Abstract: A double-resonance structure for DNP-NMR experiments and/or ENDOR experiments and methods using such a double-resonance structure. The double-resonance structure comprises a microwave resonator for generating electromagnetic fields suitable for EPR and an HF resonator for generating electromagnetic fields suitable for NMR. The HF resonator is formed by a strip resonator, a section of the strip resonator at the same time forming a portion of the microwave resonator.
Type:
Grant
Filed:
April 3, 2009
Date of Patent:
October 29, 2013
Assignee:
Johann Wolfgang Goethe-Universität Frankfurt am Main
Abstract: An integrated catheter navigation system (100) and method (200) that combines anatomical imaging (302, 304) with catheter tip-to force information (306, 308) during an ablation procedure.
Abstract: The invention relates to an apparatus (1) for non-incremental position and form measurement of moving solid bodies (7), containing a laser Doppler distance sensor (10) in wavelength multiplexing technique with at least two different wavelengths (?1, ?2) and with a modular fibre optic measurement head in its sensor design, which contains two additional modules, which are connected to the measuring head by means of fibre optics a light source unit (2) and a detection unit (4). Two laser light bundles (37) of different wavelengths (?1, ?2) in the light source unit (2) are coupled into a glass fibre (24). The bichromatic scattered light in the detection unit (4) is split into the different wavelengths (?1, ?2) corresponding to the two measurement channels (41, 42) and subsequently are detected separately by means of two photo detectors (43, 44).
Type:
Application
Filed:
September 15, 2011
Publication date:
October 24, 2013
Applicant:
TECHNISCHE UNIVERSITÄT DRESDEN
Inventors:
Thorsten Pfister, Lars Buettner, Juergen Czarske, Florian Dreier
Abstract: Substantially pure biological culture of a strain of the species Pseudomonas graminis, deposited with number CBS124167 at the depositary institution “Centraalbureau voor Schimmelcultures” (CBS) in Utrecht, Netherlands. Use of the CBS124167 culture as an antagonist for the biocontrol of foodborne pathogenic bacteria in fruit intended for human consumption. Method for treating the fruit which comprises the step of applying a preparation that comprises a culture of a strain of the species Pseudomonas graminis, deposited with number CBS124167 at the depositary institution “Centraalbureau voor Schimmelcultures” (CBS) in Utrecht, Netherlands, to the fruit. The application thereof makes it possible to reduce the growth of pathogens during the shelf life of the product, especially when the cold chain is broken.
Type:
Application
Filed:
December 29, 2011
Publication date:
October 24, 2013
Applicants:
INSTITUT RECERCA I TECNOLOGIA AGROALIMENTARIES, UNIVERSITAT DE LLEIDA
Abstract: The present invention is directed to an isolated miR-206 target site, comprising or consisting of a nucleic acid sequence with a sequence identity of at least 80% compared to wild type miR-206 target site with SEQ ID No. 1, characterized in that the nucleic acid sequence comprises at least one nucleotide substitution at a position from nucleotide 2 to 8 and/or at least one nucleotide substitution at a position from nucleotide 12 to 16 of SEQ D No. 1, wherein the nucleotide positions of SEQ ID No. 1 are numbered from the 3?- to the 5?-end; as well as to an expression cassette, vector and pharmaceutical composition comprising at least one isolated miR-206 target site of the invention.
Type:
Application
Filed:
April 18, 2012
Publication date:
October 24, 2013
Applicants:
Charite-Universitatsmedizin Berlin, Technische Universitat Berlin
Abstract: A method and a system are for compensating optical aberrations in a telescope. The method is applicable to a telescope wherein the element for receiving a primary beam is an image acquisition device (3), and involves using an algorithm without an image processing sensor for: a) detecting optical aberrations affecting the primary focus, by analyzing the images acquired by the image acquisition device (3), and b) calculating and generating first positional correction values, by processing the detected optical aberration values. The method also includes a step c) consisting in moving, in a controlled manner, the image acquisition device (3), applying suitable control signals generated from the first positional correction values. The system is suitable for implementing the proposed method.
Type:
Application
Filed:
July 22, 2011
Publication date:
October 24, 2013
Applicants:
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, UNIVERSITAT POLITECNICA DE CATALUNYA
Abstract: Parametric Motion Vector Prediction (PMVP) methodologies and components and systems for performing those methodologies are provided to more effectively and efficiently encode video content that includes complex motion such as zoom or rotation. By substituting the PMVP for a collocated MVP used in HEVC in order to reduce the amount of bit rate increase required when including the PMVP analysis in the bit stream. Further, compression of the motion vectors is provided in a three stage approach based on transformation, quantization and difference coding.
Type:
Application
Filed:
April 20, 2012
Publication date:
October 24, 2013
Applicant:
TECHNISCHE UNIVERSITAT BERLIN
Inventors:
Michael TOK, Alexander GLANTZ, Andreas KRUTZ, Thomas SIKORA
Abstract: Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which are Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention.
Type:
Grant
Filed:
June 20, 2008
Date of Patent:
October 22, 2013
Assignee:
Technische Universitat Munchen
Inventors:
Arne Skerra, Ina Theobald, Martin Schlapschy
Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.
Abstract: The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
Type:
Application
Filed:
September 19, 2011
Publication date:
October 17, 2013
Applicants:
BIONTECH AG, TRON- Translationale Onkologie an der Universi- ttttatsmedzin der Johannes Gutenberg- UNiversitat, Universitatsmedizin der Johannes Gutterberg- Universital MAinz
Inventors:
Ugur Sahin, Ozlem Tureci, Petra Simon, Tana Omokoko
Abstract: A method of manufacturing an optical element, the method comprising: growing a first layer of single crystal diamond material via a chemical vapour deposition technique using a gas phase having a first nitrogen concentration; growing a second layer of single crystal diamond material over said first layer via a chemical vapour deposition technique using a gas phase having a second nitrogen concentration, wherein the second nitrogen concentration is lower than the first nitrogen concentration; forming an optical element from at least a portion of the second layer of single crystal diamond material; and forming an out-coupling structure at a surface of the optical element for increasing out-coupling of light.
Type:
Application
Filed:
August 2, 2011
Publication date:
October 17, 2013
Applicants:
Element Six Limited, UNIVERSITAT STUTTGART
Inventors:
Daniel James Twitchen, Joseph Michael Dodson, Matthew Lee Markham, Fedor Jelezko
Abstract: The present invention discloses an immunological test for the detection and specific determination of autoantibodies against testicular antigens which are associated with inflammation-related fertility disorders of male mammals in a biological sample of a male mammal, in particular the detection of testicular ER-60 autoantibodies and/or transferrin autoantibodies. The immunological test is utilized to detect the presence of immunologically-caused and infection-related infertility in male mammals, particularly in humans.
Abstract: The invention relates to a method for the production of a photon pair source, which generates entangled photon pairs, having at least one quantum dot, wherein in the method the operational behaviour of the photon pair source is determined by adjusting the fine structure splitting of the excitonic energy level of the at least one quantum dot. It is provided according to the invention for the fine structure splitting of the excitonic energy level to be adjusted by depositing the at least one quantum dot on a {111} crystal surface of a semiconductor substrate.
Type:
Grant
Filed:
July 20, 2009
Date of Patent:
October 15, 2013
Assignee:
Technische Universitat Berlin
Inventors:
Momme Winkelnkemper, Andrei Schliwa, Dieter Bimberg
Abstract: System and method for the simultaneous and non-invasive estimation of blood glucose, glucocorticoid and pressure levels. It comprises an activity module detector for a digitalized signal acquired by a sensor, representing the distal heartbeat of a person, selecting a segment of consecutive signal samples of fixed duration Swindow(t) and using the same to generate sub-windows Sframe(t, n) of shorter duration; a signal processing module which receives the two signals Swindow(t) and Sframe(t, n) and which delivers a vector XF at its output with the parameters of a physiological model and module based on automatic learning, which receives the XF vector and information on a person's characteristics and provides an estimation of blood glucose levels (BGL), systolic pressure levels (SPL), diastolic pressure levels (DPL) and glucocorticoid levels (GCL) at its output.
Abstract: The present invention relates to the field of diagnostic tests and diagnostic tools. Specifically, contemplated is to a method for diagnosing cancer in a sample of a subject suspected to suffer from cancer comprising contacting the sample with an antibody which specifically binds to the epitope characterized by SEQ ID NO 1 on a BRAF polypeptide under conditions which allow for binding of said antibody to the epitope and determining binding of the antibody to the epitope, whereby cancer is diagnosed. Further contemplated are antibodies which specifically bind to the epitope characterized by SEQ ID NO 1 on a BRAF polypeptide and a device or kit comprising such antibodies.
Abstract: The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter.
Type:
Application
Filed:
December 22, 2011
Publication date:
October 10, 2013
Applicant:
TECHNISCHE UNIVERSITÄT WIEN
Inventors:
Astrid Mach-Aigner, Robert Mach, Matthias G. Steiger
Abstract: The present invention describes tripodal bisphosphonate derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. A fourth remaining position of the flexible framework is suitable to be optionally functionalised by so-called click reactions, for example with biomolecules, polyethylene glycol or active agents.
Type:
Application
Filed:
September 7, 2011
Publication date:
October 10, 2013
Applicant:
JUSTUS-LIEBIG-UNIVERSITAT GIESSEN
Inventors:
Wolfgang Maison, Elisa Franzmann, Faiza Khalil
Abstract: The present invention relates to compounds derived from steroids of the general formula (I) wherein L represents a linker and R# represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
Type:
Application
Filed:
October 6, 2011
Publication date:
October 10, 2013
Applicant:
Justus-Liebig-Universitat Giessen
Inventors:
Katja Becker, Reimar Krieg, Bruno Schönecker
Abstract: The invention relates to a process for generating a porous material having homogeneous, gas-containing inclusions in the micrometer and sub-micrometer range, and also to the material produced by such process.
Abstract: The present invention relates to the use of prokaryotic sphingosine-1-phosphate lyases (S1PL) and S1PLs that lack a transmembrane domain or of a nucleic acid encoding such an S1PL in the prevention or treatment of a disease condition associated with elevated levels of sphingosine-1-phosphate (S1P), and for which S1P elevation is directly or indirectly causative. In addition, the invention relates to a new product in the form of S1PL lacking the N-terminal loop domain.
Type:
Application
Filed:
November 30, 2011
Publication date:
October 3, 2013
Applicants:
UNIVERSITAT ZURICH, UNIVERSITAT BERN
Inventors:
Uwe Zangemeister-Wittke, Andrea Huwiler, Markus G. Grutter, Florence Bourquin