Abstract: Sarcomas are rare malignant tumors arising from the mesenchymal tissues at all body sites. The inventors show that in a mouse model of p16/p19 deficiency prone to tumor development, the absence of the mouse pantetheinase Vnn1 enhances the frequency of aggressive fibrosarcomas. They also show that reintroduction of a catalytically active form of the Vnn1 pantetheinase limits tumor growth in vivo. Interestingly, VNN1 expression in human sarcomas is associated with reduced aggressiveness and lower risk of metastatic relapse in patients. In conclusion, Vnn1 represents a novel marker of sarcoma and may modulate tumor aggressiveness by sustaining myofibroblast cell differentiation, thereby limiting evolution towards undifferentiated tumors. The present invention relates to the use of Vnn1 as a biomarker and a therapeutic target in sarcomas.

Abstract: The present invention relates to antibodies having specificity for BTN2 and uses thereof, in particular for the treatment of cancer.

Abstract: The method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes for identification of an epileptogenic zone in an epileptic patient’s brain includes: - providing a model of the epileptogenic zone and a model of the propagation of an epileptic discharge from the epileptic zone to a propagation zone, and loading the models in a computerized platform personalized according to the patient’s brain; - providing at least one hypothesis of the localization of the epileptogenic zone in the patient brain; - for the at least hypothesis of the localization of the epileptogenic zone, simulating, in the personalized computerized patient’s brain, epileptic seizures, and determining, for the hypothesis and epileptic seizures, a network of propagation zones; - for a plurality of intracranial implantation schemes of the electroencephalographic electrodes, obtaining, using the personalized computerized patient’s brain, simulated electroencephalographic signals activity to be measured

Abstract: A method for functionalizing a surface of a dielectric plate that is transparent to visible light—to be able to examine the dielectric plate using optical microscopy—includes depositing a negative film on the dielectric slide. The negative film comprises a polymerizable composition that polymerizes when exposed to an electron beam. The polymerizable composition is polymerized—by exposing the negative film to the electronic beam—at a set of points representing a preset pattern. Non-polymerized portions of the polymerizable composition are dissolved—to develop the negative film—forming a set of pads of polymerized portions of the polymerizable composition. Each pad corresponds to one point of the preset pattern. A metal film is disposed on the negative film, and the developed negative film is dissolved to define holes through the metal film. Each of the holes corresponds to a base of one pad of the set of pads.

Abstract: In one aspect the application relates to a computing system for providing data for modelling a human brain comprises a database including a plurality of datasets (or allow access to a plurality of datasets), each dataset including at least a dynamical model of the brain including at least one node and a neurodataset of a neuroimaging modality input. The at least one node include a representation of a local dynamic model and a parameter set of the local dynamic model.

Abstract: The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.

Abstract: Method for manufacturing microcapsules enclosing a substance referred to as the active substance, in which method: there are provided an aqueous solution of a surfactant, an oily phase comprising the active substance and at least a first monomer X, and a polar phase having at least a second monomer Y; an O/W emulsion is prepared by adding the oily phase to the aqueous solution of the surfactant; the polar phase is added to the O/W emulsion in order to obtain a polymer by polymerisation of the X and Y monomers; starting from this reaction mixture, the microcapsules are isolated and comprise a wall which is formed by the polymer and which encloses the active substance; the polymer is a poly(beta-amino ester).

Abstract: The disclosure relates to an apparatus and a system for testing the cognitive ability of a rodent, comprising a testing chamber, a retarding zone connected to the entrance chamber and including at least one obstacle configured to slow down the rodent's movement to the entrance chamber, and an optional transfer chamber connected to the entrance chamber via the retarding zone for transfer of the rodent to and from an area external to the apparatus. The testing chamber comprises an entrance chamber, a plurality of corridors each connected to the entrance chamber via a corridor's first end portion, and at least one odor diffuser for diffusing odors in the plurality of corridors.

Abstract: A vascular prosthesis configured to be implanted in a vessel, having substantially a T-shape, comprises a proximal tubular part forming the base of the “T” and a distal tubular part forming the head of the “T”. The proximal tubular part has a first lumen, the distal tubular part has a second lumen, and the first and second lumens are fluidly connected to form a common lumen. The distal tubular part comprises a first end portion, a second end portion, and an intermediate portion extending axially between the first and second end portions. The first and second end portions are radially expandable. The proximal tubular part is connected to the intermediate portion and the second end portion is movable between a retracted position in which the second end portion is axially restrained and a deployed position in which the second end portion is axially deployed.

Abstract: The disclosure may relate to a method for the characterization of the 3D orientation of an emitting dipole within a specimen. The method comprises splitting a light beam emitted by the emitting dipole and exiting an objective lens into a first and a second beams; spatially filtering said first beam by using a spatial frequency filter; splitting each of said filtered first beam and said second beam into two beams linearly polarized using polarizing beam splitters; detecting with an optical detection unit four beams linearly polarized in a detection plane optically conjugated with the front focal plane of said microscope objective lens; determining, from four intensity images, in a predefined frame of the specimen, the mean orientation and the angular aperture of the distribution of the 3D orientation of the emitting dipole, during an acquisition time of said four intensity images.

Abstract: A computer-implemented method and a system for dating a blood pool lying on a substrate are described. The method comprises: determining, based on at least one picture of a blood pool lying on a substrate taken at a given time (t), the drying front of the blood pool at the given time (t); and determining, based on the determined drying front of the blood pool at the given time (t), and on a drying model, the time elapsed between the given time (t) and an initial time (t0) at which the blood pool initiated a drying process on the substrate. Determining the drying front of the blood pool comprises determining the wet perimeter (Pt) of the blood pool, and the drying model correlates the time elapsed with a blood's diffusion coefficient (Dblood) measured for a plurality of predetermined environmental conditions and a plurality of initial blood pool conditions.

Abstract: A telescope includes an initial telescope comprising a concave first mirror and a convex second mirror that are configured so that they form, from a light beam coming from infinity, an image called the intermediate image in a focal plane called the intermediate focal plane, the intermediate image having a largest dimension along an X-axis perpendicular to an optical axis of the telescope, a segmenting module comprising a first set of n segmenting mirrors that are placed downstream of the intermediate focal plane and that are configured to divide the intermediate image obtained from the intermediate focal plane into n sub-images, a second set of n refocusing mirrors that are configured to reimage the n sub-images into n images in a focal plane of the telescope, the images being arranged in the focal plane so as to decrease the dimension along X containing the n images, a detecting device placed in the focal plane.

Abstract: Method for manufacturing microcapsules enclosing a substance referred to as the active substance, in which method: there are provided an aqueous solution of a surfactant, an oily phase comprising the active substance and at least a first monomer X, and a polar phase having at least a second monomer Y; an O/W emulsion is prepared by adding the oily phase to the aqueous solution of the surfactant; the polar phase is added to the O/W emulsion in order to obtain a polymer by polymerisation of the X and Y monomers; starting from this reaction mixture, the microcapsules are isolated and comprise a wall which is formed by the polymer and which encloses the active substance; the polymer is a poly(beta-amino ester).

Abstract: A compound of formula (I), wherein R1, R2, R3 and R4 are selected from a saturated or unsaturated, branched or unbranched, cyclic or non-cyclic alkyl, or an amide, or a functional group, or a salt or a solvate thereof, or a protonated form thereof, and to the use thereof for the treatment of cancer.

Abstract: The present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1. More, the invention relates to kits and array useful for carrying out diagnosis methods according to the present invention.

Abstract: The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.

Abstract: The present description relates according to a first aspect to a method for measurement of optical properties of at least one particle in a sample (10) and permits, for example, quantitative determination of the complex dipolar polarizability of at least one particle present in a sample. The optical characterization method comprises the illumination of said sample (10) using a light beam, the sample (10) being positioned in the object space of an optical system (120); the acquisition of at least one phase image and at least one intensity image of said at least one particle illuminated by the light beam, the acquisition being carried out in an analysis plane arranged in the image space of the optical system (120); and the determination of at least one optical property of said at least one particle from said at least one phase image and at least one intensity image.

Abstract: A three-dimensional biomaterial including particles encapsulating at least one complement active fragment dispersed therein. Also, a process of manufacturing of the three-dimensional biomaterial with at least one biocompatible and/or resorbable polymer and the particles. The three-dimensional biomaterial is useful for tissue regeneration, especially with regards to dental pulp, dentin, periodontal and gingival tissues, as well as bones tissues.

Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.

Abstract: The present invention relates to the field of diagnostic and treatment of cancer, particularly melanoma, pancreatic cancer, kidney cancer and colon cancer. In particular, the invention relates to an antibody directed specifically to CD146-positive tumors and its applications, particularly for use as a medicament for the prevention and/or treatment of cancer, for use in a method of diagnostic or prognostic of a cancer, or for use as a radiotracer when labelled with a radioactive element.