Abstract: The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analog which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino acid nucleic acid (AANA). Thereby the nucleoside analog is incorporated into DNA or RNA in the place of a single native base.

Abstract: A compound of formula (I) as defined herein is useful in the treatment and prevention of a disorder such as cachexia, stroke, atherosclerosis, coronary artery disease, and diabetes and pharmaceutical compositions of the same. Also, a method of screening for lipase inhibitors using a compound of formula (I) and determining its lipase inhibitory activity. The method includes in vitro assays of compounds using ATGL and/or HSL, and cellular assays wherein inhibition is followed by observing indicators of efficacy. Also, methods for treatment or prevention of a condition involving cachexia, stroke, artherosclerosis, coronary artery disease, diabetes, preferably diabetes type II by administering a pharmaceutical composition comprising an agent which is able to inhibit ATGL. Also contemplated herein, are compositions comprising one or more ATGL-inhibiting agents optionally in combination with one or more lipase inhibitors or inhibitors of inflammatory cytokines.

Abstract: A process for the production of frozen foods, particularly vegetables or fruits, including the stages of subjecting the food to a slight and slow dehydration, preferably by air convection, to partially eliminate its water content by between approximately 2 and 10% by weight, especially its outermost layer; allowing the food to rest to favor the redistribution of the free water contained therein and subjecting the food, after its packaging, to a rapid convection freezing treatment, either by immersion in an aqueous solution of salts or by the use of liquid nitrogen. In the case of chopped fruits, before the dehydration stage the portions are sprayed with an antioxidant product.

Abstract: Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (MSI). The vaccine contains an MSI-specific frameshift peptide (FSP) generating humoral and cellular responses against tumor cells or a nucleic acid encoding said FSP. The vaccine of the present invention is particularly useful for the prevention/treatment of colorectal cancer, endometrial cancer, gastric cancer or small bowel cancer.

Abstract: The present invention relates to the application of a platelet gel for augmenting or restoring the volume of a soft tissue, particularly breast tissue, to biological implants comprising said gel, to a kit for preparing said implants and to a process for preparing said implants.

Abstract: The present invention concerns the field of cancer therapy. In particular, it relates to an antagonist of a B-type plexin which prevents the interaction of the B-type plexin with ErbB-2 for use as a medicament, in particular, for treating metastasizing cancer. The present invention also contemplates a method for identifying an antagonist which prevents the interaction of a B-type plexin with ErbB-2. Finally, the invention provides for a polynucleotide encoding a B-type plexin polypeptide which lacks a functional intracellular domain and the said polypeptide.

Abstract: A smart pseudoscopic to orthoscopic conversion (SPOC) protocol, and method for using the SPOC protocol for three-dimensional imaging, are disclosed. The method allows full control over the optical display parameters in Integral Imaging (InI) monitors. From a given collection of elemental images, a new set of synthetic elemental images (SEIs) ready to be displayed in an InI monitor can be calculated, in which the pitch, microlenses focal length, number of pixels per elemental cell, depth position of the reference plane, and grid geometry of the microlens array (MLA) can be selected to fit the conditions of the display architecture.

Abstract: The invention relates to a method for controlling the use of hardware resources of a computer system by an application that is executed on an operating system comprising at least one application programming interface (API) that is executed on this computer system, using an executable piece of code adapted for being injected into a process belonging to the application. The method comprises: redirecting an API service to a corresponding service comprised in the piece of code; intercepting the call from the process to the API service; and acting on a software entity belonging to the process being executed on the basis of the interception of the call from the process to the API service.

Abstract: The present invention relates in general to the field of targeted drug delivery of anti-cancer drugs. More precisely, the present invention concerns polymer drug conjugates, namely, conjugates of poly(organo)phosphazenes and anti-cancer drugs, wherein the conjugates are suitable to selectively release anti-cancer drugs in tumor tissue. In addition, the present invention relates to a method for manufacturing such poly(organo)phosphazene molecule conjugates, to poly(organo)phosphazene molecule conjugates for use in medicine, in particular, to poly(organo)phosphazene molecule conjugates for use in the treatment of cancer, and to pharmaceutical compositions comprising such poly(organo)phosphazene molecule conjugates.

Abstract: An electro-optic modulator for the modulation of optical radiation of a predetermined wavelength, the electro-optic modulator having at least one optical resonator in which a standing optical wave can be formed for the predetermined wavelength. In the resonator, at least two doped semiconductor sections—as seen in the longitudinal direction of the resonator —are arranged at a distance from one another, and the at least two doped semiconductor sections respectively lie locally at an intensity minimum of the standing optical wave.

Abstract: The invention provides a cochlea stimulator for implantation comprising optical fibers of which are coupled to an irradiation source that is controlled by a modulator to generate irradiation specific for a pre-determined range of sound-frequencies. The cochlea stimulator effects a frequency-specific activation of the organ of Corti needed for speech perception especially in noisy environment and more complex sounds. For imparting excitation signals which are generated by modulated pulsed laser irradiation conducted within an optical fiber in order to elicit nervous signals in residual functional organ of Corti sections, the auditory prosthesis preferably contains optical fibers which are dimensioned to terminate in end sections within the cochlea at different sites or sections of the organ of Corti. e.g. having different lengths for locating their end sections at different internal parts of the cochlea.

Abstract: Continuous system and procedure of sterilization and physical stabilization of pumpable fluids, food, or other type of fluids, through ultra-high pressure homogenization (UHPH) includes a first heat exchanger 1 which preheats the fluid at temperature Tp between 40 and 90° C.; an ultra-homogenizer 3 through which fluid at temperature Tp is introduced at a pressure Pu between 200 and 600 MPa increasing its temperature up to a final value Tu. A second heat exchanger 4 has its cooling temperature adjusted at value Te. An aseptic tank 5 receives the cooled down fluid at value Te, from which it is pumped by sterile air pressure into an aseptic packaging machine, for the packaging of the final product.

Abstract: The invention relates to a power circuit breaker that is suitable for switching electrical voltages. The power circuit breaker according to the invention comprises two main electrodes, to each of which a respective pole of the voltage to be switched can be connected. During the switching process, at least one of said main electrodes follows a switching path. The power circuit breaker is characterized in that secondary electrodes are additionally provided, which protrude into the vicinity of the switching path and are designed and arranged in such a way that arcs can be produced (a) between the main electrodes and the secondary electrodes and (b) between the individual secondary electrodes during the switching process. The power circuit breaker according to the invention can be advantageously used in vehicles and in ultra-high-voltage AC and HVDC (high-voltage direct current) transmission systems and causes arcs to be extinguished as early as possible during the switching process.

Abstract: A radiopharmaceutical composition is disclosed comprising novel iodometomidate derivatives of formula (I) which bind specifically to adrenal enzymes and which exhibit an improved stability. The compounds of formula (I) are suitable for use in a diagnostic imaging method, e.g. for diagnosis of adrenocortical carcinoma. The compounds of formula (I) are further suitable for use in the treatment of adrenocortical carcinoma, by means of radionuclide therapy.

Abstract: The invention relates to a method for generating a multichannel audio signal (600, 700) from a stereo audio signal (100, 200), having the following steps: ascertaining a first panning coefficient (310) and a second panning coefficient (320) of the stereo audio signal; ascertaining a direct signal (515) as well as a first surroundings signal (510) and a second surroundings signal (520) from the first audio signal and the second audio signal and from the first panning coefficient and the second panning coefficient; ascertaining a plurality of repanning coefficients (410, 415, 420) from the panning coefficients, each repanning coefficient of the plurality of repanning coefficients being assigned to an audio channel (580, 585, 590) of a plurality of audio channels of the multichannel audio signal; calculating each direct signal using each of the repanning coefficients of the plurality of repanning coefficients; and converting each audio channel into a playback signal (600, 700) of the multichannel audio signal, e

Abstract: Methods and apparatus for generating a private-public key pair, for encrypting a message for transmission through an unsecure communication medium (30), and for decrypting the message are disclosed. The methods are based on the well-known McEliece cryptosystem or on its Niederreiter variant. More general transformation matrices Q are used in place of permutation matrices, possibly together with an appropriate selection of the intentional error vectors. The transformation matrices Q are non-singular n×n matrices having the form Q=R+T, where the matrix R is a rank-z matrix and the matrix T is some other matrix rendering Q non-singular. The new Q matrices, though at least potentially being dense, have a limited propagation effect on the intentional error vectors for the authorized receiver. The use of this kind of matrices allows to better disguise the private key into the public one, without yielding any further error propagation effect.

Abstract: A method for compensating cardiac and respiratory motion in atrial fibrillation ablation procedures includes (a) simultaneously determining a position of a circumferential mapping (CFM) catheter and a coronary sinus (CS) catheter in two consecutive image frames of a series of first 2-D image frames; (b) determining a distance between a virtual electrode on the CS catheter and a center of the CFM catheter for a first image frame of the two consecutive image frames, and for a second image frame of the two consecutive image frames; and (c) if an absolute difference of the distance for the first image frame and the distance for the second image frame is greater than a predetermined threshold, compensating for motion of the CFM catheter in a second 2-D image.

Abstract: The invention relates to a component with filament connection, in particular for communication, in particular for optical communication comprising: a voluminous material, a substrate, a filament and a connection component applied on the filament, where the filament has been embedded in the substrate and, at a transition point, emerges from the substrate and proceeds into the voluminous material. According to the invention, the voluminous material directly encloses the filament from the transition point and directly encloses the connection component applied on the filament and has full-area inseparable bonding to the substrate, where the voluminous material is a fully crosslinked voluminous material formed from a pliable material and the substrate has been hardened.

Abstract: An apparatus is described for detecting the location coordinates of a pressure point (8) within a sensor field, having at least one electric resistance layer (2) which is connected via electric connections (4) at the edge to a measurement and evaluation circuit (5). In order to become independent of any external supply voltage it is proposed that the electric resistance layer (2) which is provided with at least three electric connections (4) is applied to a ferroic layer (1) made of an internally charged cellular polymer.

Abstract: Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in SEQ ID: NO 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in SEQ ID: NO 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (CNTFR), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (IL-6R), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in SEQ ID: NO 2 having a non-positively charged amino acid residue.