Patents Assigned to Universite de Liege
  • Patent number: 11541129
    Abstract: Disclosed herein are biomaterial implants, medical devices, or bioprostheses wherein a surface or part thereof is coated with a nanoreservoir comprising a hydrophilic polymer or copolymer backbone crosslinked to a second polymer comprising a hydrophilic backbone and one or more reactive moieties, wherein the nanoreservoir further comprises one or more bioactive molecules, therapeutic molecules, or drugs.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: January 3, 2023
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Cécile Oury, Christine Jérôme, Christophe Detrembleur, Patrizio Lancellotti
  • Publication number: 20220317138
    Abstract: The present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample. In particular, the present invention relates to methods for determining the concentration of a carbapenem antibiotic in a biological sample, comprising the steps of: (a) providing a blaOXA-48 class D beta-lactamase (blaOXA-48) or a functionally active variant or fragment thereof; (b) providing a biological sample; (c) contacting the blaOXA-48 or functionally active variant or fragment thereof with the biological sample; and (d) determining the concentration of the carbapenem antibiotic in the biological sample.
    Type: Application
    Filed: August 21, 2020
    Publication date: October 6, 2022
    Applicant: Université De Liège
    Inventors: Bernard Joris, Ana Amoroso, Olivier Verlaine
  • Patent number: 11434241
    Abstract: Pyrimidine derivatives of formula (I): optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. Pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. Pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: September 6, 2022
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Patrizio Lancellotti, Cécile Oury, Bernard Pirotte
  • Patent number: 11406280
    Abstract: In vitro methods for diagnosing, prognosing and/or monitoring and treating neutrophilic or eosinophilic airway inflammation in a subject, including determining the amount of one or more volatile organic compounds (VOCs) in exhaled breath from said subject. The invention also provides devices for use in said methods.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: August 9, 2022
    Assignees: UNIVERSITE DE LIEGE, CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
    Inventors: Florence Schleich, Renaud Louis, Kyrylo Bessonov, Kristel Van Steen, Frederik-Jan Van Schooten, Jan Dallinga
  • Publication number: 20220195117
    Abstract: The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), at least one multifunctional thiol (compound C) and at least one catalyst (compound D), to a process for preparing said foams, to the thus obtained foams and the recycling of said foams.
    Type: Application
    Filed: January 3, 2022
    Publication date: June 23, 2022
    Applicant: Universite de Liege
    Inventors: Christophe Detrembleur, Jean-Michel THOMASSIN, Bruno GRIGNARD, Florent MONIE, Christine JEROME
  • Publication number: 20220196680
    Abstract: The present invention refers to osteomodulin (OMD) protein or fragment of osteomodulin (OMD) protein for use in the prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis of mammals, preferably human individuals. The present invention further refers to a method for prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis, comprising the following steps: i) measuring osteomodulin (OMD) protein or a fragment or fragments of osteomodulin (OMD) protein in samples of body fluids of mammalian individuals, preferably human serum samples; ii) judging that decreased levels of osteomodulin (OMD) protein or of said fragment(s) compared to levels in body fluids, preferably serum, of healthy individuals indicate onset of osteoarthritis and/or subchondral bone sclerosis.
    Type: Application
    Filed: December 28, 2021
    Publication date: June 23, 2022
    Applicant: Universitè de Liège
    Inventors: Yves HENROTIN, Christelle SANCHEZ, Edwin DE PAUW, Gabriel MAZZUCCHELLI
  • Patent number: 11329279
    Abstract: A process to prepare an electrode for an electrochemical storage device by spraying an aqueous slurry composition comprising water, xanthan gum, a source of conducting carbon particles and an active material on an electrode base. The slurry may be made by first mixing solid xanthan gum with the conducting carbon particles and the active material and secondly adding water to the resulting mixture. Alternatively the slurry is obtained by mixing solid xanthan gum with a carbon-based active material and adding water to the resulting mixture obtained.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: May 10, 2022
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Alexandre Leonard, Marie-Laure Piedboeuf, Nathalie Job
  • Patent number: 11286230
    Abstract: The invention provides a method for synthesizing a compound of formula wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; R1 and R2 each independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; R3 represents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NR4 group or a CH2 group; R4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II) wherein R, R3, Y, n and m are as defined ab
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: March 29, 2022
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Thomas Toupy, Romaric Gerardy, Jean-Christophe Monbaliu, Diego Collin, Victor-Emmanuel Kassin
  • Patent number: 11261270
    Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good. (In the formula, R1 denotes an optionally substituted aromatic group having a carbon number from 6 to 20, and R2 denotes a hydrogen atom, an alkyl group having a carbon number from 1 to 20, or an optionally substituted aromatic group having a carbon number from 6 to 20.) X·Mn/44?0.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: March 1, 2022
    Assignees: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi Takayama, Kazuhiko Maekawa, Christophe Detrembleur, Antoine Debuigne, Christine Jerome
  • Patent number: 11255862
    Abstract: The present invention refers to osteomodulin (OMD) protein or fragment of osteomodulin (OMD) protein for use in the prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis of mammals, preferably human individuals. The present invention further refers to a method for prognosis and/or diagnosis of osteoarthritis and/or subchondral bone sclerosis, comprising the following steps: i) measuring osteomodulin (OMD) protein or a fragment or fragments of osteomodulin (OMD) protein in samples of body fluids of mammalian individuals, preferably human serum samples; ii) judging that decreased levels of osteomodulin (OMD) protein or of said fragment(s) compared to levels in body fluids, preferably serum, of healthy individuals indicate onset of osteoarthritis and/or subchondral bone sclerosis.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Yves Henrotin, Christelle Sanchez, Edwin De Pauw, Gabriel Mazzucchelli
  • Patent number: 11229204
    Abstract: The present invention relates to a herbicidal composition comprising at least one phenolic active compound being myricitrin. The invention also relates to the use of such a herbicidal composition.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: January 25, 2022
    Assignee: Université de Liège
    Inventors: Sofiene Ben Kaab, Haissam Jijakli, Riadh Ksouri, Olivier Parisi, Simon Dal Maso
  • Patent number: 11180434
    Abstract: A continuous-flow process for the production of allyl compounds by deoxydehydration of glycerol includes: (a) Forming a reactive solution by mixing glycerol (1) with: a carboxylic acid (2), and/or a triethyl orthoester, preferably triethyl orthoformate (TEOF); (b) Feeding the reactive solution to an inlet of a channel of a thermolysis microreactor module wherein the channel has an inner hydraulic diameter, D=4 A/P, wherein A is the area and P the perimeter of a cross-section of the channel, of not more than 1000 ?m, (c) Exposing the reactive solution to thermolysis by driving a flow of the reactive solution along the channel from the inlet to an outlet, for a thermolysis time, t, at a pressure, P, and at a thermolysis temperature, T, larger than 200° C., to form thermolysis products including at least one allyl compound; and Recovering the thermolysis products at the outlet and separating the at least one allyl compound from the other thermolysis products.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: November 23, 2021
    Assignee: UNIVERSITE DE LIEGE
    Inventors: Jean-Christophe Monbaliu, Nelly Ntumba Tshibalonza
  • Patent number: 11047856
    Abstract: An in-vitro method for early diagnosing or prediction of immune-mediated inflammatory diseases, comprising: —obtaining a sample from a subject; —quantifying simultaneously by one LC/MS-MS analysis of said sample, a presence of V65 vitronectin fragment or fragment, variant or degradation product thereof; and a presence of a complement C3f or fragment or variant or degradation products thereof.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: June 29, 2021
    Assignees: UNIVERSITE DE LIEGE, CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
    Inventors: Michel Malaise, Dominique De Seny
  • Patent number: 10905691
    Abstract: A method for treatment of a bacterial infection in a host mammal in need of such treatment or a method of administering to the host mammal an effective amount of a Triazolo(4,5-d)pyrimidine of formula(I): wherein R1 is C3-5 alkyl optionally substituted by one or more halogen atoms; R2 is a phenyl group, optionally substituted by one or more halogen atoms; R3 and R4 are both hydroxyl; R is XOH, wherein X is CH2, OCH2CH2, or a bond, and wherein when X is a bond, R is OH; or a pharmaceutical acceptable salt, provided that when X is CH2 or a bond, R1 is not propyl; when X is CH2 and R1 is CH2CH2CF3, butyl or pentyl, the phenyl group at R2 must be substituted by fluorine; when X is OCH2CH2 and R1 is propyl, the phenyl group at R2 must be substituted by fluorine.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: February 2, 2021
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Cécile Oury, Patrizio Lancellotti
  • Publication number: 20200347121
    Abstract: The present invention provides a medicament comprising as active ingredient an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity for use in the prevention and/or treatment of osteoarthritis. Further, the present invention provides a medicament comprising as active ingredient an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity for use in the prevention and/or treatment of rheumatic and musculoskeletal diseases (RMDs).
    Type: Application
    Filed: May 4, 2020
    Publication date: November 5, 2020
    Applicants: Université de Liège, Université Paris Descartes, Assistance Publique Hopitaux de Paris, Institut National de la Santé et de la Recherche Médicale
    Inventors: Yves HENROTIN, Cécile LAMBERT, Didier BORDERIE, François RANNOU
  • Patent number: 10766978
    Abstract: A polyvinyl alcohol is produced in a method comprising: a polymerization step comprising polymerizing vinyl ester monomers by controlled radical polymerization in the presence of a radical initiator and an organic cobalt complex to obtain a polymer solution containing a polyvinyl ester; an extraction step comprising extracting a cobalt complex from the polymer solution by contacting an aqueous solution containing a water-soluble ligand with the polymer solution; and a saponification step comprising saponifying the polyvinyl ester after the extraction step to obtain a polyvinyl alcohol. A method for producing a polyvinyl alcohol is thus provided that has a narrow molecular weight distribution and a high number-average molecular weight with good hue and further good solubility in water.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 8, 2020
    Assignees: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi Takayama, Yusuke Amano, Kazuhiko Maekawa, Christophe Detrembleur, Antoine Debuigne, Christine Jerome
  • Publication number: 20200240951
    Abstract: The present invention relates to a Micro-Free Flow Electrophoresis chip for analyzing or separating a sample including a pile (1) comprising at least two plates (2A, 2B), a sheet (3) uniformly disposed between the two plates (2A, 2B), clamping means, each sheet (3) comprising at least two inlets (11) for entry and at least one outlet (12) for exit of a first fluid electrode and a second fluid electrode, the first and second fluid electrodes applying an electric field to a separation chamber (31).
    Type: Application
    Filed: October 19, 2018
    Publication date: July 30, 2020
    Applicant: Université de Liège
    Inventors: Michaël DELMARCELLE, Patrick STEFANIC, Bernard JORIS, Edith LECOMTE
  • Publication number: 20200216584
    Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good. (In the formula, R1 denotes an optionally substituted aromatic group having a carbon number from 6 to 20, and R2 denotes a hydrogen atom, an alkyl group having a carbon number from 1 to 20, or an optionally substituted aromatic group having a carbon number from 6 to 20.) X·Mn/44?0.
    Type: Application
    Filed: July 11, 2018
    Publication date: July 9, 2020
    Applicants: KURARAY CO., LTD., UNIVERSITE DE LIEGE
    Inventors: Takumi TAKAYAMA, Kazuhiko MAEKAWA, Christophe DETREMBLEUR, Antoine DEBUIGNE, Christine JEROME
  • Patent number: 10706558
    Abstract: The present invention concerns a method for assigning a pixel to one of a foreground pixel set and a background pixel set using asynchronous semantic post processing to improve motion detection by an imaging device, the pixel belonging to an image of a chronological sequence of images taken by the imaging device that includes background and foreground objects.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: July 7, 2020
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Marc Van Droogenbroeck, Marc Braham, Anthony Cioppa
  • Patent number: 10677753
    Abstract: A method and measurement device for measuring the ability of a flowing powder to electrostatically charge comprising a conduit comprised of a straight upper part fluidly connected to a straight lower part, the upper part being positioned at a first angle to the horizontal and the lower part being positioned at a second angle to the horizontal and wherein upper and lower part are positioned at a third angle relative to each other defining a bend at the intersection of the upper and lower part, wherein the upper part is provided with a supply opening for the powder and the lower part is provided with a discharge opening to discharge the powder and a faraday cup is connected to an electrometer positioned relative to the discharge opening to receive powder the from the conduit.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: June 9, 2020
    Assignee: UNIVERSITE DE LIEGE
    Inventors: Geoffroy Lumay, Julien Schockmel, Nicolas Vandewalle, Frederic Boschini