Abstract: A method for determining a focal length of a particle in a medium, wherein the method comprises: providing a sample; emitting a coherent light beam to irradiate the sample, wherein a first part of the light beam is scattered by the particle; recording an interference image; computing for a set of positions an electric field from the interference image; generating a representation comprising, for each of said positions, an intensity value of the coherent light beam calculated from the computed electric field; finding two positions, a first of which lies in the sample, a second of which lies in the beam direction behind or in front of said first position; and determining the focal length from the two found positions.

Abstract: Kinase-targeted covalent inhibitors are usually irreversibly targeting noncatalytic cysteines in the ATP-binding site. These compounds are designed by directly introducing an electrophile on a reversible-inhibitor scaffold. Our invention relates to novel triazine compounds, containing chemical reactive groups (warheads), targeting a solvent exposed cysteine at >10 ? from the core reversible inhibitor. A variety of novel linkers have been designed and used to link the warhead with the reversible scaffold. We disclose a novel chemical space for drug-like covalent modifiers of phosphoinositide 3-kinase alpha (PI3K?), an enzyme frequently altered in human malignancies. The invention relates to novel covalent inhibitors showing higher in vitro affinity, cellular potency and improved metabolic stability (rat liver microsomes).

Abstract: It is provided a storage medium for storing hydrogen chloride (HCl) comprising at least one ionic compound of the general formulae (I) Wherein R1, R2, R3 being independent from each other an alkyl moiety selected from the group of methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl and sec-butyl, preferably methyl, ethyl, n-propyl; Wherein at least one of the moieties R1, R2, R3 differs from each of the others moieties R1, R2, R3; Wherein a, b, c are independently from each other 0, 1, 2 or 3, wherein the sum of a+b+c always has to be 4; Wherein n>=1, preferably n=1-6, more preferably n=1, 2, 3, 4, with a viscosity in a range between 5 and 50 mPas, preferably between 10 and 20 mPas (25° C., 1000 hPa).

Abstract: The invention relates to a hydroxycarboxylic acid of the formula CH3(CH2)8 CHOH—(CH2)—CO2H or a pharmaceutically acceptable salt thereof, for use as a medicament, particularly for use in the treatment or prevention, including prevention of recurrence, of cancer, for example colorectal cancer. The invention further relates to a combination medicament for use in the treatment or the prevention of recurrence of cancer comprising a hydroxycarboxylic acid as specified herein, and another antineoplastic treatment. Further aspects of the invention relate to a method of measuring the presence of a hydroxydicarboxylic acid of the formula HO2C(CH2)7 CH2CHOH—(CH2)—CO2H, or CH3(CH2)10COOH to predict or to monitor the clinical outcome of a cancer patient, and/or to predict or monitor the response to an antineoplastic therapy or treatment with live bacteria.

Abstract: An automated system for inspecting Petri dishes in which multiple C. elegans nematodes coexist, such that precise mobility characteristics of each individual C. elegans nematode can be extracted. The Petri dish to be monitored is moved in a controlled manner along the X, Y, and Z axes with respect to at least one movable camera that captures a high-resolution sequence of images for each C. elegans nematode, and at least one fixed camera captures a low-resolution sequence of global images that allow the entire Petri dish to be framed. The movable camera is mounted on a movable head in order to move along the Z axis, enabling focusing, and the fixed camera is mounted on a movable trolley, together with the Petri dish, in order to move along the X and Y axes.

Abstract: Our invention relates to novel triazine compounds, containing chemical reactive groups (warheads) and behaving as reversible and irreversible covalent inhibitors. Linkers have been introduced to target a solvent exposed, distal cysteine at >10 ? from the core reversible inhibitor. Different exit vectors have been investigated to modulate inhibitor intrinsic reactivity and efficiency in covalent bond formation. We disclose novel, optimized covalent modifiers of phosphoinositide 3-kinase alpha (PI3K?), an enzyme frequently altered in human malignancies. The compounds of the invention could be exploited as therapeutic agents and chemical probes useful for the investigation of the role of PI3K isoforms in cancer and metabolism, and for treatment of PI3K?-driven cancers and malformations.

Abstract: The present application relates to a compound having the formula (I); A-L-B (I) wherein A is represented by; L is a bond or a self-immolative spacer; B is represented by; The compound is capable of releasing molecular cargo in the presence of a reductase and is thus suitable for treating, ameliorating, preventing or diagnosing a disorder selected from a neoplastic disorder; atherosclerosis; an autoimmune disorder; an inflammatory disease; a chronic inflammatory autoimmune disease; ischaemia; and reperfusion injury.

Abstract: Provided is an (A)-(B)-(A) triblock copolymer comprising two hydrophilic polymer blocks (A) as further defined herein, and a polymer block (B), said polymer block (B) comprising at least one type of repeating unit of the following formula (I) wherein R1 is an aliphatic hydrocarbon group which is optionally substituted with one or more of —OR5, —SR5, —NR6R7, —(NR6R7R8)+, —CONR6R7, —C(O)OR9 and —C(O)R10, wherein R5 to R10 are independently selected from H, aliphatic and aromatic residues, and wherein R1 is selected such that the polymer block (B) is more hydrophobic than the polymer block (A); and compositions, such as pharmaceutical compositions, formed with the block copolymer.

Abstract: The invention relates to a method for operating a sorption system (1), the sorption system comprising the following: a cooling fluid circuit (8), which has a cooling fluid; a process medium circuit (6), which has a refrigerant and a solvent; an absorber (3), which is connected to the cooling fluid circuit (8) and to the process medium circuit (6); a condenser (5), which is connected to the cooling fluid circuit (8) and to the process medium circuit (6); and a control device. During operation of the sorption system (1), the cooling fluid is fed to the absorber (3) and to the condenser (5), and a feed of the cooling fluid to the absorber (3) and a feed of the cooling fluid to the condenser (5) are controlled differently from each other by means of the control device. The invention further relates to an arrangement for a sorption system (1) and to a sorpotion system (1).

Abstract: A multilayer structure for photovoltaic applications includes a n-type high-work function transition metal oxide (TMO) layer deposited on a support structure, a thin n-type low-work function transition metal oxide (TMO) layer covering the n-type high-work function TMO layer, and a first absorber cell based on a perovskite material on the n-type low-work function TMO layer, the n-type high-work function TMO layer and the thin n-type low-work function TMO layer forming a hole-selective contact structure.

Abstract: The present invention relates to transmission elements (1, 1a, 1b; 12, 12a, 12b) for testing/determining the tensile or shear strength of a bonding between two elongated shaped specimen elements by transmitting a tensile or shear force (10, 22) to a specimen element (5a, 5b; 12a, 12b).

Abstract: The method object of the invention enables the scalable configuration and performance optimisation to be carried out for programmable optical circuits based on meshed structures, in such a way that they can perform optical/quantum signal processing functions. The object of the invention can be applied in circuits with arbitrary degrees of complexity implemented by means of programming a waveguide mesh. The method object of the invention enables not only the analysis and evaluation of performance to be carried out, but also the subsequent programming and optimisation of programmable optical devices.

Abstract: The present invention provides a pharmaceutical composition for use in prevention or treatment of a human rhinovirus (HRV) infection. The composition comprises an aldohexose, wherein the hydroxyl group at carbon 2 of the aldohexose is replaced by any one of H, F, Cl, Br, I, SH, Me, OMe and SMe, such as a 2-deoxy-glucose. Furthermore, a dispenser for intranasal administration, such as a nasal spray or nose drop applicator containing said pharmaceutical composition is provided. In addition, an inhalation device, such as a metered-dose inhaler, a dry-powder inhaler or a nebuliser, comprising said composition is provided.

Abstract: A method for user command-guided editing of an initial textured 3D morphable model of an object comprising: obtaining the initial textured 3D morphable model of the object comprising an initial texture map and an initial 3D mesh model of the object; and determining an edited texture map of the object corresponding to the user command by editing the initial texture map of the object based on a first artificial neural network; and/or determining an edited 3D mesh model of the object corresponding to the user command by editing the initial 3D mesh model of the object based on a second artificial neural network; and generating an edited textured 3D morphable model of the object corresponding to the user command based on the edited texture map of the object and/or the edited 3D mesh model of the object.

Abstract: The present invention relates to a device (10) for generating optical tweezers comprising a laser beam source (11) for generating a laser beam (12) and at least one acousto-optic deflector (13) for generating an array (15) of partial beams (14) of the laser beam (12), wherein the array (15) comprises rows (15c). The device (10) further comprises a stepped mirror unit (16) comprising at least a first stepped mirror (25) for reducing a row distance (15d) of the partial beams (14) of the array (15), wherein the first stepped mirror (25) comprises mirrors (30), a stepped distance (25a) between adjacent mirrors (30) and a stepped height (25b).

Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.

Abstract: A passive micromechanical counter for counting and storing a number of mechanical pulses includes at least one memory cell, the memory cell having a cell input, a latching mechanism and an electromechanical coding unit, the cell input being designed to mechanically transmit the mechanical pulse to the latching mechanism, and the latching mechanism being designed to store the number of mechanical pulses transmitted by means of its discrete latching position. It is provided that an electrical digital signal can be generated by applying an electrical voltage to the electromechanical coding unit, the electrical digital signal representing the discrete latching position of the latching mechanism.

Abstract: A method for determining at least one physical parameter of a system comprising at least two reflection objects is presented, comprising: producing a transmission signal comprising at least one modulated electromagnetic or acoustic wave; receiving a first reception signal that is based on the transmission signal reflected by a first reflection object; receiving a second reception signal that is based on the transmission signal reflected by a second reflection object; receiving a third or further reception signal(s) that is/are based on the transmission signal reflected by a first or second or further reflection object(s); ascertaining the at least one physical parameter of the system on the basis of the first reception signal and further reception signals; ascertaining unknown distances between reflection objects or material properties, composition or nature of the media between the reflection objects of the system on the basis of the first reception signal and further reception signals.

Abstract: The invention relates to a method and to a measurement system for determining and localizing incorrect positioning of support rollers (1) in support roller stations (13) of belt conveyor installations, wherein a unit of pressure sensors (4) is detachably mounted on the underside of a conveyor belt (2); the number of pressure sensors (4) corresponds at least to the number of support rollers (1) of a support roller station (13); and as the sensor (4) is led over a support roller (1), a signal of the contact pressure point is generated upon contact and the signal is measured and evaluated.

Abstract: A method for analyzing or optimizing the operation of waste incinerator systems. The content of CO2 is measured in the exhaust gas and is used to determine the ratio of biogenic carbon to fossil carbon in the incinerated waste, if necessary after resetting to the CO2 reference quantity. The variability of the CO2 reference or the ratio of biogenic carbon to fossil carbon in the incinerated waste is determined and recorded according to quantity and duration. When optimizing the operation, the location of the waste in the bunker, from which the incinerated waste originates with a composition or variability that has now been ascertained using the method, is used to further remove or mix the waste.