to the outside of the matrix, a movable fiber at least partly contained in the guiding duct, and able to undergo within the guiding duct, and at least along some part of the fiber, at least one action selected among a sliding, or a deformation, or a rotation and at least one of the movable fiber or the guiding duct is elastic or is non linear along at least part of its length, or at least part of the matrix is elastic.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 22, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE PIERRE ET MARIE CURIE
    Inventors: Bastien Venzac, Ayako Yamada, Jean-Louis Viovy, Stephanie Descroix, Laurent Malaquin
  • Patent number: 10765412
    Abstract: The invention relates to an endoscopic instrument (1) having an elongate body with a distal end (4) designed to be introduced into the body of the patient so as to come into proximity with an internal organ, the distal end carrying a tool (7) for intervention on the internal organ. The endoscopic instrument has a fool (10) rigidly connected to the distal end and designed to bear on the internal organ, and also controllable means (13) for conferring movements on the tool, at least in directions transverse to a longitudinal axis (X) of the distal end of the endoscopic instrument, when the foot is bearing against the internal organ.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: September 8, 2020
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MAUNA KEA TECHNOLOGIES, ENDOCONTROL
    Inventors: Benoît Rosa, Benoît Herman, Jérôme Szewczyk, Guillaume Morel, Clément Vidal, Patrick Henri, François Lacombe, Jérôme Lopez
  • Patent number: 10736927
    Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 11, 2020
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Harry Sokol, Mathias Lavie-Richard, Marie-Laure Michel, Bruno Michel Lamas, Philippe Langella
  • Patent number: 10711232
    Abstract: The invention relates to a bioreactor comprising a tank containing a culture medium in which a cell culture composed of algae cells is dispersed. The cell culture of algae has a concentration greater than 0.1 g/L in the culture medium, and each algal cell has a minimum absorption in a specific range of wavelengths of light. The bioreactor comprises a light source that is capable of emitting incident light in the direction of the tank, 60% of the photons of the incident light having a wavelength which is included in said specific range of wavelengths of light. The invention also relates to the use of the bioreactor for the production of biomass.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: July 14, 2020
    Assignees: Inria Institut National De Recherche En Informatique Et En Automatique, Centre National De La Recherche Scientifique (C.N.R.S.), Universite Pierre Et Marie Curie (Paris 6)
    Inventors: Francis Mairet, Olivier Bernard, Antoine Sciandra, Eric Pruvost, Charlotte Combe
  • Patent number: 10680241
    Abstract: The present application describes a process for the preparation of titanium-based compounds having an anatase type structure with cationic vacancies arising from a partial substitution of oxygen atoms by fluorine atoms and hydroxyl groups. Electrochemically active materials comprising the titanium-based compounds for use in lithium-ion battery electrodes are also described.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: June 9, 2020
    Assignees: HYDRO-QUEBEC, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Damien Dambournet, Wei Li, Henri Groult, Sandrine Leclerc, Christian Julien, Karim Zaghib
  • Patent number: 10668129
    Abstract: The present invention relates to the synergistic combination of the short and long Rod-Derived Cone Viability Factors and to methods for treating retinal degenerative diseases.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: June 2, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Thierry Leveillard, John Flannery, Xin Mei, Leah Byrne, José-Alain Sahel, Emmanuelle Clerin-Lachapelle, Junwei Sun, Jean Bennett, Jeannette Bennicelli
  • Patent number: 10661274
    Abstract: Disclosed is a fluidic device including at least: a) a solid matrix; b) a textile component, embedded in the matrix and mechanically cohesive with the matrix; c) at least one channel embedded in the matrix and entangled with the textile component, the channel being at least partly open. A method for making a fluidic device includes providing a textile component including support fibers and at least a movable fiber entangled with the textile, embedding at least part of the textile and part of the movable fiber, in a matrix precursor material, applying a treatment in order to obtain a solid matrix.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: May 26, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE PIERRE ET MARIE CURIE
    Inventors: Jean-Louis Viovy, Bastien Venzac, Laurent Malaquin, Stephanie Descroix
  • Patent number: 10653387
    Abstract: Method for functional imaging of the brain, comprising the following steps: (a) a brain is imaged by ultrasound imaging in order to obtain a vascular image to be studied (IVO), (b) the vascular image to be studied (IVO) is compared automatically, by shape recognition, with a cerebral vascular atlas (AV), and the vascular image to be studied (IVO) is thus located in the cerebral vascular atlas (AV), (c) a cerebral functional atlas (AF) corresponding to said cerebral vascular atlas (AV) and comprising cerebral functional zones (1c) located in this cerebral vascular atlas (AV) is used in such a way as to identify cerebral functional zones (1e) on the vascular image to be studied (IVO).
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 19, 2020
    Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ÉCOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITÉ PARIS DIDEROT—PARIS 7
    Inventors: Mickaél Tanter, Jean-luc Gennisson, Thomas Deffieux, Mathieu Pernot
  • Patent number: 10639472
    Abstract: The invention relates to a process for manufacturing at least one implant for focal electrical stimulation of a nervous structure, said implant being of the type including in a supporting structure a network of cavities at the bottom of which are placed microelectrodes, the cavities being bounded by walls erected and located around the microelectrodes, the supporting structure being produced beforehand by implementing the following steps: deposition and etching, in a planar manner, on an insulating substrate, of electrical contacts, of electrical tracks and of microelectrodes, first tracks electrically connecting the microelectrodes and the electrical contacts, second electrical tracks being electrically connected to a ground.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: May 5, 2020
    Assignees: Chambre de Commerce et D'Industrie de Region Paris Ile de France (ESIEE Paris), Universite Pierre Et Marie Curie (Paris 6), Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Lionel Rousseau, Gaëlle Lissorgues, Myline Cottance, Serge Picaud, Julie Degardin