Patents Assigned to Universitat
  • Publication number: 20140024702
    Abstract: The invention relates to the gene therapeutic treatment of cancer using co-expressed nucleic acids encoding US28 and a G-protein. e.g. GNA-13, or functional fragments thereof, or using nucleic acids encoding fusion polypeptides of US28 and a G-protein or functional fragments thereof. The pharmaceutical compositions according to the invention are used in the treatment of cancer patients to induce apoptosis in tumor cells.
    Type: Application
    Filed: December 9, 2011
    Publication date: January 23, 2014
    Applicant: Medizinische Universitat Graz
    Inventors: Helmut Schaider, Shripad Joshi
  • Publication number: 20140021472
    Abstract: A printable medium is proposed, such as can be used, for example, during the production of metal contacts for silicon solar cells which are covered with a passivation layer on a surface of a silicon substrate. A corresponding production method and a correspondingly produced solar cell are also disclosed. The printable medium contains at least one medium that etches the passivation layer and metal particles such as nickel particles, for example. By locally applying the printable medium to the passivation layer and subsequent heating, the passivation layer can be opened locally with the aid of the etching medium. As a result, the nickel particles can form a mechanical and electrical contact with the substrate surface, preferably with the formation of a nickel silicide layer. The printable medium and the production method made possible therewith are cost-effective owing to the use of nickel particles, for example, and allow both good electrical contact and avoidance of undesirable high-temperature steps.
    Type: Application
    Filed: April 5, 2012
    Publication date: January 23, 2014
    Applicant: UNIVERSITÄT KONSTANZ
    Inventors: Giso Hahn, Bernd Raabe, Stefan Braun
  • Patent number: 8633348
    Abstract: The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and expression, of said recombinant fusion protein renders said genetically-modified non-human animal sterile. Tools for generating such sterile genetically-modified non-human animal as well as methods of use thereof are also provided.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: January 21, 2014
    Assignees: Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute for Biomedical Research, Universität Zürich
    Inventors: Pawel Pelczar, Thorsten Buch, Antoine Peters
  • Publication number: 20140015725
    Abstract: A method and an arrangement for modeling antenna emission characteristics are disclosed. A slotted microwave waveguide is implemented by separate mechanical modules having slot groups respectively implemented therein. For this purpose, the modules are arranged along at least one first spatial direction, so that the modules sectionally form a part of the delimitation of the waveguide. The waveguide formed can be fed by exciting a waveguide mode and the mode propagates through the interior of the module in the waveguide formed. Screens are arranged in front of the modules, to partially cover the slot groups. Arbitrary emission characteristics can be simulated, wherein no separate feed network is necessary due to the use of a modular waveguide.
    Type: Application
    Filed: March 22, 2012
    Publication date: January 16, 2014
    Applicant: TECHNISCHE UNIVERSITAT BRAUNSCHWEIG
    Inventors: Achim Enders, Robert Geise
  • Patent number: 8628750
    Abstract: Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N?-methyl derivative of a basic amino acid.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: January 14, 2014
    Assignee: Technische Universitat Munchen
    Inventors: Hans Jürgen Wester, Norman Koglin, Markus Schwaiger, Horst Kessler, Burkhardt Laufer, Oliver Demmer, Martina Anton
  • Publication number: 20140011698
    Abstract: The present invention provides methods, immunoassays, kits and devices pertaining to the detection of multiple biomolecules from single cells or other biological entities. It also enables the highly parallel detection of interacting biomolecules from such entities.
    Type: Application
    Filed: November 30, 2011
    Publication date: January 9, 2014
    Applicants: MorphoSys AG, ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG, HSG-IMIT Institut für Mikro-und Informationstechnik
    Inventors: Markus Enzelberger, Andreas Boll, Beate Diefenbach-Streiber, Guenter Roth, Felix von Stetten, Fabian Stumpf
  • Patent number: 8623264
    Abstract: A method and a device for processing light-polymerizable material for the assembly of a mold, utilizing a lithography-based generative manufacturing technique wherein a layer of a light-polymerizable material, the material being located in at least one trough (4) having a particularly light-transmissive, horizontal bottom (6), is polymerized by illumination on at least one horizontal platform (12), the platform having a prespecified geometry and projecting into a trough (4), in an illumination field, wherein the platform (12) is displaced vertically to form a subsequent layer, light-polymerizable material is then added to the most recently formed layer, and repetition of the foregoing steps leads to the layered construction of the mold in the desired form, which arises from the succession of layer geometries.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: January 7, 2014
    Assignees: Ivoclar Vivadent AG, Technische Universitat Wien
    Inventors: Gottfried Rohner, Wolfgang Wachter, Christoph Appert, Johannes Patzer, Jürgen Stampfl
  • Patent number: 8624190
    Abstract: The invention relates to a method and a device (1, 100) for determining the sex of fertilized, nonincubated bird eggs (13, 130), where an egg (13, 130) has a solid egg shell (14), an egg yolk (2) which is surrounded by the egg shell and further egg integuments and a blastodisc (3) associated with the egg yolk (2), and where a probe (4, 40) for measuring a spectrum is introduced through a hole (17) of the egg shell (14) towards the blastodisc (3) with blastodisc cells (23), with the following steps: —positioning of the probe (4, 40) in the region of the blastodisc (3), —spectroscopic in-ovo characterization of the blastodisc cells (23), and —identification of the sex by an automatic classification of spectra.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: January 7, 2014
    Assignees: Technische Universität Dresden, Universität Leipzig
    Inventors: Gerald Steiner, Edmund Koch, Maria-Elisabeth Krautwald-Junghanns, Thomas Bartels
  • Patent number: 8623353
    Abstract: The present invention is directed to a cross-reactive antibody that specifically inhibits or blocks mammalian Toll-like receptor 2 (TLR2)-mediated immune cell activation. The invention is further directed to an isolated nucleic acid or vector coding for the variable regions of the heavy and/or light chain of such an antibody. Also provided is a pharmaceutical composition comprising such an antibody, or a nucleic acid or vector encoding it. Further provided are methods of use of such compositions in the prevention and/or treatment of inflammatory processes or any other process induced by bacterial infection, trauma, or chronic inflammation, or for the prevention and/or treatment of bacteriaemia or sepsis.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: January 7, 2014
    Assignees: Technische Universitat Munchen, Amgen Inc.
    Inventors: Carsten Juergen Kirschning, Guangxun Meng, Hermann Wagner
  • Patent number: 8623607
    Abstract: The present invention relates to a method for determining or predicting the progression of chronic kidney disease in a subject suspected of having chronic kidney disease, comprising determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention relates to a use of a specific detection molecule for FGF23 or adiponectin for the preparation of a diagnostic composition for the detection of chronic kidney disease or the progression of chronic kidney diseases in a subject suspected to suffer from said disease. In particular, the present invention also provides for use of FGF23 and/or of adiponectin as an in vitro marker for the presence, absence or progression of a chronic kidney disease and kits comprising a specific detection molecule for FGF23 or a specific detection molecule for adiponectin for use in the method of the present invention.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: January 7, 2014
    Assignee: Medizinische Universitat Innsbruck
    Inventors: Florian Kronenberg, Barbara Kollerits, Danilo Fliser
  • Patent number: 8625644
    Abstract: The invention relates to a Q-switched laser comprised of a pump light source (1), an optical resonator accommodating a laser medium (6), and a passive Q-switch (5). It is the object of the present invention to provide an improved Q-switched laser which is of a simple and compact setup while having the least possible jitter of the repetition time. To achieve this target, the invention proposes that by means of a beam splitter (8) part of the light coupled out of the optical resonator is passed on to an optical delay line (9) and coupled back into the optical resonator upon having passed through the optical delay line (9).
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: January 7, 2014
    Assignees: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V., Friedrich-Schiller-Universitat Jena
    Inventors: Andreas Tünnermann, Dirk Nodop, Alexander Steinmetz, Jens Limpert
  • Patent number: 8623593
    Abstract: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: January 7, 2014
    Assignee: Rheinische Friedrich-Wilhelms-Universität Bonn
    Inventors: Evi Kostenis, Andreas Spinrath, Stephanie Hennen, Lucas Peters, Christa E. Muller, Rhalid Akkari, Younis Baqi, Kirsten Ritter
  • Publication number: 20140007309
    Abstract: The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumour, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 ?m and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumour tissue biopsy sample.
    Type: Application
    Filed: December 12, 2011
    Publication date: January 2, 2014
    Applicant: UNIVERSITAT BASEL
    Inventors: Marija Plodinec, Roderick Lim, Marko Loparic
  • Publication number: 20140001513
    Abstract: The invention relates to a layer system composed of a silicon-based carrier having a single-crystal surface and of a heterostructure applied directly to the single-crystal surface of the carrier. The layer system according to the invention is characterized in that the carrier comprises a silicon substrate doped with one or more dopants, wherein the doped portion extends across at least 30% of the thickness of the doped silicon substrate and a concentration of the dopants in the doped portion of the silicon substrate is predetermined such that a corrected limiting concentration GK meets the condition of formula (1): GK = ? m = i n ? ? N dot i 1 + 5 × 10 22 ? ? cm - 3 N dot i ? ? - E A i / 0.
    Type: Application
    Filed: August 31, 2011
    Publication date: January 2, 2014
    Applicant: Otto-von-Guericke-Universität Magdeburg
    Inventors: Armin Dadgar, Alois Krost
  • Patent number: 8618816
    Abstract: A measuring device has a micro-electromechanical capacitive sensor which has electrodes which move toward and away from each other for measurement of a mechanical deflection of a test mass. The measuring device has a charge integrator which has an operating amplifier which has at least one amplifier input connected to the sensor and an amplifier output which is fed back to the amplifier input via an integration capacitor. The amplifier input is connected via a high-resistance electrical resistor to a terminal for an electrical common-mode reference potential. In addition to the amplifier input, the operating amplifier has an auxiliary input. The amplifier output is connected to the auxiliary input via a deep pass.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: December 31, 2013
    Assignee: Albert-Ludwigs-Universität Freiburg
    Inventors: Lin He, Yiannos Manoli, Alexander Buhmann, Armin Taschwer, Thomas Northemann
  • Patent number: 8617237
    Abstract: The invention relates to a tubular supporting prosthesis, comprising two terminal regions relative to the longitudinal supporting prosthesis axis and a center region disposed between the two terminal regions, wherein every terminal region is provided with a mesh structure made of at least two structural rings, which are connected to each other via connecting members and are disposed point-symmetrically about the longitudinal supporting prosthesis axis. The center region is formed by elongated connecting members, which are connected to the structural rings respectively disposed adjacent to the center of the longitudinal supporting prosthesis axis. An aortic valve, which is produced by means of tissue engineering, is fastened and/or integrated in the center region.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: December 31, 2013
    Assignee: Universität Zürich
    Inventors: Simon-Philipp Hoerstrup, Gregor Zund, Thilo Fliedner, Frank Baaijens
  • Publication number: 20130344486
    Abstract: The present invention relates to methods of diagnosing a breast carcinoma, determining the prognosis of a patient diagnosed with breast carcinoma and determining the efficacy of a treatment regimen of breast carcinoma in a patient, using Calponin-h2 and/or CALML 5 as markers. Furthermore, the invention relates to a kit and a marker panel for use in these methods.
    Type: Application
    Filed: February 28, 2012
    Publication date: December 26, 2013
    Applicant: Rheinische Friedrich-Wilhelms-Universitat Bonn
    Inventors: Manuel Debald, Gisela Walgenbach-brunagel
  • Publication number: 20130345281
    Abstract: The present invention relates to 3-(Indolyl)- and 3-(azaindolyl)-4-phenylmaleimide compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, and the physiologically acceptable salts, solvates and solvates of the salts of the compounds of formula (I). The compounds of formula (I) are suitable for treating tumors.
    Type: Application
    Filed: December 15, 2011
    Publication date: December 26, 2013
    Applicant: JOHANNES GUTENBERG-UNIVERSITAT MAINZ
    Inventors: Gerd Dannhardt, Stanislav Plutizki, Christopher Ganser, Eva Lauermann
  • Patent number: 8614290
    Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.
    Type: Grant
    Filed: September 1, 2008
    Date of Patent: December 24, 2013
    Assignee: Technische Universitat Munchen
    Inventors: Hans Jürgen Wester, Horst Kessler, Oliver Demmer, Ingrid Dijkgraaf
  • Publication number: 20130338035
    Abstract: The invention relates to the novel use of gene markers in a method of predicting the risk of or diagnosing a subject to develop graft versus host reaction (GvHR) or graft versus host disease (GvHD). In other aspects the invention also relates to methods of monitoring the efficacy of treatment of GvHR or GvHD, and methods of screening a candidate substance for the treatment of GvHR or GvHD.
    Type: Application
    Filed: December 14, 2011
    Publication date: December 19, 2013
    Applicants: UNIVERSITY OF NEWCASTLE UPON TYNE, GEORG-AUSUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS, UNIVERSITATSMEDIZIN, DEUTSCHES PRIMATENZENTRUM GMBH
    Inventors: Ralf Dressel, Anne Dickinson, Bent Rolstadt, Lutz Walter