Abstract: The present invention relates to a sensor for non-invasive optoacoustic measurements of biomechanical and/or morphological features of skin and/or other tissue.

Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

Abstract: The present invention relates to a measuring device (10) and a method for determining a depth of field of an optical structure (100). In this case, the measuring device comprises a device body (12) with a measuring axis (14), the device body (12) being formed such that, in a measuring position, it can be placed in a stationary manner on a deposit plane of the optical structure such that the measuring axis (14) of the device body (12) coincides with an optical axis of the optical structure, wherein the device body (12) has a measurement scale (18) arranged along a scale line (16) such that the scale line (16) encloses with the direction of the measuring axis (14) a scale angle ? greater than 0° and less than 90° and the measurement scale (18) can be optically detected in the measuring position of the device body (12) by the optical structure (100) for determining the depth of field.

Abstract: A device for the detection of gamma rays presents a high resolution in the three-dimensional position of the impact of the gamma ray within one or more scintillation crystal blocks coupled to an array of photosensors, for the determination of the impact energy of said gamma ray, the determination of the instant in time when said impact occurred, the interaction depth and the determination of the time-of-flight. Advantageously, in said device, the scintillation crystal detection blocks are optically isolated, in such a way that the scintillation light can only exit said blocks via the output region; and the scintillation crystal detection blocks and the array of photosensors are disposed in direct optical coupling.

Abstract: A process for carrying out an allergy test is based on a blood sample being taken. The blood sample is contacted in vitro with at least one allergen. At least one allergic reaction or the absence of the at least one allergic reaction is observed via a microscope (11) directly and/or optically. To make it possible to carry out an allergy test with a higher validity and/or better accuracy, a position of granules is observed via the microscope (11). The granules are observed in different planes or horizontal planes.

Abstract: The invention relates to a synthesis of cholesterol; a ring opening step of the compound of formula (I) and subsequent activation and reduction step yielding cholesterol. The inventions relates also to intermediates achieved during said synthesis.

Abstract: The present invention relates to the provision of new means and methods for the treatment of proliferative and inflammatory diseases. In particular, the invention relates to a pharmaceutical composition comprising a modified Filamin A encoded by a nucleic acid molecule, wherein the nucleic acid molecule is characterized in that the codon in the wildtype sequence encoding glutamine corresponding to position 2333 of SEQ ID NO: 27 is replaced by a codon encoding arginine and/or a modified Filamin B encoded by a nucleic acid molecule, wherein the nucleic acid molecule is characterized in that the codon in the wildtype sequence encoding glutamine corresponding to position 2327 of SEQ ID NO: 29 is replaced by a codon encoding arginine.

Abstract: The present invention relates to a composition for producing an enamel functional layer, especially an antistatic layer or an electronically conductive corrosion protection layer, to the use of this composition, to a process for producing an enamel coating on a substrate, and to articles having a base body and an enamel functional layer.

Abstract: A compound of general formula I Also, the use of the compound for the complexation of a metal ion, including lutetium ions or actinium ions, and the method for the complexation of a metal ion in which the compound is contacted with the metal ion at a reaction temperature in the range of from 20 to 50° C.

Abstract: The invention relates to a method for producing a lens for an ultrasound apparatus, as well as to an apparatus comprising the lens. The method comprises choosing a source point, providing a treatment volume situated inside a bone tissue model, providing a plurality of nodes distributed inside the treatment volume, and simulating the emission of a spherical wave from each of the nodes. Thus, a simulated wave front is created, in which each spherical wave has an amplitude and a phase, there being at least two nodes with different amplitudes and/or phases. The simulated wave front is received on a receiving surface. On the basis of the processed results, a holographic lens surface is designed, which can generate a wave pattern equivalent to the simulated wave.

Abstract: The invention relates to shaped parts produced from popcorn which has previously been hydrophobised with a polymer. This allows very light and flexible shaped parts to be produced.

Abstract: It is provided a thermoresponsive hydrogel, comprising dendritic polyglycerol units and poly(N-isopropylacrylamide)-co-polyethylene glycol units that are covalently bound to each other via a linker, wherein the linker is chosen from the group consisting of a cyclic triazol moiety and a diazacyclohexadiene moiety. This thermoresponsive hydrogel serves as microniche environment for the robust cultivation of cells such as induced pluripotent stem cells. The thermoresponsive hydrogel has a specific thermoreversible degradation capability enabling a controlled release of the expanded cells by only changing the temperature. This dramatically simplifies the process of cell harvesting.

Abstract: The invention pertains to a method for immortalising cells that are used for the harvesting of extracellular vesicles (EV). EV, derived for example from mesenchymal stromal cells, but also from other cell types, are known to induce beneficial effects during treatment of for example autoimmune disorders. However, the generation of secreting mesenchymal stromal cells is often dependent on donor material or the fact that isolated cells have a limited life span and limited number of passages of cell culture. The present invention provides a method of immortalising such secreting cells, the immortalised cells and medical applications thereof.

Abstract: The present description relates to a method for automatically determining an optimal individual dosing regimen of at least one drug. The method includes providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient. The method includes utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model. The method includes automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen. The method includes adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen.

Abstract: The disclosure relates to a method for identification via channels in a system having a plurality of data processing devices. The method comprises selecting, in a first data processing device, an identifier indicative of a target second data processing device of a plurality of second data processing devices; determining, in the first data processing device, an outer codeword from the identifier using an outer code comprising a first outer code and a second outer code; determining, in the first data processing device, an optical orthogonal codeword from the outer codeword using an optical orthogonal code; determining, in the first data processing device; a randomly selected codeword from the optical orthogonal codeword using an error correction code; and emitting the selected codeword from the first data processing device via a channel. Further, a computer program product and a system for identification via channels are provided.

Abstract: Method for producing multiply-charged helium nanodroplets and charged dopant clusters and nanoparticles out of the helium nanodroplets, the method comprising: •producing neutral helium nanodroplets in a cold head (1) via expansion of a pressurized, pre-cooled, supersonic helium beam of high purity through a nozzle (3) into high vacuum with a base pressure under operation preferably below 20 mPa, •ionizing the helium nanodroplets by electron impact (15), wherein the electron impact (15) leads to multiply-charged helium nanodroplets, •doping the charged helium nanodroplets with dopant vapor in the pickup cell (19), wherein the doped nanodroplets form cluster ions with the initial charges acting as seeds, wherein the size of the nanoparticles can vary from a few atoms up to 105 atoms by arranging the size of the neutral helium nanodroplets, the charge of the helium nanodroplets and the density of dopant vapor in the pickup cell (19).

Abstract: The present invention relates to an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from the subject. Finally, the present invention relates to nucleic acids suitable for application of the invention.

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more N protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises a two or more polymerization domains (PD).

Abstract: A medical ventilator system and a method for predicting transient states of a ventilated patient upon changes in mechanical ventilator settings are provided. The system includes a mechanical ventilator connected to a ventilated patient; and a modeling component to receive clinical and/or physiological variables of the ventilated patient and ventilator settings.

Abstract: The invention relates to a method for producing dry film (3), wherein a dry powder mixture is processed into the dry film (3) by a rolling device comprising a first roller (2a) and a second roller (2b). The first roller (2a) has a higher circumferential rotational peripheral speed than the second roller (2b), and the dry film (3) is placed on the first roller (2a) wherein the rotational peripheral speed of the first roll to the rotational peripheral speed of the second roll of 10:9 to 10:1 is maintained.