Patents Assigned to Universite de Strasbourg
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Patent number: 10822400Abstract: The present disclosure relates to an inhibitor of Dynamin 2 or composition comprising the same for use in the treatment of Duchenne's muscular dystrophy.Type: GrantFiled: April 22, 2016Date of Patent: November 3, 2020Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jocelyn Laporte, Belinda Cowling
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Patent number: 10823711Abstract: This invention relates to a micro-device for detecting volatile compounds comprising: an input (E) and an output (S); collection means (2) for taking a gas sample containing at least one compound to be detected; sampling means enabling a gas volume of 100 mL or less to be sampled, arranged after the collection means; injection means (3) of said gas sample; separation means (5) of the compound to be detected in the gas sample; compound detection means (6); and a gas circulation circuit (1) located downstream of the collection means and passing through the sampling means, injection means (3), separation means (5) and detection means (6); characterized in that the gas circulation circuit (1) has a volume of between 0.2 cm3 and 2.0 cm3.Type: GrantFiled: December 4, 2015Date of Patent: November 3, 2020Assignees: Universite de Strasbourg, Centre National de la Recherche ScientifiqueInventors: Stéphane Le Calve, Rouba Nasreddine, Vincent Person, Christophe Serra
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Patent number: 10815298Abstract: Use of anti-Claudin 1 monoclonal antibodies and pharmaceutical compositions thereof, for the prevention and/or treatment of hepatocellular carcinoma in patients suffering from liver disease, in particular liver disease that is not associated with HCV infection or in patients who have been cured from HCV infection. Methods of preventing and/or treating hepatocellular carcinoma by administration of such a monoclonal antibody, or a pharmaceutical composition thereof, are also described. Experimental results with the hepatocarcinoma cell line HuH-7.5.1 are given.Type: GrantFiled: March 18, 2016Date of Patent: October 27, 2020Assignees: Institut Hospitalier Universitaire de Strasbourg, Institut National de la Sante et de la Recherche Medicale, Universite de StrasbourgInventors: Thomas Baumert, Eric Robinet, Mirjam Zeisel
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Patent number: 10752976Abstract: The present invention is in the field of surfactants to extract a platinum group metal or gold, in particular palladium, from organic compositions. In particular, the invention concerns the use of surfactants to back-extract a platinum group metal or gold, in particular palladium, from organic compositions further comprising an extractant of said platinum group metal or gold, in particular palladium from an aqueous solution.Type: GrantFiled: May 19, 2017Date of Patent: August 25, 2020Assignees: Universite de Strasbourg, Centre National de la Recherche Scientifique, Avignon Universite, Comissariat a l'Energie Atomique et aux Energies AlternativesInventors: Frédéric Jean-Jacques Bihel, Damien Bourgeois, Stéphane Desgranges, Daniel Meyer, Christiane Contino-Pepin, Martine Schmitt, Patrick Hervé Denis Wagner
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Patent number: 10734591Abstract: A compound is provided which has dual emission properties and which is useful in light devices, and which has formula (I): wherein: A represents an electron-withdrawing group; D represents an electron-donating group; X is selected from the group consisting of: O, S and NR, wherein R is selected from the group consisting of: H, an alkyl group preferably comprising from 1 to 20 carbon atoms, an aryl group preferably comprising from 6 to 22 carbon atoms, and a heteroaryl group; n is an integer from 1 to 4; m is an integer from 1 to 6; and represents a condensed bicyclic aromatic radical comprising from 6 to 22 carbon atoms, and from 1 to 3 heteroatom(s) selected from the group consisting of: N, S and O; the OH group being in ortho position of the condensed bicyclic aromatic radical relative to the radical.Type: GrantFiled: July 21, 2015Date of Patent: August 4, 2020Assignees: UNIVERSITÉ DE STRASBOURG, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Karima Benelhadj, Julien Massue, Gilles Ulrich, Raymond Ziessel, Denis Jacquemin, Adèle Laurent
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Patent number: 10718946Abstract: An optical guide for a near-eye display device includes a first guide element having a light input zone and a second guide element having an output zone. The first guide element is superimposed on the second guide element. The optical guide also includes an optical coupling system between the first guide element and the second guide element, and the first and second guide elements have, on the first part of their length, a mutual spacing so as to delimit a thin layer of air between said guide elements extending between a first longitudinal end of the guide elements and the optical coupling system. The optical coupling system, located at a second longitudinal end of the first and second guide elements, includes a single-piece portion of the guide elements, associated with an optical reflection member to propagate the beams of light from the input zone toward the output zone.Type: GrantFiled: January 12, 2017Date of Patent: July 21, 2020Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DES SCIENES APPLIQUEESInventors: Jianming Yang, Patrice Twardowski, Joël Fontaine
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Patent number: 10687838Abstract: Disclosed is an inflatable balloon for medical use, intended to be inserted deflated into a human or animal body cavity and then inflated once inside this cavity so as to apply pressure against the cavity. The inflatable balloon includes a balloon body, the wall of which is made from a flexible inflatable material, the balloon body having a generally elongated shape with a proximal inflation end and a distal positioning end at the back of the cavity. It further includes an inflation opening formed in the proximal end through which a fluid is introduced into the balloon body so as to inflate it under pressure. The wall of the balloon body locally has an elongated portion called the sole that is stiffer than the rest of the wall, this sole extending from the proximal end to the distal end.Type: GrantFiled: October 14, 2016Date of Patent: June 23, 2020Assignees: DIANOSIC, UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, HOPITAUX UNIVERSITAIRES DE STRASBOURGInventors: Marc Augustin, Christian Debry
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Publication number: 20200181618Abstract: RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness of the bound complexes, and their thermal and salt stability, provide distinct aspects of the disclosed aptamers.Type: ApplicationFiled: April 23, 2018Publication date: June 11, 2020Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG, SIMON FRASER UNIVERSITY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICInventors: Michael Ryckelynck, Alexis Autour, Peter Unrau, Elena Dolgosheina, Sunny Chiu Yuk Jeng, Shanker Shyam Sundhar Panchapakesan, Amir Abdolahzadeh, Razvan Cojocaru, Adrian Ferré D'Amaré, Robert Trachman
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Publication number: 20200181093Abstract: A subject of the present invention is a compound having the general formula (I): a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B3, B4, B5, Y, X, B1 and B2 are as defined in any one of claims 1 to 10. Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.Type: ApplicationFiled: July 13, 2017Publication date: June 11, 2020Applicants: Centre National de la Recherche Scientifique (CNRS, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg, Universite Paris-Sud, Centre International de Recherche aux Frontieres d e la ChimieInventors: Dominique Bonnet, Nelly Frossard, Jean-Luc Galzi, Christophe Guignabert, Marcel Hibert, Frédéric Simonin, Sylviane Muller
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Publication number: 20200171204Abstract: The application pertains to the field of biomaterials and their use, in particular for the production of implants to support the growth and recovery of biological tissues. More particularly, a fibrous polymer material is described comprising a first layer of aligned fibroin fiber, a second layer of fibroin fibers, wherein the fibroin fibers are randomly oriented within said second layer, a third layer of aligned fibroin fibers; and polymer scaffolds comprising thereof.Type: ApplicationFiled: July 12, 2018Publication date: June 4, 2020Applicants: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, UNIVERSITE DE PICARDIE JULES VERNE, CENTRE HOSPITALIER UNIVERSITAIRE AMIENS - PICARDIEInventors: Bernard Devauchelle, Anne Hebraud, Guy Schlatter, Kayla Belanger, Christophe Egles
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Patent number: 10660719Abstract: A master interface device for remotely controlling at least one instrument mounted in an endoscope. The device includes at least one control handle device in the form of a subassembly able to be manipulated in the same degrees of freedom as the associated control instrument. The control device includes on the one hand a gripping and manoeuvring shaft, designed for gripping with the whole hand by the operator, and on the other hand a mounting bracket supporting said shaft. Translation and pivoting of the bracket controls respectively translation and rotation around itself of the associated instrument, and the pivoting of the shaft relative to the bracket controls the bending of the end of the instrument concerned.Type: GrantFiled: January 22, 2015Date of Patent: May 26, 2020Assignees: Universite De Strasbourg, Centre National De La Recherche Scientifique, Institut De Recherche Sur Les Cancers De L'Appare-Inventors: Michel De Mathelin, Florent Le Bastard, Florent Nageotte, Philippe Zanne, Lucile Zorn
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Patent number: 10647677Abstract: The present invention relates to hydroxychloroquine analogues having an activity superior to that of hydroxychloroquine but free from retinal cytotoxicity of formula (I), their pharmaceutically acceptable salts, solvates or hydrates: their method of preparation and their use in the treatment of lupus erythematosus.Type: GrantFiled: June 6, 2016Date of Patent: May 12, 2020Assignees: INOVIEM SCIENTIFIC, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMEInventors: Anne-Sophie Korganow, Pierre Eftekhari, Alain Wagner, Corinne Baehr
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Patent number: 10647986Abstract: The present disclosure relates to an inhibitor of Dynamin 2 for use in the treatment of centronuclear myopathies. The present disclosure relates to pharmaceutical compositions containing Dynamin 2 inhibitor and to their use for the treatment of centronuclear myopathies. It also deals with a method for identifying or screening molecules useful in the treatment of a centronuclear myopathy.Type: GrantFiled: October 20, 2014Date of Patent: May 12, 2020Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jocelyn Laporte, Belinda Cowling, Hichem Tasfaout
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Patent number: 10639125Abstract: A system for an automatic multimodal real-time tracking of moving instruments for image plane alignment inside an MRI scanner includes: an MRI scanner, an MRI multi-plane pulse sequence generating unit allowing to interactively modify the position and orientation of one or several image planes in real-time, one or several external optical sensors with high frame rate, preferably a RGB-D sensor or other similar camera system like a stereovision systems, a multimodal marker including at least one MR visible feature and one visual feature able to be tracked by both the MRI scanner and the at least one external optical sensor, a computer for processing in real-time images from both MRI and optical sensor to fuse the detected marker position and orientation or pose from both modalities, and predict the next image plane position and orientation based on the estimated motion of the moving marker.Type: GrantFiled: February 24, 2015Date of Patent: May 5, 2020Assignees: UNIVERSITE DE STRASBOURG (ETABLISSEMENT PUBLIC NATIONAL A CARACTERE SCIENTIFIQUE, CULTUREL ET PROFESSIONNEL), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (ETABLISSEMENT PUBLIC NATIONAL A CARACTERE SCIENTIFIQUE ET TECHNOLOGIQUE), INSTITUT HOSPITALO-UNIVERSITAIRE DE CHIRURGIE MINI-INVASIVE GUIDEE PAR L'IMAGE (FONDATION DE COOPERATION SCIENTIFIQUE APPROUVEE PAR DECRET MINISTERIEL DU 25 NOVEMBRE 2011 PUBLIE AU JOURNAL OFFICIEL DU 27 NOVEMBRE 2011)Inventors: Michel De Mathelin, Markus Neumann, Loic Cuvillon, Elodie Breton
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Patent number: 10643058Abstract: The present invention is directed to a method for detection of microbial colonies on a surface, comprising the steps of obtaining one or a plurality of digital images I0, I1, I2, I3, I4 of the surface, said digital images I0, I1, I2, I3, I4 being represented by at least two-dimensional matrices of pixel values, calculating a statistical noise distribution based on at least one of the digital images I0, applying the statistical noise distribution calculated in the calculation step to the one or the plurality of digital images I0, I1, I2, I3, I4, and detecting an object of interest as a candidate for a microbial colony based on deviation of pixel values from the noise distribution.Type: GrantFiled: August 17, 2016Date of Patent: May 5, 2020Assignees: MERCK PATENT GMBH, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Marine Bouthillon, Luc Felden, Ola Ahmad, Christophe Collet
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Patent number: 10617542Abstract: An elastic ring, defining an inner opening, an outer contour and an annular bearing surface between the inner opening and the outer contour. The ring is deformable between a rest position and an insertion position in which the inner opening has a diameter greater than its diameter in the rest position. The ring is also elastically biased towards the rest position. The ring includes at least three strands passing through the ring, each strand having a first end and a second end positioned on the outer contour, the inner contour of the opening being defined by a portion of each strand and having a pseudo-polygonal shape.Type: GrantFiled: October 26, 2016Date of Patent: April 14, 2020Assignees: ID Nest Medical, UNIVERSITE DE STRASBOURGInventors: Nabil Chakfe, David Contassot
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Patent number: 10597339Abstract: A method is described for chiral resolution of chiral species contained in a liquid placed in a cell formed by an inner wall and an outer wall surrounding the inner wall over at least a portion of the inner wall, where each of the outer and inner walls are a solid of revolution about a longitudinal axis and are coaxial to one another, where the method comprises rotating the outer wall in one direction of rotation with respect to the inner wall for generating a Taylor-Couette flow within the liquid; collecting at least one of the chiral species.Type: GrantFiled: August 7, 2015Date of Patent: March 24, 2020Assignees: Universite de Strasbourg, Centre National de la Recherche Scientifique—CNRSInventors: Thomas Marinus Hermans, Akihiro Sato, Vincent Marichez
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Patent number: 10566551Abstract: The present invention concerns fluorescent boron thienyldipyrromethene type compounds, their preparation process, as well as their use as an electron donor in the field of organic electronics, in particular for the production of a photoactive layer in photovoltaic cells of the bulk heterojunction type or for the production of field effect transistors.Type: GrantFiled: July 18, 2013Date of Patent: February 18, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURGInventors: Thomas Bura, Nicolas Leclerc, Sandra Rihn, Raymond Ziessel, Antoine Mirloup, Thomas Heiser, Patrick Leveque, Sadiara Fall
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Patent number: 10501501Abstract: The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.Type: GrantFiled: September 9, 2016Date of Patent: December 10, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Lorene Belval, Gerard Demangeat, Caroline Hemmer, Christophe Ritzenthaler
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Publication number: 20190345532Abstract: Embodiments of the present disclosure relate to methods of screening and optionally designing compounds as inhibitors of Mfd (Mutation Frequency Decline), such compounds being useful for the treatment of bacterial infections. Embodiments of the methods include culturing pathogenic bacteria expressing functional Mfd with various concentrations of 1 mM or less, incubating the cultures with and without nitric oxide stress conditions, evaluating bacterial survival in each of the cultures, and calculating the concentration of the molecule required to decrease by 50% the survival rate of the bacteria (IC50) by comparing the cfu of the untreated cultures and cultures following nitric oxide stress.Type: ApplicationFiled: May 3, 2017Publication date: November 14, 2019Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURGInventors: Nalini Rama Rao, Didier Rognan, Didier Lereclus