Abstract: The present invention relates to a method and an assembly for chromatic confocal spectral interferometery, in particular also for spectral domain OCT (SD-OCT) using multi-spectral light. A multiple (e.g. two, three, four, etc.) axial splitting of foci in the interferometric object arm is performed using a multifocal (e.g. bifocal, trifocal, quattro-focal, etc.) optical component, forming thereby at least two, three or even several groups of chromatically split foci in the depth direction. The multifocal optical component is made of a diffractive optical element (712) and a Schwarzschild objective (5). At least two, three, four or even more differently colored foci of different groups of foci coincide in at least one confocal point in the object space of the setup.

Abstract: The present invention relates to an arrangement and a method for single-shot interferometry which can be used for detecting distance, profile, shape, undulation, roughness or the optical path length in or on optically rough or smooth objects or else for optical coherence tomography (OCT). The arrangement comprises a light source, an interferometer, in which an end reflector is arranged in the reference beam path, and also a detector for detecting an interferogram. In the reference beam path of the interferometer, the end reflector can be embodied with three plane reflecting surfaces as a prism mirror or air mirror assembly in order to generate between reference and object beams a lateral shear of magnitude delta_q for obtaining a spatial interferogram. The embodiment of said assembly with regard to the angles and the arrangement of the reflecting surfaces makes possible a large aperture angle for a high numerical aperture.

Abstract: A method and a device for testing, the device comprising a learning arrangement adapted to provide scenarios for test cases and principles to be tested, in particular comprising a digital representation of one or more of a law, an accident report, a log, or human expertise or a combination thereof, wherein the learning arrangement is adapted to determine at least one rule for test case generation from the scenarios and the principles, and wherein a modelling arrangement is adapted to determine, store and/or output a model for test case generation depending on the at least one rule.

Abstract: A method and a device for testing, the device including a learning arrangement adapted to provide scenarios for test cases and principles to be tested, in particular comprising a digital representation of one or more of a law, an accident report, a log, or human expertise or a combination thereof, wherein the learning arrangement is adapted to determine at least one rule for test case generation from the scenarios and the principles, and wherein a modelling arrangement is adapted to determine, store and/or output a model for test case generation depending on the at least one rule.

Abstract: The present invention provides a polypeptides comprising a heavy chain domain 2 (HD2) from IgM or IgE and at least one pharmaceutically active moiety, complexes thereof and their use for therapy and prophylaxis.

Abstract: The invention relates to a drilling device comprising a light source configured to provide a light beam and a diffractive beam propagation device having a substantially planar surface, wherein the light source is configured such that the light beam is incident on the planar surface of the diffractive beam propagation device, and wherein the diffractive beam propagation device is configured to propagate the light beam as one or more propagated beams such that the one or more propagated beams, at least when being integrated over time, surround an area with a substantially circular shape. A use of the drilling device for drilling a hole in a work piece and a method suitable for drilling a hole in a work piece are also provided.

Abstract: The present invention relates to a method and a device for a nucleic acid based diagnostic approach including the determination of a deviant condition of a sample, wherein the deviant condition is preferably a health condition and/or a pathogenic condition.

Abstract: The present invention relates to an arrangement and a method for single-shot interferometry which can be used for detecting distance, profile, shape, undulation, roughness or the optical path length in or on optically rough or smooth objects or else for optical coherence tomography (OCT). The arrangement comprises a light source, an interferometer, in which an end reflector is arranged in the reference beam path, and also a detector for detecting an interferogram. In the reference beam path of the interferometer, the end reflector can be embodied with three plane reflecting surfaces as a prism mirror or air mirror assembly in order to generate between reference and object beams a lateral shear of magnitude delta_q for obtaining a spatial interferogram. The embodiment of said assembly with regard to the angles and the arrangement of the reflecting surfaces makes possible a large aperture angle for a high numerical aperture.

Abstract: The present invention provides a polypeptides comprising a heavy chain domain 2 (HD2) from IgM or IgE and at least one pharmaceutically active moiety, complexes thereof and their use for therapy and prophylaxis.

Abstract: Proposed are an arrangement and a method for depth-scanning strip triangulation with internal or external depth scan, particularly also for the 3D shape measurement in microscopy and mesoscopy. The robustness of the measurement with wavelet signal generation from an image stack is to be increased. The occurrence of the known and very undesirable 2Pi phase jumps in the phase map is to be avoided as much as possible. To do this, with a measurement instead of a wavelet at least two wavelets with contrast envelope are generated. This is done by a concurrent—then preferably with spectral separation—or by a sequential projection of two strip images with different triangulation wavelengths on the measured object.

Abstract: The invention relates to the coding and decoding of data, in particular for visual representation. For this, a method (100) is provided for coding an initial data set (110), in which a respective initial data value (P1, P2, P3, P4) is established for a respective plurality of initial data points (112), for generating a compressed data set (114), comprising a primary coding of the initial data set (110) to generate an intermediate data set (116) and a secondary coding of the intermediate data set (116) to generate the compressed data set (114).

Abstract: Summarizing, the present invention relates to a control system for a wind turbine including—a feed forward controller having a rotor effective wind speed of the wind turbine as an input parameter and having a plurality of output parameters—a feedback controller wherein an input parameter is based on a rotor speed or a generator speed of the wind turbine and having at least one output parameter and wherein o one output parameter of the feed forward controller is provided to the feedback controller as an input parameter and o another output parameter of the feed forward controller is used as a feed-forward control parameter for controlling the wind turbine and o one output parameter of the feedback controller is used as a feed-back control parameter for controlling the wind turbine, as well as a wind turbine and a control method.

Abstract: A method for producing a component by means of an additive manufacturing method using a laser is proposed, the method comprising the following steps: (a) providing a metal powder, (b) applying a powder layer (18) of the metal powder to a build platform (14) of a process chamber (12), (c) introducing a first process gas into the process chamber (12), (d) melting a first selected region (36) of the applied powder layer (18) by means of a laser in a first atmosphere which includes the first process gas, (e) introducing a second process gas into the process chamber (12), wherein the second process gas differs from the first process gas at least in terms of its composition and/or its pressure, and (f) melting a second selected region (38) of the applied powder layer (18) by means of the laser in a second atmosphere which includes the second process gas, wherein the second selected region (38) differs from the first selected region (36).

Abstract: The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further relates to cells, non-human organisms. pharmaceutical compositions and kits comprising the cytokine fusion proteins or the nucleic acid molecules encoding them, as well as to their use as medicaments.

Abstract: The invention relates to a method for compressing an input data set, which comprises one or more input values, comprising the following steps: determining, for each input value, a tolerance range; generating encoded lossy values by a lossy encoding of the input values; generating output values associated with the input values, in particular by decoding the encoded lossy values; generating difference values by subtracting each decoded lossy value from the respectively associated input value; comparing each difference value with the respectively associated determined tolerance range; generating encoded correction values associated with the encoded lossy values on the basis of the difference values, wherein the encoded correction values are offset values, which can be added to the associated encoded lossy values; and providing an output data record as a function of a comparison of the difference values with the tolerance ranges and on the basis of the encoded lossy values and/or the encoded correction values.

Abstract: The invention discloses the use of an artificial protein for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer, wherein the artificial protein comprises a first histone modification binding domain of 50 to 200 amino acids binding to a first histone modification, a second histone modification binding domain of 50 to 200 amino acids binding to a second histone modification, a linker of 5 to 50 amino acids connecting the first and the second histone modification binding domain, and an affinity tag. Further disclosed are a nucleic acid encoding the artificial protein, a host cell comprising the nucleic acid and a kit for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer. Further disclosed is an in-vitro method for isolating a nucleosome having a first and a second histone modification.

Abstract: The invention provides for an inhibitor of the huTNFRI receptor which is a human or humanized antibody construct that monovalently recognizes huTNFRI through an antigen-binding moiety, which is characterized by specific CDR sequences, a pharmaceutical preparation thereof, method of producing the inhibitor and the medical use of the inhibitor.

Abstract: The present invention relates in general to the field of TNF ligand family members. In more detail the present invention relates to polypeptides comprising at least three components A, each of which comprises the sequence of a TNF homology domain (THD) of a TNF ligand family member, or a functional derivative thereof, and comprising at least one component B consisting of a VL region and a VH region linked directly to each other with a linker sequence L which has a length of <12 amino acids. Furthermore, the present invention also relates to nucleic acids encoding such polypeptides and pharmaceutical compositions thereof.

Abstract: The present invention relates to an optical module configured to be optically coupleable to a laser amplifier module, the optical module comprising an inner optical element having a plurality of M inner reflective elements arranged around a center of the inner optical element; and a plurality of N outer reflective elements arranged around the inner optical element, the plurality of N outer reflective elements being configured to face the inner optical element, wherein the plurality of M inner reflective elements and the plurality of N outer reflective elements are configured to provide an optical path for a laser beam.

Abstract: The present disclosure provides a method and to a device for quantitatively sensing the power fraction of a radiation background of a pulsed laser. The disclosure further relates to the use of a saturable element. The method includes modulating a measurement beam, which is emitted by the laser, by means of a saturable element in accordance with the fluence of the measurement beam, detecting, by means of a modulation beam power detector, the power of the measurement beam modulated by the saturable element, and determining the power fraction of the radiation background of the pulsed laser on the basis of the detected power of the measurement beam modulated by means of the saturable element.