Patents Assigned to UNIVERSITE DE LILLE
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Patent number: 10323016Abstract: The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.Type: GrantFiled: June 11, 2015Date of Patent: June 18, 2019Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Manuel Lassalle, Barbara Dubanchet
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Publication number: 20190130258Abstract: An artificial neuron including: a membrane capacitor; an input of an external synaptic excitation in current, the membrane capacitor integrating the input current; a negative-feedback impulse circuit, supplied by a power supply at a negative voltage between ?200 mV and 0 mV and at a positive voltage between 0 mV and +200 mV, including: a bridge based on pMOS and nMOS transistors in series and linked by a midpoint to the membrane capacitor, the midpoint defining the output of the artificial neuron, at least one delay capacitor between the gate and the source of one of the transistors of the bridge, at least two CMOS inverters between the membrane capacitor and the gates of the transistors of the bridge.Type: ApplicationFiled: April 7, 2017Publication date: May 2, 2019Applicants: UNIVERSITE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Alain CAPPY, Francois DANNEVILLE, Virginie HOEL, Christophe LOYEZ
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Patent number: 10265302Abstract: The present invention relates to the compound of formula (I) for use in the treatment of a nonsense-mutation-mediated genetic disease.Type: GrantFiled: January 29, 2018Date of Patent: April 23, 2019Assignees: UNIVERSITE DE LILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR DE LILLEInventors: Fabrice Lejeune, Benoit Deprez, Terence Beghyn, Sara Sofia Gonzalez-Hilarion
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Publication number: 20190091683Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.Type: ApplicationFiled: March 15, 2016Publication date: March 28, 2019Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, SORBONNE UNIVERSITEInventors: Michaël Aymeric BAUDOIN, Olivier Khalil BOU MATAR-LACAZE, Antoine Jean-Pierre RIAUD, Jean-Louis Pierre THOMAS
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Patent number: 10179761Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.Type: GrantFiled: June 15, 2015Date of Patent: January 15, 2019Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)Inventors: Patricia Melnyk, Patrick Vermersch, Pascal Carato, Bénédicte Oxombre-Vanteghem, Hélène Zephir, Marion Donnier-Marechal
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Publication number: 20180307330Abstract: The invention discloses a method to measure end-to-end and partial latency between an input interface and an output interface of a processing device. The invention uses a generator of a calibrated output to be output by the processing device through the output interface and a sensor configured to capture the calibrated output and send it to a processing unit of the processing device through the input interface. An advantageous arrangement of a calibrated output is a specific texture to be output by a screen and captured by an optical sensor. A specific texture comprises elementary patterns which have a defined number of pixels and a defined proportion and location of dark and light pixels. According to certain aspects of the invention, a calibration of latency is performed based on a number of parameters defining the hardware and/or software configuration of the processing device, and/or its conditions of operation.Type: ApplicationFiled: October 17, 2016Publication date: October 25, 2018Applicants: ECOLE NATIONALE DE L'AVIATION CIVILE, UNIVERSITE DE LILLE, INRIAInventors: Stéphane CONVERSY, Géry CASIEZ, Nicolas ROUSSEL, Stéphane HUOT, Matthieu FALCE
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Patent number: 10105326Abstract: The present invention is directed to pharmaceutical solution comprising at least dopamine for use in treating Parkinson's disease, wherein said pharmaceutical solution is kept under anaerobic conditions from its formulation to its administration.Type: GrantFiled: May 12, 2015Date of Patent: October 23, 2018Assignees: Centre Hospitalier Regional Et Universitaire De Lille (Chru), Universite De Lille 2 Droit Et Sante, Universite Du Littoral Cote D'OpaleInventors: David Devos, Caroline Moreau, Charlotte Laloux, Jean-christophe Devedjian
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Patent number: 10072041Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An??(I) in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.Type: GrantFiled: February 15, 2012Date of Patent: September 11, 2018Assignees: Centre National de la Recherche Scientifique, Universite de Lille 1 Sciences et TechnologiesInventors: Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
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Patent number: 10058328Abstract: An anastomosis device for joining hollow lumens or viscera, suitable for deployment at the surface of two superposed adjacent lumens. The device has a main tubular body of longitudinal axis (L), having first and second open ends and opposite outside and inside faces. The main tubular body has at least three columns of loops and at least three rows of loops and sets of proximal and distal radial projections extending along at least a depth (E) at the peripheries of the first and second ends respectively. The distal and proximal sets are spaced apart by a minimum internal distance (D), and further include a set of intermediate radial projections extending along at most a depth (e) and arranged between the sets of proximal and distal radial projections. The depth (e) is less than (E), and the minimum internal distance (D) is determined so as to receive two superposed adjacent lumens.Type: GrantFiled: July 9, 2014Date of Patent: August 28, 2018Assignees: COUSIN BIOTECH, UNIVERSITE DE LILLEInventors: Valéry Dalle, Gilles Solecki, François Pattou, Jacques Himpens, Robert Caiazzo
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Patent number: 10017476Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.Type: GrantFiled: March 16, 2016Date of Patent: July 10, 2018Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTEInventors: Nicolas Sergeant, Luc Buee, Patricia Melnyk, Marion Gay, Nicolas Le Fur
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Patent number: 9932309Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.Type: GrantFiled: July 28, 2015Date of Patent: April 3, 2018Assignees: Universite de Lille 2 Droit et Sante, Institut Pasteur de Lille, INSERMInventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Sylvain Picon, Karen Aknin, Rajaa Boulahjar, Barbara Dubanchet
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Patent number: 9919029Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.Type: GrantFiled: July 25, 2014Date of Patent: March 20, 2018Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite de Droit et de la Sante de Lille 2, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Lille, Universite de Lille 1 Sciences et Technologies, ETH Zurich, Universidad de la RepublicaInventors: Wolf-Dietrich Hardt, Patrick Kaiser, Jean-Claude Sirard, Christophe Carnoy, Delphine Fougeron, Jose Alejandro Chabalgoity, Natalia Munoz
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Publication number: 20180072679Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.Type: ApplicationFiled: March 16, 2016Publication date: March 15, 2018Applicants: INSERM ( Institut National de la Sante et de la Recherche Medicale), CENTER HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTEInventors: Nicolas SERGEANT, Luc BUEE, Patricia MELNYK, Marion GAY, Nicolas LE FUR
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Publication number: 20170350757Abstract: A method refocuses on an optical assembly target surface, using at least one beam originating from a short-pulse optical source, having at least one optical system for focusing the beam on the surface. Refocusing occurs after learning reference conditions for which the assembly is considered as focused. A focusing signal is detected representing a time overlap of the pulses between a beam reflected and a reference beam not reflected by the surface and comes from the source, one of the beams delayed by a delay line, the beam optical path on which the delay line is placed is varied, on the basis of the reference conditions, to cause the focusing signal to reach or go beyond a predetermined threshold. The focus is adjusted on the basis of variation knowledge in the path between the reference conditions and the conditions for which the focusing signal reaches or goes beyond the threshold.Type: ApplicationFiled: December 22, 2015Publication date: December 7, 2017Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE 1, ISENInventor: Arnaud DEVOS
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Patent number: 9714245Abstract: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.Type: GrantFiled: June 27, 2014Date of Patent: July 25, 2017Assignees: ALZPROTECT, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Patricia Melnyk, Pascal Carato, Stephane Burlet, Emilie Nguyen, Philippe Verwaerde, Nicolas Sergeant, Cecilia Estrella
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Patent number: 9671397Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.Type: GrantFiled: October 11, 2011Date of Patent: June 6, 2017Assignees: Centre National De La Recherche Scientifique, Innobiochips, Universite De Lille 2 Droit Et Sante, Universite De Lille 1 Sciences Et TechnologiesInventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
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Publication number: 20150224129Abstract: The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with iNKT cell agonists.Type: ApplicationFiled: October 1, 2013Publication date: August 13, 2015Applicants: INSERM (Institut National de la Santé et de la Recherche Médicale), INSTITUT PASTEUR DE LILLE, UNIVERSITÉ DE LILLE 1 - SCIENCES ET TECHNOLOGIES, UNIVERSITÉ DU DROIT ET DE LA SANTÉ LILLE 2, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Francois Trottein, Christelle Faveeuw, Stoyan Ivanov, Josette Fontaine
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Publication number: 20140200313Abstract: A process for the preparation by ethylene polymerization of at least one dialkyl magnesium compound of formula R—(CH2—CH2)n—Mg—(CH2—CH2)m—R? in which R and R?, identical or different, represent aryl, benzyl, allyl or alkyl groups and in which the integers n and m, identical or different, represent average —CH2—CH2— chain formation numbers greater than 1, the process including a single stage of mixing the following components: at least one ligand or one ligand precursor, at least one rare earth salt, at least one dialkyl magnesium compound of formula R—Mg—R?, and ethylene, in a medium allowing contact between the components of the above mixture.Type: ApplicationFiled: July 20, 2012Publication date: July 17, 2014Applicant: UNIVERSITE DE LILLE 1 SCIENCE ET TECHNOLOGIESInventors: Thomas Chenal, Andre Mortreux, Marc Visseaux
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Publication number: 20130331545Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An ??(I) in which A1, A2, A3, . . . Ai . . . An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.Type: ApplicationFiled: February 15, 2012Publication date: December 12, 2013Applicants: UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
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Publication number: 20130203629Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.Type: ApplicationFiled: October 11, 2011Publication date: August 8, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INNOBIOCHIPSInventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier