Abstract: The invention relates to a system (21) for receiving a light beam, comprising an array of light sensors (26). The system also comprises a pixelated light switch array (24), in which each switch is adapted to receive at least one portion of the light beam and direct it to the array of light sensors (26), and the pixelated light switch array (24) comprises a higher number of switches than the number of light sensors comprised in the array of light sensors (26).

Abstract: A flow cytometer disinfection module is useful for disinfecting a sheath fluid in a flow cytometer. The module includes a flow cell and at least one UV-C and/or UV-B light source.

Abstract: An apparatus (1) for the impedance matching of an electrical load (2) to a generator (3) has input connections (6a, 6b) for connection to the generator (3) and output connections (7a, 7b) for connection to the load (2). The apparatus (1) has a converter (9) which connects the input connections (6a, 6b) to the output connections (7a, 7b) and by means of which an input voltage which is applied between the input connections (6a, 6b) can be converted into an output voltage which is produced between the output connections (7a, 7b). The converter (9) has at least one energy storage means which is connected to at least one of the output connections (7a, 7b) by means of an active diode (15), a controllable switching device which is connected to said energy storage means, and an actuation device (16) for said switching device.

Abstract: A shaft power plant for energy conversion of a discharge between a headwater and a tailwater, comprising a vertical shaft, the top of which forms an inflow plane which is parallel to the bed and extends below the headwater water level, wherein the shaft is open toward the top and is closed by a base at its bottom end, a unit composed of a turbine and an electrical machine, wherein the unit is arranged entirely under water in the shaft and wherein the turbine is arranged for water to pass through horizontally, and an outflow, which is connected to the turbine, represents a closed flow channel and leads through a through-passage in the shaft to the tailwater, wherein a horizontal first cross-sectional area of the shaft is much larger than a vertical second cross-sectional area taken up by the turbine runner.

Abstract: A compression method for a data transfer that is independent of computer architecture and/or a decompression method for a data record that contains structural indicators and variable values are provided. The method includes the following steps: provision of a string automaton, which represents the structuring rules of the data record in a unit that compresses the original data record; input of the data record into the string automaton; generation of a second, shorter data record by the string automaton, the record containing the variable values of the first data record and control symbols that are specific to the string automaton equipment, the symbols representing a switch from an automaton condition to a sequence condition; and transmission of the second data record to a similar string automaton, which interprets the control symbols, whereby a copy of the original data record with an identical data structure is generated.

Abstract: The present invention relates to a hydraulic energy store (1) having a first (2) and a second fluid reservoir (6), the fluid levels (4, 12) of which extend at different heights, which are connected to one another via a turbine/pump arrangement (10) and during the operation of which a fluid (3) can be moved to and fro between the first (2) and second fluid reservoir (6) and energy can be converted in the process. The second fluid reservoir (6) is configured as a container which is arranged within the fluid (3) in the first fluid reservoir (2), wherein, during operation, the fluid level (12) in the second fluid reservoir (6) can be changed in such a way that, as a result, the immersion depth (h1) of said second fluid reservoir (6) in the first fluid reservoir (2) can Ere changed owing to buoyancy.

Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.

Abstract: A method of establishing a DC bias in front of at least one electrode in a plasma operating apparatus by applying an RF voltage with at least two harmonic frequency components with a controlled relative phase between the components, where at least one of the higher frequency components is established as an even multiple of the lower frequency component.

Abstract: Template-fixed ?-hairpin mimetics and libraries including a plurality of these mimetics are provided. The template-fixed ?-hairpin mimetics are of the following general formula: R1-Cys-Z-Cys-R2??I wherein the two cysteine residues are bridged by a disulfide bond, thereby forming a cyclic peptide; R1 and R2 are di- or tripeptide moieties of certain types, as defined herein; and Z is a chain of n amino acid residues with n being an integer from 4 to 20 and with each of these n amino acid residues being, independently, derived from any naturally occurring L-?-amino acid.

Abstract: The present invention relates to enhancing RNA expression in a cell such as a cell transfected with RNA by reducing the activity of RNA-dependent protein kinase (PKR). Thus, the present invention provides methods for expressing RNA in a cell comprising the step of reducing the activity of RNA-dependent protein kinase (PKR) in the cell. Reducing the activity of RNA-dependent protein kinase (PKR) in the cell increases the stability of RNA and/or increases the expression of RNA in the cell.

Abstract: An in vitro method of screening candidate compounds for the preventive or curative treatment of rosacea is described. The method can include determining the capacity of a compound to modulate the expression or activity of the Transient Receptor Potential (TRPs), as well as the use of modulators of the expression or activity of this transcription factor for the treatment of rosacea. The method can also include in vitro diagnosis or prognosis of this pathology.

Abstract: Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions.

Abstract: The invention concerns a method and means for distinguishing malignant from benign tumor samples of the thyroid, by performing a RNA extraction in a standard fine needle aspiration biopsy (FNAB) sample, in particular an air dried FNAB smear. The presence of gene-rearrangements and/or the expression of miRNA is analyzed in the isolated RNA, wherein the presence of a gene-rearrangement and/or the differential expression of miRNA is indicative for a malignant tumor.

Abstract: The invention relates to a tubular supporting prosthesis capable of growing, comprising a mesh structure, wherein the mesh structure comprises at least two structural rings, which are connected to each other via connecting members and are disposed point-symmetrically about the longitudinal supporting prosthesis axis, wherein the structural rings and/or the connecting members have at least one predetermined breaking point.

Abstract: A printable medium is proposed, such as can be used, for example, during the production of metal contacts for silicon solar cells which are covered with a passivation layer on a surface of a silicon substrate. A corresponding production method and a correspondingly produced solar cell are also disclosed. The printable medium contains at least one medium that etches the passivation layer and metal particles such as nickel particles, for example. By locally applying the printable medium to the passivation layer and subsequent heating, the passivation layer can be opened locally with the aid of the etching medium. As a result, the nickel particles can form a mechanical and electrical contact with the substrate surface, preferably with the formation of a nickel silicide layer. The printable medium and the production method made possible therewith are cost-effective owing to the use of nickel particles, for example, and allow both good electrical contact and avoidance of undesirable high-temperature steps.

Abstract: The invention relates to the gene therapeutic treatment of cancer using co-expressed nucleic acids encoding US28 and a G-protein. e.g. GNA-13, or functional fragments thereof, or using nucleic acids encoding fusion polypeptides of US28 and a G-protein or functional fragments thereof. The pharmaceutical compositions according to the invention are used in the treatment of cancer patients to induce apoptosis in tumor cells.

Abstract: The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and expression, of said recombinant fusion protein renders said genetically-modified non-human animal sterile. Tools for generating such sterile genetically-modified non-human animal as well as methods of use thereof are also provided.

Abstract: A method and an arrangement for modeling antenna emission characteristics are disclosed. A slotted microwave waveguide is implemented by separate mechanical modules having slot groups respectively implemented therein. For this purpose, the modules are arranged along at least one first spatial direction, so that the modules sectionally form a part of the delimitation of the waveguide. The waveguide formed can be fed by exciting a waveguide mode and the mode propagates through the interior of the module in the waveguide formed. Screens are arranged in front of the modules, to partially cover the slot groups. Arbitrary emission characteristics can be simulated, wherein no separate feed network is necessary due to the use of a modular waveguide.

Abstract: Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N?-methyl derivative of a basic amino acid.

Abstract: The present invention provides methods, immunoassays, kits and devices pertaining to the detection of multiple biomolecules from single cells or other biological entities. It also enables the highly parallel detection of interacting biomolecules from such entities.