Patents Assigned to Universite de Liege
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Patent number: 10905691Abstract: A method for treatment of a bacterial infection in a host mammal in need of such treatment or a method of administering to the host mammal an effective amount of a Triazolo(4,5-d)pyrimidine of formula(I): wherein R1 is C3-5 alkyl optionally substituted by one or more halogen atoms; R2 is a phenyl group, optionally substituted by one or more halogen atoms; R3 and R4 are both hydroxyl; R is XOH, wherein X is CH2, OCH2CH2, or a bond, and wherein when X is a bond, R is OH; or a pharmaceutical acceptable salt, provided that when X is CH2 or a bond, R1 is not propyl; when X is CH2 and R1 is CH2CH2CF3, butyl or pentyl, the phenyl group at R2 must be substituted by fluorine; when X is OCH2CH2 and R1 is propyl, the phenyl group at R2 must be substituted by fluorine.Type: GrantFiled: November 19, 2019Date of Patent: February 2, 2021Assignee: UNIVERSITÉ DE LIÈGEInventors: Cécile Oury, Patrizio Lancellotti
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Publication number: 20200347121Abstract: The present invention provides a medicament comprising as active ingredient an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity for use in the prevention and/or treatment of osteoarthritis. Further, the present invention provides a medicament comprising as active ingredient an inhibitor of Coll2-1 peptide activity and/or an inhibitor of Coll2-1NO2 peptide activity for use in the prevention and/or treatment of rheumatic and musculoskeletal diseases (RMDs).Type: ApplicationFiled: May 4, 2020Publication date: November 5, 2020Applicants: Université de Liège, Université Paris Descartes, Assistance Publique Hopitaux de Paris, Institut National de la Santé et de la Recherche MédicaleInventors: Yves HENROTIN, Cécile LAMBERT, Didier BORDERIE, François RANNOU
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Patent number: 10766978Abstract: A polyvinyl alcohol is produced in a method comprising: a polymerization step comprising polymerizing vinyl ester monomers by controlled radical polymerization in the presence of a radical initiator and an organic cobalt complex to obtain a polymer solution containing a polyvinyl ester; an extraction step comprising extracting a cobalt complex from the polymer solution by contacting an aqueous solution containing a water-soluble ligand with the polymer solution; and a saponification step comprising saponifying the polyvinyl ester after the extraction step to obtain a polyvinyl alcohol. A method for producing a polyvinyl alcohol is thus provided that has a narrow molecular weight distribution and a high number-average molecular weight with good hue and further good solubility in water.Type: GrantFiled: March 30, 2017Date of Patent: September 8, 2020Assignees: KURARAY CO., LTD., UNIVERSITE DE LIEGEInventors: Takumi Takayama, Yusuke Amano, Kazuhiko Maekawa, Christophe Detrembleur, Antoine Debuigne, Christine Jerome
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Publication number: 20200240951Abstract: The present invention relates to a Micro-Free Flow Electrophoresis chip for analyzing or separating a sample including a pile (1) comprising at least two plates (2A, 2B), a sheet (3) uniformly disposed between the two plates (2A, 2B), clamping means, each sheet (3) comprising at least two inlets (11) for entry and at least one outlet (12) for exit of a first fluid electrode and a second fluid electrode, the first and second fluid electrodes applying an electric field to a separation chamber (31).Type: ApplicationFiled: October 19, 2018Publication date: July 30, 2020Applicant: Université de LiègeInventors: Michaël DELMARCELLE, Patrick STEFANIC, Bernard JORIS, Edith LECOMTE
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Publication number: 20200216584Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, wherein the polyvinyl alcohol contains an end group represented by a formula (I) below, and a molar ratio (X) of the end group based on total monomer units and the number-average molecular weight (Mn) satisfy a formula (1) below. Such a polyvinyl alcohol has a narrow molecular weight distribution and a high number-average molecular weight with hue good. (In the formula, R1 denotes an optionally substituted aromatic group having a carbon number from 6 to 20, and R2 denotes a hydrogen atom, an alkyl group having a carbon number from 1 to 20, or an optionally substituted aromatic group having a carbon number from 6 to 20.) X·Mn/44?0.Type: ApplicationFiled: July 11, 2018Publication date: July 9, 2020Applicants: KURARAY CO., LTD., UNIVERSITE DE LIEGEInventors: Takumi TAKAYAMA, Kazuhiko MAEKAWA, Christophe DETREMBLEUR, Antoine DEBUIGNE, Christine JEROME
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Patent number: 10706558Abstract: The present invention concerns a method for assigning a pixel to one of a foreground pixel set and a background pixel set using asynchronous semantic post processing to improve motion detection by an imaging device, the pixel belonging to an image of a chronological sequence of images taken by the imaging device that includes background and foreground objects.Type: GrantFiled: February 28, 2019Date of Patent: July 7, 2020Assignee: UNIVERSITÉ DE LIÈGEInventors: Marc Van Droogenbroeck, Marc Braham, Anthony Cioppa
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Method to measure the ability of a flowing powder to electrostatically charge and measurement device
Patent number: 10677753Abstract: A method and measurement device for measuring the ability of a flowing powder to electrostatically charge comprising a conduit comprised of a straight upper part fluidly connected to a straight lower part, the upper part being positioned at a first angle to the horizontal and the lower part being positioned at a second angle to the horizontal and wherein upper and lower part are positioned at a third angle relative to each other defining a bend at the intersection of the upper and lower part, wherein the upper part is provided with a supply opening for the powder and the lower part is provided with a discharge opening to discharge the powder and a faraday cup is connected to an electrometer positioned relative to the discharge opening to receive powder the from the conduit.Type: GrantFiled: August 13, 2015Date of Patent: June 9, 2020Assignee: UNIVERSITE DE LIEGEInventors: Geoffroy Lumay, Julien Schockmel, Nicolas Vandewalle, Frederic Boschini -
Patent number: 10633633Abstract: The present invention provides a new method of obtaining muscle-derived mesenchymal stem cells from microbiopsies of mammalian origin. The invention provides for a minimally invasive methodology yielding high amounts of MSCs that can differentiate into different cell lineages.Type: GrantFiled: December 11, 2014Date of Patent: April 28, 2020Assignee: Universitè De LiègeInventors: Didier Serteyn, Justine Ceusters
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Patent number: 10614736Abstract: The present invention concerns a method for assigning a pixel to one of a foreground pixel set and a background pixel set. In this method, if a first condition is met the pixel is assigned to the background pixel set, and if the first condition is not met and a second condition is met, the pixel is assigned to the foreground pixel set. The method comprises a step (S100) of calculating a probability that the pixel belongs to a foreground-relevant object according to a semantic segmentation algorithm, the first condition is that this probability that the pixel belongs to a foreground-relevant object does not exceed a first predetermined threshold, and the second condition is that a difference between this probability that the pixel belongs to a foreground-relevant object and a baseline probability for the pixel equals or exceeds a second predetermined threshold.Type: GrantFiled: May 18, 2018Date of Patent: April 7, 2020Assignee: UNIVERSITÉ DE LIÈGEInventors: Marc Van Droogenbroeck, Marc Braham, Sébastien Pierard
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Publication number: 20200085970Abstract: Nanoreservoirs and uses thereof, in particular the use of nanoreservoirs to coat a surface of a medical device, biomaterial or bioprosthetic.Type: ApplicationFiled: December 28, 2017Publication date: March 19, 2020Applicant: Université de LiègeInventors: Cecile OURY, Christine JÈRÔME, Christophe DETREMBLEUR, Patrizio LANCELLOTTI
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Publication number: 20190330607Abstract: A method of providing a polypeptide having sugar-tolerant beta-glucosidase activity for hydrolysis of a lignocellulosic substrate to yield glucose and/or other sugars. Also provided is a host cell comprising and/or secreting said polypeptide and a kit-of-parts comprising said polypeptide and one or more other cellulases for hydrolyzing a lignocellulosic substrate in a sugar-tolerant manner.Type: ApplicationFiled: February 16, 2017Publication date: October 31, 2019Applicant: Universitè de LiègeInventors: Samuel JOURDAN, Sébastien RIGALI
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Publication number: 20190334164Abstract: A process to prepare an electrode for an electrochemical storage device by spraying an aqueous slurry composition comprising water, xanthan gum, a source of conducting carbon particles and an active material on an electrode base. The slurry may be made by first mixing solid xanthan gum with the conducting carbon particles and the active material and secondly adding water to the resulting mixture. Alternatively the slurry is obtained by mixing solid xanthan gum with a carbon-based active material and adding water to the resulting mixture obtained.Type: ApplicationFiled: February 26, 2019Publication date: October 31, 2019Applicant: Université de LiegeInventors: Alexandre Leonard, Marie-Laure Piedboeuf, Nathalie Job
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Publication number: 20190314459Abstract: The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered.Type: ApplicationFiled: June 3, 2019Publication date: October 17, 2019Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, UNIVERSITE DE LIEGE, CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGEInventors: Albert Beckers, Adrian Francis Daly, Fabio Rueda Faucz, Constantine A. Stratakis, Giampaolo Trivellin
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Publication number: 20190307118Abstract: A method for the cryopreservation of biological material comprising a single step of exposing the biological material to a vitrifying solution enriched with at least one cryoprotectant, for a period of less than 90 sec before cooling to a temperature for cryopreservation of the biological material.Type: ApplicationFiled: December 15, 2017Publication date: October 10, 2019Applicant: UNIVERSITE DE LIEGEInventors: Delphine Connan, Fabien Ectors, Pierre Vanderzwalmen, Luc Grobet
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Publication number: 20190267619Abstract: A process to prepare an electrode for an electrochemical storage device by spraying an aqueous slurry composition comprising water, xanthan gum, a source of conducting carbon particles and an active material on an electrode base. The slurry may be made by first mixing solid xanthan gum with the conducting carbon particles and the active material and secondly adding water to the resulting mixture. Alternatively the slurry is obtained by mixing solid xanthan gum with a carbon-based active material and adding water to the resulting mixture obtained.Type: ApplicationFiled: May 17, 2017Publication date: August 29, 2019Applicant: Université de LiègeInventors: Alexandre LEONARD, Marie-Laure PIEDBOEUF, Nathalie JOB
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Patent number: 10385372Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in some aspects, relate to genetically modified Streptomyces bacteria capable of increased thaxtomin production, genetically modified Streptomyces bacteria with reduced activity of a CebR protein encoded by a cebR gene and/or reduced activity of a ?-glucosidase enzyme encoded by the bglC gene, genetically modified Streptomyces bacteria including a mutation of a native cebR gene and/or a native bglC gene, methods of increasing thaxtomin production in Streptomyces bacteria, methods of suppressing CebR and/or BglC activity, methods of producing thaxtomin, and thaxtomin produced by the methods of the present disclosure.Type: GrantFiled: September 17, 2015Date of Patent: August 20, 2019Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., UNIVERSITE DE LIEGEInventors: Rosemary Loria, Samuel Jourdan, Sebastien Rigali, Isolde Maria Francis
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Publication number: 20190251695Abstract: The present invention concerns a method for assigning a pixel to one of a foreground pixel set and a background pixel set. In this method, if a first condition is met the pixel is assigned to the background pixel set, and if the first condition is not met and a second condition is met, the pixel is assigned to the foreground pixel set. The method comprises a step (S100) of calculating a probability that the pixel belongs to a foreground-relevant object according to a semantic segmentation algorithm, the first condition is that this probability that the pixel belongs to a foreground-relevant object does not exceed a first predetermined threshold, and the second condition is that a difference between this probability that the pixel belongs to a foreground-relevant object and a baseline probability for the pixel equals or exceeds a second predetermined threshold.Type: ApplicationFiled: February 5, 2019Publication date: August 15, 2019Applicant: Universite de LiegeInventors: Marc VAN DROOGENBROECK, Marc BRAHAM, Anthony CIOPPA
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Patent number: 10350273Abstract: The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered.Type: GrantFiled: November 12, 2015Date of Patent: July 16, 2019Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Université de Liége and Centre Hospitalier Universitaire De LiégeInventors: Albert Beckers, Adrian Francis Daly, Fabio Rueda Faucz, Constantine A. Stratakis, Giampaolo Trivellin
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Publication number: 20190197696Abstract: The present invention concerns a method for assigning a pixel to one of a foreground pixel set and a background pixel set using asynchronous semantic post processing to improve motion detection by an imaging device, the pixel belonging to an image of a chronological sequence of images taken by the imaging device that includes background and foreground objects.Type: ApplicationFiled: February 28, 2019Publication date: June 27, 2019Applicant: Université de LiègeInventors: Marc VAN DROOGENBROECK, Marc BRAHAM, Sébastien PIERARD, Anthony CIOPPA
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Publication number: 20190119414Abstract: A polyvinyl alcohol is produced in a method comprising: a polymerization step comprising polymerizing vinyl ester monomers by controlled radical polymerization in the presence of a radical initiator and an organic cobalt complex to obtain a polymer solution containing a polyvinyl ester; an extraction step comprising extracting a cobalt complex from the polymer solution by contacting an aqueous solution containing a water-soluble ligand with the polymer solution; and a saponification step comprising saponifying the polyvinyl ester after the extraction step to obtain a polyvinyl alcohol. A method for producing a polyvinyl alcohol is thus provided that has a narrow molecular weight distribution and a high number-average molecular weight with good hue and further good solubility in water.Type: ApplicationFiled: March 30, 2017Publication date: April 25, 2019Applicants: KURARAY CO., LTD., UNIVERSITE DE LIEGEInventors: Takumi TAKAYAMA, Yusuke AMANO, Kazuhiko MAEKAWA, Christophe DETREMBLEUR, Antoine DEBUIGNE, Christine JEROME