Patents Assigned to Universite dé Lorraine
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Publication number: 20220338784Abstract: Systems and methods are disclosed for visualizing reentrant circuits in the heart via pseudo-activation maps. Techniques disclosed comprise receiving sets of ECG data and respective pacing sites. Each of the sets is generated by pacing heart tissue at a respective site of the pacing sites. Techniques disclosed further comprise computing correlation gradients representative of morphological changes across sets, of the sets of the ECG data, of respective neighboring sites of the pacing sites. Based on the computed correlation gradients, a core zone associated with a reentrant circuit is identified. Then, relative to the identified core zone, one or more pseudo-activation maps are generated.Type: ApplicationFiled: April 19, 2022Publication date: October 27, 2022Applicants: Johnson & Johnson Medical SAS, L'Université de Lorraine, The Centre Hospitalier Regional Universitaire de NancyInventors: Philip Hoyland, Freddy Odille, Christian de CHILLOU de CHURET
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Patent number: 11404761Abstract: A method for depositing an electrically conductive metal onto at least one portion of the inner surface (3) of an internal cavity (2) of a waveguide (1) includes: preparing a suspension containing at least one liquid and at least one precursor of the electrically conductive metal in suspension in said at least one liquid; coating at least one portion of the inner surface (3) of the internal cavity (2) of the waveguide (1) with the suspension, and heat-treating at least said portion of the inner surface (3) of the internal cavity (2) of the waveguide (1) coated with the suspension. A method for manufacturing a metallized waveguide can implement this deposition method.Type: GrantFiled: July 31, 2020Date of Patent: August 2, 2022Assignees: AML FINANCES, UNIVERSITE DE LORRAINEInventors: Jean-Yves Milojevic, Régis Limbach, Léo Portebois, Nicolas Ramenatte, Thierry Mazet
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Publication number: 20220236432Abstract: A device for radioactivity counting and characterization for a solution. The device includes a container having at least two recesses, a first recess for receiving a vial and a second recess for receiving a radioactivity sensor, a radioactivity sensor having a semiconductor sensor presenting a cone of detection directed to the first recess of the container for receiving a vial, a removable closure element, an armored cover around the container and its upper face, the upper face of the armored cover having an opening for introducing the vial into the container and a plate for supporting the device.Type: ApplicationFiled: June 18, 2020Publication date: July 28, 2022Applicant: UNIVERSITÉ DE LORRAINEInventors: Guénolé MATHIAS-LAOT, Quentin THOMAS
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Publication number: 20220162537Abstract: A fluidic system for loading a therapeutic or imaging agent into the lumen of extracellular vesicles from producer cells, including at least one container, a liquid medium contained in the container, producer cells, a liquid medium stirrer and a device for controlling the speed of the stirrer suitable for the growth of the producer cells, wherein it also includes a device for controlling the speed of the stirrer and the stirrer, of which the shape and dimensions of the container are suitable for generating a turbulent flow of the liquid medium in the container for exerting shear stresses on the producer cells in order to carry out the loading of a therapeutic or imaging agent into the lumen of the extracellular vesicles produced simultaneously by the fluidic system.Type: ApplicationFiled: December 27, 2019Publication date: May 26, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LORRAINE, UNIVERSITE DE PARISInventors: Iris MARANGON, Marie MILLARD, Lina BOLOTINE, Amanda SILVA, Alice GRANGIER, Florence GAZEAU, Claire WILHELM, Max PIFFOUX
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Publication number: 20220064076Abstract: The present invention relates to the field of crop fertilization, and particularly to a biofertilizing bacterial strain. In particular, the present invention relates to the bacterial strain deposited on Oct. 24, 2018, at the Collection Nationale de Culture de Microorganismes (CNCM), 28 rue du Dr. Roux, 75724 PARIS CEDEX 15, under the Budapest Treaty under number CNCM I-5372, and to the uses of this strain. The invention also relates to a composition comprising the above-mentioned bacterial strain and to a fertilization process comprising the application of this composition to a plant or to a soil.Type: ApplicationFiled: December 19, 2019Publication date: March 3, 2022Applicants: Université de Lorraine, Institut National de la Recherche AgronomiqueInventors: Sophie SLEZACK - DESCHAUMES, Séverine PIUTTI, Pierre L'YVONNET, Sandro ROSELLI
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Publication number: 20220055960Abstract: The present invention relates to the field of crop fertilization, and particularly to a biofertilizing bacterial strain. In particular, the present invention relates to the bacterial strain deposited on Oct. 24, 2018, at the Collection Nationale de Culture de Microorganismes (CNCM), 28 rue du Dr. Roux, 75724 PARIS CEDEX 15, under the Budapest Treaty under number CNCM I-5373, and to the uses of this strain. The invention also relates to a composition comprising the above-mentioned bacterial strain and to a fertilization process comprising the application of this composition to a plant or to a soil.Type: ApplicationFiled: December 19, 2019Publication date: February 24, 2022Applicants: Université de Lorraine, Institut National de la Recherche AgronomiqueInventors: Sophie SLEZACK - DESCHAUMES, Séverine PIUTTI, Pierre L'YVONNET, Sandro ROSELLI
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Publication number: 20220044834Abstract: The present invention relates to a process for treating aqueous effluents from the primary circuit of a nuclear power plant implementing a separation of boric acid using a reverse osmosis membrane, characterized by the fact that it comprises steps consisting of treating the effluents using a multi-stage assembly composed of reverse osmosis modules comprising a membrane with a high boron rejection rate, arranged in parallel and in series, and recycling of the intermediate products to different points in the assembly.Type: ApplicationFiled: December 4, 2019Publication date: February 10, 2022Applicants: Electricite de France, Centre National de la Recherche Scientifique (CNRS), Universite de LorraineInventors: Thibaut Neveux, Eve Bailleul, Christophe Castel, Eric Favre
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Publication number: 20210117883Abstract: A method for process analysis, where the process includes at least one succession of steps associated to objectives to be achieved to obtain the target objective. The steps include receiving a process map, receiving a progression value of each node of the process map and the state of each node of the process map, updating the process map for each node.Type: ApplicationFiled: October 17, 2019Publication date: April 22, 2021Applicant: UNIVERSITÉ DE LORRAINEInventors: Corentin KERBIRIOU, Henri REYDON, Jeffrey HONION, Laurie PACINI
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Patent number: 10951119Abstract: To this end, the invention relates to a method for controlling a switched electronic circuit connecting an electrical voltage source u to a load R and forming a system having an output y and a plurality of operating modes i, at least some of which thus can be activated by following a switching rule o. According to the invention, the following steps are provided: —measuring state variables x of the system having equilibrium values xr; —introducing at least one parameter p into the system, representing a measuring error of an electrical unknown of the operation of the circuit; —estimating the parameter from a state monitor and applying a Lyapunov function thereto; —deducing therefrom the equilibrium values of the system in order to obtain the control rule.Type: GrantFiled: May 22, 2018Date of Patent: March 16, 2021Assignees: SAFRAN ELECTRONICS & DEFENSE, UNIVERSITE DE LORRAINEInventors: Gaetan Beneux, Jamal Daafouz, Louis Grimaud, Pierre Riedinger
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Patent number: 10948498Abstract: A cardiovascular event or disease is prevented or treated in a subject by measuring the expression level of soluble Triggering Receptors Expressed on Myeloid cells-1 (sTREM-1) level in a sample from the subject and comparing it to a reference level. Based on this comparison, subjects that are at risk of having or developing a cardiovascular event or disease are identified, and administered a suitable therapy.Type: GrantFiled: August 8, 2014Date of Patent: March 16, 2021Assignees: INOTREM, APHP (Assistance Publique-Hôpitaux de Paris), INSERM (Institut National de la Santé et de la Recherche Médicale), Université de LorraineInventors: Marc Derive, Sebastien Gibot, Hafid Ait-Oufella, Amir Boufenzer, Tabasomme Simon, Nicolas Danchin
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Publication number: 20210036397Abstract: A method for depositing an electrically conductive metal onto at least one portion of the inner surface (3) of an internal cavity (2) of a waveguide (1) includes: preparing a suspension containing at least one liquid and at least one precursor of the electrically conductive metal in suspension in said at least one liquid; coating at least one portion of the inner surface (3) of the internal cavity (2) of the waveguide (1) with the suspension, and heat-treating at least said portion of the inner surface (3) of the internal cavity (2) of the waveguide (1) coated with the suspension. A method for manufacturing a metallized waveguide can implement this deposition method.Type: ApplicationFiled: July 31, 2020Publication date: February 4, 2021Applicants: AML FINANCES, UNIVERSITE DE LORRAINEInventors: Jean-Yves Milojevic, Régis Limbach, Léo Portebois, Nicolas Ramenatte, Thierry Mazet
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Patent number: 10895503Abstract: A bimodal optical spectroscopy device for producing spectra of autofluorescence and diffuse reflectance signals from a biological sample such as skin.Type: GrantFiled: November 30, 2016Date of Patent: January 19, 2021Assignees: UNIVERSITE DE LORRAINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Marine Amouroux, Walter Blondel, Alain Delconte
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Patent number: 10891728Abstract: A method is provided for identifying an isthmus in a three-dimensional map of a cardiac cavity by means of a processing unit configured to perform the following steps: a) correlation between a set of stimulated points of the cardiac cavity, each stimulated point being represented by a set of signals that are obtained following surface electrocardiography (ECG), excluding ventricular tachycardia; b) identification of a watershed line on the basis of the above correlation results and of the 3D coordinates of the stimulated points in the 3D map; and c) determination of the isthmus based on a 3D corridor substantially transverse to the watershed line.Type: GrantFiled: April 1, 2016Date of Patent: January 12, 2021Assignees: UNIVERSITE DE LORRAINE, CENTRE HOSPITALIER REGIONAL DE NANCYInventor: Christian De Chillou
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Publication number: 20200397018Abstract: A process for producing a protein isolate from an oilseed meal, and the isolate thus obtained, said isolate comprising proteins and an amount of 4 wt. % or less of phytic acid, said amount of phytic acid being by weight of proteins in said isolate. The process may comprise the following steps: a) providing an oilseed meal; b) mixing the oilseed meal with a first aqueous solvent to form a slurry at a pH ranging from 6 to 7.8, said slurry having a solid phase; c) separating said solid phase from said slurry, d) mixing said separated solid phase with a second aqueous solvent at a pH ranging from 1 to 3.Type: ApplicationFiled: November 14, 2018Publication date: December 24, 2020Applicants: Avril, Universite de Lorraine, Centre National de la Recherche ScientifiqueInventors: Claire DEFAIX, Romain KAPEL, Olivier GALET
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Patent number: 10854807Abstract: Some embodiments are directed to a piezoelectric sensor, including a body with a central cavity; and a membrane extending over the cavity, which membrane is fastened to the body via its periphery and includes a carrier layer made of polymer and a sensitive layer made of piezoelectric polymer, the membrane being able to deform or vibrate. The sensitive layer is made of a material including a polymer filled with inorganic nanomaterials. Instrument including such a sensor.Type: GrantFiled: March 24, 2016Date of Patent: December 1, 2020Assignee: UNIVERSITÉ DE LORRAINEInventors: Didier Rouxel, Brice Vincent, Laurent Badie
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Patent number: 10844459Abstract: A method for extracting the tantalum from an acid aqueous phase A1 comprising at least one step comprising the bringing of the aqueous phase A1 into contact with a phase A2 not miscible with water, and then the separation of the aqueous phase A1 from the phase A2, the phase A2 consisting of one ionic liquid or a mixture of ionic liquids as an extractant. A method for recovering the tantalum that implements this extraction method and to a use of an ionic liquid or of a mixture of ionic liquids as an extractant, in order to extract the tantalum from such an aqueous phase A1.Type: GrantFiled: August 10, 2016Date of Patent: November 24, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, UNIVERSITE DE CHAMBERY, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, TND, UNIVERSITE DE LORRAINEInventors: Raphael Turgis, Guilhem Arrachart, Stéphane Pellet-Rostaing, Micheline Draye, Sophie Legeai, David Virieux, Christian Thomas
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Patent number: 10751947Abstract: An additive manufacturing device processes voxels representing an object to be additively manufactured by determining two graphs depending on whether the voxels indicate full or empty spaces, and redefines some of the voxels indicating an empty space as full spaces in order to ensure mechanical stability.Type: GrantFiled: June 28, 2016Date of Patent: August 25, 2020Assignees: Inria Institut National De Recherche En Informatique et en automatique, Universite De LorraineInventors: Sylvain Lefebvre, Jeremie Dumas, An Lu
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Patent number: 10755828Abstract: A device for preparing radioactive solutions, in particular radiopharmaceutical solutions, including: a movable support block with at least two cells capable of accommodating a vial; and a shielded covering, including a side wall surrounding the periphery of the support block and an upper wall covering the upper face of the support block, an opening being provided in the upper wall of the covering. A means for driving the support block is configured to selectively displace the support block into positions, referred to as working positions, in which a given cell is aligned with the opening to allow access to the cell from the outside of the covering. The support block is configured such that it can be further brought to a position, referred to as closing position, in which the opening is sealed by a shielded element carried by the support block.Type: GrantFiled: December 5, 2017Date of Patent: August 25, 2020Assignee: UNIVERSITE DE LORRAINEInventors: Guénolé Mathias-Laot, Quentin Thomas
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Patent number: 10658561Abstract: A thermoelectric element, particularly for a thermoelectric converter, includes an assembly of constituent layers comprising a central layer made of p- or n-type thermoelectric material, then, in an assembly direction, and on each side of said central layer, an intermediate layer forming a diffusion barrier followed by a buffer layer made of composite metal material. The buffer layers are intended to be secured to metal electrodes, characterized in that the cumulative thickness of the two buffer layers is greater than or equal to 50% of the thickness of the central layer, and preferably greater than or equal to 100% of the thickness of the central layer and very preferably greater than or equal to 200% of the thickness of the central layer, and in that the constituent material of the buffer layers is an alloy of two metals chosen from the family: TixAg1-x, VxFe1-x, VxAg1-x, TixFe1-x, where 0<x<1.Type: GrantFiled: August 18, 2016Date of Patent: May 19, 2020Assignees: UNIVERSITE DE LORRAINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Alexandre Jacquot, Bertrand Lenoir, Eugen Geczi, Iurii Kogut, Driss Kenfaui, Philippe Masschelein
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Patent number: 10619494Abstract: A part include a refractory alloy including a niobium matrix having metal silicide inclusions present therein, the surface of the part being coated by a protective coating, the protective coating including a phase having the following stoichiometry: (NbxTi1-x)3M?Cr?Si?X? where M designates Fe, Co, or Ni, X designates one or more other elements that might be present, x lies in the range 0 to 1, x lies in the range 5 to 8.5, and the sum ?+? lies in the range 3 to 7; or Nb4M??Si?X??? where M? designates Fe, Co, or Ni, X? designates one or more other elements that might be present, ? lies in the range 3.2 to 4.8, and ? lies in the range 6 to 8.Type: GrantFiled: May 21, 2018Date of Patent: April 14, 2020Assignees: SAFRAN AIRCRAFT ENGINES, UNIVERSITE DE LORRAINEInventors: Stéphane Knittel, Stéphane Mathieu, Michel Vilasi