Abstract: The invention relates to a device and method for measuring the density of a plasma by determining an impulse response to a high-frequency signal coupled into a plasma. The density, electron temperature and/or collision frequency as a function of the impulse response can be determined. A probe having a probe head and a probe shaft can be introduced into the plasma, wherein the probe shaft is connected to a signal generator for electrically coupling a high-frequency signal into the probe head. The probe core is enclosed by the jacket and has at its surface mutually insulated electrode areas of opposite polarity. A balun is arranged at the transition between the probe head and an electrically unbalanced high-frequency signal feed to convert electrically unbalanced signals into balanced signals.

Abstract: A shaft power plant for energy conversion of a discharge between a headwater and a tailwater, comprising a vertical shaft, the top of which forms an inflow plane which is parallel to the bed and extends below the headwater water level, wherein the shaft is open toward the top and is closed by a base at its bottom end, a unit composed of a turbine and an electrical machine, wherein the unit is arranged entirely under water in the shaft and wherein the turbine is arranged for water to pass through vertically, and an outflow, which is connected to the turbine, represents a closed flow channel and leads through a through-passage in the shaft to the tailwater, wherein, in a horizontal plane of a turbine runner of the turbine, a first cross-sectional area of the shaft is much larger than a second cross-sectional area taken up by the turbine runner.

Abstract: Use of Mycobacterium brumae for the treatment of bladder cancer. The present invention relates to the treatment of bladder cancer, preferably superficial, non-invasive bladder cancer by using mycobacteria Mycobacterium brumae. Therapy described in this invention is particularly effective in grade 1 (well differentiated) and grade 2 (moderately differentiated) tumor cells. This makes it possible to treat the disease, which is still in an early stage, by reducing the risk of disease progression to a more harmful stage and/or preventing the risk of metastasis.

Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Abstract: The invention relates to a device for orienting at least one object in at least a first or a second orientation or for placing it in a first or a second spatial location, comprising: a substrate (10) having a surface (10a), at least one object (3) levitated above said surface (10a),wherein the device (1) is designed to generate an e.g. electrostatic potential with help of the substrate (10) for trapping the at least one object (3), the potential having at least a first minimum and a second minimum, so that the at least one object (3) is oriented in the first orientation (or located in a first spatial location) when being trapped in the first minimum, and in the second orientation (or located in the second spatial location) when being trapped in the second minimum, and wherein said at least one object (3) is trapped in one of said minima.

Abstract: A device (1) for coating a substrate made of particles by means of cathode atomisation with a movable substrate dish (4) tilted relative to the horizontal plane, wherein the substrate dish (4) is arranged loose in a plate (3) which is rotatable about an axis of rotation (10), is tilted and has a side wall (8), wherein an outer wall (19) of the substrate dish (4) is intermittently in contact with the inner side (17) of the side wall (8) of the plate (3).

Abstract: 1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents

Abstract: A gas sensor is used for detecting gas in the air, especially formaldehyde. The sensor comprises at least one gas-sensitive zone which is preferably a layer on a substrate and which contains the ternary compound In4Sn3O12 as the gas-sensitive material. In order to produce the gas-sensitive zone, a flame spray pyrolysis (FSP) is carried out, organometallic compounds of indium and tin being used as the reactants. The gas sensor is especially suitable for online gas detection.

Abstract: A fluidized-bed reactor system with at least two fluidized-bed reactors, each being a circulating fluidized bed, a particle line with a particle separator for transferring fluidized-bed particles from the first to the second reactor, and a particle line exiting at the lower half of the second reactor for transferring fluidized-bed particles back to the first reactor, wherein, at least in the second reactor, two or more reaction zones separated by one or more flow controllers and that the particle line opens into the second reactor above at least one flow controller.

Abstract: The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto.

Abstract: The present invention relates to an in vitro method for diagnosing and/or monitoring in a subject a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising detecting and/or analyzing in a test sample derived from the subject one or more mutations at the DNA level in any one or both of the marker genes cKIT (GenBank acc. no. NM_000222.2) and PDGFRA (GenBank acc. no. NM_006206.4), wherein the DNA is circulating DNA, and wherein the presence of any one of the mutations detected in the test sample is indicative of a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor in the subject.

Abstract: The present invention relates to a method and a suitable apparatus for determining the state of a rechargeable battery and for checking contact resistances in a battery system. According to the invention, an impedance curve is determined using signals at different frequencies and a value for an area, which results from the impedance curve, is then calculated from a predetermined threshold value and an x axis. The value for the area is a measure of the ageing of the battery. A control signal is generated on the basis thereof. In one preferred embodiment, said control signal is used to drive a signaling apparatus and thus to present the state of the battery to a user. The present invention can be used, for example, in motor vehicles that are electrically driven.

Abstract: The present invention is directed to methods for diagnosing breast cancer, metastasizing breast cancer, or for determining the CTC status in a subject. Moreover, the present invention is concerned with devices and kits for carrying methods of the invention. The methods comprise determining in a sample of a subject suspected to be afflicted with breast cancer the amount of at least one miRNA selected from a recited list of miRNAs, followed by comparing the amount with one or more references, whereby breast cancer is to be diagnosed.

Abstract: The present invention relates to a method for the in vitro determination of the presence of or a predisposition of a patient to the development of cancer. In the method according to the invention, the presence of a marker is determined in a biological sample of the patient, said marker being selected from a) the amino acid sequence SEQ ID No. 2 from the sequence protocol that is provided, or b) a nucleic acid that encodes the amino acid sequence with the SEQ ID No. 2. The invention further relates to the amino acid and the encoding nucleic acid and to the use thereof in diagnostics and for molecular therapeutic approaches.

Abstract: The invention relates to a method for the layered construction of a shaped body made of highly viscous photopolymerizable material.

Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.

Abstract: The invention relates to an in vitro method for predicting disease risks, progression of diseases, drug risks, success of treatment and for finding drug targets by looking for one or more genetic modifications in the promoter region of the CHK1 (CHEK1) gene on human chromosome 11q23, the genetic modifications being a substitution thymine for guanine in position ?1143 in the promoter of CHK1, of thymine for cytosine in position ?1400, a substitution of cytosine for thymine in position ?1453 or an insertion of one cytosine in position ?1454 and the genetic modifications being detected individually or in any combinations by way of known methods.

Abstract: Dye conjugates of template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 14 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties, and are useful for cancer therapy; diagnostic imaging; for detection of tumors and other abnormalities; for photoacoustic tumor imaging, detection and therapy; and for sonofluorescence tumor imaging, detection and therapy. The various dyes forming part of these conjugates are useful over the range of 300-1200 nm, the exact range being dependent upon the particular dye. These dye conjugates of ?-hairpin peptidomimetic can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

Abstract: The present invention relates to a method for predicting the non-response or response to a monoaminergic antidepressant of a patient to be treated with a monoaminergic antidepressant comprising the steps: (i) determining the DNA-methylation status of a brain-derived neurotrophic factor (BDNF)-gene promoter in a sample of said patient; (ii) attributing a hypomethylation of said BDNF-gene promoter to the non-response to a monoaminergic antidepressant of said patient; and (iii) attributing normal methylation or hypermethylation of said BDNF-gene promoter to the response to a monoaminergic antidepressant of said patient. Furthermore, a kit and the use of a kit in said method is disclosed.

Abstract: The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.