Abstract: A semiconductor layer and a method and an apparatus for its manufacturing are disclosed. The semiconductor layer includes at least one compound of the formula M1aM21-aN, where M1 is selected from group 13 of the periodic table and M2 is selected from the group including scandium, yttrium, erbium, and europium and where the parameter a is selected between 0.01 and 0.99. The method includes supplying a first precursor into a reaction chamber, the first precursor including at least M2 and being supplied to the reaction chamber at a molar flow rate of at least 1·10?6 mol/min by providing the first precursor by means of a first bubbler from which it is evaporated and supplied to the reaction chamber, the temperature of the first bubbler being more than 90° C.

Abstract: The invention relates to a boundary layer probe for determining a fluid flow, comprising a measuring surface which is formed on a probe wall and with which a fluid flow to be determined is in contact during a measuring operation. The boundary layer probe also comprises an assembly of measuring obstacles that are formed in the region of the measuring surface as obstacles which disrupt the fluid flow in a flow region adjacent to the measuring surface, each of which has an elongated obstacle course extending over a particular obstacle length, and which are arranged at substantially equidistant angular distances in the circumferential direction. The boundary layer probe additionally has pressure measuring points, each of which is radially adjacent to an associated obstacle in order to detect a local pressure in the region of the measuring surface. The invention additionally relates to a measuring assembly and to a method for determining a fluid flow.

Abstract: The present invention relates to a circuit arrangement having an active rectifier circuit, in particular on a secondary side of an inductive energy transmission path. The circuit arrangement has a half or full bridge of power transistors for rectifying an AC voltage induced in an input inductor of the circuit arrangement. The power transistors are connected to the input inductor in such a way that an auxiliary voltage is split off from the induced AC voltage for switching the power transistors. As a result, even large currents, which result in a low output voltage, can be transmitted without endangering the operation of the rectifier circuit.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

Abstract: The invention relates to a method for producing a component by means of layered construction, by combining a plurality of crystallites of a metallic material to form a single crystal. The single crystal is formed by thermomechanically activated successive anisotropic plastic deformation. The metallic material is heated during the construction of a new layer, with the result that the metallic material is melted in a linear region. The linear region is moved in order to construct the new layer.

Abstract: A modified nanoparticle for use in a therapeutic method, wherein the therapeutic method comprises the administration of the modified nanoparticle to an organism, the targeting of the modified nanoparticles to a specific site in the organism followed by an uptake of the modified nanoparticle into a cell, and wherein the modified nanoparticle is obtainable by a process comprising the steps of i) providing a nanoparticle and ii) contacting the nanoparticle with one or more antibodies as at a pH value of less than 7.0 so as to non-covalently bind the one or more antibodies via its/their Fc region onto the surface of the nanoparticle, wherein the nanoparticle provided in step i) is made of a material having at least one protonable or deprotonable group on the surface thereof and/or the one or more targeting moieties contacted with the nanoparticle in step ii) has at least one protonable or deprotonable group.

Abstract: A method of manufacturing a core for a production process and to a core manufactured in accordance with the method are provided. The method includes providing a mold containing a soluble substance and one or more fibers and causing the soluble substance to solidify around the one or more fibers.

Abstract: The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E.-coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

Abstract: A method and a device for non-contact determination of temporal color and/or intensity variations in objects in a scene. Monoscopic overview images of the scene are detected with first and second overview cameras from two different viewing directions, and calculated to form a stereoscopic overview map. A two-dimensional detail image is detected by a detail camera from a third viewing direction and is projected on the overview map. Measurement surfaces in the scene are selected based on criteria which are predetermined depending on parameters on which conclusions are to be drawn from the color variations and/or intensity variations. Light emitted by the measurement surfaces is detected in a spatially-resolved and wavelength-resolved manner in a continuously-captured series of measurement images in a predetermined spectral range. The measurement surfaces are analyzed in the measurement images with respect to temporal variation of the intensity and/or color of the light, and the results displayed.

Abstract: The invention relates to a method for identifying and quantifying a polypeptide from a library of polypeptides. The method comprises the steps of: 1—providing a polypeptide library and a detection tag library, 2—generating a nested library comprising the polypeptides and the detection tags, 3—sequencing the nested library, 4—selecting a member of the nested library in one or several selection steps that are independent of a physical genotype-phenotype linkage, 5—isolating the detection tag from the selected polypeptide, 6—identifying and quantifying the detection tag by mass spectrometry, 7—obtaining the sequence of the selected polypeptide. The invention also relates to a collection of polypeptides, a collection of detection tags, and a collection of plasmid vectors.

Abstract: A method for the exchange of electrical energy between at least two moving, electrically powered vehicles, comprising the steps: providing a first and a second electrically powered vehicle, having a respective electrical energy store, the energy store of the first and the second vehicle can emit or receive electrical energy, and the first and second vehicles move or are to be moved along a first or second route; changing the first and second routes in such a way that both changed routes coincide along a route section; steering the first and second vehicle along the changed first and second route in such a way that both the vehicles move along the coinciding route section at a distance to one another that is smaller than a predefined maximum distance; and transferring electrical energy from the energy store of the first vehicle to the energy store of the second vehicle.

Abstract: The invention relates to a specific panel of circulating synaptic protein related miRNAs for use in the diagnosis of Mild Cognitive Impairment (MCI) and/or early diagnosis of Alzheimer's disease (AD). The invention also relates to a method and to a kit for the diagnosis of said diseases using said specific panel of circulating miRNAs biomarkers.

Abstract: The present invention provides valuable peptidomimetics for therapeutic and diagnostic purposes as well as compositions, methods, uses and kits based on these peptidomimetics. In particular, the peptidomimetics of the present invention are incorporated by CCK2R expressing cells, for instance, cancer cells. This allows, for instance, to selectively destroy cancer cells or to selectively image cancer cells that express CCK2R.

Abstract: Compositions comprising aptamers, and methods of thereof as carrier molecules in cell-mediated immunotherapies, and activation of antigen-specific T-cell responses.

Abstract: The invention relates to a combination medicament for treatment of malignant neoplastic disease. The combination medicament comprises an IL-12 polypeptide having a biological activity of IL-12 or a nucleic acid expression vector comprising a sequence encoding such IL-12 polypeptide, and a non-agonist blockade of T-cell inhibitory molecules, including non-agonist LAG-3 ligand, non-agonist TIM-3 ligand, non-agonist BLTA ligand, non-agonist TIGIT ligand, non-agonist VISTA ligand, non-agonist B7/H3 ligand, non-agonist CTLA-4 ligand or non-agonist PD-1 ligand, particularly an anti-CTLA-4 or anti-PD-1 immunoglobulin G.

Abstract: An occlusion device is provided for occluding a left atrial appendage (LAA), including a compliant balloon defining a fluid-tight balloon chamber, and an actuating shaft, which is disposed at least partially within the balloon chamber for setting a distance between distal and proximal end portions of the balloon. A proximal LAA-orifice cover includes a frame and a covering fixed to the frame. An orifice-support stent is fixed to and extends distally from the proximal LAA-orifice cover, and is generally cylindrical when in a radially-expanded state. Other embodiments are also described.

Abstract: The invention relates to a method for producing mesoporous metal carbide layer with defined nano-structuring, wherein during a first method step a mesoporous metal oxide layer is made available and in a second step, the metal oxide layer is brought in contact in a reducing atmosphere with a carbon source in the atmosphere, wherein the temperature is at least 650° C. and the heat-up rate ranges from 0.5 to 2 kelvin per minute.

Abstract: The invention relates to a method of identifying selective covalently binding inhibitors by using a reversibly inhibiting scaffolds modified by a warhead comprising a fast-reacting Michael acceptor moiety and a linker of different length, determining kinact, and replacing the warhead of the covalently binding inhibitor with the highest kinact by a warhead comprising a moderately reacting Michael acceptor.

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

Abstract: A fuel cell system arranged for the conversion of pure hydrogen comprising a) at least one fuel cell comprising an anode, a cathode and an electrolyte, and arranged for an internal reformation of methane, b) a fuel conduit connecting a fuel conduit inlet with an anode inlet, c) an anode exhaust conduit connecting an anode outlet and a methanation unit capable of producing methane from anode exhaust, and d) a methanation unit exhaust conduit connecting a methanation unit exit and the fuel conduit, and e) a water removal and/or water condenser unit coupled to the methanation unit exhaust conduit, wherein the fuel introduced into an inlet of the fuel conduit is pure hydrogen, and the amount of methane produced in the methanation unit is equal to the amount of methane reformed inside of the fuel cell so that the content of methane cycling through the fuel cell system is constant.