Abstract: Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.

Abstract: The present invention relates to an in vitro method for the prognosis of survival of a patient suffering from a solid cancer, comprising the quantification of the cell density of CD8+ cells and DC-LAMP+ dendritic cells present in a tumor tissue sample from said patient, wherein a high density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has a favorable prognosis, a high density of CD8+ cells and a low density of DC-LAMP+ dendritic cells indicates that the patient has a poor prognosis, and a low density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has the worst prognosis.

Abstract: A straight, branched or cross-linked polymer, including, per 100 mol %: a) a mole fraction from 75% to 99.95% of monomer units from an N,N-dialkyl acrylamide; b) a mole fraction from 0.05% to 1% of monomer units from a monomer of formula (I): CH2=C(Ri)-C(?O)—O—[(CH2-CH(R2)-O]n-R3 (I); c) optionally a mole fraction higher than 0% to 24% either of monomer units from a monomer including a free strong acid function, partially or totally salified, or of monomer units from a monomer of formula (II): CH2=C(R4)-C(?O)—Y—(CH2)m-N(R5)(R6) (II); d) optionally a mole fraction higher than 0% to 1% of a diethylene or polyethylene cross-linking monomer. Also, a method for treating a surface made of a hydrophobic material, using the polymer, and an aqueous, hydro-organic or organic solution including the polymer for modifying interactions between the species contained the solution and the hydrophobic surface.

Abstract: The present invention relates to methods and composition for use in the treatment of retinal degeneration, in particular retinal degeneration due to retinal pigment epithelium dysfunction.

Abstract: The present invention is directed to an entity comprising a particle attached to at least one polymer M through one or several supramolecular interactions -A-B- constituted by 2 to 8 hydrogen bonds X-H-Y, wherein A and B are functional groups respectively grafted to P and M thus forming the particle-containing entity P-(A-B-M)x with x being greater than or equal to 1, functional group(s) B being positioned at one end of the polymeric chain of polymer M, X and Y are heteroatoms present in A and B functional groups, H is hydrogen, and M has a degree of polymerization comprised between 5 and 1000, preferably ranging from 5 to 500. The invention is also directed to a method for preparing this particle-containing entity P-(A-B-M)x, a method for sequentially forming and breaking the supramolecular interactions -A-B- in said particle-containing entity P-(A-B-M)x and dispersions comprising the same.

Abstract: A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a —O—R12 group, wherein R12 is a C1-C7 alkyl, a group —CH2—O—CO—R5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group —O—R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a —CH2-amine, R?1 represents a group chosen among hydrogen and —O—R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.

Abstract: The invention relates to a system for electroencephalographic detection of an improper adjustment of a ventilator used on a mammal. The system includes an electroencephalograph, capable of measuring, as a function of time, an electroencephalographic signal representative of a breathing process; and an input for receiving a respiratory initiation signal, different from the electroencephalographic signal, capable of indicating a respiratory initiation time. The detection system further includes means for specifying a beta frequency band comprised between 15 and 30 Hz and with a width comprising between 5 and 10 Hz; means for processing the measured electroencephalographic signal, configured for processing the measured electroencephalographic signal as it is being acquired, in the sole specified beta frequency band; and means for identifying, for each breathing cycle, an improper adjustment of the ventilator from the electroencephalographic signals processed in the sole beta frequency band.

Abstract: The invention relates to pharmaceutical compositions using a polypeptide comprising at least one CXXC motif, such as Giardia parasite's variable surface proteins (VSP) or a fragment thereof to raise by oral or mucosal vaccination an immune response against a heterologous selected antigen, such as tumor antigen, microbial antigen or other antigen.

Abstract: The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.

Abstract: A method and a device allow optical properties of a sample to be estimated. The method includes the illumination of the sample by a first light source, and the formation of an image of the sample thus illuminated, on the basis of which a first optical property is estimated, at various points on a surface of the sample. The method also includes measuring an auxiliary optical property of the sample and estimating the first optical property, taking account of the auxiliary optical property measured on the sample.

Abstract: A method for determining electrical parameter values of the transistors of an analog circuit of a system on chip includes breaking the circuit down into a set of blocks connected to one another; establishing the wiring diagram of said circuit; defining a set of electrical constraints that are specific to said circuit, blocks and transistors of each block; defining electrical parameters of the circuit, block and transistors; selecting for each transistor of the circuit an operator for calculating the electrical parameter values of said transistor; generating structured diagrams of each block of the circuit from the defined constraints and the chosen operators; assembling said structured diagrams of blocks into a general diagram of the circuit; identifying whether there is any conflict; and, if so, emitting an alarm signal.

Abstract: The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. In particular, the said method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid molecule. More specifically, the method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; providing a single-stranded nucleic acid molecule; renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid.

Abstract: The present invention relates to compositions and methods for producing an immune response or reaction, as well as to vaccines, kits, processes, cells and uses thereof. This invention more particularly relates to compositions and methods of using a synthetic viral particle to produce, modify or regulate an immune response in a subject. In a more preferred embodiment, the invention is based, generally, on compositions using synthetic viral particles as an adjuvant and/or vehicle to raise an immune response against selected antigen(s) or epitopes, in particular a cellular and/or a humoral immune response.

Abstract: The present invention is directed to a particle-containing entity P-(A--B-M)x wherein P is a solid particle attached to at least one polymer M through one or several reversible covalent bonds -A---B-, wherein A and B are functional groups respectively grafted to P and M thus forming the P-(A---B-M)x particle-containing entity with x being greater than or equal to 1, M has a degree of polymerization comprised between 5 and 1000, preferably ranging from 5 to 500, and wherein the reversible covalent bond -A---B- is chosen among an imine, a disulfide, a boronic ester or an acetal. The invention is also directed to a method of preparing this particle-containing entity, a method for sequentially forming and breaking the reversible covalent bond -A---B- in said particle-containing entity P-(A---B-M)x and dispersions comprising same.

Abstract: The invention relates to an assistance terminal (5, 6a, 6b) including a housing (5) and at least one terminal (6a, 6b) for remotely monitoring a person (1) connected to a medical assistance and/or monitoring device (3).

Abstract: The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.

Abstract: A haptic system for establishing an interaction between at least one part of the body of a user called stimulation zone and a virtual environment comprises means for estimating the position of the stimulation zone; means for emitting, toward the stimulation zone, at least one flow rate-controlled air jet, the air jet being emitted at a point of emission and its flow rate being determined as a function of the estimated position of the stimulation zone in space and of the characteristics of the virtual environment; a robotized structure controlled so as to move the point of emission of the air jet so that said point of emission remains at a constant distance from the stimulation zone.

Abstract: The invention relates to the A1 peptide of the sequence RRKYGRDFLLRF, as well as to certain variants thereof, for treating cancers, in particular malignant hematopoietic diseases, and more particularly for treating chronic lymphoid leukaemia.

Abstract: The invention relates to polymer particles in the form of filaments formed by block copolymers, as well as to the method for preparing same by means of controlled radical polymerization in emulsion in the presence of a specific living macroinitiator derived from a nitroxide. The invention is characterized in that the filamentous particles are obtained in a dispersed aqueous medium by means of the synthesis of said block copolymers, performed by heating the reaction medium at a temperature of 60 to 120° C., the final block copolymer containing between 10 and 50 mol. % of the macroinitiator which is water soluble and the hydrophobic monomer conversion rate being at least 50%. According to the invention, the weight ratio of hydrophilic fraction of the filamentous particles is less than 25 wt %.

Abstract: The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.