Abstract: The present invention provides cyclic antimicrobial pseudopeptides that are useful in a variety of applications. Also provided are pharmaceutical compositions, products and kits comprising such cyclic antimicrobial peptides and methods of using these antimicrobial peptides for modifying infectivity, killing microorganisms or inhibiting microbial growth or function and for preventing and/or treating an infection or contamination caused by such microorganisms.

Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.

Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.

Abstract: A beamformer comprises a transmission line fed by at least one input feed source, the transmission line comprising two stacked metal plates extending, along two directions, longitudinal X and transverse Y. The transmission line further comprises at least one protuberance extending in the directions X, Y, and in a direction Z orthogonal to the plane XY, the protuberance comprising a metal insert extending in the directions X and Y and extending height-wise in the direction Z, the insert comprising a base fastened to one of the two metal plates and a free end and having a contour of variable length between the two lateral edges of the transmission line. In the protuberance, the transmission line is adjoining the insert and forms, in the direction Z, a circumvolution around the insert.

Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

Abstract: A measurement device for magnetic resonance applications includes, in a measurement case: a first sensor for measuring radiofrequency magnetic fields; a second sensor for measuring magnetic field gradients; and a third sensor for measuring the radiofrequency electric field; and a stage for converting the electric signals delivered by the different measurement sensors into light signals. The device also in a controller for controlling and processing the signals, connected to the stage for conditioning the measurement case via a beam for transmitting light signals. The controller includes a stage for converting light signals into electric signals delivered by the sensors.

Abstract: A method is provided for transmitting a sequence of data symbols including at least two data symbols of distinct values, delivering an electromagnetic wave carrying an orbital angular momentum. The method includes, for at least one data symbol to be transmitted: a bijective selection of an order of orbital angular momentum associating, with each distinct value of a data symbol, a distinct order of orbital angular momentum, and delivering a selected order of orbital angular momentum that is representative, by bijection, of the value of the at least one data symbol to be transmitted; and transmitting the electromagnetic wave carrying an orbital angular momentum, the order of orbital angular momentum of which corresponds to the selected order of orbital angular momentum.

Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.

Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

Abstract: The invention relates to a module (6) for producing an MRI and/or MRS reference signal (S0), characterized in that the module comprises: a first receiving input (621) for receiving of an MRI and/or MRS synchronization signal (S3), a second receiving input (612) for receiving of a time signal (S8) of external stimulation, supply means (62) for supplying of a prescribed signal (RV) representing an MRI and/or MRS virtual object (RVV), generating means for generating of the MRI and/or MRS reference signal (S0), for temporally varying the MRI and/or MRS reference signal (S0) in the same way as a time characteristic determined from the time signal (S8) of external stimulation and in synchronization with the MRI and/or MRS synchronization signal (S3), a supply output (632) for supplying of the MRI and/or MRS reference signal (S0).

Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.

Abstract: This deals with a luminescent salt comprising a metal cluster anion and an organic cation, wherein the metal cluster anion comprises a metal cluster with at least two metal atoms, and ligands, the metal atoms being chosen from the group consisting of molybdenum, rhenium, tungsten, thallium, niobium, and mixtures thereof, wherein the organic cation comprises a cationic head substituted by at least one substituent including a polymerizable functional group. It also deals with a polymeric material comprising a polymer matrix which has polymerized with this luminescent salt.

Abstract: A compact Butler matrix consists a planar multilayer structure comprising N parallel metal plate waveguides PPW, stacked one on top of the other, two adjacent waveguides PPW comprising a common wall consisting of one of the metal plates. The couplers, the phase-shifters and the crossover devices of the Butler matrix consist of metasurfaces incorporated in the metal plates. The planar two-dimensional beam-former can comprise a Butler matrix with waveguides PPW associated with optical lenses incorporated in each waveguide PPW. Alternatively, the planar two-dimensional beam-former can comprise an upper stage consisting of a Butler matrix with waveguides PPW, and a lower stage comprising waveguides PPW equipped with incorporated reflectors, the two stages being connected in series.

Abstract: A method is provided for evaluating a procedure for determining an aggregate radiotherapy dose received in the course of a radiotherapy treatment. The method includes: defining a deformable model of at least one organ to be treated and of at least one neighboring organ, generating a series of simulated images, interpretable by the procedure to be evaluated, with aid of the model; comparing the aggregate dose calculated by the procedure to be evaluated, applied to at least one of the simulated images, with a reference aggregate dose, so as to deliver at least one item of information representative of the quality of the procedure, the reference aggregate dose being obtained by taking into account anatomical deformations applied to the organs, so as to determine a reference dose actually received at each treatment session by the organs, as a function of their actual shape and/or actual position during this session.

Abstract: An analysis system comprises a transmitting device (1.1) and a receiving device (1.2). The transmitting devices comprises means for illuminating an object (1.3), or a part of the object, by a first light beam (1.8) consisting of signals with two distinct frequencies and first orthogonal polarisation states. The receiving device comprises means (1.6) for detecting, in a second light beam with second polarisation states and resulting from the illumination of the object to be analysed by the first light beam, a signal at a beat frequency equal to a difference between the two frequencies of the first light beam; and means (1.7) for obtaining information relating to the depolarising or dichroic character of the object, or of the part of the object, according to the detection or not of a signal at the beat frequency.

Abstract: A system for assessing a sympathovagal balance of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and outputs a stimulation energy, a sensor configured to measure a physiological signal, and a processor. The processor is configured to control the generator during a plurality of sequences to produce the stimulation pulses over a test period, determine a biological parameter of a current activity of the patient derived from the physiological signal, determine a variation of the biological parameter resulting from the stimulation pulses, and determine a sympathovagal balance index according to the variation in the biological parameter.

Abstract: The present invention relates to oligonucleotides useful for inhibiting or reducing bacterial biofilms.

Abstract: A method of programming a FPGA, wherein the FPGA comprises an array of macrocells, each comprising at least a configurable hardware block and a configurable interconnection network, the method comprises the steps of: providing a high-level configuration file containing: first data defining a set of macrocells and their relative positions; second data defining a configuration of the hardware blocks of the macrocells; and third data defining interconnections between the macrocells; wherein said high-level configuration file contains neither data defining an absolute position of the macrocells within the FPGA, nor local routing information fully defining a configuration of their interconnection networks; converting said high-level configuration file into a bitstream file; and uploading the bitstream file into the FPGA. A semiconductor chip comprising a FPGA and a device configured for programming the FPGA are provided.