Patents Assigned to Universite d'Aix-Marseille
  • Publication number: 20240115371
    Abstract: A vascular prosthesis may be implanted in a vessel, having substantially a T-shape, that includes a proximal tubular part forming the base of the “T” and a distal tubular part forming the head of the “T”. The second end portion of the distal tubular part is formed by a flap. The flap is opposed to a circumferential indentation in the deployed position. The structural frame of the flap includes an arched segment connected at its ends to the intermediate portion of the distal tubular part. The arched segment is bendable so as to form a joint for the folding/unfolding movement of the flap.
    Type: Application
    Filed: April 6, 2022
    Publication date: April 11, 2024
    Applicants: UNIVERSITÉ D'AIX MARSEILLE, ASSISTANCE PUBLIQUE-HÔPITAUX DE MARSEILLE, Université Gustave Eiffel, Bypass Solutions
    Inventors: Yves Simon Alimi, Frédéric Mouret, Vincent Garitey, David Baas
  • Patent number: 11947101
    Abstract: According to one aspect, the invention relates to a device (200) for transporting and controlling light beams comprising a light guide (40) comprising a bundle (50) of uncoupled single-mode optical fibers (Fi), each single-mode optical fiber (Fi) being intended to receive an elementary light beam (B1i) at a proximal end and to emit a light beam (B2i) at a distal end, said bundle of single-mode optical fibers comprising, in operation, a minimum radius of curvature corresponding to a maximum curvature of the bundle of fibers.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: April 2, 2024
    Assignees: Centre National de la Recherche Scientifique, Université d'Aix-Marseille, Université de Lille, Ecole Centrale de Marseille
    Inventors: Hervé Rigneault, Géraud Bouwmans, Esben Andresen, Siddarth Sivankutty, Viktor Tsvirkun, Olivier Vanvincq
  • Patent number: 11944445
    Abstract: A method for automatically detecting elements of interest in electrophysiological signals includes: delivering electrophysiological signals; producing a whitened time-frequency representation of the electrophysiological signals; setting a threshold; applying this threshold to the whitened time-frequency representation; and, in the whitened time-frequency representation, detecting local maxima that are higher than or equal to the applied threshold.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: April 2, 2024
    Assignees: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, ASSISTANCE PUBLIQUE—HÔPITAUX DE MARSEILLE (AP-HM)
    Inventors: Nicolas Roehri, Christian George Benar, Fabrice Bartolomei
  • Patent number: 11927737
    Abstract: The disclosure may relate to a method for the characterization of the 3D orientation of an emitting dipole within a specimen. The method comprises splitting a light beam emitted by the emitting dipole and exiting an objective lens into a first and a second beams; spatially filtering said first beam by using a spatial frequency filter; splitting each of said filtered first beam and said second beam into two beams linearly polarized using polarizing beam splitters; detecting with an optical detection unit four beams linearly polarized in a detection plane optically conjugated with the front focal plane of said microscope objective lens; determining, from four intensity images, in a predefined frame of the specimen, the mean orientation and the angular aperture of the distribution of the 3D orientation of the emitting dipole, during an acquisition time of said four intensity images.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: March 12, 2024
    Assignees: Université d'Aix-Marseille, Centre National de la Recherche Scientifique, CENTRALE MARSEILLE
    Inventors: Sophie Brasselet, Valentina Curcio
  • Patent number: 11914083
    Abstract: This dosimeter comprises: a transducer material capable, when it is excited by a secondary ionizing radiation, of generating photons or electric charges, an amplifying layer capable, in response to its excitation by the primary ionizing radiation, of generating the secondary ionizing radiation. This amplifying layer comprises a first and a second amplifying sublayer stacked on top of one another. The first and the second amplifying sublayers are composed of at least 70%, by weight, respectively, of at least one first and one second material, the atomic numbers of which are greater than or equal to 29. The atomic number of the first material being less than the atomic number of the second material. The first sublayer is interposed between the second sublayer and the transducer material.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: February 27, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES CENTRE REGIONAL DE LUTTE CONTRE LE CANCER
    Inventors: Sree Bash Chandra Debnath, Julien Darreon, Carole Fauquet, Didier Tonneau, Agnès Tallet
  • Patent number: 11904004
    Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: February 20, 2024
    Assignees: INSERM, UNIVERSITE D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES, CNRS, UNIVERSITE DE NANTES
    Inventors: Daniel Olive, Marc Bonneville, Emmanuel Scotet, Christelle Harly, Yves Guillaume
  • Patent number: 11892489
    Abstract: A device for determining a measurand, includes a first pattern made from a first conductive material, the first pattern having a first impedance and having a first end and a second end spaced apart from the first end, a second pattern at least arranged between the first end and the second end of the first pattern, being in electrical contact with the first pattern. The second pattern has a second impedance that changes continuously as a function of the measurand, such that the impedance or the inductance of the assembly formed by the first and second patterns changes continuously as a function of the measurand. The device also comprises a means for determining the impedance or the inductance of the assembly, formed by the first and second patterns.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: February 6, 2024
    Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE TOULON
    Inventor: Evangéline Benevent
  • Patent number: 11875848
    Abstract: The present description concerns a memory device (200) including a non-volatile memory circuit (101); a buffer memory circuit (203) comprising a volatile memory circuit (221); an input-output circuit (105); a first data link (104) coupling the non-volatile memory circuit (101) to the buffer memory circuit (203); a second data link (106) coupling the buffer memory circuit (203) to the input-output circuit (105); and a control circuit (225), wherein the buffer memory circuit (203) is adapted to implementing calculations having as operands data stored in the volatile memory circuit (221).
    Type: Grant
    Filed: January 20, 2022
    Date of Patent: January 16, 2024
    Assignees: Commissariat à l'Energie Atomique et aux Energies Alternatives, Université d'Aix-Marseille, Centre National De La Recherche Scientifique
    Inventors: Valentin Egloff, Jean-Philippe Noel, Jean-Michel Portal
  • Patent number: 11875847
    Abstract: Memory devices such as phase change memory (PCM) devices utilizing Ovonic Threshold Switching (OTS) selectors may be used to fill the gap between dynamic random-access memory (DRAM) and mass storage and may be incorporated in high-end microcontrollers. Since the programming efficiency and reading phase efficiency of such devices is directly linked to the leakage current of the OTS selector as well as sneak-path management, a sense amplifier disclosed herein generates an auto-reference that takes into account the leakage currents of unselected cells and includes a regulation loop to compensate for voltage drop due to read current sensing. This auto-referenced sense amplifier, built utilizing the principle of charge-sharing, may be designed on a 28 nm fully depleted silicon-on-insulator (FDSOI) technology, provides robust performance for a wide range of sneak-path currents and consequently for a large range of memory array sizes, and is therefore suitable for use in embedded memory in high-end microcontroller.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: January 16, 2024
    Assignees: Universite D'Aix Marseille, Centre National De La Recherche Scientifique, STMicroelectro (Crolles 2) SAS, STMicroelectronics (Rousset) SAS
    Inventors: Jean-Michel Portal, Vincenzo Della Marca, Jean-Pierre Walder, Julien Gasquez, Philippe Boivin
  • Publication number: 20240002521
    Abstract: Novel anti-human CD25 antibodies and their use for treating cancer and infectious diseases. Also, a nucleic acid encoding an anti-human CD25 antibody or an antigen-binding fragment thereof, and a fusion protein including an isolated anti-human CD25 antibody or an antigen-binding fragment thereof. Further, a pharmaceutical composition including an isolated anti-human CD25 antibody or an antigen-binding fragment thereof.
    Type: Application
    Filed: November 19, 2021
    Publication date: January 4, 2024
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), INSTITUT JEAN PAOLI & IRENE CALMETTES, ALDERAAN BIOTECHNOLOGY, UNIVERSITE D'AIX MARSEILLE, UNIVERSITÉ PARIS CITÉ, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Daniel OLIVE, Armand BENSUSSAN, Jérôme GIUSTINIANI, Anne MARIE-CARDINE, Amaud FOUSSAT, Jemila HOUACINE
  • Publication number: 20240002522
    Abstract: Novel anti-human CD25 antibodies or antigen-binding fragments thereof and their use for treating cancer and infectious diseases. Also, a nucleic acid encoding an anti-human CD25 antibody or antigen-binding fragment thereof, and a fusion protein including an isolated anti-human CD25 antibody or antigen-binding fragment thereof. Further, a pharmaceutical composition including an isolated anti-human CD25 antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: November 19, 2021
    Publication date: January 4, 2024
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INSTITUT JEAN PAOLI & IRENE CALMETTES, ALDERANN BIOTECHNOLOGY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE, UNIVERSITE PARIS CITE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Daniel OLIVE, Armand BENSUSSAN, Jerome GIUSTINIANI, Anne MARIE-CARDINE, Amaud FOUSSAT, Jemila HOUACINE
  • Publication number: 20230372078
    Abstract: A percutaneous bypass method for implanting a bypass graft between two vessels is described. The bypass graft comprises a first part and a second part, each having a tubular shape and comprising respective lumens. The method comprises the step of inserting a second sheath, from the outside to the inside of a bypass portion of the first part, through a puncture therein, and retracting the second sheath so as to deploy and implant a hook portion of the second part into the second vessel, and deploy a bypass portion of the second part outside the second vessel, from the second vessel to the first part, and within the lumen of the first part.
    Type: Application
    Filed: October 6, 2020
    Publication date: November 23, 2023
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE, ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE, Université Gustave Eiffel
    Inventor: Yves Alimi
  • Publication number: 20230368839
    Abstract: A memory cell, includes first and second main terminals, an auxiliary terminal; M memristor(s) between the main terminals, M?1; M primary switch(es), each in parallel with a memristor; and a secondary switch between the second main terminal and the auxiliary terminal. It is configured for writing to at least one memristor by opening each primary switch in parallel with the at least one memristor, closing each other primary switch, closing the secondary switch and applying a corresponding programming voltage between the first main terminal and the auxiliary terminal; and for reading at least one memristor by opening each primary switch in parallel with the at least one memristor, closing each other possible primary switch, opening the secondary switch and measuring a corresponding electrical quantity between the main terminals.
    Type: Application
    Filed: May 10, 2023
    Publication date: November 16, 2023
    Applicants: Commissariat à l'énergie atomique et aux énergies alternatives, Université d'Aix-Marseille, Centre national de la recherche scientifique
    Inventors: Djohan BONNET, Tifenn HIRTZLIN, Elisa VIANELLO, Eduardo ESMANHOTTO, Jean-Michel PORTAL
  • Publication number: 20230340546
    Abstract: The use of UV-activated Copper Radical Oxidase (CRO) enzymes in the implementation of oxidation reactions. Also, a process for oxidizing organic compounds using enzymes which are activated by UV light. The process also leads to concomitant formation of hydrogen peroxide, that can optionally be used in hydrogen peroxide mediated processes. Further, the process relates to the oxidation of alcohols in aldehydes.
    Type: Application
    Filed: July 21, 2021
    Publication date: October 26, 2023
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE, ECOLE CENTRALE DE MARSEILLE
    Inventors: Bastien BISSARO, Jean-Guy BERRIN, Michael LAFOND
  • Publication number: 20230324485
    Abstract: A system is described for emitting a radiofrequency field for a magnetic resonance imaging device, including a volumetric antenna that emits a radiofrequency field, a device for homogenizing the radiofrequency field arranged between said volume antenna and a part of the body to be imaged. The device may include a first continuous metal track with an overall length of approximately 0.5 to approximately 1.5 times said wavelength of the radio frequency field. The first metallic track may occupy a surface with a largest dimension ranging between approximately 5% and approximately 15% of said wavelength of the radio frequency field. The first metal track is arranged in a pattern including a plane of symmetry that is normal to the electrical component of the radio frequency field, so as to give the device an electric dipole property including a natural frequency strictly greater than the frequency of the radio frequency field.
    Type: Application
    Filed: June 15, 2021
    Publication date: October 12, 2023
    Applicants: UNIVERSITÉ D'AIX MARSEILLE, Centre National de la Recherche Scientifique, Ecole Centrale de Marseille, Multiwave Imaging
    Inventors: Marc Dubois, Kaizad Rustomji, Tania Del Socorro Vergara Gomez, Elodie Virginie Emilia Georget, Frank Kober, Redha Abdeddaim, Stanislas Pierre Alain Rapacchi, Stefan Enoch, Tryfon Antonakakis
  • Publication number: 20230260574
    Abstract: Memory devices such as phase change memory (PCM) devices utilizing Ovonic Threshold Switching (OTS) selectors may be used to fill the gap between dynamic random-access memory (DRAM) and mass storage and may be incorporated in high-end microcontrollers. Since the programming efficiency and reading phase efficiency of such devices is directly linked to the leakage current of the OTS selector as well as sneak-path management, a sense amplifier disclosed herein generates an auto-reference that takes into account the leakage currents of unselected cells and includes a regulation loop to compensate for voltage drop due to read current sensing. This auto-referenced sense amplifier, built utilizing the principle of charge-sharing, may be designed on a 28 nm fully depleted silicon-on-insulator (FDSOI) technology, provides robust performance for a wide range of sneak-path currents and consequently for a large range of memory array sizes, and is therefore suitable for use in embedded memory in high-end microcontroller.
    Type: Application
    Filed: February 16, 2022
    Publication date: August 17, 2023
    Applicants: Universite D'Aix Marseille, Centre National De La Recherche Scientifique, STMicroelectronics (Crolles 2) SAS, STMicroelectronics (Rousset) SAS
    Inventors: Jean-Michel PORTAL, Vincenzo DELLA MARCA, Jean-Pierre WALDER, Julien GASQUEZ, Philippe BOIVIN
  • Patent number: 11712486
    Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 1, 2023
    Assignees: VECT-HORUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Cédric Malicet, Pascaline Lecorche, Jonathan Nowak, Marion David, Jamal Temsamani, Michel Khrestchatisky
  • Patent number: 11690856
    Abstract: The present invention relates the field of CMV and CMV related diseases. Using a powerful rat model of CMV infection of the embryonic brain, the inventors have looked for the existence of postnatal neurological and neurosensory manifestations, and have tested whether the early pharmacological targeting of microglia during pregnancy impacts on postnatal phenotypes. Particularly, the inventors tested the clodronate and the doxycycline and showed that these compounds improve the postnatal outcome of the baby. Thus, the invention relates to a compound which modifies the microglia for use in the treatment of CMV related diseases in a subject in need thereof.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: July 4, 2023
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX MARSEILLE
    Inventors: Pierre Szepetowski, Robin Cloarec, Sylvian Bauer, Nadine Bruneau
  • Publication number: 20230178250
    Abstract: The method for inferring epileptogenicity of a brain region not observed as recruited or not observed as not recruited, in a seizure activity of an epileptic patient brain, includes: providing a computerized model modelling various regions of a primate brain and connectivity between the regions; providing the computerized model with a model able to reproduce an epileptic seizure dynamic in the primate brain; providing structural data of the epileptic patient brain and personalizing the computerized model using the structural data to obtain a virtual epileptic patient (VEP) brain model; translating a state-space representation of the VEP brain model into a probabilistic programming language (PPL) using probabilistic state transitions to obtain a probabilistic virtual epileptic patient brain model (BVEP); and acquiring electro- or magneto-encephalographic data of the patient brain and fitting the probabilistic VEP brain model against the data to infer the epileptogenicity of the brain region that is not observe
    Type: Application
    Filed: April 3, 2020
    Publication date: June 8, 2023
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Viktor Jirsa, Meysam Hashemi, Michael Marmaduke Woodman, Viktor Sip, Anirudh Nihalani Vattikonda
  • Publication number: 20230159447
    Abstract: Chemoenzymatic process for coproducing a disulfide and a sulfoxide or a sulfone The present invention relates to a chemoenzymatic process for coproducing disulfide and sulfoxide or sulfone from a composition M comprising: 1) a sulfide, 2) optionally an oxidizing agent, 3) an organic compound bearing at least one thiol group, 4) an enzyme E catalyzing the oxidation of said sulfide to sulfoxide or to sulfone, 5) an enzyme D catalyzing the formation of a disulfide bridge between two equivalents of said organic compound bearing at least one thiol group to form a dimer, and 6) a cofactor common to the two enzymes E and D; and also to a composition enabling especially the implementation of this process. The present invention also relates to the use of a mercaptan for reducing a disulfide bridge formed between two equivalents of an organic compound bearing at least one thiol group, and more particularly to the use thereof as regeneration substrate of the process described above.
    Type: Application
    Filed: March 3, 2021
    Publication date: May 25, 2023
    Applicants: Arkema France, Centre National De La Recherche Scientifique - CNRS, Universite d'AIX-Marseille
    Inventors: Georges Fremy, Hugo Brasselet, Jean-Christophe Lec, Véronique Alphand, Katia Duquesne