Abstract: An apparatus for additively manufacturing a heterogeneous structure (50) using a plastic fiber (10) and an energy transfer material (20) is disclosed. Additive manufacturing is performed in a vertical direction (z) perpendicular to a horizontal plane (x-y). The apparatus comprises: a nozzle device (110) adapted to provide the plastic fiber (10) for additive manufacturing; a feeding device (120) adapted to move the energy transfer material (20) back and forth in a vertical direction (z); and moving device (130) adapted to independently move (or rotate) the feeding device (120) and the nozzle device (110) in the horizontal plane (x-y) to fabricate the heterogeneous structure (50) in the horizontal plane (x-y).

Abstract: A hydrogen bonded organic framework (HOF) includes at least one kind of organic linker with at least one functional group forming a hydrogen-bonded network, the functional group includes a hydroxyl group and a central atom of tetrahedral geometry, the HOF is semi-conductive, proton-conductive and porous, and can even be microporous. In some embodiments, the at least one functional group is phosphonic acid, phosphinic acid, arsonic acids, arsinic acids, phosphonate, arsonate and/or esters thereof including at least one hydroxylgroup. A covalent organic framework (COF), is also provided based on an HOF for transforming the hydrogen bonds between the functional groups into covalent anhydride bonds via a condensation reaction or reactions known to form anhydrides.

Abstract: It is provided a composition comprising a hyperbranched polyester polyol derivative and a small molecule comprising at least one cyclic amine. The hyperbranched polyester polyol derivative is obtainable by a method comprising the following steps: a) reacting only glycidol and ?-caprolactone at a temperature lying in a range of between 40° C. and 140° C. to obtain a hyperbranched polyester polyol derivative in which caprolactone residues and glycerol residues are randomly arranged; b) reacting the hyperbranched polyester polyol derivative of step a) with a sulfation reagent to obtain a sulfated hyperbranched polyester polyol as hyperbranched polyester polyol derivative.

Abstract: The present invention refers to a microfluidic system based on passive capillary valves and pumps, that allows a discontinuous and autonomous measurement process for extensive periods of time. The microfluidic system comprises: at least one measuring chamber, at least one inlet for the input of a biofluid, a microfluidic intake channel fluidly communicating the inlet with the measuring chamber, at least one sensor suitable for measuring a parameter of an analyte of a biofluid. A passive fluid pump is fluidly communicated with the measuring chamber, and it is adapted to generate a capillary pressure greater than the biofluid generation pressure. A retention valve is interposed between the measuring chamber and the fluid pump, and the retention passive valve is configured to stop flow of biofluid for a certain period of time, when the measuring chamber if filled with biofluid.

Abstract: The present invention relates to a perfusion loop assembly for an ex vivo liver perfusion including: a pump for providing a fluid flow of a perfusion fluid through a first branch line and a second branch line; the first branch line being configured to provide a first portion of the perfusion fluid to the hepatic artery of the liver; the first branch line being coupled with a first gas exchanger, the second branch line being configured to provide a second portion of the perfusion fluid to the portal vein of the liver; the second branch line further including a first valve for controlling the flow of the perfusion fluid into the portal vein of the liver, a liver chamber assembly configured to hold the liver ex vivo, a liver outlet line attached to the vena cava of the ex vivo liver, at least one reservoir connected to the liver outlet and upstream from the pump.

Abstract: Technology is disclosed herein that the enhances the measurability and scalability of qubits in a quantum computing environment. In an implementation, a superconducting amplifier device comprises a parametric amplifier and a tunable coupling between the parametric amplifier and a readout cavity external to the superconducting amplifier device. The tunable coupling allows an entangled signal, associated with a qubit in the readout cavity, to transfer from the readout cavity to the parametric amplifier. The parametric amplifier amplifies the entangled signal to produce an amplified signal as output to a measurement sub-system.

Abstract: Disclosed is a method for analysing cells, in which cells are separated and the individual cells pass via a measurement region of a unit for spatially resolved radiation intensity measurement, wherein, for at least one of the separated cells, when passing via the measurement region, a time sequence of spatial intensity patterns of an electromagnetic radiation emitted from and/or influenced by the cell is created, the optical flow of a respective two of the spatial intensity patterns is calculated for at least one portion of the sequence of intensity patterns using a computer unit, and an evaluation of the calculated optical flows occurs. Also disclosed is a device for analysing cells, comprising a device for separating cells, a unit for spatially resolved radiation intensity measurement, and a computer unit for calculating the optical flow of a respective two of the created intensity patterns, and for evaluating the calculated optical flows.

Abstract: An optical detection device having a light detection device and a light emission device is arranged such that the light detection side of the light detection device is optically coupled to a light emission side of a light source array of the light emission device via an examination region. The light detection device generates an electrical signal n response to light that reaches the light detection side. The light source array includes a plurality of separately actuatable electric light sources which are arranged in a matrix structure or two dimensional geometric arrangement. The object to be examined can be arranged in a desired fashion, and the light emitted by the light sources radiates via the examination region on the light detection side of the light detection device. An optical reduction is system is arranged in the beam path from the light emission side to the examination region and is configured to demagnify the light pattern which is emitted by the light sources.

Abstract: Summarizing the invention, a computer-implemented method is provided. The computer-implemented method comprises: allocating, by an operating system kernel, a physical memory block for a privileged function; storing, by the operating system kernel, the privileged function in the physical memory block; creating, by the operating system kernel, an entry for the physical memory block in a mapping table, wherein the entry associates the physical memory block to a virtual memory block in an address space of a program; setting, by the operating system kernel, a security bit for the entry in the mapping table; executing, by a processor, the program in unprivileged mode; and if the program requests the privileged function: checking, by the processor, whether the security bit is set; if the security bit is set, switching, by the processor, execution to kernel mode for performing the privileged function.

Abstract: The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure. The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.

Abstract: The invention relates to a device for detecting water flow through or over at least one layer of biological cells, the device containing a first and a second container, the second container being situated at least in part within the first container such that two separate compartments are formed. The base of the second container consists, at least in regions, of a planar, water-permeable substrate for growing biological cells, and the base of the first container has an electrode pair, the electrodes of which each have an electrical connection which leads into a space outside the first container. By means of the device according to the invention, water flow over at least one layer of biological cells can be detected easily, quickly, robustly, and reproducibly, with a high temporal resolution. The invention also relates to a method for detecting water flow over at least one layer of biological cells.

Abstract: A device and a method for computer-aided processing of data are disclosed, the method including: providing configuration data of an application, determining a first application identification, wherein the first application identification is assigned to the application, determining a configuration identification, wherein the configuration identification is assigned to the configuration data of the application, individualizing the data by means of a second application identification, wherein the second application identification is determined using the first application identification and the configuration identification.

Abstract: The present invention relates to a modular multivalent antigen-binding protein complex, use of the antigen-binding protein complex in medicine and use of the antigen-binding protein complex in the prophylaxis, treatment or diagnosis of a disorder or disease.

Abstract: An implantable electrical connecting device includes a first elastic multi-ply layer and a second elastic multi-ply layer. The first elastic multi-ply layer has a first electrically conductive layer and a plurality of first electrical contacts electrically conductively connected to the first electrically conductive layer of the first elastic multi-ply layer. The second elastic multi-ply layer has a first electrically conductive layer and a plurality of second electrical contacts electrically conductively connected to the first electrically conductive layer of the second elastic multi-ply layer. The second electrical contacts make contact with the first electrical contacts.

Abstract: There are provided a method for producing a photovoltaic element with stabilised efficiency, and a device which may be used to carry out the method, for example in the form of a specially adapted continuous furnace. A silicon substrate to be provided with an emitter layer and electrical contacts is thereby subjected to a stabilisation treatment step. In that step, hydrogen, for example from a hydrogenated silicon nitride layer, is introduced into the silicon substrate, for example within a zone (2) of maximum temperature. The silicon substrate may then purposively be cooled rapidly in a zone (3) in order to avoid hydrogen effusion. The silicon substrate may then purposively be maintained, for example in a zone (4), within a temperature range of from 230° C. to 450° C. for a period of, for example, at least 10 seconds. The previously introduced hydrogen may thereby assume an advantageous bond state.

Abstract: The invention relates to a device for connecting a cannula to a container under reduced pressure, in particular a blood culture flask, including an inflow opening for connecting to the cannula or to a connection tube connected to the cannula, an outflow opening for connecting to a hollow pin for piercing a closure of the container, and a tight fluidic connection of the inflow opening to the outflow opening. According to the invention, a reservoir which is separated from the fluidic connection and contains a specified gas quantity is connected to the fluidic connection with the interposition of a valve which is preferably open towards the fluidic connection.

Abstract: The present invention relates to an isolated antisense oligonucleotide for use in a method of preventing or treating an inflammatory disease or condition of the buccal cavity in a canine subject, wherein said antisense oligonucleotide is directed against canine ICAM-1. The present invention further relates to compositions or articles of manufacture comprising said antisense oligonucleotide.

Abstract: The present invention relates to a method for determining the fertility of spermatozoa, said method comprising determining the total content of Vimentin variant 3 (Vim3) per spermatozoon and/or the spatial localization of the Vim3 in the spermatozoa, wherein a decreased amount of total content and/or decreased amount of (or even missing) accumulation of Vim3 in the mid piece of the spermatozoa indicates decreased fertility. Further, the present invention refers to a dipstick usable for this method. Moreover, the present invention relates to further methods and uses in the context of the present invention.

Abstract: The invention provides a human IL-2 (hlL-2)-specific monoclonal antibody, wherein a complex of hlL-2 and the monoclonal induces IL-2 signalling preferentially via CD25 and the trimeric IL-2R. The invention further provides a pharmaceutical composition comprising hlL-2 and said hlL-2-mAb for use treating inflammatory disease.

Abstract: A method, a software application, and a reader for evaluating a matrix code in an image, in which the patterns of the individual symbol rows are reconstructed, and scanning values are determined at the intersections of the symbol row patterns. Firstly, the approximate position of each of the symbols along the symbol rows in the direction of a first dimension of the image is determined successively, with the determined pixel positions being used as the position of the symbols in the direction of the first dimension, and subsequently the patterns of the individual symbol rows along the other dimension of the complete image are determined successively. These two steps are then repeated for the other dimension. The scanning points are determined on the basis of the properties of the data modulation taking into consideration the channel distortions. A decorrelation of the scanned symbols reduceS the local inter-symbol interferences.