Abstract: The present invention relates to a genetically modified fungal cell of the genus Trichoderma capable to express the regulatory protein VEL1 in a higher amount compared to the unmodified wild type fungal cell.

Abstract: The invention relates to a method for the real-time-capable, computer-assisted analysis of an image sequence of an object consisting of elements that can be moved relative to each other and are interconnected, said sequence containing a variable pose, wherein the individual images of the image sequence are recorded by way of a time-of-flight (TOF) camera such that said images can be processed by a computer, and contain brightness and distance data as functions of the pixel coordinates of the camera for each image of the sequence, comprising the following steps: a. Capturing the pixels of an individual image forming the object, b. calculating a three-dimensional (3D) point cloud in a virtual space, said point cloud representing the surface of the object that is visible to the camera, by a computational projection of object-depicting pixels in such a space, while taking captured distance data to the object into consideration, c.

Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.

Abstract: Method for determining polycyclic aromatic hydrocarbon (PAH) concentration in a solid state sample. The method includes exposing the sample to diffuse reflectance infrared spectroscopy, recording at least one spectroscopic parameter of infrared diffuse reflection of the sample, which is a signal obtained at one or more frequencies within a range of frequencies (+/?10 cm?1) selected from the group consisting of 3000-3100 cm?1, 740, 777, 814, 842, 1430, 1510, 1600, 4055-4056, 4642-4646, 5924, and 5951-5953 cm?1, and performing data analysis by correlating the at least one spectroscopic parameter with variables of a trained multivariate calibration model related to PAH concentrations, thereby determining PAH concentrations in the sample.

Abstract: The invention relates to a friction stir welding apparatus for joining workpieces 1, 2, having a welding pin 3, which is rotatable about its center axis 9 by means of a drive, and having at least one clamping apparatus for clamping the workpieces 1, 2 to be joined, characterized in that the clamping apparatus comprises at least two clamping elements 10, 11, which respectively have an undercut guideway 12, the guideways 12 being arranged parallel to one another and parallel to a joining region 8, in that between the clamping elements 10, 11 is arranged a sliding element 13, which is secured by the guideways 12 against the workpieces 1, 2 and is translatorily displaceable along the guideways 12, and in that the sliding element 12 is provided with an opening 14 for the lead-through of the welding pin 3, and further relates to a method for friction stir welding, using the above-stated apparatus.

Abstract: There is disclosed a method for detecting spatially structured sample volumes by means of coherent light and digital holography. There is also disclosed a method for analyzing the depth structure of samples in accordance with optical coherence tomography.

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

Abstract: The invention related to a device (1) for spraying charged droplets of a liquid towards a target along a spraying direction, comprising: a reservoir (10) for storing the liquid (L), a first electrode (100) being arranged at an outlet (11) of said reservoir (10), a second electrode (200) forming a counter electrode to the first electrode (100) for accelerating said droplets (D) along the spraying direction (S), and a housing (30) holding the reservoir (10) as well as said electrodes (100, 200).

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

Abstract: The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target nucleic acid sequence (targetss) into a repetitive cluster of double-stranded target nucleic acid sequences (targetds), and subsequently cloning the construct into a vector (aptagene vector). The aptagene vector is transformed into host cells for replication of the aptagene and isolated in order to optain single-stranded target sequences (targetss). The invention also relates to single-stranded nucleic acids, produced by a method of the invention.

Abstract: The present invention relates to two new gain of function variants of the cytokinin receptor proteins AHK2 and AHK3, namely rock2 and rock3, to transgenic organisms comprising at least one of said new gain-of-function cytokinin receptor variants and to a method for the manufacturing of a transgenic plant comprising at least one of the new gain-of-function variants.

Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.

Abstract: A hanging drop plate and a method of cultivating cells or of producing molecular aggregates in at least one liquid volume that adheres to a drop contact area of such a hanging drop plate. The hanging drop plate has a body with a first surface and a second surface that is essentially coplanar to the first surface. The second surface has a drop contact area for adherently receiving a liquid volume. The drop contact area is distinguished from a surrounding area by a relief structure that prevents spreading of the liquid volume on the second surface of the body. The body has at least one conduit that mouths into the drop contact area from the direction of the first surface of the body. A liquid volume is applied to the drop contact area through a communicating conduit. Cells and/or molecules can be introduced into this liquid volume.

Abstract: The invention relates to the non-covalent, self-organizing hydrogel matrix for biotechnological applications containing a covalent polymer peptide conjugate, wherein the covalent polymer peptide conjugate includes conjugates of two or more peptides that are coupled to a polymer chain and the peptide sequence contains a recurring dipeptide motif (BA)n wherein B is an amino acid having positively charged side chain, A is alanine and n is an integer between 4 and 20.

Abstract: It comprises a supporting structure in which at least one arm is slidably attached. Each arm comprises first and second members hinged to each other. The first member is rotatably hinged to the supporting structure and it can be rotated about a longitudinal axis and the second member may receive a joint having at least two degrees of freedom for attaching a tool. The longitudinal axis of the first member is substantially perpendicular to an axis joining the first member and the second member to each other. A simplified architecture is obtained allowing for accurate and efficient spatial movement of the tool holding arm.

Abstract: A method for spatially determining the series resistance of a semiconductor structure by generating luminescent radiation in the semiconductor structure under measurement conditions A and B, by determining a local calibration parameter CV,i for a plurality of prescribed locations of the semiconductor structure and determining local series resistances RS,i for a plurality of prescribed locations of the semiconductor structure. It is essential that the local series resistances RS,i are each determined as a function of a global series resistance RSg of the semiconductor structure that is identical for all local series resistances.

Abstract: An optical pulse generator and a method for using the same, where the optical pulse generator includes a source to deliver a chirped pulse and a chirped pulse compressor, and a first manipulation device and a second manipulation device capable of wavelength dependent manipulating the propagation direction of the chirped pulse and a focusing device having a predetermined focus point. The second manipulation device is arranged after the first manipulation device in propagation direction of the chirped pulse and the first and the second manipulation device are capable of manipulating the propagation direction of the chirped pulse such that the chirped pulse is transformed, after passing the second manipulation device, into a pulse, wherein different chromatic parts of the pulse are spatially spread and temporarily fully aligned.

Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.

Abstract: A device for in situ milling of joint surfaces, including a milling device and a joint clamping device. The joint clamp device is designed to be inserted between two joint components forming a joint, particularly bones, and for pushing the joint components apart with a predetermined or adjustable tension, wherein the joint clamping device includes a recess in which the milling device can be inserted, wherein the milling device includes a face milling cutter.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.