Abstract: The present invention relates to small-molecule inhibitors of the FRS2-FGFR interaction. The present invention relates the small-molecule inhibitors for use as a medicament and for use in cancer or metastasis treatment or prevention.

Abstract: A system comprising a first electroacoustic transducer connected to an interrogation unit and at least one second electroacoustic transducer connected to a resonator, wherein the first electroacoustic transducer and the second electroacoustic transducer form an acoustic channel and the second electroacoustic transducer forms with the resonator a passive cooperative target which, upon receiving an interrogation signal from the interrogation unit, transmits a response signal via the acoustic channel, and the interrogation signal has a higher energy than the response signal.

Abstract: A method is provided for producing a microfiber-reinforced high-strength concrete, comprising a cement matrix with a microfiber addition. The fiber elements have a shape-memory alloy. The method has at least the following steps: training a fiber shape of the fiber elements at a temperature above a transition temperature, wherein the fiber shape allows the fiber elements to latch; cooling the trained fiber elements; plastically deforming the fiber elements from the trained fiber shape into an intermediate form by means of which the fiber elements are prevented from latching; introducing the fiber elements into the cement matrix in order to form a fresh concrete; and casting the fresh concrete and heating the fresh concrete to the transition temperature such that the fiber elements reform into the fiber shape, thereby latching the fiber elements. The invention additionally relates to a microfiber-reinforced concrete which is produced using such a method.

Abstract: Multinuclear complexes and methods for preparing them are provided. The discrete multinuclear complexes include a one or more transition metals and a radioisotope having the same coordination geometry as the transition metal. A bridging ligand is coordinated to the transition metal and the radioisotope to link the transition metal and the radioisotope and pendent ligands are coordinated to each of the transition metal and the radioisotope to stabilise the complex. The multinuclear complexes may include a radioisotope or radioelement that can be detected by medical equipment and may find use in therapy and/or the diagnosis of disease in patients.

Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).

Abstract: The present invention relates to the use of a corrosion inhibition composition for protection of metals and/or metallic surfaces from corrosion and a method for inhibition of corrosion of metallic surfaces using the corrosion inhibition composition.

Abstract: Embodiments are directed to the field of ceramics and relate to electron-emitting ceramics such as those which can be used as cathode material for electron emissions in space flight systems, for example. Embodiments specify an electron-emitting ceramic which has an improved temperature conductivity with a simultaneously continuous electron emission. The electron-emitting ceramic contains at least>70 vol. % C12A7 electride and a proportion of Zr, Hf, V, Nb, Ta, Cr, Mo, W, Mn, Re, Fe, Ru, Os, Ni, Pd, Pt, Cu, Ag, Au, Zn, Cd, In, Sn, Sb, Te, Tl, Pb, or Bi as metal and/or with Ti, wherein the proportion of the metals lies between>0 and<30 vol. %, and the ceramic has a density of at least 85% of the theoretical density of the ceramic and the ceramic contains 0 to maximally 10 vol. % production-specific impurities.

Abstract: Described herein is a gene construct comprising a nucleotide sequence encoding a fibroblast growth factor 21 (FGF21), for use in the treatment and/or prevention of a central nervous system (CNS) disorder or disease, or a condition associated therewith.

Abstract: A catalyst/initiator system that can be used for polymerizing ?-butyrolactone is described. The catalyst/initiator system includes a rare earth metal, a chiral ligand, at least one nucleophilic ligand, optionally at least one solvent ligand, and optionally an alkali based co-catalyst. The chiral ligand can have the structure of Formula A, as shown below: wherein Y represents rare earth metal Yttrium, Ph represents Phenyl radical and thf represents tetrahydrofuran solvent ligand.

Abstract: The invention relates to a method for classifying a tissue sample obtained from mammary carcinoma. The method comprises determining a stiffness value for each of a plurality of points on said tissue sample, resulting in a stiffness distribution, and assigning said sample to a breast cancer subtype and nodal status based on said stiffness distribution.

Abstract: The present invention concerns a tissue-engineered medical device, as well as a method for the production said medical device, comprising the following steps: providing a polymer scaffold comprising a mesh comprising polyglycolic acid, and a coating comprising poly-4-hydroxybutyrate; application of a cell suspension containing preferably human cells to the polymer scaffold; placement of the seeded polymer scaffold in a bioreactor and mechanical stimulation by exposure to a pulsatile flux of incremental intensity, thereby forming an extracellular matrix; mounting of the graft on a conduit stabilizer and incubation in cell culture medium; decellularisation of the graft in a washing solution; nuclease treatment of the graft; and rinsing of graft. The invention further comprises and various steps of quality control of the tissue-engineered medical device.

Abstract: A threaded sleeve for assembling with heat input in a component manufactured by FDM process is provided. The threaded sleeve includes a groove along its longitudinal axis. Further, the outwardly facing surface of the threaded sleeve includes a self-tapping thread which is divided into two sections along the threaded sleeve's longitudinal axis. The first section includes a constant pitch diameter and the second area comprises a pitch diameter decreasing along its longitudinal axis. The inwardly facing surface of the threaded sleeve comprises a metric thread. Furthermore, a kit, a system and a method for assembling with heat input the above-mentioned threaded sleeve in a component manufactured by FDM process is provided.

Abstract: An information processing device, wherein the information processing device includes circuitry configured to: copy, in response to an instruction for play back of a content, encrypted content data; decrypt the copied encrypted content data for obtaining the content data representing the content; and apply a data protection algorithm on the content data to generate protected content data representing protected content, wherein the protected content is played back.

Abstract: The present invention relates to a cyclic peptide, a conjugate comprising said cyclic peptide and a lipopeptide building block, a bundle of said conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said cyclic peptide, said conjugate said bundle of conjugates, said synthetic virus-like particle and said pharmaceutical compositions for use as a medicament, preferably for use in a method for preventing of an infectious disease or reducing the risk of an infectious disease, more preferably for use in a method for preventing or reducing the risk of an infectious disease associated with or caused by a respiratory syncytial virus.

Abstract: The present invention relates to human tissue kallikrein 7 (KLK7) selective inhibitor compounds, combinations including these compounds, process to obtain the referred compounds, and methods of using the same. The present invention belongs to the field of chemistry, pharmacology and medicine.

Abstract: A method for determining a property of at least one particle (P) in a medium (M), comprising: emitting a coherent light beam (6) to irradiate a sample (5) of the medium (M); recording an interference image (10) of a first part of the light beam (6) scattered by the at least one particle (P) and a second part of the light beam (6) not scattered by particles (P); computing (S1), for positions (13) within the sample (5), an electric field (E1) of the first part from the interference image (10); generating (S2) a representation (16) comprising for each position (13), a phase value (?), determined from the computed electric field (E1) and from an estimated electric field (E2) of the second part, and an intensity value (I), determined from the intensity (I1) of the first part and from the phase value (?); and determining (S3), therefrom, said property.

Abstract: The present invention relates to a solid or liquisolid formulation comprising corallopyronin A, wherein the formulation comprises an amorphous solid dispersion of corallopyronin A embedded in a water-soluble polymer or corallopyronin A loaded onto porous silica.

Abstract: A method for the exchange of electrical energy between at least two moving, electrically powered vehicles, comprising the steps: providing a first and a second electrically powered vehicle, having a respective electrical energy store, the energy store of the first and the second vehicle can emit or receive electrical energy, and the first and second vehicles move or are to be moved along a first or second route; changing the first and second routes in such a way that both changed routes coincide along a route section; steering the first and second vehicle along the changed first and second route in such a way that both the vehicles move along the coinciding route section at a distance to one another that is smaller than a predefined maximum distance; and transferring electrical energy from the energy store of the first vehicle to the energy store of the second vehicle.

Abstract: The device for locating cardiac arrhythmias comprises a three-dimensional reconstruction of the patient's torso and a number of surface electrodes, wherein the three-dimensional reconstruction of the patient's torso is generated through a number of images obtained by means of at least one camera. In particular, the device comprises elements for locating the surface electrodes, which detect the position of the electrodes with respect to the patient's torso, and data processing elements that generate, on the basis of the three-dimensional reconstruction and the position of the electrodes, a surface electrocardiographic map, and said surface electrocardiographic map has a number of data corresponding to readings of the surface electrodes related to areas of the three-dimensional reconstruction.

Abstract: The disclosure relates to a drive device (V) for producing a translational motion of a movable tappet (8) by means of an electromagnetic rotating machine. The drive device includes an inner rotor (4) and an outer coaxial stator (5) and has a movement-thread pair integrated coaxially in the stator. The movement-thread pair comprising a lead screw (6), which is coupled to the rotor for conjoint rotation, and a threaded nut (7), which is linearly guided in a stator sleeve (2) in a rotationally fixed manner and is rigidly coupled to the tappet. The rotor is guided for rotation around the stator and a torque being transferred from the rotor to the lead screw by means of a thin-walled flange (10). A rotational fixation (11) of the threaded nut in the cavity of the stator sleeve is provided as a result of interlocking joining of the two.