Abstract: A motorized, modular instrumentation device and an endoscopy system including such device. The motorized, modular instrumentation device includes at least one operational unit mounted on at least one support structure and integrating a motorized medical instrument module including, first, an elongated medical instrument with a tool arranged on one distal end, it being possible to bend the corresponding end portion of the instrument, and second, at least one electrical actuating element controlling the operation of the tool and/or the bending of the distal end portion, via transmission elements extending within the elongated body of the instrument. The actuating element(s) is/are installed in a hollow body connected to the proximal end of the instrument and the hollow body is itself arranged, with rotational guiding, within a reception housing adapted to move, at least translationally, on the support structure, the movements of the hollow body and the reception housing being motorized.

Abstract: Some embodiments are directed to the use of creatine kinase or fragments thereof which induce analgesia, and also to the use of pharmaceutical compositions including the same, to relieve pain.

Abstract: The present invention relates to disintegratable mesoporous silica materials, a method for producing the same, and uses thereof.

Abstract: The present invention is in the field of surfactants to extract a platinum group metal or gold, in particular palladium, from organic compositions. In particular, the invention concerns the use of surfactants to back-extract a platinum group metal or gold, in particular palladium, from organic compositions further comprising an extractant of said platinum group metal or gold, in particular palladium from an aqueous solution.

Abstract: A device for determining a dose deposited in a scintillator by an ionizing radiation, comprises: a scintillator configured to be irradiated by the ionizing radiation and capable of emitting scintillation photons during interaction with the ionizing radiation; a measurement device comprising a single photodetector, the photodetector being a low-noise photodetector, the determination device being configured in such a way that the photodetector functions in single photon counting mode, the photodetector supplying, at the output of same, a measurement of the total intensity of light received by the photodetector from the scintillator; and an analyzer configured to determine a dose deposited in the scintillator by the ionizing radiation from the total intensity alone of light measured by the photodetector and a predetermined constant dependent only on the scintillator, the light output of the determination device and the type of ionizing radiation.

Abstract: A method for preventing or treating cardiomyopathy due to energy failure in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of a vector which comprises a nucleic acid sequence encoding a gene that can reverse energy failure. An exemplary cardiomyopathy is that which is associated with Friedreich ataxia and an exemplary nucleic acid sequence comprises a nucleic acid that encodes frataxin (FXN).

Abstract: A flexible or semi-flexible foam, or a composition making it possible to obtain a flexible or semi-flexible foam, including a polyester polyol or a polymer comprising a polyester polyol. The polyester polyol is obtained by a first polycondensation (a) of an alcohol sugar Z in C3 to C8 and of two identical or different diacids Y and Y? in C4 to C36 and a second polycondensation (b) of the product obtained in (a) with two identical or different diols X and X? in C2 to C12.

Abstract: A rigid foam or a composition allowing a rigid foam to be obtained, including a polyester polyol or a polymer including a polyester polyol, the polyester polyol being obtained by a first polycondensation (a) of a C3 to C8 sugar alcohol Z and two identical or different C4 to C36 diacids Y and Y? and a second polycondensation (b) of the product obtained in (a) with two identical or different C2 to C12 diols X and X?.

Abstract: A polyester polyol of formula produced by a first polycondensation (a) of a sugar alcohol Z in C3 to C8 and two diacids Y and Y? which are the same or different in C4 to C36, and a second polycondensation (b) of the product produced in (a) with two diols X and X? which are the same or different in C2 to C12, the polymer including such a polyester polyol. Also, a method for producing the polyester polyols and the use thereof in foams, adhesives, coatings or elastomers of polyurethane or polyisocyanurate.

Abstract: A method for estimating a spatial distribution of the hazardousness of radiation doses for individuals evolving in a medical operating room defining a three-dimensional environment surrounding at least one source of radiation. First a three-dimensional model of the environment is obtained. Then a simulation of radiation doses attributable to ionizing radiation emitted from the source and scattered by the environment is computed in the model. Then, an image indicating the spatial distribution of the hazardousness for an individual of the radiation doses is generated and displayed. The three-dimensional model comprises models of individuals when the individuals are present in the environment and the image is a three-dimensional image generated for at least a portion of the model including said models of individuals.

Abstract: The invention concerns a new family of discriminating molecules for neutron rays and gamma rays, and method for preparing the same. These molecules are also useful to detect radiation (X, gamma, electrons, protons, ions), and hence for the manufacture of instruments for radiation detection, industrial or medical dosimetry.

Abstract: The present invention relates to humanized anti-claudin-1 antibodies and uses thereof. Hepatitis C virus infection is a leading cause of chronic liver disease and a major indication for liver transplantation. The tight junction protein claudin-1 (CLDN1) is an essential entry factor for HCV and a promising target for therapy. For clinical development, the inventors have humanized a rat anti-CLDN1 antibody produced by genetic immunization that prevent HCV infection and also cure chronically infected human liver chimeric mice. The lead humanized anti-CLDN1 antibody (H3L3) pan-genotypically inhibited HCV pseudoparticle infection of primary human hepatocytes (PHH) without detectable escape. H3L3 efficiently inhibited infection by diverse HCV genotype 3 strains and exhibited marked synergy with direct-acting antivirals (DAAs). The inventors also demonstrate that anti-CLDN1 H3L3 cures persistent HCV infection in human-liver chimeric uPA-SCID mice in monotherapy.

Abstract: The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.

Abstract: The present invention relates to a random lasing photo-curable composition (1) for use as random lasing gain medium comprising:—laser dye molecules (11);—an optical glue (12) for the laser dye molecules to be suspended therein; wherein the optical glue is mercapto ester-based and comprises methacrylate and/or derivatives thereof. The present invention also relates to a random lasing system with a gain medium made of at least partially of random lasing photo-curable composition, and methods for manufacturing such random lasing system.

Abstract: The present invention relates to hydroxychloroquine analogues having an activity superior to that of hydroxychloroquine but free from retinal cytotoxicity of formula (I), their pharmaceutically acceptable salts, solvates or hydrates: their method of preparation and their use in the treatment of lupus erythematosus.

Abstract: The present invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as medicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. These molecules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulates neuronal proliferation.

Abstract: A device for analyzing and/or generating a polarization state of a measurement point of a target object includes a polarizer suitable for selecting, in an incident light wave, a light beam which is linearly polarized in a predefined direction; a first birefringent element suitable for having the light beam pass therethrough; a second birefringent element identical to the first element and suitable for having the light beam pass therethrough, the light beam then being directly or indirectly directed toward the object in order to be reflected in the form of a reflected beam. The device includes an optical assembly having one or more optical elements located in an optical path between the first element and the second element, and the optical assembly includes an odd number of mirrors, or, an odd number of half-wave plates, or, an odd number of a mix of mirrors and half-wave plates.

Abstract: The present invention relates to chemically defined culture medium comprising at least one osmoprotectant compound and at least one fatty acid for the detection of a broad range of microorganisms.

Abstract: The present invention is directed to a method for detection of microbial colonies on a surface, comprising the steps of obtaining one or a plurality of digital images I0, I1, I2, I3, I4 of the surface, said digital images I0, I1, I2, I3, I4 being represented by at least two-dimensional matrices of pixel values, calculating a statistical noise distribution based on at least one of the digital images I0, applying the statistical noise distribution calculated in the calculation step to the one or the plurality of digital images I0, I1, I2, I3, I4, and detecting an object of interest as a candidate for a microbial colony based on deviation of pixel values from the noise distribution.

Abstract: The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.