Abstract: Novel amino acids derivatives, in particular some amino acid amides derivatives, their process of preparation and their use for inhibiting Met-triggered disorders, in particular cancer.
Type:
Grant
Filed:
November 28, 2012
Date of Patent:
September 2, 2014
Assignees:
Universite d'Aix-Marseille, Universite de Lorraine, Oreste Piccolo Studio di Consulenza Scientifica, Universitat de Barcelona, Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Flavio Maina, Rosanna Dono, Oreste Piccolo, Daniele Passarella, Francesco Colombo, Joan Bosch, Bernard Maigret, Vincent Leroux
Abstract: The invention relates to a method of estimating BEM coefficients of the Channel taps of a transmission Channel of an OFDM System having a given pilot arrangement, comprising, at the receiver side of the transmission Channel, the Steps of a) subsampling a received OFDM symbol in the frequency domain into a set of subsequences, b) inverse Fourier transforming each subsequence into a transformed subsequence, and c) estimating Fourier coefficients of a truncated Fourier series expansion model of the Channel taps from the set of transformed subsequences.
Type:
Grant
Filed:
March 4, 2011
Date of Patent:
September 2, 2014
Assignees:
Universitat Wien, Technische Universitat Wien
Inventors:
Tomasz Hrycak, Saptarshi Das, Hans Georg Feichtinger, Gerald Matz
Abstract: A double-resonance structure 10 for DNP-NMR and/or ENDOR experiments is described. The double-resonance structure 10 comprises a microwave resonator 30 for generating electromagnetic field suitable for EPR, and an HF resonator 12 for generating electromagnetic fields suitable for NMR. The HF resonator 12 comprises a plurality of electrically conductive strips 14, which are electrically connected so that an HF current can be generated in the plurality of strips 14 such that the HF currents flow in the same direction in the individual strips 14 at the same time. A section of the HF resonator 12 at the same time forms a part of the microwave resonator 30.
Type:
Grant
Filed:
March 16, 2010
Date of Patent:
September 2, 2014
Assignee:
Johann Wolfgang Goethe-Universität Frankfurt am Main
Abstract: A plasma glucose estimation system is provided comprising a sensor which generates a signal from a glucose concentration measured in a medium, filtering means and a glycemic estimator. Also a method comprising: i) generating a signal which represents the glucose concentration measured in the medium; ii) filtering the signal generated; iii) applying a set of local estimation models, to the previous signal, obtaining a set of local plasma glucose estimates; iv) applying a weighting to each one of the local estimates previously obtained; v) estimating a plasma glucose concentration by the sum of the weighted local estimates obtained in the previous step; vi) correcting the signal obtained from the previous step from reference glycemia measurements and obtaining the final plasma glucose estimate.
Type:
Application
Filed:
May 21, 2012
Publication date:
August 28, 2014
Applicants:
UNIVERSIDAD POLITECNICA DE VALENCIA, UNIVERSITAT DE GIRONA
Inventors:
Jorge Bondía Company, Fátima Barceló Rico, José Luís Díez Ruano, Paolo Rossetti, Josep Vehi Casellas, Yenny Teresa Leal Moncada
Abstract: Substituted tricyclic diproline analogues of the formula (I): wherein the variables are as defined herein. Also disclosed are methods for the production thereof, the use thereof for the induction of an alpha-helix conformation in peptides and/or proteins, pharmaceuticals containing said compounds, methods for the production of a peptide library containing said compounds, and peptide libraries containing said compounds.
Type:
Grant
Filed:
July 9, 2010
Date of Patent:
August 26, 2014
Assignees:
Universität zu Köln, Forschungsverbund Berlin E. V.
Inventors:
Hans-Günther Schmalz, Ronald Kuhne, Verena Hack, Cédric Reuter
Abstract: The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.
Abstract: The compounds of formula (I) substantially in exo form or salts thereof, wherein: X is a biradical selected from —(CH2)n—*, —(CH2CH2O)nCH2CH2—*, methylcyclohexyl and methylphenyl; n is an integer ranging between 1 and 30; Y is a radical selected from —COOH, a substituted phosphoramidite radical and N-hydroxysuccinimide ester (or other active ester) of carboxylic acid; and * represents the place through which X binds to Y, are useful in a general process for solid-phase preparation of maleimide-oligonucleotide derivatives.
Type:
Grant
Filed:
May 2, 2011
Date of Patent:
August 26, 2014
Assignee:
Universitat de Barcelona
Inventors:
Ana María Grandas Sagarra, Albert Sánchez González, Enrique Pedroso Muller
Abstract: An embodiment of the present invention relates to a photon-to-plasmon coupler for converting photons to plasmons or vice versa, said photon-to-plasmon coupler comprising a photonic waveguide for guiding photons, a plasmonic waveguide for guiding plasmons, and two plasmonic strip waveguides, each of said two plasmonic strip waveguides being connected to said plasmonic waveguide and embracing an end section of the photonic waveguide such that each of said plasmonic strip waveguides is optically coupled to the end section of the photonic waveguide.
Type:
Application
Filed:
February 19, 2013
Publication date:
August 21, 2014
Applicant:
HUMBOLDT-UNIVERSITÄT BERLIN
Inventors:
Andreas SCHELL, Rico Henze, Prof. Dr. Oliver Benson, Günter Kewes
Abstract: The invention provides permeable magnetically responsive filtration membranes that include a filtration membrane polymer base suitable for fluid filtration; hydrophilic polymers conjugated to the surface of the filtration membrane polymer; and magnetic nanoparticles affixed to the ends of a plurality of the hydrophilic polymers, wherein the hydrophilic polymers are movable with respect to the surface of the filtration membrane polymer surface in the presence of an oscillating magnetic field.
Type:
Application
Filed:
August 8, 2012
Publication date:
August 21, 2014
Applicants:
Colorado State University Research Foundation, The Board of Trustees of the University of Arkansas, Lehrstuhl fur Technische Chemie II, Universitat Duisburg-Essen
Inventors:
Sumith Ranil WICKRAMASINGHE, Xianghong QIAN, Heath H. HIMSTEDT, Mathias ULBRICHT, Michael J. SEMMENS
Abstract: The invention relates to an in vitro or ex vivo method for increasing the immunoreactivity of cells of the immune system, which were contacted with an antigen, said method comprising the reduction or inhibition of the Cbl-b function of said cells, thereby increasing the immunoreactivity of the cells towards the antigen.
Type:
Grant
Filed:
December 10, 2008
Date of Patent:
August 19, 2014
Assignees:
Medizinische Universitat Innsbruck, Apeiron Biologics AG
Inventors:
Gottfried Baier, Hans Loibner, Manfred Schuster, Gunther Lametschwandtner, Dominik Wolf
Abstract: A method and a device for processing a light-polymerizable material (5, 55) for building up an object (27) in layers, using a lithography based generative manufacture having a construction platform (12) for building up the object (27), a projecting exposure unit (10, 60) that can be controlled for locally selected exposing of a surface on the construction platform (12, 62) to an intensity pattern having a prescribed shape, and a control unit (11, 61) prepared for polymerizing overlapping layers (28) on the construction platform (12, 62) in successive exposure steps, each having a prescribed geometry, by controlling the projecting exposure unit (10, 60), in order to thus successively build up the object (27) in the desired shape, said shape resulting from the sequence of layer geometries.
Type:
Application
Filed:
April 17, 2014
Publication date:
August 14, 2014
Applicants:
Ivoclar Vivadent AG, Technische Universitat Wien
Inventors:
Robert LISKA, Johannes PATZER, Jurgen STAMPFL, Wolfgang WACHTER, Christoph APPERT
Abstract: An electronic device (1) includes a semiconductor substrate (3) having a front surface (7), a first electrode (8) and a second electrode (9) disposed on the front surface (7) of the substrate (3), wherein the first electrode (8) and the second electrode (9) each have at least one epitaxial graphene monolayer (10). The at least one epitaxial graphene monolayer (10) of the first electrode (8) forms an ohmic contact with the substrate (3) and the at least one epitaxial graphene monolayer (10) of the second electrode (9) forms a Schottky barrier with the substrate (3).
Abstract: Method for producing a substrate with Au (gold) nanoclusters affixed to the surface thereof and substrate and catalyst obtained by means of said method. The method consists in preparing a solution containing, in disperse form, Au nanoclusters and, also in disperse form, a substrate with a surface functionalised with a polyelectrolyte that confers a net electric charge thereon, and in intensely agitating said solution to affix Au nanoclusters to the substrate surface. This results in a substrate that has a surface with Au nanoclusters affixed in disperse form, significantly without clusters. The invention also relates to a catalyst that comprises said substrate with Au nanoclusters affixed to the surface thereof. Said catalyst is particularly suitable for use in oxidation reactions.
Type:
Application
Filed:
October 17, 2012
Publication date:
August 14, 2014
Applicant:
UNIVERSITAT POLITECNICA DE CATALUNYA
Inventors:
Ernest Mendoza Gómez, Jordi Llorca Piqué
Abstract: The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azido-formate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.
Type:
Application
Filed:
June 20, 2012
Publication date:
August 14, 2014
Applicant:
Technische Universitat Graz
Inventors:
Frank Wiesbrock, Clemens Ebner, Franz Stelzer, Annelie-Martina Weinberg, Klaus-Dieter Kühn
Abstract: The invention relates to a method for the sequence-specific analysis of nucleic acids in a sample in which the nucleic acid is present at least partially as a double strand, which method uses electrochemical detection methods (e.g. with [OsO4(bipy)]). In particular, the methods comprise steps in which the at least partially double-stranded nucleic acid strands are converted by thermal denaturation to single strands which are termed target strands, and at least one nucleic acid strand designated protective strand is added, which protective strand can hybridize with a target strand, in order to form partial double-stranded segments, wherein the protective strands are shorter than the target strands, wherein the temperature of the sample is rapidly lowered to a temperature of below 5° C., preferably below 0° C.
Abstract: A method and apparatus for continuous, non-intermittent, detection of vehicles based on a light detector for detecting a change in illumination when a vehicle arrives or departs, and on a use of the light detection to activate a magnetic sensor, a sensitivity of which is adjusted to detect only those magnetic disturbances sufficiently large to be able to be attributed to a vehicle which is over the sensor. Both the light detector and the magnetic sensor are connected directly to a digital controller without a need for active electronic components or their own or a shared power supply source. The light detector may be fixed or portable, wireless or connected by cables, and may operate independently or as part of a sensor network.
Type:
Grant
Filed:
August 31, 2010
Date of Patent:
August 12, 2014
Assignee:
Universitat Politecnica de Catalunya
Inventors:
Ramon Pallàs Areny, Jaime Oscar Casas Piedrafita, Ernesto Sifuentes De La Hoya
Abstract: According to the invention, a computer-implemented method for processing digital stereo image content, comprises the steps of estimating a perceived disparity of the stereo image content and processing the stereo image content, based on the estimated perceived disparity.
Type:
Application
Filed:
May 18, 2012
Publication date:
August 7, 2014
Applicants:
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V, UNIVERSITAT DES SAARLANDES
Inventors:
Piotr Didyk, Tobias Ritschel, Elmar Eisemann, Karol Myszkowski, Hans-Peter Seidel
Abstract: The present invention relates to novel bacteriophages and bacteriophage cocktails containing the novel bacteriophages and or parts and/or products of them, all of them belonging to the Caudovirales order. The novel bacteriophages and the bacteriophage cocktails containing the novel bacteriophages and or parts and/or products of them are Salmonella specific bacteriophages and have lytic activity against Salmonella.
Type:
Application
Filed:
July 27, 2012
Publication date:
August 7, 2014
Applicant:
UNIVERSITAT AUTONOMA DE BARCELONA
Inventors:
Montserrat Llagostera, Jorge Barbé, Carlota Bardina, Maria Pilar Cortés, Denis Augusto Spricigo
Abstract: A method of screening for template-fixed ?-hairpin mimetics and libraries including a plurality of these mimetics is provided. The template-fixed ?-hairpin mimetics are of the following general formula: R1-Cys-Z-Cys-R2??I wherein the two cysteine residues are bridged by a disulfide bond, thereby forming a cyclic peptide; R1 and R2 are di- or tripeptide moieties of certain types, as defined herein; and Z is a chain of n amino acid residues with n being an integer from 4 to 20 and with each of these n amino acid residues being, independently, derived from any naturally occurring L-?-amino acid.
Type:
Grant
Filed:
August 2, 2011
Date of Patent:
August 5, 2014
Assignees:
Polyphor Ltd., Universität Zürich
Inventors:
Jan Wim Vrijbloed, Daniel Obrecht, Sergio Locurio, Frank Otto Gombert, Christian Ludin, Françoise Jung