Abstract: The present invention relates to the use of a composition selected from the group consisting of antibodies, antibody fragments, insulin-like growth factor antagonists, Toll-like receptor antagonists and mixtures thereof for the treatment or the prophylaxis of certain diseases.
Abstract: A sequence is received of time domain digital audio samples representing sound (e.g., a sound generated by a human voice or a musical instrument). The time domain digital audio samples are processed to derive a corresponding sequence of audio pulses in the time domain. Each of the audio pulses is associated with a characteristic frequency. Frequency domain information is derived about each of at least some of the audio pulses. The sound represented by the time domain digital audio samples is transformed by processing the audio pulses using the frequency domain information. The sound transformation utilizes overlapping windows and a computational cost function which depends on a product of the number of the pitch periods and the inverse of the minimum fundamental frequency within the window is determined.
Abstract: The spatial center of mass and a mass of an object can be determined by orientating the suspended object in at least two different spatial positions and measuring the orientation of the object in each of the different spatial positions the forces acting on the suspension devices because of the suspended object, the forces acting on the suspension devices being resolved into three independent force components. A center of area of the object and the associated force effect lines are determined for each of the at least two spatial positions, the center of area of the respective spatial position being determined with an inclined tension compensation of the suspension devices. The spatial center of mass is determined by superimposing at least two force effect lines.
Type:
Grant
Filed:
April 9, 2008
Date of Patent:
April 22, 2014
Assignees:
Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V., Universität Rostock
Inventors:
Oliver Wurst, Martin-Christoph Wanner, Birger Schubert
Abstract: This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues.
Type:
Grant
Filed:
May 6, 2009
Date of Patent:
April 22, 2014
Assignees:
Institut Quimic de Sarria Cets, Fundacio Privada, Universitat Ramon Llull, Fundacio Privada
Inventors:
Salvador Borros Gómez, David Horna Tomás
Abstract: A microstructured composite component is provided including structures for carrying out fluid processes. A device is provided for producing microstructured composite components. A method provided includes a first step during which a first film is arranged above a second film between first and second mold parts. The first and/or second mold parts have microstructured cavities to be filled. In a second step, the first and second mold parts are heated in at least one region in which they contact one of the films. An excess pressure is then produced between the first film and the second film to force the first and/or second films into the cavities. In a further step, the first and second mold parts are pressed together by a pressing force. Once the first mold part, the second mold part, the first film and the second film are cooled, they form a microstrutured composite component.
Type:
Grant
Filed:
February 24, 2010
Date of Patent:
April 22, 2014
Assignee:
Technische Universitat Ilmenau
Inventors:
Andreas Schober, Alexander Gross, Joerg Hampl
Abstract: Methods and apparatus for generating a private-public key pair, for encrypting a message for transmission through an unsecure communication medium (30), and for decrypting the message are disclosed. The methods are based on the well-known McEliece cryptosystem or on its Niederreiter variant. More general transformation matrices Q are used in place of permutation matrices, possibly together with an appropriate selection of the intentional error vectors. The transformation matrices Q are non-singular n×n matrices having the form Q=R+T, where the matrix R is a rank-z matrix and the matrix T is some other matrix rendering Q non-singular. The new Q matrices, though at least potentially being dense, have a limited propagation effect on the intentional error vectors for the authorized receiver. The use of this kind of matrices allows to better disguise the private key into the public one, without yielding any further error propagation effect.
Type:
Application
Filed:
April 2, 2012
Publication date:
April 17, 2014
Applicant:
UNIVERSITAT ZURICH
Inventors:
Marco Baldi, Marco Bianchi, Franco Chiaraluce, Joachim Jakob Rosenthal, Davide Mose' Schipani
Abstract: A method of establishing a DC bias in front of at least one electrode in a plasma operating apparatus by applying an RF voltage with at least two harmonic frequency components with a controlled relative phase between the components, where at least one of the higher frequency components is established as an even multiple of the lower frequency component.
Type:
Application
Filed:
November 8, 2013
Publication date:
April 17, 2014
Applicant:
Ruhr-Universitat Bochum
Inventors:
Brian George Heil, Uwe Czarnetzki, Ralf Peter Brinkmann, Thomas Mussenbrock
Abstract: The present invention discloses an immunological test for the detection and specific determination of autoantibodies against testicular antigens which are associated with inflammation-related fertility disorders of male mammals in a biological sample of a male mammal, in particular the detection of testicular ER-60 autoantibodies and/or transferrin autoantibodies. The immunological test is utilized to detect the presence of immunologically-caused and infection-related infertility in male mammals, particularly in humans.
Abstract: The invention relates to an apparatus for picking up particles from the surface of a water system, in particular oil, algae or dirt particles, comprising a particle separation space, which is connected to an inflow opening through which water that contains particles can enter the particle separation space, a particle-collecting space into which particles that have been separated from the water that contains particles reach from the particle separation space via a separation mechanism and an adjustment mechanism, which is configured to regulate a filling level of the water that contains particles in the particle separation space. In addition, the invention relates to a method for picking up particles, in particular oil, algae or dirt particles, from the surface of a water system.
Abstract: The present invention relates to new heterocyclic compounds as modulators of sphingolipid signaling and uses thereof of as pharmaceutically active agents, suitable for treating proliferative, degenerative, infectious, and other diseases.
Type:
Application
Filed:
April 2, 2012
Publication date:
April 10, 2014
Applicants:
UNIVERSITÄT BERN, JOHANN WOLFGANG GOETHE-UNIVERSITÄT
Inventors:
Holger Stark, Aleksandra Zivkovic, Andrea Huwiler, Josef Pfeilschifter
Abstract: The invention relates to a method for the real-time-capable, computer-assisted analysis of an image sequence of an object consisting of elements that can be moved relative to each other and are interconnected, said sequence containing a variable pose, wherein the individual images of the image sequence are recorded by way of a time-of-flight (TOF) camera such that said images can be processed by a computer, and contain brightness and distance data as functions of the pixel coordinates of the camera for each image of the sequence, comprising the following steps: a. Capturing the pixels of an individual image forming the object, b. calculating a three-dimensional (3D) point cloud in a virtual space, said point cloud representing the surface of the object that is visible to the camera, by a computational projection of object-depicting pixels in such a space, while taking captured distance data to the object into consideration, c.
Type:
Application
Filed:
May 6, 2010
Publication date:
April 10, 2014
Applicant:
Universitat Zu Lubeck
Inventors:
Martin Haker, Erhardt Barth, Thomas Martinetz
Abstract: The present invention relates to methods for modulating, i.e. increasing or decreasing, the length and/or the complexity of the dendrites of a neuronal cell by influencing the amount of vascular endothelial growth factor D (VEGFD)-related signaling. The present invention further relates to methods for treating age- and/or disease-related cognitive dysfunctions, or for impairing the memory of a subject. Finally, the present invention relates to recombinant VEGFD (rVEGFD) for use in the treatment of age- and/or disease-related cognitive dysfunctions.
Type:
Application
Filed:
June 1, 2012
Publication date:
April 3, 2014
Applicant:
UNIVERSITAT HEIDELBERG
Inventors:
Hilmar Bading, Daniela Mauceri, Chistian Klein
Abstract: The present invention relates to a method of predicting the course of disease in a patient having a malignant melanoma, the method comprising determining in melanoma cells comprised in a sample obtained from said malignant melanoma the presence or amount of at least five biomarkers selected from the group comprising or consisting of MTAP, PTEN, Bax, Bcl-X, ?-Catenin, CD20, Cox-2, CD49d and MLH1, wherein the absence or decreased amount of MTAP and ?-Catenin and/or the presence or increased amount of PTEN, Bax, Bcl-X, CD20, Cox-2, CD49d and MLH1, is associated with a disadvantageous course of disease.
Type:
Application
Filed:
March 30, 2012
Publication date:
April 3, 2014
Applicants:
Universität Regensburg
Inventors:
Stefanie Meyer, Anja Bosserhoff, Peter Wild, Thomas Fuchs
Abstract: The invention relates to a device for detecting electromagnetic radiation in the THz frequency range, comprising at least one transistor (FET1, FET2), which has a first electrode, a second electrode, a control electrode, and a channel between the first electrode and the second electrode, and comprising an antenna structure. An electrode is connected to the antenna structure such that an electromagnetic signal which lies in the THz-frequency range and which is received by the antenna structure (1) can be fed into the channel between electrodes and the control electrode is connected to an electrode via a capacitor and/or the control electrode and the first electrode or the control electrode and the second electrode have an intrinsic capacitor such that no AC voltage drop occurs between the control electrode and the first electrode or the second electrode.
Type:
Application
Filed:
May 31, 2012
Publication date:
April 3, 2014
Applicant:
JOHANN WOLFGANG GOETHE-UNIVERSITAT FRANKFURT A.M.
Inventors:
Sebastian Boppel, Alvydas Lisauskas, Hartmut Roskos, Viktor Krozer
Abstract: There is disclosed a method for detecting spatially structured sample volumes by means of coherent light and digital holography. There is also disclosed a method for analyzing the depth structure of samples in accordance with optical coherence tomography.
Type:
Application
Filed:
October 21, 2013
Publication date:
April 3, 2014
Applicants:
UNIVERSITAT ZU LUBECK, THORLABS GMBH, MEDIZINISCHES LASERZENTRUM LUBECK GMBH
Inventors:
Dierck HILLMANN, Gereon HUTTMANN, Peter KOCH, Christian LUHRS, Alfred VOGEL
Abstract: The invention relates to a device (1) and a method, comprising a workpiece-receiving portion (2) for receiving a workpiece (28) to be mechanically machined. At least one vibrating device (9) is connected to the workpiece-receiving portion (2), and the vibrating device (9) causes the workpiece-receiving portion (2) to vibrate, the vibration of the workpiece-receiving portion (2) having a frequency that is lower than the frequency of ultrasound. The vibrating device (9) has a vibrating body (8) to which a compensating mass (7) that vibrates in the opposite direction is associated.
Type:
Application
Filed:
May 18, 2012
Publication date:
April 3, 2014
Applicant:
TECHNISCHE UNIVERSITAT WIEN
Inventors:
Friedrich Bleicher, Johannes Bernreiter
Abstract: The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P. multocida . Said mutants are defective in fur ompH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P. multocida , or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants.
Type:
Grant
Filed:
January 29, 2009
Date of Patent:
April 1, 2014
Assignee:
Universitat Autonoma de Barcelona
Inventors:
Jorge Barbe Garcia, Ignacio Badiola Saiz, Montserrat Llagostera Casas, Maria Elena Garrido Ocana, Montserrat Bosch Gallego, Ana Maria Perez De Rozas Ruiz De Gauna
Abstract: The present disclosure describes compositions containing cyclodextrin and methods of using cyclodextrins to stimulate or enhance the immune system and response in fish. Methods of enhancing the efficacy of a fish vaccine by administering cyclodextrin to the fish are also described.
Type:
Application
Filed:
May 8, 2012
Publication date:
March 27, 2014
Applicants:
UNIVERSITAT AUTONOMA DE BARCELONA, UWM RESEARCH FOUNDATION, INC.
Inventors:
Frederick W. Goetz, Rebecca Klaper, Simon MacKenzie
Abstract: The invention relates to a method of joining substrates. It is the object of the invention in this respect to join substrates of substrate materials together without having to exert an increased effort for a coating with additional coating processes to be carried out and to be able to achieve a good quality of the join connection in so doing. In the method in accordance with the invention a pretreatment of at least one join surface of a substrate to be joined is carried out in low pressure oxygen plasma prior to the actual joining. On the joining, a contact force acts on the substrates to be joined in the range 2 kPa to 5 MPa and in this process a heat treatment is carried out at an elevated temperature of at least 100° C. and at under pressure conditions of a maximum of 10 mbar, preferably <10?3 mbar.
Type:
Application
Filed:
February 21, 2012
Publication date:
March 27, 2014
Applicants:
Friedrich-Schiller-Universität Jena, FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.
Inventors:
Gerhard Kalkowski, Carolin Rothhardt, Mathias Rohde, Ramona Eberhardt
Abstract: The invention relates to a method for the computer-assisted analysis of buggy source code in a hardware description language describing the structure and the operation of an integrated circuit. A correction model is provided, which includes a hierarchical structure of nodes arranged in a plurality of hierarchical levels, the nodes being transformation instructions, wherein a transformation instruction describes a group of transformations which are applied to at least one type of a source code section and thereby change the source code section and wherein a transformation instruction, which is a child node of another transformation instruction, constitutes a subset of the group of transformations of the other transformation instruction. Those transformation instructions, which change the source code in such a manner that the changed source code leads to a correct output of the integrated circuit, are determined and output together with the associated source code sections as corrections.
Type:
Application
Filed:
June 5, 2012
Publication date:
March 27, 2014
Applicant:
UNIVERSITÄT BREMEN
Inventors:
Gorschwin Fey, André Sülflow, Rolf Drechsler