Abstract: A method and apparatus for characterizing a sample using a nuclear magnetic resonance spectrameter in which an effective field is generated. The field has an effective vector and results from a static magnetic field and a radiofrequency magnetic field. The effective vector rotates relative to a terrestrial reference frame.

Abstract: The invention relates to new PI3K/AKT/m TOR inhibitors and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.

Abstract: The multi-beam former comprises: two stages connected together and intended to synthesize beams focused along two directions in space; each stage comprises at least two multi-layer plane structures (P11, P1Ny), (P21, P2Mx), superposed one above the other; each multi-layer structure (P11, P1Ny, P21, P2Mx) comprises an internal reflector, at least two first internal sources disposed in front of the internal reflector and linked to two input/output ports (27, 26) aligned along an axis (V, V?), at least two second internal sources disposed in a focal plane of the internal reflector and linked to two second input/output ports (25, 28) aligned along an axis (U, U?) perpendicular to the axis (V, V?); the two second internal sources of the same multi-layer structure (P11) of the first stage are respectively linked to two first internal sources of two different multi-layer structures (P21), (P2Mx) of the second stage.

Abstract: The invention relates to a powder of an alloy based on uranium and molybdenum in a metastable ? phase, which is formed of particles which have an elongation index at least equal to 1.1, a non-zero closed porosity value and which are composed of grains having a molybdenum content, for which the variations within the same grain are of at most 1% by mass. It also relates to a method allowing preparation of this alloy powder as well as to the use of said powder for manufacturing nuclear fuels and targets for producing radioisotopes. Applications: Manufacturing of nuclear fuels, notably for experiment nuclear reactors; manufacturing of targets for producing radioisotopes, notably for the medical industry.

Abstract: A luminescent hybrid nanomaterial comprising: at least one inorganic nanomaterial comprising an inorganic first compound; and at least one second compound comprising a first aggregation-induced emission moiety, wherein the at least one second compound is grafted on at least part of a surface of the inorganic first compound.

Abstract: The present invention relates to oligonucleotides useful for inhibiting or reducing bacterial biofilms.

Abstract: Chalcogenide glass-ceramic having, for example, the following composition GeSe2—Sb2Se3—CuI, this glass-ceramic comprising at least one crystalline phase, characterised in that the crystallisation rate and the dimensions of the crystals in the crystalline phase are such that the crystals are substantially in contact with each other in such a way that this crystalline phase has an electrical conductivity greater than or equal to 10?4 s·cm?1 which increases under lighting due to the creation of charge carriers within the crystalline phase.

Abstract: The present invention relates to a recombinant vector for expressing and secreting, by a Propionibacterium, at least one eukaryotic peptide or protein of interest, comprising at least: under the control of at least one suitable promoter, at least one nucleic acid sequence encoding a propionibacterial signal peptide and, at least one nucleic acid sequence encoding said eukaryotic peptide or protein of interest; wherein said at least one nucleic acid sequence encoding a propionibacterial signal peptide is translationally fused to said at least one nucleic acid sequence encoding said eukaryotic peptide or protein of interest. The invention further relates to the uses of such a vector in the pharmaceutical field or for the large-scale production of peptides or proteins of interest.

Abstract: An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A1+X1?, A1+ representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X1? an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.

Abstract: The invention relates to new PI3K/AKT/m TOR inhibitors and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.

Abstract: A method for the isotopic separation of at least two different isotopes of a body in gaseous form by: (a) converting into the form of a gas (SF6, UF6 or MoF6) the body of interest containing the sought isotope; (b) creating a flow of said gas at supersonic speed, of the laminar or slightly turbulent type; (c) exciting the molecules by laser; (d) inhibiting, by means of a laser, the nucleation of one of the isotopologs, thus forming less massive aggregates of said isotopolog than the aggregates formed by the molecules of the other isotopolog; (e) ionizing the molecules and aggregates of said gas; (f) submitting the ionized molecules and aggregates of molecules to an electromagnetic field to make the ionized molecules and aggregates of one of the isotopologs migrate towards the outside of the flow; and (g) retrieving the part of the gas flow with the highest concentration in the sought isotope.

Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.

Abstract: Computer tool characterised in that it comprises: a working memory (206) to receive input data, an auxiliary memory (204) to store several approximation dictionaries, a reducer (202) arranged for the iterative calculation of the approximation data of the input data, where the successive iterations are of the “matching pursuit” type, a selector (200) arranged to choose an approximation dictionary in the auxiliary memory based on a selection rule based on at least some of the preceding iterations, in which the reducer (202) calls the selector (200) in each iteration, and uses the dictionary thus selected in the adaptive matching.

Abstract: The invention relates to the cosmetic use of a compound chosen from the compounds of formula (A) and the salts of same as an agent for depigmenting the skin and/or keratinous appendages.

Abstract: A multilayer antenna is provided, which includes a power supply portion generating a wave, a radiating portion, and a guide portion that makes it possible to guide the wave from the power supply portion to the radiating portion. The guide portion includes: at least two stacked guide layers having parallel planes and, for each pair of adjacent layers, a transition between the adjacent layers, including a reflector engaging with a slot-coupling. For at least one pair of adjacent layers, for which the guide portion includes a non-planar reflector, the slot-coupling includes a plurality of slots. Each slot includes a main body that is elongate along at least one axis. The slots are placed on at least one row and together form a pattern that extends along the reflector and has a shape that is dependent on the shape of the reflector.

Abstract: This invention relates to a new portable device with no solid frame, which makes it possible to carry out instrumented indentation of a material to deduct its mechanical properties. Continuous or instrumented indentation consists in measuring the force and displacement when an indenter is pushed into the tested material. The device is made up of a sleeve with a reduced volume and its lower base, which may be of variable shapes adapted to that of the material to test, a piston sliding in the sleeve, the displacement of which is controlled by the hand of a user, a manipulating arm, a mechanical column or a robot, an elastic ring or a spring limiting the displacement of the piston, three displacement sensors arranged in an equilateral triangle around a single-piece indenter having any shape, and a force sensor that makes it possible to measure the change in the force depending on the depression made by the indenter in the tested material.

Abstract: This deals with a luminescent salt comprising a metal cluster anion and an organic cation, wherein the metal cluster anion comprises a metal cluster with at least two metal atoms, and ligands, the metal atoms being chosen from the group consisting of molybdenum, rhenium, tungsten, thallium, niobium, and mixtures thereof, wherein the organic cation comprises a cationic head substituted by at least one substituent including a polymerisable functional group. It also deals with a polymeric material comprising a polymer matrix which has polymerised with this luminescent salt.

Abstract: Testicular germline markers and their use for predicting the presence or not of reproductive cells in testis of an infertile or hypo fertile male subject are provided. More particularly, identification of specific protein biomarkers of post-meiotic germ cells in the human seminal plasma was carried out by an integrative genomics approach. It was demonstrated that the presence of such biomarkers could be monitored in the seminal plasma of azoospermic subjects in order to select for a testis biopsy and testicular sperm extraction (TESE) only subjects for which there are high probabilities to find reproductive cells. The results indicate the analysis of seminal plasma is a non-invasive approach for predicting the presence of reproductive cells.

Abstract: The present invention relates to methods for diagnosing cornification disorders and metabolic diseases. More specifically, the present invention relates to an in vitro method for diagnosing and/or predicting a cornification disorder in a subject, comprising determining the presence or the absence of a genetic variation in the Patatin-like phospholipase domain-containing protein 1 (PNPLA1) gene sequence in a biological sample from said subject, as compared with the PNPLA1 gene sequence of a healthy non-carrier subject, wherein the presence of said genetic variation indicates that said subject suffers from or is at risk of suffering from said cornification disorder. The method according to the invention allows for example diagnosing ichthyosis in dogs of the Golden Retriever breed.

Abstract: The subject matter of the invention is a process for synthesizing a saturated long-chain ?,?-amino ester (acid) obtained in a first step by cross-metathesis between an acrylic first compound and a monounsaturated second compound comprising at least one nitrile, acid or ester trivalent function, one of these compounds comprising a nitrile function and the other an acid or ester function, in the presence of a ruthenium carbene metathesis catalyst, and in a second step by hydrogenation of the monounsaturated nitrile ester (acid) obtained in the presence of the metathesis catalyst of the preceding stop, acting as a hydrogenation catalyst.