Abstract: Fluorescent polymeric coating films visible in near-infrared light for coating a medical device are provided, and a method for preparing said NIR visible polymeric coating films. In particular, the fluorescent polymeric coating films visible in near-infrared light for coating a medical device are in the form of a single layer or multiple layers where said single layer or at least one of said multiple layers comprises a hydrophobic polymer, a ionic fluorescent dye and a counterion of said ionic fluorescent dye. The fluorescent dye is a near-infrared dye which belongs to the family of long-chain cyanine 7.5 derivatives, and their analogues.

Abstract: The present invention relates to a process and a system for the production of hydrogen and carbon by catalytic non-oxidative decomposition of hydrocarbons, such as saturated C1+ hydrocarbons, such as methane, in the presence of a fresh or a spent catalyst composition comprising at least one carbon catalyst. The process of the invention is characterised in that the fresh or spent catalyst composition is heated by means of induction heating to a temperature comprised between 500° C. and 1100° C. The catalyst compositions as applied in accordance with the invention comprise, and preferably consist of, (I) a first component, wherein said first component is selected from one or more non-porous carbon catalysts and/or one or more porous carbon catalysts; and (II) optionally, a second component, wherein said second component consists of a non-carbon material, and preferably is a ceramic or zeolitic support material.

Abstract: A hydroelectric facility for generating electrical energy from the flow of water circulating in a water network, includes at least one cross-flow pico-turbine mounted on a shaft extending perpendicular to a direction of the water flow, the pico-turbine including a substantially annular blade installed in the water flow in order to generate a mechanical energy of rotation, at least one generating unit, installed outside of the water flow and coupled to the shaft of the pico-turbine in order to transform the mechanical energy of rotation into electrical energy, at least one measurement and control unit, installed outside of the water flow, connected to the generating unit, controlling the distribution of the collected electrical energy as well as the rotation of the pico-turbine depending on the characteristics of the water flow.

Abstract: The present invention relates to a method for analyzing the platelets present in a blood sample, said method comprises the steps of (a) adding to said sample a ligand which binds to the MCH I coupled to a fluorochrome, (b) measuring the mean fluorescence intensity of the platelets (MFIplatelets) with a flow cytometer and c) measuring the mean “Forward Scatter” parameter (FSC) with said flow cytometer and determining the MFIplatelets/FSC ratio. The invention also relates to an in vitro method for diagnosing a peripheral or central thrombocytopenia in a subject.

Abstract: The invention relates to a chemical synthesis method, the said method comprising “Spray Flash Evaporation”, also commonly referred to by the corresponding initialism SFE, which comprises the chemical reaction of at least one first compound with at least one second compound, under conditions in which the first compound and the second compound react to form at least one third compound. The invention also relates to a device for implementing this method and the compounds obtained by this method.

Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula I or of formula II: wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.

Abstract: Novel bispidine-based compounds including at least an optionally substituted ethanoic acid moiety at the N7-position of the bispidine scaffold, these bispidine-based compounds representing metal chelating ligands able to form metallic complexes having good properties in terms of relaxivity and stability, to complexes including a metal ion complexed with these bispidine-based compounds, and to the use of these bispidine-based compounds in the field of medical imaging or therapy, and more specifically MRI (magnetic resonance imaging) contrast agents and/or nuclear imaging agents for PET (positron emission tomography) and/or SPECT (single photon emission tomography).

Abstract: The invention relates to a method for producing, applying and fixing a multilayer surface coating (2a, 3a) on at least one surface (1a) to be coated of a host substrate (1) in order to produce a host substrate assembly. Starting with a fixative product (2) and a functional product (3) based on single-walled or multi-walled graphene, the method consists in successively applying: a layer (2a) of fixative product to the or to each surface (1a) to be coated of the host substrate (1); and a layer of the functional product to said fixative layer (2a). The assembly can be finished with a protective layer deposited directly onto the layer (3a) that contains the functional product. The invention also relates to a host substrate assembly which can be obtained by said method, a heating element, an anti-corrosion and/or anti-fouling/dirt-repelling element and a hydrophobic element each comprising such an assembly.

Abstract: The present invention provides a method for the preparation of organoids that allow the 3D culture or co-culture of cells in an environment that closely mimics the natural in vivo situation. The organoids are prepared from liquid pearls. They may be used in the variety of applications including drug testing and screening and personalized medicine.

Abstract: The present invention relates to a compound of formula (I), or one of its pharmaceutically acceptable salts: (I) wherein R1, R2 and —X—Y— have specific definitions. It also relates to the use of such a compound in therapy; and to a process for preparing it.

Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula (I) or of formula (II): wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.

Abstract: The present invention relates to a process for the non-oxidative conversion of saturated C1+ hydrocarbons into unsaturated C2+ hydrocarbons and hydrogen in the presence of an unsupported carbon-based catalyst having a carbon content of at least 90.0 wt % and a metal concentration which is less than 0.3 wt %; with wt % expressed based on the total weight of said carbon-based catalyst. The present invention also provides a process for producing a graphite derivative. Further provided are a graphite derivative, and uses thereof, and systems for carrying out the processes of the invention.

Abstract: Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.

Abstract: The invention relates to a NCO-terminated urethane preprolymer based on at least a polyol oligomer and a diisocyanate, wherein the polyol oligomer is polyhydroxyalkanoate-diol oligomers (oligoPHA-diol) having a hydroxyl value of more than or equal to 149 mgKOH/g, and the diisocyanate is selected from the list consisting of 1,4-butane diisocyanate (BDI), hexamethylene diisocyanate (6-HDI), dimeryl diisocyanate (DDI), pentamethylene diisocyanate (PDI), L-lysine diisocyanate (LDI), 1,7-heptamethylene diisocyanate (7-HDI), and mixtures thereof. The invention also relates to a method for preparing such a NCO-terminated urethane prepolymer and for a method for preparing polyhydroxyalkanoate-diol oligomers (oligoPHA-diol). The invention also relates to a hemostatic tissue adhesive composition and a hemostatic tissue adhesive. The invention also relates to a kit for the preparation of a hemostatic tissue adhesive.

Abstract: The present invention relates to a fusion peptide having one of the following formulae: P1-L-P2 (I) or P2-L-P1 (II) wherein P1 is chosen from the proline-rich antimicrobial peptides; Lisa peptide linker; and P2 has the following formula (III): wherein m is 0 or 1; n is an integer comprised between 0 and 9; p is an integer comprised between 0 and 10; r is 0, 1 or 2; s is 0 or 1; Gln is glutamine; R1 is the side chain of arginine or lysine; R2 is for example a —(CH2)—C3-6-cycloalkyl group optionally substituted; R3 is for example a C1-8-alkyl group; R4 is in particular a C1-8-alkyl group optionally substituted by a C3-6-cycloalkyl group; R5 is for example a —(CH2)—C3-6-cycloalkyl group; R6 is in particular —COOH, wherein, when the fusion peptide has the formula (II), its C-terminus contains a —CO— group engaged in a peptide bond with said linker.

Abstract: A method of filtering an ion beam to isolate ions having a targeted charge to mass ratio includes providing a quadrupole mass filter device (2), and emitting an ion beam (1?) from a source (1) towards a quadrupole mass filter device (2). An electrical field is applied between the rods (3, 3?) of each pair of opposite rods (3, 3?) of the device (2), each field being defined by combined direct and alternative potentials, calibrating each of the electrical fields in order to create at least one exact focusing point (8) at the exit (5) The method includes generating, by means of rods (3, 3?) which are segmented longitudinally, an electrical field extending between and along each pair of segmented rods (3, 3?), and calibrating the local field segments by adjusting the settings of their respective individual DC and AC potentials in order to create at least one intermediate node.

Abstract: Inhibitors of glucosylceramide degradation, to pharmaceutical compositions containing same and to the use of same in the treatment of diseases of the motor units, such as amyotrophic lateral sclerosis.

Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).

Abstract: The invention relates to the field of retinoid X receptor (RXR) signaling and a novel vitamin A pathway called Vitamin A5 pathway. Compounds which are useful to provide (R)-9-cis-13,14-dihydroretinoic acid, an endogenous RXR ligand, are claimed as well as their uses and method for preparation thereof. The compounds of the invention are useful for pharmaceutical and nutritional uses.

Abstract: Disclosed is a process for preparation of heterogeneous monodisperse mixtures of protein conjugates with a defined degree of conjugation (1-8) obtained by using a tri-functional reagent allowing affinity concentration followed by subsequent simultaneous release-functionalization.