Abstract: The present invention refers to a compound as defined in formula (I) or a salt thereof for use in a method of treating or preventing BEST1-related retinopathies such as autosomal dominant Best vitelliform macular dystrophy. The present invention also refers to a pharmaceutical composition comprising a compound as defined in formula (I) or a salt thereof and a pharmaceutical acceptable excipient and/or carrier for use in a method of treating or preventing BEST1-related retinopathies such as autosomal dominant Best vitelliform macular dystrophy. In addition, the present invention refers to a pharmaceutical pack comprising one or more compartments, wherein at least one compartment comprises a compound as defined in formula (I) or a salt thereof or the pharmaceutical composition of the present invention for use according to the present invention.

Abstract: Compositions comprising aptamers, and methods of thereof as carrier molecules in cell-mediated immunotherapies, and activation of antigen-specific T-cell responses.

Abstract: Method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, in particular for the lithography-based additive production of magnetic resonance imaging phantoms, the method comprising at least the following steps: providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid, and mixing the at least partially filled particles with a light-curable resin.

Abstract: A method of contrast enhancement of a three-dimensional light sheet microscopy image formed from N individual images each corresponding to a light sheet plane and spaced apart from each other in the z-direction by at least a distance d, the x/y-plane being the light sheet plane and the x-direction being the propagation direction of the light sheet of the light sheet plane, comprising: Deconvolution of the three-dimensional image in the z-direction, comprising: For each intensity vector of N intensities (Ix,y,1, . . . , Ix,y,N) having the same x/y value, performing a multiplication with a tridiagonal N×N deconvolution matrix, which assigns to each voxel (x, y, n) a correction parameter f1, with which, by the multiplication of the deconvolution matrix with the intensity vector, for a component I(x, y, n) of the intensity vector the intensities Ix, y, n+1 and Ix, y, n?1 of the corresponding voxels of the neighboring image plane are multiplied, before they are subtracted from the intensity value I(x, y, n).

Abstract: Provided is a block copolymer comprising a polymer block (A) formed from repeating units of formula (I): wherein R1 is methyl or ethyl, and a polymer block (B) formed from repeating units of formula (II): as well as a hydrogel comprising the block copolymer.

Abstract: A plasma thruster comprises a cylindrical discharge channel (1), an injector (4), a RF antenna surrounding the discharge channel (1) and a device (3) for generating an axial static magnetic field in the discharge channel (1). The RF antenna is a cylindrical birdcage antenna (2) formed of several electrically conductive parallel legs (10) connected by two end rings (11) including capacitors (12) between adjacent legs (10) in each case. The two end rings (11) with the capacitors (12) are formed on two printed circuit boards (14) to which the legs (10) are attached, said printed circuit boards (14) having a through opening for the discharge channel (1). The antenna maximizes electrical coupling efficiency and provides resulting electromagnetic fields for quasi-neutral plasma acceleration along with the magnetic field effect provided by the externally applied magnetic field.

Abstract: The present invention relates to antibodies binding to human interleukin-2 (hIL-2). The invention more specifically relates to humanized antibodies specifically binding a particular epitope of hIL-2 and, when bound to this epitope, displaying a unique capability of inhibiting binding of hIL-2 to CD25.

Abstract: The present invention relates to a method for preparing a radioactive polymerizable solution and the solution per se. The solution is prepared by using a cationic radionuclide with a half-life >5 d that is dissolved in an aqueous solution. The radionuclide is extracted into an organic solvent or monomer solution by using a lipophilic ligand for forming a radioactive complex. The ligand is characterized by a ?2:1 ratio of carbon and/or silicon atoms to specific heteroatoms. If an organic solvent is used for extraction, the organic phase obtained is subsequently diluted in a monomer solution to obtain the radioactive polymerizable solution. The invention further relates to the use of said solution in a method for preparing a radioactive object such as a phantom for medical imaging and the object per se.

Abstract: The invention relates to a computer-assisted tomography (CT) system having the following features: a) at least one X-ray source, b) at least one patient couch for supporting a patient, c) at least one first X-ray detector, provided permanently or at least temporarily in the ray path of the X-rays radiated by the X-ray source through the patient couch, d) at least one second X-ray detector, provided permanently or at least temporarily in the ray path of the X-rays radiated by the X-ray source through the patient couch, e) at least one actuable drive mechanism, using which the first and/or second X-ray detector can be moved from a position in the ray path of the X-rays radiated by the X-ray source through the patient couch, to a position outside the ray path and vice versa, f) at least one electronic control device that is configured to actuate the drive mechanism.

Abstract: An input apparatus for operating and/or controlling a technical device includes a plurality of sensor elements which can be arranged spatially distributed in the oral cavity of a user. An interface circuit is coupled to the sensor elements and is configured to detect a respective current tongue position and/or tongue movement by means of the sensor elements. The interface circuit generates one or more control signals depending on the respective current tongue position and/or tongue movement and transmits the one or more control signals to the technical device. Advantageously, the sensor elements each include a transponder which is configured to receive an interrogation signal from the interface circuit and, in response thereto, to transmit an individually coded response signal to the interface circuit.

Abstract: The present invention relates to a perivascular implant comprising (i) a housing comprising a receptacle for an effector matrix, and (ii) a fastening element adapted for at least partially embracing a tubular bodily structure, wherein said housing, said receptacle for an effector matrix, and said fastening element are arranged such that after implantation of the device the receptacle for an effector matrix at least partially is in contact with said tubular bodily structure and/or a vasculature originating from said tubular bodily structure, and to uses, methods, and kit related thereto.

Abstract: The present invention relates to a method for obtaining elastic properties of a soft solid by means of quasi-omnidirectional transverse waves generated by a focused ultrasound beam, with a helical phase profile that produces an acoustic vortex that generates a transverse wave front, not only in the direction perpendicular to the ultrasound beam but also in the same direction as the ultrasound beam. The invention also allows control of the transverse wave front generated, which facilitates the carrying out of elastography studies at different frequencies and increases the amplitude of the transverse waves produced, thereby improving the signal-to-noise ratio.

Abstract: A method is used for managing a flow of data in at least one database, wherein said database is configured with at least two data models of data storage. In said method, during a first period of time, a first data flow portion is received in a computer, and the first data flow portion is then stored in a first data pool of the database according to the first data model. Then, after the first period of time, a transformation is made on the first portion of the data and the transformed first data is assigned to a second data model, and the first data flow portion is then transferred from the first data pool to a second data pool. The process is repeated with at least a second data flow portion and can be extended to more transformations, and, thus, to more data models, and more data pools accordingly.

Abstract: Disclosed herein is a sensor chip for parallelized magnetic sensing of a plurality of samples, a system for parallelized magnetic sensing of a plurality of samples and a method for probing a plurality of samples using optically addressable solid-state spin systems. The sensor chip comprises an optically transparent substrate comprising a plurality of optically addressable solid-state spin systems arranged in a plurality of sensing regions in a surface layer below a top surface of the substrate. The sensor chip further comprises a plurality of sample sites, wherein each sample site is arranged above a respective sensing region. The sensor chip has a light guiding system configured to provide an optical path through the substrate connecting each of the sensing regions.

Abstract: The present invention relates to an endograft device (101) for treatment of ruptures (104.9) in one or more inner layers of a blood vessel (104), in particular, an aorta, comprising an anchoring unit (101.1) and a sleeve unit (101.2). The endograft device (101) defines an upstream endograft end (101.3) and a downstream endograft end (101.4), upstream and downstream being defined, in an implanted state of the endograft device (101), in relation to a general natural blood flow defining a blood flow direction within the blood vessel (104). The anchoring unit (101.1) is a collapsible unit located at the upstream endograft end (101.3), wherein the anchoring unit (101.1) is configured to anchor, in the implanted state, the endograft device (101) within the blood vessel (104) by engaging an inner surface of the blood vessel (104) with an expanded anchoring section (101.5). The sleeve unit (101.2) is located downstream of the anchoring unit (101.1), wherein the sleeve unit (101.

Abstract: A print head for additively manufacturing fiber-reinforced composite materials includes a feed channel, a heating block, a nozzle and a cutting unit. A filament of the fiber-reinforced material enters an inlet of the nozzle through the feed channel, leaves the nozzle via an outlet of the nozzle, and is deposited on a print bed. The cutting unit is located inside the heating block which has a beneficial effect on the cut and/or the shearing of the material to be printed. The invention also relates to a method in which the filament is cut and/or sheared, wherein the cutting unit performs a linear movement or rotation, or the print head per se performs a linear movement or rotation, as a result of which the filament is cut and/or sheared off.

Abstract: A Gunn diode is disclosed which comprises a first contact layer, a second contact layer, and an active layer based on a gallium nitride (GaN) semiconductor material having a base surface and a side surface non-parallel thereto. Optionally, related materials such as aluminum indium gallium nitride (AlInGaN) materials may also be used as the active layer. The first contact layer electrically contacts the side surface to form a side contact. The second contact layer forms an electrical contact for the base surface, so that a maximum of the electric field strength is formed when an electric voltage is applied between the first contact layer and the second contact layer at the side contact.

Abstract: The present invention relates to a system for obtaining useful data for analysis of body morphometry and associated method determining body morphometry, in newborns or non-newborns, from 3D models in an automatic, non-invasive, rapid and low-cost manner. Furthermore, the system and the method obtain the measurement and 3D modelling of the patient, newborn or non-newborn, in a conscious state, as movement has no influence thereon.

Abstract: A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.

Abstract: The invention relates to a device and a method for UV antisepsis, in particular for intracorporeal in vivo UV antisepsis on the human and animal body in the event of colonization with multiresistant pathogens (MRPs) such as methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE). The device comprises a light emitting diode chip, LED chip, configured to emit radiation in the UVC spectral range, wherein the LED chip forms a light emitting diode, LED, with a package; a spectral filter element set up to limit the radiation emitted by the LED chip substantially to wavelengths below 235 nm; and an optical element for directional emission of the radiation emitted by the LED.