Patents Assigned to UNIVERSITE DE LILLE
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Publication number: 20240148778Abstract: A composition of yeast polysaccharides including ?(1,6)-glucans, preferably also mannans and ?-glucans. The yeast polysaccharides are extracted from yeast cell wall fragments. Typically, the ?-glucans are ?(1,6)-glucans. Also, a method for obtaining such a composition, including at least one step of fractionating a composition of yeast cell walls and extracting an insoluble fraction, and at least one step of extracting a soluble fraction from the insoluble fraction obtained in step a). Further, a composition with a human or veterinary therapeutic objective, for the treatment of gastrointestinal pathologies associated with pathogenic microorganisms, as well as to its non-therapeutic use for improving intestinal comfort.Type: ApplicationFiled: March 15, 2022Publication date: May 9, 2024Applicants: LESAFFRE ET COMPAGNIE, UNIVERSITÉ CLERMONT AUVERGNE, UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRSInventors: Nathalie BALLET, Pascal VANDEKERCKOVE, Yann GUERARDEL, Shin-Yi YU, Adeline SIVIGNON, Nicolas BARNICH
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Publication number: 20240142457Abstract: The use of CASD1 as a biomarker of a cancer expressing the O-acetylated-GD2 ganglioside. Also, a method of diagnosing a cancer expressing the O-acetylated-GD2 ganglioside, a method of selecting a subject suffering from a cancer expressing the O-acetylated-GD2 ganglioside for treatment targeting the cancer, or a method of monitoring the response of a subject suffering from a cancer expressing the O-acetylated-GD2 ganglioside to a treatment targeting the cancer.Type: ApplicationFiled: June 10, 2022Publication date: May 2, 2024Applicants: OGD2 PHARMA, UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Sophie GROUX-DEGROOTE, Philippe DELANNOY, Sumeyye CAVDARLI, Jean-Marc LE DOUSSAL, Angélina KASPROWICZ
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Patent number: 11919854Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.Type: GrantFiled: March 29, 2019Date of Patent: March 5, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CHRU DE LILLE, UNIVERSITE COTE D'AZUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE LILLE, JUNIAInventors: Valérie Vouret, Laetitia Douguet, Alina Ghinet, Germain Homerin, Benoît Guy Marie Rigo, Davy Jérémy Baudelet, Xavier Dezitter, Régis Millet, Christophe Furman
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Publication number: 20240043626Abstract: A method for the selective cleavage of a compound comprising an aromatic ring and a C—O—C linkage in the presence of a heterogeneous catalyst is provided. The heterogenous catalyst may be a supported noble metal catalyst doped with a halogen selected from the group consisting of chlorine and bromine. By using this method, it is possible to increase the selectivity and/or yield (preferably both) of aromatic compounds.Type: ApplicationFiled: December 14, 2020Publication date: February 8, 2024Applicants: RHODIA OPERATIONS, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE, CENTRALE LILLE INSTITUTInventors: Dan Wu, Vitaly Ordomsky, Andrei Khodakov, Stephane Streiff, Jianxia Zheng
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Patent number: 11894830Abstract: A surface acoustic wave device includes at least one transducer; two acoustic reflectors disposed on either side of the at least one transducer so as to form a cavity, each acoustic reflector comprising an array of electrodes in the form of lines parallel with each other, each array comprising a subset of electrodes connected to a reference potential denoted mass defining a first connection type, and a subset of electrodes that are not connected to any potential, i.e. that have a floating connection defining a second connection type; at least one switching circuit configured to modify the distribution of the connections of at least one part of the electrodes of each array between the different connection types.Type: GrantFiled: December 27, 2019Date of Patent: February 6, 2024Assignees: THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SOITEC SA, YNCREA HAUTS DE FRANCE ISEN LILLE, UNIVERSITE DE LILLE, ECOLE CENTRALE DE LILLE, UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCEInventors: Thi Mai Pham Colomban, Claude Prévot, Paolo Martins, Anne-Christine Hladky-Hennion, Bertrand Dubus, Marianne Sagnard, Thierry Laroche, Sylvain Ballandras, Charles Croenne
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Patent number: 11802836Abstract: A process for detecting the sensitivity of one or more polymers and/or of one or more, mixtures of polymers to a compound, including the steps of exposing at least one lens-shaped micro-deposit, including the polymer(s) and/or the mixture(s) of polymers, to the compound, and detecting, by illuminating the surface of this micro-deposit, a change in the spatial distribution of the intensity of the light reflected or transmitted by this micro-deposit, linked to a variation in the dimensions and/or refractive index of this micro-deposit, under the effect of an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.Type: GrantFiled: June 1, 2018Date of Patent: October 31, 2023Assignees: Universite De Lille, Centre National De La Recherche ScientifiqueInventors: Alexis Vlandas, Julien Wengler, Sebastien Lamant, Vincent Senez
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Patent number: 11744863Abstract: Process for preparing a heat-treated pooled human platelet lysate, said process comprising the steps of: a) Providing a pooled human platelet lysate (p HPL), b) Heat-treating the pooled human platelet lysate at a temperature of 50° C. to 70° C. during 20 to 40 minutes, c) Purifying the heat-treated pooled human platelet lysate of step b).Type: GrantFiled: June 15, 2018Date of Patent: September 5, 2023Assignees: Centre Hospitalier Regional et Universitaire De Lille (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTE, UNIVERSITE DU LITTORAL COTE D'OPALE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), TAIPEI MEDICAL UNIVERSITYInventors: David Devos, Thierry Burnouf, Jean-christophe Devedjian, Ming-Li Chou, Flore Gouel
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Patent number: 11731127Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.Type: GrantFiled: March 15, 2016Date of Patent: August 22, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, SORBONNE UNIVERSITEInventors: Michaël Aymeric Baudoin, Olivier Khalil Bou Matar-Lacaze, Antoine Jean-Pierre Riaud, Jean-Louis Pierre Thomas
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Publication number: 20230233483Abstract: The disclosure relates to the use of clofoctol in the prevention or treatment of a disease caused by a coronavirus, in particular Covid-19.Type: ApplicationFiled: June 8, 2021Publication date: July 27, 2023Applicants: Apteeus, Universite De Lille, Centre National De La Recherche Scientifique, Institut National De La Sante Et De La Recherche Medicale, Centre Hospitalier Universitaire De LilleInventors: Terence Beghyn, Benoît Deprez, Sandrine Belouzard, Priscille Brodin
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Publication number: 20230207300Abstract: A system and method for analyzing volatile organic compounds (VOCs) adsorbed on an adsorbent membrane, by low-temperature plasma and mass spectrometry (LTP-MS). The system includes a receptacle for receiving the adsorbent membrane, a low-temperature plasma ionizer configured to emit a plasma stream in a plasma emission direction, thereby ionizing the VOCs adsorbed by the membrane and forming a VOC-laden ionized gas, and a mass spectrometer for analyzing the ionized VOCs.Type: ApplicationFiled: May 20, 2021Publication date: June 29, 2023Applicants: UNIVERSITE DE LILLE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)Inventors: Isabelle SALZET, Julien FRANCK, Michel SALZET, Flore HERVE
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Publication number: 20230157994Abstract: A method of treating COVID-19 in a patient. The patient may be in moderate to advanced stages of COVID-19 infection. The method includes administering to the patient a therapeutically effective amount of at least one antagonist or inhibitor of chemokine receptor CXCR4. The at least one antagonist or inhibitor of chemokine receptor CXCR4 is distinct from hydroxychloroquine.Type: ApplicationFiled: May 5, 2021Publication date: May 25, 2023Applicants: 4LIVING BIOTECH, UNIVERSITE DE BORDEAUX, CENTRE HOSPITALIER DE BORDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM, INSTITUT PASTEUR DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLEInventors: Patrick BERGER, Isabelle DUPIN, Renaud PREVEL, Chloé JAMES, Pierre-Olivier GIRODET, Keren BISMUTH, Revital RATTENBACH, Jérôme BRETON, Francois TROTTEIN, Valentin SENCIO
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Publication number: 20230148181Abstract: A protein capable of converting chlorogenic acid into isochlorogenic acid. The protein includes or is an amino acid sequence SEQ ID No. 1, a sequence having at least 80% identity with this sequence or a fragment of this sequence. Also, a process for producing isochlorogenic acid from chlorogenic acid, which includes producing the protein and bringing it into contact with chlorogenic acid.Type: ApplicationFiled: March 12, 2021Publication date: May 11, 2023Applicants: UNIVERSITE DE LORRAINE, UNIVERSITE DE LILLE, CELLENGOInventors: Frédéric Jean BOURGAUD, Sissi MIGUEL, Aleksander SALWINSKI, Cindy SIGNE, Alain HEHN, Jean-Louis HILBERT, David GAGNEUL, Guillaume LEGRAND
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Patent number: 11635372Abstract: A process for detecting the sensitivity of one or more polymers and/or of one or more mixtures of polymers to a compound, including the steps of exposing a plurality of individualized micro-deposits including the polymer(s) and/or the mixture(s) of polymers to the compound, and detecting, by interferometry, a variation in appearance of an assembly of micro-deposits exposed to the compound and/or a variation in the dimensions and/or refractive index of at least one of the micro-deposits exposed to the compound, linked to an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.Type: GrantFiled: June 1, 2018Date of Patent: April 25, 2023Assignees: Universite De Lille, Centre National De La Recherche Scientifique, Institut National De La Recherche Agronomique, Institute National Des Sciences Appliquees De ToulouseInventors: Vincent Senez, Alexis Vlandas, Sebastien Lamant, Bernard Cathala, Celine Moreau, Gabrielle Veronese, Sophie Bozonnet, Elisabeth Laville, Megane Cleret
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Patent number: 11634519Abstract: Disclosed is a functionalizing method for the end functionalisation of trans-1,4 stereo-regular polydiene chains obtained by the coordination catalytic polymerisation of at least one conjugated diene monomer. It also relates to a polydiene having a trans-1,4 chain formation rate of at least 85%, preferably at least 90%, and an end functionalisation rate higher than 70%, preferably higher than 80%, and more preferably higher than 90%.Type: GrantFiled: July 11, 2018Date of Patent: April 25, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ARTOIS, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLEInventors: Marc Visseaux, Philippe Zinck, Sébastien Georges, Yohan Champouret
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Publication number: 20230075405Abstract: The invention relates to a touch interface comprising, on the one hand, an interfacial surface able to generate a haptic-feedback effect in response to a touch of said surface by a user, and, on the other hand, at least one piezoelectric actuator configured to generate, in said interfacial surface, at least one wave of ultrasonic frequency able to endow the particles of this surface with an elliptical movement having a movement component tangential to said surface, which component is denoted ut(t), and a movement component normal to said surface, which component is denoted un(t), wherein said wave of ultrasonic frequency is chosen so that the amplitude Ut of the tangential component ut(t) and the amplitude Un of the normal component un(t) are substantially equal.Type: ApplicationFiled: January 29, 2021Publication date: March 9, 2023Applicants: HAP2U, UNIVERSITÉ DE LILLEInventors: Matthieu RUPIN, Pierre GARCIA, Frederic GIRAUD, Christophe GIRAUD-AUDINE, Betty SEMAIL, Michel AMBERG
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Patent number: 11580374Abstract: An artificial neuron including: a membrane capacitor; an input of an external synaptic excitation in current, the membrane capacitor integrating the input current; a negative-feedback impulse circuit, supplied by a power supply at a negative voltage between ?200 mV and 0 mV and at a positive voltage between 0 mV and +200 mV, including: a bridge based on pMOS and nMOS transistors in series and linked by a midpoint to the membrane capacitor, the midpoint defining the output of the artificial neuron, at least one delay capacitor between the gate and the source of one of the transistors of the bridge, at least two CMOS inverters between the membrane capacitor and the gates of the transistors of the bridge.Type: GrantFiled: April 7, 2017Date of Patent: February 14, 2023Assignees: UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Alain Cappy, Francois Danneville, Virginie Hoel, Christophe Loyez
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Patent number: 11556180Abstract: A system includes sensor-actuator units fixed onto a plate to be actuated according to at least one predetermined vibratory mode, each sensor-actuator unit having an electromechanical actuator and a deformation or vibratory speed sensor, wherein the electromechanical actuator and the sensor are colocated on the surface, that is to say that the measurement by the sensor is performed in immediate proximity to the electromechanical actuator, this proximity being such that the actuator and the sensor can respectively actuate and measure the same predetermined vibratory mode.Type: GrantFiled: February 27, 2020Date of Patent: January 17, 2023Assignees: HAP2U, UNIVERSITÉ DE LILLEInventors: Frederic Giraud, Christophe Giraud-Audine, Michel Amberg, Betty Lemaire-Semail, Bruno Challiol
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Patent number: 11534761Abstract: Electroacoustic device that includes a body, an electrode to be electrically powered, named hot electrode, and an electrode to be electrically grounded, named ground electrode. The body includes a piezoelectric part or the electroacoustic device further including a piezoelectric part different from the body. The hot electrode includes a hot track spiraling around a spiral axis. The radial step between two consecutive coils of the hot track decreasing radially from the spiral axis. The hot electrode and the ground electrode are arranged on the piezoelectric part such as to define a wave transducer configured to generate a focalised ultrasonic vortex propagating in the body and/or, when a fluid medium is acoustically coupled with the electroacoustic device, in the fluid medium.Type: GrantFiled: October 23, 2018Date of Patent: December 27, 2022Assignees: UNIVERSITE DE LILLE, ECOLE CENTRALE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITEInventors: Michaël Aymeric Cyril Baudoin, Olivier Khalil Nizar Bou Matar-Lacaze, Antoine Jean-Pierre René Riaud, Jean-Louis Pierre Thomas
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Publication number: 20220356390Abstract: The invention relates to a dynamic method for determining the formation of a Winsor III microemulsion system, the method comprising the steps of: providing a mixture of an aqueous medium and a hydrocarbon medium in a chamber; continuously altering the concentration of at least one component in the mixture, while the ratio of the aqueous medium to the hydrocarbon medium remains constant and while stirring the mixture; and continuously measuring at least one physicochemical property of the mixture. The invention further relates to a device for determining the formation of a Winsor III microemulsion system.Type: ApplicationFiled: September 9, 2019Publication date: November 10, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE, UNIVERSITE DE LILLE, TotalEnergies OneTechInventors: Guillaume Lemahieu, Jesus Fermin Ontiveros, Jean-Marie Aubry, Valérie Molinier
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Patent number: 11496049Abstract: A continuous time digital signal processing (CT DSP) token includes a first signal indicating a change has occurred and a second signal indicating a direction of the change. An amplitude generation circuit operates to generate an amplitude value x in response to the token. A power estimation circuit processes the amplitude value x to generate a digital power signal in accordance with the formula: x2±2x+1.Type: GrantFiled: February 13, 2020Date of Patent: November 8, 2022Assignees: Universite de Lille, Centre National De La Recherche Scientifique, ISEN Yncrea Hauts-de-France, STMicroelectronics SAInventors: Angel de Dios Gonzalez Santos, Andreas Kaiser, Antoine Frappe, Philippe Cathelin, Benoit Larras