Abstract: Proposed are an arrangement and a method for depth-scanning strip triangulation with internal or external depth scan, particularly also for the 3D shape measurement in microscopy and mesoscopy. The robustness of the measurement with wavelet signal generation from an image stack is to be increased. The occurrence of the known and very undesirable 2Pi phase jumps in the phase map is to be avoided as much as possible. To do this, with a measurement instead of a wavelet at least two wavelets with contrast envelope are generated. This is done by a concurrent—then preferably with spectral separation—or by a sequential projection of two strip images with different triangulation wavelengths on the measured object.

Abstract: Summarizing, the present invention relates to a control system for a wind turbine including—a feed forward controller having a rotor effective wind speed of the wind turbine as an input parameter and having a plurality of output parameters—a feedback controller wherein an input parameter is based on a rotor speed or a generator speed of the wind turbine and having at least one output parameter and wherein o one output parameter of the feed forward controller is provided to the feedback controller as an input parameter and o another output parameter of the feed forward controller is used as a feed-forward control parameter for controlling the wind turbine and o one output parameter of the feedback controller is used as a feed-back control parameter for controlling the wind turbine, as well as a wind turbine and a control method.

Abstract: A method for producing a component by means of an additive manufacturing method using a laser is proposed, the method comprising the following steps: (a) providing a metal powder, (b) applying a powder layer (18) of the metal powder to a build platform (14) of a process chamber (12), (c) introducing a first process gas into the process chamber (12), (d) melting a first selected region (36) of the applied powder layer (18) by means of a laser in a first atmosphere which includes the first process gas, (e) introducing a second process gas into the process chamber (12), wherein the second process gas differs from the first process gas at least in terms of its composition and/or its pressure, and (f) melting a second selected region (38) of the applied powder layer (18) by means of the laser in a second atmosphere which includes the second process gas, wherein the second selected region (38) differs from the first selected region (36).

Abstract: The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further relates to cells, non-human organisms. pharmaceutical compositions and kits comprising the cytokine fusion proteins or the nucleic acid molecules encoding them, as well as to their use as medicaments.

Abstract: The invention relates to a method for compressing an input data set, which comprises one or more input values, comprising the following steps: determining, for each input value, a tolerance range; generating encoded lossy values by a lossy encoding of the input values; generating output values associated with the input values, in particular by decoding the encoded lossy values; generating difference values by subtracting each decoded lossy value from the respectively associated input value; comparing each difference value with the respectively associated determined tolerance range; generating encoded correction values associated with the encoded lossy values on the basis of the difference values, wherein the encoded correction values are offset values, which can be added to the associated encoded lossy values; and providing an output data record as a function of a comparison of the difference values with the tolerance ranges and on the basis of the encoded lossy values and/or the encoded correction values.

Abstract: The invention discloses the use of an artificial protein for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer, wherein the artificial protein comprises a first histone modification binding domain of 50 to 200 amino acids binding to a first histone modification, a second histone modification binding domain of 50 to 200 amino acids binding to a second histone modification, a linker of 5 to 50 amino acids connecting the first and the second histone modification binding domain, and an affinity tag. Further disclosed are a nucleic acid encoding the artificial protein, a host cell comprising the nucleic acid and a kit for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer. Further disclosed is an in-vitro method for isolating a nucleosome having a first and a second histone modification.

Abstract: The invention provides for an inhibitor of the huTNFRI receptor which is a human or humanized antibody construct that monovalently recognizes huTNFRI through an antigen-binding moiety, which is characterized by specific CDR sequences, a pharmaceutical preparation thereof, method of producing the inhibitor and the medical use of the inhibitor.

Abstract: The present invention relates to an optical module configured to be optically coupleable to a laser amplifier module, the optical module comprising an inner optical element having a plurality of M inner reflective elements arranged around a center of the inner optical element; and a plurality of N outer reflective elements arranged around the inner optical element, the plurality of N outer reflective elements being configured to face the inner optical element, wherein the plurality of M inner reflective elements and the plurality of N outer reflective elements are configured to provide an optical path for a laser beam.

Abstract: The present invention relates in general to the field of TNF ligand family members. In more detail the present invention relates to polypeptides comprising at least three components A, each of which comprises the sequence of a TNF homology domain (THD) of a TNF ligand family member, or a functional derivative thereof, and comprising at least one component B consisting of a VL region and a VH region linked directly to each other with a linker sequence L which has a length of <12 amino acids. Furthermore, the present invention also relates to nucleic acids encoding such polypeptides and pharmaceutical compositions thereof.

Abstract: The present disclosure provides a method and to a device for quantitatively sensing the power fraction of a radiation background of a pulsed laser. The disclosure further relates to the use of a saturable element. The method includes modulating a measurement beam, which is emitted by the laser, by means of a saturable element in accordance with the fluence of the measurement beam, detecting, by means of a modulation beam power detector, the power of the measurement beam modulated by the saturable element, and determining the power fraction of the radiation background of the pulsed laser on the basis of the detected power of the measurement beam modulated by means of the saturable element.

Abstract: The present invention relates to a method and an apparatus for establishing residual stresses in objects, in particular in coated objects, and to a method and an apparatus for coating objects. The method comprises: impinging a surface (8) of the object (5) with laser light and generating a hole or a pattern of holes and/or locally heated points in the object (5); establishing the surface deformations by an optical deforming measuring method after the object (5) is impinged by laser light; establishing the residual stresses present in the object (5) from the measured surface deformations, wherein the generation of the hole pattern is carried out by an optical scanning apparatus which comprises an optical deflection and/or modulation arrangement for controllable deflection and/or modulation of the laser light, and/or a focusing arrangement for controllable focusing of the laser light.

Abstract: The present invention relates to complexes comprising (i) an immunoglobulin (Ig) binding moiety and (ii) a pharmaceutically active moiety, wherein the Ig binding moiety specifically binds to the constant domain 1 of the heavy chain (CH1) of an Ig molecule and their use for therapy and prophylaxis.

Abstract: The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector.

Abstract: The present invention relates to a method and a computer program product for generating a high-resolution three-dimensional (3D) voxel data set of an object. The high-resolution three-dimensional (3D) voxel data set is generated with the aid of a computed tomography scanner. In some aspects of the present disclosure a 3D image data set is generated by acquiring computed tomography images of the object. In other aspects of the present disclosure the 3D voxel data set of the object is generated with the aid of an image data reconstruction algorithm.

Abstract: The present invention relates to cytokine fusion proteins and to nucleic acid molecules encoding such cytokine fusion proteins. The present invention further relates to cells, non-human organisms. pharmaceutical compositions and kits comprising the cytokine fusion proteins or the nucleic acid molecules encoding them, as well as to their use as medicaments.

Abstract: The present invention relates to a method and a computer program product for generating an artifact-reduced voxel data record of an object. The artifact-reduced voxel data record of the object is generated with the aid of a computed tomography scanner. In some aspects of the present disclosure, a first image data record and a second image data record is generated by acquiring computed tomography images of the object. In still other aspects of the present disclosure, the artifact-reduced voxel data record of the object is generated with the aid of an image data reconstruction algorithm.

Abstract: The present invention provides a flexible high-density fiberboard which is essentially free of formaldehyde and isocyanates and comprises 70 to 90% by weight of straw fibers, and 30 to 10% by weight of a thermoplastic elastomer and one or more optional additive(s). Furthermore, the present invention provides a method for manufacturing such a flexible high-density fiberboard comprising the steps of providing straw fibers, providing a thermoplastic elastomer in powder form, optionally providing one or more additive(s), dry mixing the straw fibers, the thermoplastic elastomer powder and optionally the one or more additive(s), such that a mixture comprising 70 to 90% by weight of the straw fibers, and 30 to 10% by weight of the thermoplastic elastomer and one or more of the optional additive(s) is obtained, extruding the obtained mixture at a temperature such that the thermoplastic elastomer powder is in a molten state, and pressing the extruded mixture.

Abstract: In a method for impregnating semi-finished fibrous products using resin as the impregnating means, winding or laying the semi-finished fibrous products in a plurality of layers on top of one another onto a receiving carrier is initially performed. Here, lower layers lie close to the receiving carrier, and upper layers lie more remote therefrom. The receiving carrier is configured so as to be permeable to the impregnating means. The impregnating means is then introduced through the receiving carrier into the semi-finished fibrous products, wherein the impregnating means initially permeates the lower layers and then permeates the upper layers of the semi-finished fibrous products.

Abstract: The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2 stands for CR2 R2?, NR2, PR2, 0 or S, A3 stands for N or P, and C stands for a carbene carbon atom, ring B is an unsubstituted or a mono or poly-substituted 5 to 7-membered ring, substituents R2 and R2? stand, inter alia, for a linear or branched C1-Cw-alkyl group and, if N and N each stand for NR2 or PR2, are the same or different, M in formulas I, II, III or IV stands for Cr, Mo or W, X 1 or X2 in formulas I to IV are the same or different and represent, inter alia, C1-C1s carboxylates and C1-C1s-alkoxides, Y is inter alia oxygen or sulphur, Z is inter alia a linear or branched C1-Cw-alkylenoxy group, and R 1 and R1? in formulas I to IV are, inter alia, an aliphatic or aromatic group.

Abstract: The invention relates to methods and to devices for generating multispectral illuminating light having an addressable spectrum, for adaptive multispectral imaging and for capturing structural and/or topographical information of an object or of the distance to an object. The illuminating device comprises a multispectral light source and a modulator for temporal modulation of the individual spectral components of the multispectral light source having modulation frequencies. The multispectral light source comprises at least one light source having a continuous, quasi-continuous, or frequency comb spectrum and wavelength-dispersive means, or an assembly or array of monochromatic or quasi-monochromatic light sources having emission wavelengths or emission wavelength bands which are different from one another in each case.