Abstract: The present invention relates to a mutant thymidine kinase, specifically a mutant human thymidine kinase 1 (Tkl1). The activity of the mutant thymidine kinase is increased compared to the activity of wildtype thymidine kinase. Provided herein are uses of the mutant thymidine kinase in therapy, such as in cancer therapy. Also methods of treating cancer comprising administering the mutant thymidine kinase are disclosed herein. The present invention relates, inter alia, to a nucleic acid for use hi treating cancer, wherein said nucleic acid comprises a nucleotide sequence, wherein said nucleotide sequence encodes a mutant thymidine kinase.

Abstract: The present invention relates to a method and a device for a nucleic acid based diagnostic approach including the determination of a deviant condition of a sample, wherein the deviant condition is preferably a health condition and/or a pathogenic condition.

Abstract: The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

Abstract: The present invention is directed to a compound for use in the prevention or treatment of a neurodegenerative disease, in particular of a synucleinopathy. The present invention further is directed to a pharmaceutical composition containing an effective amount of said compound and one or more pharmaceutically acceptable auxiliaries.

Abstract: The present invention relates to a method for assessing whether a patient suffers from cancer, such as hepatocellular carcinoma, or is prone to suffering from cancer, such as hepatocellular carcinoma, wherein said method comprises determining the amount of soluble AXL in a sample from the patient. The patient is assessed to suffer from cancer or to be prone to suffering from cancer when the amount of soluble AXL is increased in comparison to a control. The present invention relates to the use of soluble AXL for assessing whether a patient suffers from cancer, such as hepatocellular carcinoma, or is prone to suffering from cancer, such as hepatocellular carcinoma. Also a kit for use in the methods of the present invention is provided.

Abstract: Radically polymerizable silane according to the general formula I in which R1 is a linear or branched aliphatic C1-C9-alkyl radical, phenyl or alkylated phenyl radical, R2, R3 independently of each other in each case are absent or are a linear or branched aliphatic C1-C20-alkylene radical, which can be interrupted by S or O atoms, R4, R5, R6 independently of each other in each case are —Cl, —O—CH3, —O—C2H5, —CH3 or —C2H5, X is CH2 or O, Y is absent, or is O or NR?, wherein R? is H or a C1-5-alkyl radical, and Z is absent, or is O, NR?, —CO—O—, —CO—NR?—, —O—CO—O—, —O—CO—NR?—, or —NR?—CO—NR?—, wherein R? is H or a C1-5-alkyl radical and wherein the radicals R2 and R3 cannot be absent at the same time and Z is absent if R2 or R3 is absent, polycondensates based thereon and fillers surface-modified therewith.

Abstract: A stereolithography device having a trough (2) for accommodating free-flowing, photopolymerizable material, a construction platform (4) suspended above the trough bottom on a lifting unit (6), and having a heating unit for heating the photopolymerizable material in the trough. The heating unit has a transparent, electrically conductive layer (33), which covers the entire area of at least the exposure region above the trough bottom, and which is provided outside the exposure region on opposing sides of the layer with electrical contacts (20) extended over the opposing sides, which are connected to a controlled electrical supplier to enable heating of the entire area of photopolymerizable material above the trough bottom in the exposure region by current flow through the layer.

Abstract: Radically polymerizable dental material, which contains at least one sulphonic acid ester of Formula 1: in which A is H, CN, an aromatic, cycloaliphatic, linear or branched aliphatic C1-C30-hydrocarbon radical or a combination thereof; X is COO— or —CON(R1)— or is absent; B is an aromatic, cycloaliphatic, linear or branched aliphatic C1-C30-hydrocarbon radical, or a combination thereof; R1 is hydrogen or an aromatic, cycloaliphatic, linear or branched aliphatic C1-C10-hydrocarbon radical; m is an integer from 1 to 6, n is an integer from 1 to 6 and p is an integer from 1 to 6; wherein m and p cannot simultaneously be greater than 1. The compounds of Formula 1 are active as chain transfer agents in radical polymerization.

Abstract: A photothermal interferometry apparatus and method for detecting a molecule in a sample, in particular for detecting a trace gas species, comprising: a Fabry-Perot interferometer with a first mirror, a second mirror and a first cavity for containing the sample extending between the first and the second mirror, a probe laser for passing a probe laser beam through the first cavity of the Fabry-Perot interferometer, an excitation laser for passing an excitation laser beam through the first cavity of the Fabry-Perot interferometer for exciting the molecule in the sample, and a photodetector unit for detecting the transmitted probe laser beam passed through the first cavity of the Fabry-Perot interferometer.

Abstract: The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

Abstract: The present invention relates generally to the field of ocular therapeutics and the development thereof for use in humans and animals including mammals and birds. More particularly, it relates to subunit vaccines that are effective against pathogens causing infections thereof for use in humans and animals including mammals and birds. The present invention specifically provides a novel vaccine formulation suitable for ocular immunization comprising a subunit vaccine antigen in an amount to provoke a protective immune response and at least two adjuvants of which one is corpuscular. It further provides a method for inducing a local and systemic immune response and methods for preventing recurrence of ocular infections and/or modulates the occurrence and/or severity of sequels.

Abstract: A substance exchange device for intracorporal use includes a cavity for receiving blood having at least one blood inlet and at least one blood outlet, a substance exchange membrane adjoining the cavity, a supply duct for supplying an exchange fluid to the substance exchange membrane, a blood pump arranged within the cavity and a drive unit for the blood pump. The blood pump is configured to pump blood in a direction from a blood inlet to a blood outlet of the cavity. The drive unit includes a turbine, which is connected to the supply duct and may be driven by an exchange fluid supplied via the supply duct, where the turbine includes at least a rotor coupled to the blood pump and a stator (turbine nozzle) arranged upstream of the rotor.

Abstract: Disclosed is a magnetic coupling for transmitting torque along an axis of rotation, comprising two coupling parts which can be rotated relative to each other, wherein a drive-side coupling part has a drive-side permanent magnet and wherein an output-side coupling part has an output-side permanent magnet that lies opposite and at a distance from the drive-side permanent magnet along the axis of rotation. One of the coupling parts comprises a diverting element which is at least partially ferromagnetic and is non-rotatably connected to the permanent magnet of said coupling part and one part of the diverting element is disposed radially outside the opposite permanent magnet.

Abstract: Monolithic phononic crystal for vibration isolation comprising: a two-dimensional array of a plurality of resonant masses, said resonant masses being connected by bridges; wherein transition regions between bridges and resonant masses have a concave shape in the plane of the two-dimensional array, respectively; wherein the resonant masses each have convex edges in the plane of the two-dimensional array; wherein the bridges are recessed with respect to the thickness of the resonant masses.

Abstract: The disclosed subject matter relates to a method for determining phase offsets in a complex-valued image in Magnetic Resonance Imaging, including the steps of, immobilising an object and acquiring a first image thereof at a predetermined first echo time and a second image thereof at a predetermined second echo time, the first and second images being separated into first and second magnitude images and first and second phase images, respectively, wherein a ratio between said first echo time and said second echo time is chosen to be n:(n+1), n being a positive integer; generating, pixel by pixel, a phase evolution image; and subtracting, pixel by pixel, an n-fold of the phase evolution image from the first phase image to obtain a phase offset image containing said phase offsets.

Abstract: Disclosed is a method for the detection of an IgM antibody specific for a flavivirus in a sample, comprising the steps of (a) contacting the sample with a solid support comprising immobilised IgM-binding molecules, (b) allowing binding of IgM antibodies in the sample to the IgM binding molecules on the solid support so that the IgM antibodies are also immobilised on the solid support, and (c) detecting IgM antibodies specific for a flavivirus by allowing binding of a complex comprising (i) an antiparallel dimer of soluble flavivirus Protein E (sE) and (ii) a marker and identifying the binding of the complex to the specific flavivirus IgM antibody by detecting the marker; and a kit suitable for performing the method.

Abstract: A solvothermal synthesis process for polyimides is provided. The process uses solution polymerization of monomers in an appropriate solvent, by mixing the solvent and the monomers and heating the mixture under pressure at temperatures exceeding the respective boiling point at normal pressure. The process produces essentially completely crystalline polyimides by a) mixing and heating the solvent and the monomers by either (i) heating the solvent up to solvothermal conditions and subsequently adding the monomers to initiate the reaction, or (ii) mixing the monomers with the solvent and heating the mixture up to solvothermal conditions within a period of 5 min, the reaction temperature TR being held below the solid-state polymerization temperature TP of the monomers during the polymerization; and b) carrying out the solution polymerization until essentially complete conversion is achieved.

Abstract: An apparatus and a method for analysing a solid specimen material by means of ablating particles of the solid specimen material by laser into a carrier liquid, having: a specimen holder for arranging the solid specimen material covered by the carrier liquid, a laser apparatus for irradiating the solid specimen material to produce a suspension of particles of the solid specimen material and the carrier liquid, an analysis apparatus for analysing the particles, an ablation cell with the specimen holder, having a liquid channel for the carrier liquid and having an entry window made of a material that transmits the laser beam, a supply line for supplying the carrier liquid into the liquid channel of the ablation cell and a discharge line for discharging the suspension of particles of the solid specimen material and the carrier liquid from the liquid channel of the ablation cell into the analysis apparatus.

Abstract: The invention relates to a method for producing a reference frequency ?f. According to the invention, the use of a first optical resonator (3a; 24) and of a second optical resonator (25) is provided, wherein the first resonator (3a; 24) has a first resonator mode having a first frequency f1 and the second resonator (25) has a second resonator mode having a second frequency f2, wherein the frequencies of the two resonator modes are functions of an operating parameter BP and assume the values f1 and f2 at a specified value BP0 of the operating parameter such that f1(BP0)=f1 and f2(BP0)=f2 apply, wherein the resonators (3a; 24, 25) are designed in such a way that the respective first derivatives of the frequencies f1(BP), f2(BP) with respect to BP or at least respective difference quotients around BP0 correspond within a deviation of at most ±0.

Abstract: The invention relates to a method and to a device for determining a material property, in particular the aging state or the aging resistance, of a bitumen material, comprising the steps: applying a substantially monochromatic first excitation radiation of a first excitation wavelength to the bitumen material; measuring the intensity of a first fluorescence radiation, excited by the first excitation radiation, at a measurement wavelength; applying a substantially monochromatic second excitation radiation of a first excitation wavelength to the bitumen material; measuring the intensity of a second fluorescence radiation, excited by the second excitation radiation, at the measurement wavelength; determining a first key figure for the material property of the bitumen material from the ratio between the intensity of the second fluorescence radiation to the intensity of the first fluorescence radiation.