Abstract: It is applied to bifocal, multifocal or progressive intraocular lenses or contact lenses, multifocal corneal ablation or other multifocal configurations, comprising means for projecting the image of a point light source on the retina of a patient and an assembly for directly recording the light reflected in said retina after the double passage of the light through the ocular means, integrating a first focus corrector device inserted in the path of the light beam guided towards the retina and a second focus correction device inserted in the light beam reflected from the retina, to be guided towards the mentioned recording means, each of said focus correction devices having independent control means for controlling the operation thereof.

Abstract: In a method for producing a whey protein hydrolysate, a whey substrate, selected from the group consisting of whey, commercially available whey powder, whey protein isolate, whey protein preparations, and ?-Lactalbumin obtained from whey, is enzymatically hydrolyzing at least with alcalase and trypsin as enzymes at a ratio of g enzymes/g whey substrate between 1:10 and 1:10,000 and at a temperature of between 30° C. and 70° C. within an incubation period of between 18 hours and 30 hours, until a hydrolysis degree of more than 50% of the protein of the whey substrate have a molecular weight of less than 4 kDa. The enzymes are inactivated by heating the enzymes to a temperature of 80° C. to 100° C. after the desired hydrolysis degree has been reached.

Abstract: The invention relates to a method and a device (1) for the online-detection of a deterioration in the state of an insulation in an electric machine (2). A stepped voltage is applied to the winding(s) (3) of the machine (2) with the aid of a converter (41), and the current (i) induced in this manner, and/or the time derivative (di/dt) thereof, is acquired as a measurement signal with the aid of at least one sensor (6, 7, 8) and is then oversampled with a frequency higher than the frequencies characteristic for settling. The signal obtained by said oversampling is then evaluated with regard to parameters of the settling process such as overshooting (Ah) and/or natural frequency (1/?T) and/or a damping constant, in order to detect any deterioration in the insulation.

Abstract: A method for automated decision making includes using situated agents with real time reactivity skills for making decisions according to their individual perceptions and motivations, and further includes integrating into the situated agents one or more pre-established plans by using a model representing sequences of causally related events for supporting the decision making to fulfil coordinately the one or more pre-established plans.

Abstract: What is described is an actuator system (2) comprising at least one actuator (29, 29?) and an associated control system (8) which is designed for at least two operating modes, at least one of which may be deactivated, whereby one of the operating modes is a high efficiency operating mode.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in SEQ ID: NO 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in SEQ ID: NO 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (CNTFR), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (IL-6R), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in SEQ ID: NO 2 having a non-positively charged amino acid residue.

Abstract: Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing IFN-? secretion of T cells or inducing proliferation of T cells and the use of said fragments for immunizing an individual against HPV-associated or other p16INK4a expressing carcinomas, preferably advanced carcinomas.

Abstract: Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (MSI). The vaccine contains an MSI-specific frameshift peptide (FSP) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said FSP. The vaccine of the present invention is particularly useful for the prevention/treatment of colorectal cancer, endometrial cancer, gastric cancer or small bowel cancer.

Abstract: A method of equalizing a signal received over transmission channel defined by BEM coefficients of a basis expansion model of its channel taps, comprising the step of approximately solving the relation (I) for x[n] by an iterative method, n being the index of time, y[n] being the received signal, x[n] being the equalized signal, Bm[n] being the mth basis function of the basis expansion model, M being the model order of the basis expansion model, and blm being the BEM coefficient of the mth of the basis function of the lth channel tap, and w[n] being optional noise.

Abstract: The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumor, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 ?m and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumor tissue biopsy sample.

Abstract: The invention relates to methods for diagnosing bone disorders and/or cardiovascular disorders in a subject, by contacting a biological sample from the subject with (a) a nucleic acid molecule which hybridizes to miR-31 or its 5 or 3? isoforms or variants, or (b) an agent that binds to miR-31 or its 5? or 3? isoforms or variants; detecting and evaluating the hybridization signal of the nucleic acid molecule or agent with a polynucleotide or said miR-31 or its 5? or 3? isoforms or variants; and comparing the detected and evaluated hybridization or binding signal with that of a control sample, wherein a stronger hybridization signal or a stronger binding signal in the sample of the subject compared to that of the control sample is indicative for a risk of developing or having a bone disorder and/or cardiovascular disorder

Abstract: The present invention relates to a transmitting device for producing an analog-modulated pulse train and for emitting the same, comprising a pulse generator, with which a pulse train with an individual pulse form can be produced such that the pulse train falls in a predefined frequency band and/or into a predefined frequency mask, a modulation unit connected to the pulse generator and with which a pulse train can be analog-modulated by means of a predefined modulation scheme with respect to the amplitude thereof and/or the position of the individual pulses thereof, and an emitting unit, in particular an antenna, connected to the pulse generator and/or to the modulation unit and suitable for emitting in the predefined frequency band and/or in the frequency range of the predefined frequency mask, with which emitting unit the analog-modulated pulse train can be emitted, in particular beamed.

Abstract: The invention relates to an electrolyte, comprising at least one lithium salt, a solvent, and at least one compound according to general formula (1). The invention further relates to lithium-based energy stores comprising such an electrolyte.

Abstract: This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues.

Abstract: An embodiment of the invention relates to a method for providing a compressed video bitstream related to consecutive pictures of a video sequence, wherein the pictures are defined by pixels, said method comprising the steps of: (a) applying at least one higher-order motion model to a motion vector field and generating at least one higher-order motion parameter set for said motion vector field, wherein said motion vector field comprises a plurality of first motion vectors, each first motion vector being assigned to a pixel block and describing the local displacement of the pixel block from the preceding picture to the consecutive picture, and wherein each pixel block comprises a plurality of pixels; (b) calculating a second motion vector for each pixel block based on the higher-order motion parameter set; (c) calculating the deviation between the first motion vector and the second motion vector for each pixel block; and (d) generating a video bitstream comprising the higher-order motion parameter set, and f

Abstract: The present invention pertains to a method and a device for the determination of thermo-optical properties, particularly the size or size distribution, of fluorescently labeled biomolecules or biomolecule complexes, particularly nucleic acids, in a reaction solution.

Abstract: Substantially pure biological culture of a strain of the species Pseudomonas graminis, deposited with number CBS136973 at the depositary institution “Centraalbureau voor Schimmelcultures” (CBS) in Utrecht, Netherlands. Use of the CBS136973 culture as an antagonist for the biocontrol of foodborne pathogenic bacteria in fruit intended for human consumption. Method for treating the fruit which comprises the step of applying a preparation that comprises a culture of a strain of the species Pseudomonas graminis, deposited with number CBS136973 at the depositary institution “Centraalbureau voor Schimmelcultures” (CBS) in Utrecht, Netherlands, to the fruit. The application thereof makes it possible to reduce the growth of pathogens during the shelf life of the product, especially when the cold chain is broken.

Abstract: The present invention relates to an optical coherence tomography system having an interferometer, in particular a Michelson interferometer, having a reference arm for variable adjustment of an optical reference path length and having a measuring arm in which an object to be scanned can be disposed and/or is disposed in a sample volume, wherein a focusing system which is configured for focusing divergently incident light beams on a common point situated in the sample volume is disposed in the measuring arm between the beam splitter of the interferometer and the sample volume.

Abstract: The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.