Abstract: The invention relates to a tunnel lining segment of reinforced concrete, wherein the tunnel lining segment has a load transfer area for a longitudinal joint, with at least one steel bar with an end face being installed in the tunnel lining segment, the steel bar being arranged in the tunnel lining segment in such a way that a tangent to a centroidal axis of the steel bar encloses an angle of between 0° and 45° in the end face with a normal to the load transfer area, and wherein the end face is arranged at a distance (a) from the load transfer area which is between 0 mm and 50 mm, preferably between 0 mm and 10 mm.

Abstract: The present invention relates to a method for producing shaped bodies (5) from a building material, in which a layered structure of a shaped body (5) takes place by successively solidifying layers of the building material by exposure to electromagnetic radiation in a layer area having a contour specified for the respective layer. The method provides that together with the shaped body (5), a sleeve-like frame (6) surrounding the shaped body at a distance is constructed layer by layer from the building material, and that in addition, a plurality of pin-like connections (10) are constructed integral with the frame (6) and the shaped body (5), which are distributed around the shaped body (5) and which connect the shaped body (5) with the frame (6).

Abstract: Method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, in particular for the lithography-based additive production of magnetic resonance imaging phantoms, the method comprising at least the following steps: providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid, and mixing the at least partially filled particles with a light-curable resin.

Abstract: The invention relates to a device for connecting a cannula to a container under reduced pressure, in particular a blood culture flask, including an inflow opening for connecting to the cannula or to a connection tube connected to the cannula, an outflow opening for connecting to a hollow pin for piercing a closure of the container, and a tight fluidic connection of the inflow opening to the outflow opening. According to the invention, a reservoir which is separated from the fluidic connection and contains a specified gas quantity is connected to the fluidic connection with the interposition of a valve which is preferably open towards the fluidic connection.

Abstract: The present invention relates to a method for the in vitro detection of a latent tuberculosis infection (LTBI) in a subject, wherein said method comprises determining at least one nucleotide sequence and/or at least one polypeptide of Mycobacterium tuberculosis (Mtb) in a blood cell population of said subject, and wherein the presence of said at least one nucleotide sequence and/or said at least one polypeptide is indicative for said latent tuberculosis infection. In particular, the blood cell population is enriched for hematopoietic stem cells. The invention also relates to a pharmaceutical composition for use in the treatment of the LTBI in the subject, wherein it is determined if the nucleotide sequence and/or the polypeptide of Mtb is/are present in the blood cell population. Further, the invention relates to kits for carrying out the methods of the invention. The invention also relates to the use of the kits.

Abstract: The invention relates to a stoichiometric salt of a tetracarboxylic acid and a diamine of the following general formula (I), wherein R1 is selected from tetravalent residues of butane, cyclobutane, cyclopentane, cyclohexane, tetrahydrofurane and benzophenone and R2 is selected from divalent residues of unbranched, branched or cyclic aliphatic hydrocarbons with 3 to 15 carbon atoms, with the proviso that the salt of the formula (I) is water-soluble and is selected from compounds (1) to (28); and to the polyimides prepared from these salts by polycondensation.

Abstract: The invention relates to a method for preparing polybenzimidazoles of formula (1) or (2) below, wherein n is ?2: by polycondensation of corresponding dicarboxylic acids or dialdehydes and tetraamines by jointly heating the reactants, characterized in that the preparation of polybenzimidazoles of formula (1) or (2) is carried out by using the dialdehydes as starting material and substantially without the formation of any intermediates, wherein a) first, the dialdehyde and the tetraamine are mixed in water at room temperature, which results in the formation of a polyimine by-product; whereafter b) polycondensation is carried out under hydrothermal conditions by heating, in water as a solvent and under pressure, to temperatures above 100° C.

Abstract: A safety system is provided for a machine tool which has a frame and a tool. The safety system has a clamping device and a motion device. The clamping device is movable by the motion device from a working position, in which the tool is extended and can be used for working, to a safety position, in which the tool is retracted. The motion device has a first magnetic means connected to or arranged on the tool and a second magnetic means connected to or arranged on the frame, such that movement of the tool by the motion device from the working position to the safety position can be triggered and/or at least partially performed by magnetic force.

Abstract: The present invention relates to an antibody specifically binding the carboxymethylated catalytic subunit of protein phosphatase 2A (PP2Ac). Also provided are diagnostic uses of said antibody and screening methods employing the inventive antibody.

Abstract: The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

Abstract: The present invention relates to a new pestivirus useful in the fields of veterinary virology and vaccines. Specifically, it relates to an isolated polynucleotide originating from pestivirus and a pestivirus, to vaccines and medical uses thereof, to chimeric virus comprising the polynucleotide and to expression vectors for heterologous expression of polypeptides.

Abstract: A light-curable composition is provided which may be used as a photopolymerizable material in an additive manufacturing process. The additive manufacturing process involves heating the light-curable composition which has a viscosity at 20° C. of at least 20 Pa·s. The light-curable composition includes a photopolymerizable matrix material, at least one thermoplastic polymer dissolved therein, and at least one photoinitiator. Polycaprolactone or a derivative thereof is used as the dissolved thermoplastic polymer.

Abstract: A computer-implemented method and an electronic device for detecting, in an electrical circuit with electrical components (Mg) subject to variations (?) of their model parameters (xj), those components (Mg*) the model parameter variations (?) of which have the strongest influence on a performance (yn) of the circuit, comprising: providing a topology (Q) of the circuit and the model parameters (xj) of all components (Mg) therein; determining, therefrom, topological patterns (Pk) of interconnected components (Mg); generating variation samples (vn), each comprising a different set of candidate variations (x?j) of the model parameters (xj); calculating, for each variation sample (vn), the circuit's performance (yn) and a deviation from a standard performance and forming a deviation vector (yD) therefrom; and using the variation samples (vn), the deviation vector (yD) and the topological patterns (Pk) in a regression model for detecting the most influential components (Mg*).

Abstract: The present invention provides a pharmaceutical composition for use in prevention or treatment of a human rhinovirus (HRV) infection. The composition comprises an aldohexose, wherein the hydroxyl group at carbon 2 of the aldohexose is replaced by any one of H, F, Cl, Br, I, SH, Me, OMe and SMe, such as a 2-deoxy-glucose. Furthermore, a dispenser for intranasal administration, such as a nasal spray or nose drop applicator containing said pharmaceutical composition is provided. In addition, an inhalation device, such as a metered-dose inhaler, a dry-powder inhaler or a nebuliser, comprising said composition is provided.

Abstract: Compounds of general Formula (I) wherein the elements A, L, R1 and R2 have a defined meaning, and their medical and non-medical use. The compounds may be used treatment of a subject in need of any one or more of anti-inflammatory, anti-oxidative, anti-ageing, or lipid metabolism modulation therapy or prophylaxis. The compounds may also be used as food or feed products, dietary supplements or cosmetic preparations.

Abstract: Method and apparatus to produce a wideband RF signal covering an increased first bandwidth, utilizing at least one narrowband transceiver (1) capable of producing an output RF signal with a base frequency fbase and a second bandwidth, wherein the second bandwidth is lower than the first bandwidth, and wherein the base frequency Case depends on the setting of at least one frequency register (2, 2?, 2?), which is adjustable by a control unit, as well as method to estimate the position of a narrowband RF transceiver (1) using a multitude of coherent wideband RF receivers (12) and computer-readable medium comprising computer-executable instructions causing an electronic device to perform the method.

Abstract: The invention relates to an in vitro method of determining a subjects risk of liver dysfunction, specifically after partial liver resection, said method comprising the steps of providing a sample from said subject, determining in said sample the expression level of at least one miRNA, selected from the group consisting of miR-151a, miR-192 and miR-122, and comparing these expression level(s) with at least one reference expression level, or identifying the ratios of the expression levels of miR-15 la to miR-192 and/or of miR-122 to miR-151a and comparing said expression level ratios with reference expression level ratios, and classifying the sample from the outcome of the comparison into one of at least two classes, wherein each class is one of the at least two categories “high-risk” and “low-risk”.

Abstract: A device for feeding and setting an implant into a blood vessel includes a hollow cylindrical portion formed of an expandable wire mesh netting with a first end and a second end, with a sleeve for receiving the implant in a radially compressed state. The sleeve is arrangeable along a guide wire. The sleeve for receiving the implant in the radially compressed state is formed by an inner sleeve, around which at least one outer sleeve with a distal end and a proximal end is arranged. The implant is arranged in the inner sleeve in such a way that the second end of the hollow cylindrical portion is arranged on the end facing the proximal end of the outer sleeve, so that during setting of the implant, the inner sleeve surrounding the implant can be moved into the outer sleeve in the distal direction so that the implant expands, beginning from the second end.

Abstract: A method for automatic detection of a functional primitive in a model of a hardware system, the model being a netlist having cells and net links therebetween, comprising the steps: a) mapping the cells to target nodes, each of which having a target node type, and the net links to edges of a target graph, and mapping the functional primitive to a search pattern having search nodes and connections therebetween; b) selecting candidates from those target nodes the target node types of which match a search node type, and selecting a candidate structure from those selected candidates the target nodes and edges of which match the search nodes and connections of the search pattern; c) reverse-mapping the target nodes and edges of the selected candidate structure to the cells and net links of the netlist; and d) outputting said cells and net links as detected functional primitive.

Abstract: A method of producing a test body for diffusion tensor imaging, which comprises a plurality of channels in a structuring material, the channels preferably having a maximum cross-section of 625 ?m2, wherein a virtual model of the test body is created and the virtual model is fed to a structuring device which produces the test body by means of a 3D printing-based, in particular lithography-based, structuring process, the structuring process being designed as a multiphoton lithography process, in particular as a multiphoton absorption process, in which the structuring material containing a photosensitizer or photoinitiator is irradiated in a location-selective manner, wherein the radiation is successively focused on focal points lying within the structuring material, resulting in that in each case a volume element of the material located in the focal point is subjected to a change in state by means of a photochemical reaction as a result of multiphoton absorption.