Patents Assigned to Universite de Strasbourg
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Patent number: 12291654Abstract: Fluorescent polymeric coating films visible in near-infrared light for coating a medical device are provided, and a method for preparing said NIR visible polymeric coating films. In particular, the fluorescent polymeric coating films visible in near-infrared light for coating a medical device are in the form of a single layer or multiple layers where said single layer or at least one of said multiple layers comprises a hydrophobic polymer, a ionic fluorescent dye and a counterion of said ionic fluorescent dye. The fluorescent dye is a near-infrared dye which belongs to the family of long-chain cyanine 7.5 derivatives, and their analogues.Type: GrantFiled: January 28, 2019Date of Patent: May 6, 2025Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT HOSPITALO-UNIVERSITAIRE DE CHIRURGIE MINI-INVASIVE GUIDEE PAR L'IMAGE, INSTITUT DE RECHERCHE CONTRE LES CANCERS DE L'APPAREIL DIGESTIF (IRCAD)Inventors: Andrey Klymchenko, Bohdan Andreiuk, Seong-Ho Kong, Michele Diana, Renato Soares
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Publication number: 20250128943Abstract: The present invention relates to a process and a system for the production of hydrogen and carbon by catalytic non-oxidative decomposition of hydrocarbons, such as saturated C1+ hydrocarbons, such as methane, in the presence of a fresh or a spent catalyst composition comprising at least one carbon catalyst. The process of the invention is characterised in that the fresh or spent catalyst composition is heated by means of induction heating to a temperature comprised between 500° C. and 1100° C. The catalyst compositions as applied in accordance with the invention comprise, and preferably consist of, (I) a first component, wherein said first component is selected from one or more non-porous carbon catalysts and/or one or more porous carbon catalysts; and (II) optionally, a second component, wherein said second component consists of a non-carbon material, and preferably is a ceramic or zeolitic support material.Type: ApplicationFiled: October 26, 2022Publication date: April 24, 2025Applicants: TOTALENERGIES ONETECH, UNIVERSITÉ DE STRASBOURG-UNISTRA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Loïc FRANCKE, Christophe BENQUET, Jean-Pierre DATH, Lai TRUONG PHUOC, Cuong PHAM-HUU, Jean-mario NHUT
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Patent number: 12276246Abstract: A hydroelectric facility for generating electrical energy from the flow of water circulating in a water network, includes at least one cross-flow pico-turbine mounted on a shaft extending perpendicular to a direction of the water flow, the pico-turbine including a substantially annular blade installed in the water flow in order to generate a mechanical energy of rotation, at least one generating unit, installed outside of the water flow and coupled to the shaft of the pico-turbine in order to transform the mechanical energy of rotation into electrical energy, at least one measurement and control unit, installed outside of the water flow, connected to the generating unit, controlling the distribution of the collected electrical energy as well as the rotation of the pico-turbine depending on the characteristics of the water flow.Type: GrantFiled: June 23, 2021Date of Patent: April 15, 2025Assignees: ECOLE NATIONALE DU GÉNIE DE L'EAU ET DE L'ENVIRONNEMENT DE STRASBOURG, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Nicolas Dellinger, Guilhem Dellinger, José Vasquez
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Patent number: 12265084Abstract: The present invention relates to a method for analyzing the platelets present in a blood sample, said method comprises the steps of (a) adding to said sample a ligand which binds to the MCH I coupled to a fluorochrome, (b) measuring the mean fluorescence intensity of the platelets (MFIplatelets) with a flow cytometer and c) measuring the mean “Forward Scatter” parameter (FSC) with said flow cytometer and determining the MFIplatelets/FSC ratio. The invention also relates to an in vitro method for diagnosing a peripheral or central thrombocytopenia in a subject.Type: GrantFiled: July 29, 2019Date of Patent: April 1, 2025Assignees: ETABLISSEMENT FRANCAIS DU SANG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE STRASBOURGInventors: Blandine Maitre, Catherine Angenieux, Henri De La Salle, Christian Gachet
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Patent number: 12251673Abstract: The invention relates to a chemical synthesis method, the said method comprising “Spray Flash Evaporation”, also commonly referred to by the corresponding initialism SFE, which comprises the chemical reaction of at least one first compound with at least one second compound, under conditions in which the first compound and the second compound react to form at least one third compound. The invention also relates to a device for implementing this method and the compounds obtained by this method.Type: GrantFiled: October 22, 2019Date of Patent: March 18, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ISL—INSTITUT FRAN CO-ALLEMAND DE RECHERCHES, UNIVERSITÉ DE STRASBOURGInventors: Denis Spitzer, Marc Comet, Valérie Keller, Martin Klaumünzer
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Publication number: 20250075125Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula I or of formula II: wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.Type: ApplicationFiled: November 20, 2024Publication date: March 6, 2025Applicants: Université De Strasbourg, Centre National De La Recherche Scientifique, Université Paris Saclay, Hong Kong Baptist UniversityInventors: Ka-Leung WONG, Joan GOETZ, Loïc CHARBONNIERE, Niko HILDEBRANDT, Aline NONAT, Cyrille CHARPENTIER, Marcelina CARDOSO DOS SANTOS, Vjona CIFLIKU
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Publication number: 20250064993Abstract: Novel bispidine-based compounds including at least an optionally substituted ethanoic acid moiety at the N7-position of the bispidine scaffold, these bispidine-based compounds representing metal chelating ligands able to form metallic complexes having good properties in terms of relaxivity and stability, to complexes including a metal ion complexed with these bispidine-based compounds, and to the use of these bispidine-based compounds in the field of medical imaging or therapy, and more specifically MRI (magnetic resonance imaging) contrast agents and/or nuclear imaging agents for PET (positron emission tomography) and/or SPECT (single photon emission tomography).Type: ApplicationFiled: December 23, 2022Publication date: February 27, 2025Applicants: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Loïc CHARBONNIERE, Maryame SY, Eva JAKAB TÓTH, Aline NONAT
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Patent number: 12220723Abstract: The invention relates to a method for producing, applying and fixing a multilayer surface coating (2a, 3a) on at least one surface (1a) to be coated of a host substrate (1) in order to produce a host substrate assembly. Starting with a fixative product (2) and a functional product (3) based on single-walled or multi-walled graphene, the method consists in successively applying: a layer (2a) of fixative product to the or to each surface (1a) to be coated of the host substrate (1); and a layer of the functional product to said fixative layer (2a). The assembly can be finished with a protective layer deposited directly onto the layer (3a) that contains the functional product. The invention also relates to a host substrate assembly which can be obtained by said method, a heating element, an anti-corrosion and/or anti-fouling/dirt-repelling element and a hydrophobic element each comprising such an assembly.Type: GrantFiled: November 27, 2019Date of Patent: February 11, 2025Assignees: BLACKLEAF, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURGInventors: Housseinou Ba, Armel Bahouka, Yannick Lafue, Cuong Pham-Huu
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Publication number: 20250034515Abstract: The present invention provides a method for the preparation of organoids that allow the 3D culture or co-culture of cells in an environment that closely mimics the natural in vivo situation. The organoids are prepared from liquid pearls. They may be used in the variety of applications including drug testing and screening and personalized medicine.Type: ApplicationFiled: December 8, 2022Publication date: January 30, 2025Applicants: Université de Strasbourg, Centre National de la Recherche ScientifiqueInventors: Christian Muller, Fathi Emhemmed
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Patent number: 12209090Abstract: The present invention relates to a compound of formula (I), or one of its pharmaceutically acceptable salts: (I) wherein R1, R2 and —X—Y— have specific definitions. It also relates to the use of such a compound in therapy; and to a process for preparing it.Type: GrantFiled: February 14, 2020Date of Patent: January 28, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG, ETAT FRANCAIS (MINISTÈRE DES ARMÉES), REPRESENTE PAR LA DIRECTION CENTRALE DU SERVICE DE SANTÉ DES ARMEESInventors: Rachid Baati, Richard Brown, José Dias, Alex Maryan-Instone, Jagadeesh Yerri
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Patent number: 12163077Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula (I) or of formula (II): wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.Type: GrantFiled: July 4, 2019Date of Patent: December 10, 2024Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SACLAY, HONG KONG BAPTIST UNIVERSITYInventors: Ka-Leung Wong, Joan Goetz, Loïc Charbonniere, Niko Hildebrandt, Aline Nonat, Cyrille Charpentier, Marcelina Cardoso Dos Santos, Vjona Cifliku
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Publication number: 20240391851Abstract: The present invention relates to a process for the non-oxidative conversion of saturated C1+ hydrocarbons into unsaturated C2+ hydrocarbons and hydrogen in the presence of an unsupported carbon-based catalyst having a carbon content of at least 90.0 wt % and a metal concentration which is less than 0.3 wt %; with wt % expressed based on the total weight of said carbon-based catalyst. The present invention also provides a process for producing a graphite derivative. Further provided are a graphite derivative, and uses thereof, and systems for carrying out the processes of the invention.Type: ApplicationFiled: October 26, 2022Publication date: November 28, 2024Applicants: TOTALENERGIES ONETECH, UNIVERSITÉ DE STRASBOURG-UNISTRA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Stijn VAN DAELE, Nikolai NESTERENKO, Jean-Pierre DATH, Miroslave KETTNER, Cuong PHAM-HUU, Jean-Mario NHUT, Zhenxin XU
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Patent number: 12146150Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.Type: GrantFiled: September 13, 2022Date of Patent: November 19, 2024Assignees: VOYAGER THERAPEUTICS, INC., INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE STRASBOURGInventors: Dinah Wen-Yee Sah, Martin Goulet, Holger Patzke, Yanqun Shu, Jinzhao Hou, Hélène Puccio
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Publication number: 20240317923Abstract: The invention relates to a NCO-terminated urethane preprolymer based on at least a polyol oligomer and a diisocyanate, wherein the polyol oligomer is polyhydroxyalkanoate-diol oligomers (oligoPHA-diol) having a hydroxyl value of more than or equal to 149 mgKOH/g, and the diisocyanate is selected from the list consisting of 1,4-butane diisocyanate (BDI), hexamethylene diisocyanate (6-HDI), dimeryl diisocyanate (DDI), pentamethylene diisocyanate (PDI), L-lysine diisocyanate (LDI), 1,7-heptamethylene diisocyanate (7-HDI), and mixtures thereof. The invention also relates to a method for preparing such a NCO-terminated urethane prepolymer and for a method for preparing polyhydroxyalkanoate-diol oligomers (oligoPHA-diol). The invention also relates to a hemostatic tissue adhesive composition and a hemostatic tissue adhesive. The invention also relates to a kit for the preparation of a hemostatic tissue adhesive.Type: ApplicationFiled: December 22, 2021Publication date: September 26, 2024Applicants: Peters Surgical, Centre National de la Recherche Scientifique (CNRS), Universite De StrasbourgInventors: Valerie Vidal, Sophie Wendels, Luc Averous
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Patent number: 12098217Abstract: The present invention relates to a fusion peptide having one of the following formulae: P1-L-P2 (I) or P2-L-P1 (II) wherein P1 is chosen from the proline-rich antimicrobial peptides; Lisa peptide linker; and P2 has the following formula (III): wherein m is 0 or 1; n is an integer comprised between 0 and 9; p is an integer comprised between 0 and 10; r is 0, 1 or 2; s is 0 or 1; Gln is glutamine; R1 is the side chain of arginine or lysine; R2 is for example a —(CH2)—C3-6-cycloalkyl group optionally substituted; R3 is for example a C1-8-alkyl group; R4 is in particular a C1-8-alkyl group optionally substituted by a C3-6-cycloalkyl group; R5 is for example a —(CH2)—C3-6-cycloalkyl group; R6 is in particular —COOH, wherein, when the fusion peptide has the formula (II), its C-terminus contains a —CO— group engaged in a peptide bond with said linker.Type: GrantFiled: January 17, 2020Date of Patent: September 24, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG, INSTITUT POLYTECHNIQUE DE BORDEAUX, UNIVERSITÉ DE BORDEAUXInventors: Dominique Burnouf, Gilles Guichard, Jerôme Wagner
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Patent number: 12087570Abstract: A method of filtering an ion beam to isolate ions having a targeted charge to mass ratio includes providing a quadrupole mass filter device (2), and emitting an ion beam (1?) from a source (1) towards a quadrupole mass filter device (2). An electrical field is applied between the rods (3, 3?) of each pair of opposite rods (3, 3?) of the device (2), each field being defined by combined direct and alternative potentials, calibrating each of the electrical fields in order to create at least one exact focusing point (8) at the exit (5) The method includes generating, by means of rods (3, 3?) which are segmented longitudinally, an electrical field extending between and along each pair of segmented rods (3, 3?), and calibrating the local field segments by adjusting the settings of their respective individual DC and AC potentials in order to create at least one intermediate node.Type: GrantFiled: May 23, 2019Date of Patent: September 10, 2024Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Emil Traykov
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Patent number: 12083091Abstract: Inhibitors of glucosylceramide degradation, to pharmaceutical compositions containing same and to the use of same in the treatment of diseases of the motor units, such as amyotrophic lateral sclerosis.Type: GrantFiled: September 29, 2020Date of Patent: September 10, 2024Assignees: SPEDDING RESEARCH SOLUTIONS, UNIVERSITE DE STRASBOURG, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Michael Spedding, Alexandre Henriques, Jean-Philippe Loeffler
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Patent number: 12036237Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).Type: GrantFiled: April 20, 2023Date of Patent: July 16, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURGInventors: Sébastien Roux, Thierry Plouvier, Julie Le Merrer, Jérôme Becker
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Patent number: 12029715Abstract: The invention relates to the field of retinoid X receptor (RXR) signaling and a novel vitamin A pathway called Vitamin A5 pathway. Compounds which are useful to provide (R)-9-cis-13,14-dihydroretinoic acid, an endogenous RXR ligand, are claimed as well as their uses and method for preparation thereof. The compounds of the invention are useful for pharmaceutical and nutritional uses.Type: GrantFiled: August 13, 2018Date of Patent: July 9, 2024Assignees: University of Debrecen, Universidade de Vigo, Université de StrasbourgInventors: Wojciech Krezel, Ralph Rühl, Angel R. De Lera
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Patent number: 11975075Abstract: Disclosed is a process for preparation of heterogeneous monodisperse mixtures of protein conjugates with a defined degree of conjugation (1-8) obtained by using a tri-functional reagent allowing affinity concentration followed by subsequent simultaneous release-functionalization.Type: GrantFiled: July 6, 2018Date of Patent: May 7, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG, SYNDIVIAInventors: Sergii Kolodych, Oleksandr Koniev, Alain Wagner, Igor Dovgan