Abstract: The present patent application relates to a method for diagnosing angioedema with a gain-of-function mutation of kinin formation, and for determining the amount of BK or des-Arg9 -BK antagonist required for halting the effects of angioedema, from a plasma sample of a patient. The invention also relates to a kit for said determination.

Abstract: The invention relates to polysaccharides grafted with a unit including a carbon-carbon double bond, to polysaccharides grafted with a unit including a carbon-carbon double bond functionalized by a thioether unit, to the methods for preparing said compounds, to the compositions including such compounds and to the materials including such materials or compositions.

Abstract: A device for crystallising a molecule to be crystallised, which includes: at least one crystallisation cell that includes a crystallisation chamber for receiving a first solution S1 containing the molecule to be crystallised and the crystal seeds thereof, a dialysis membrane, and a container to be filled with a second solution S2 that contains constituents selected from the group containing crystallisation agents, additives and buffers; and at least one image acquisition means. The crystallisation device is characterized in that it includes: at least one addition means arranged to add, to the container, constituents selected from the group containing crystallisation agents, additives and buffers of solution S2; and/or at least one sampling means arranged to collect, from the container, all or a portion of solution S2. The invention also relates to a crystallisation method.

Abstract: The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

Abstract: The present invention concerns devices and methods for controlling actin filaments growth and organization with micro patterned nucleation sites, their uses for studying actin network formation, for screening of drugs or for preparing complex structures.

Abstract: The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.

Abstract: A system is provided for managing services in a living place, including: a supervision system, an anticipative solving system, the anticipative solving system including a processing and memory system for: storing service type problem generators and powers and occupants' satisfaction-related transversal problem generator; collecting service type and related parameters for each service; generating instantiated constraint data for each service according to its type and an anticipative service type problem data based on the constraint data; generating global anticipative problem data; computing set-point data for each service based on the solved global anticipative problem; sending set-point data to the supervision system; and a reactive system adapted to adjust the set-point data computed by the anticipative system depending on the current state of each service.

Abstract: The present patent application concerns a method for diagnosing infertility related to the DPY19L2 protein, in a male human subject, and a method for treating said subject with a view to restoring fertility. The present invention also concerns the use of molecules inhibiting the action of the DPY19L2 polypeptide in a wild-type carrier male subject, for example of anti-DPY19L2 interfering nucleic acid type selectively inhibiting the expression of the DPY19L2 polypeptide.

Abstract: Process for preparing a compound of the formula (I) R1-S(O)x—S(O)yR2 in which R1 represents a molecular hydrocarbon radical which can be substituted and/or interrupted by one or more atoms and/or by one or more groups containing one or more atoms, said atoms being selected from N, O, P, S, Si and X, where X represents a halogen; R2, independently of R1, represents a carbon-containing group or a molecular hydrocarbon radical which can be substituted and/or interrupted by one or more atoms and/or by one or more groups containing one or more atoms, said atoms being selected from N, O, P, S, Si and X, where X represents a halogen, and x and y are selected from 0 and 1 in such a way that the sum of x and y is not more than 1, characterized in that a compound of formula (II) R1-S(O)x—R3-Si(R4)(R5)(R6) in which R3 represents a hydrocarbon chain of two carbon atoms, which is optionally unsaturated and/or substituted, and R4, R5 and R6, which are identical or different, each represent, independently of one another, a

Abstract: Method and system for detecting abnormal situations of a person in a living place. One such method involves: receiving information provided by a sensor carried by the person, which information relates to at least one vital variable of the person, receiving information originating from a series of motion sensors provided at various locations in the living place, and comparing said information with predetermined rules involving timeouts established as a function of the location and of the period of the day, or else different timeouts depending on whether an anomaly has been detected at the level of the vital variable, or else according to a common process relaunched upon each arrival in a new location although no abnormal situation exists, and in response to the previous step, triggering or otherwise a signalling of abnormal situation. Application in particular to the telesurveillance of the elderly, with improved discrimination between normal, anomalous and alert situations.

Abstract: The present disclosure relates to a surgical instrument for sampling molecules in an organ which can be accessed directly or via a surgical portal, including: a device for capturing the molecules, a stylet supporting the capture device, capable of entering the organ, a guide for inserting the stylet into the body as far as the organ, wherein the distal end of the guide is provided with a damping block intended to come to bear upon the organ.

Abstract: The disclosure concerns a method for treating a material in a static magnetic field having an intensity of more than 1 Tesla, including the following steps: a first step to heat the material, a second step to apply to the material a thermal shock and/or thermomechanical treatment and/or chemical treatment, wherein during at least the second treatment step, the material is subjected to the magnetic field while being held in position within the magnetic field.

Abstract: The present invention relates to a method for preparing a cyclic peptide with antiparasite activity and anticancer activity. The invention also relates to this peptide as an antiparasite agent, for example in the treatment of toxoplasmosis and as an anticancer agent. The invention also relates to the use of this cyclic peptide for treating organs ex vivo before transplantation.

Abstract: The disclosure relates to an image processing method for estimating a brain shift in a patient, the method involving: the processing of a three-dimensional image of the brain of a patient, acquired before a surgical operation, in order to obtain a reference cerebral arterial tree structure of the patient; the processing of three-dimensional images of the brain of the patient, acquired during the operation, in order to at least partially reconstitute a current cerebral arterial tree structure of the patient; the determination from the combination of the reference and current cerebral arterial tree structures, of a field of shift of the vascular tree representing the shift of the current vascular tree in relation to the reference vascular tree; the application of the determined field of shift of the vascular tree to a biomechanical model of the brain of the patient in order to estimate the brain shift of the patient; and the generation, from the estimated brain shift, of at least one image of the brain of the p

Abstract: The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory is activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

Abstract: The invention relates to a device for producing and/or confining a plasma (10), said device comprising a chamber (13) in the space of which the plasma is produced and/or confined, said chamber (13) including a wall (1) defining a housing (15) inside the chamber (15) and encompassing said space, wherein said device is characterised in that it comprises at least one assembly (30) for producing and/or confining plasma, each assembly (30) being composed of magnets (3) having only an axial magnetisation direction and being recessed in the wall (1) defining the housing, so that the magnetisation direction of all the magnets (3) defining each assembly (30) is substantially perpendicular to the housing (15) defined by the wall (1) and so that the assembly (30) is substantially symmetrical to the housing, wherein the magnetic field lines (5) do not extend through the wall (1) of the chamber. The invention also relates to a method for producing and/or confining a plasma.

Abstract: The disclosure relates to an image processing method for estimating a brain shift in a patient, the method involving: the processing of a three-dimensional image of the brain of a patient, acquired before a surgical operation, in order to obtain a reference cerebral arterial tree structure of the patient; the processing of three-dimensional images of the brain of the patient, acquired during the operation, in order to at least partially reconstitute a current cerebral arterial tree structure of the patient; the determination from the combination of the reference and current cerebral arterial tree structures, of a field of shift of the vascular tree representing the shift of the current vascular tree in relation to the reference vascular tree; the application of the determined field of shift of the vascular tree to a biomechanical model of the brain of the patient in order to estimate the brain shift of the patient; and the generation, from the estimated brain shift, of at least one image of the brain of the p

Abstract: The disclosure relates to a surgical intervention device, including a surgical instrument capable of passing through human or animal tissue and a system comprising so-called “passive” components capable of measuring deformation or a local strain of the instrument and/or so-called “active” components capable of imposing a local strain on the instrument, the system comprising at least two series of passive components arranged at the surface of the instrument so as to establish a biunivocal relation between the position of the instrument or the position of the distal end of the instrument and all the data originating from the series, and, where required, at least two series of active components arranged at the surface of the instrument. The disclosure also relates to a process for determining the position of the distal end of a surgical instrument capable of passing through human or animal tissue.

Abstract: The present invention relates to a plastidial microarray comprising a solid support which comprises a multiplicity of elemental sites, each elemental site comprising several copies of the same nucleic acid probe, said probe being single-stranded, comprising between 50 and 70 nucleotides and corresponding to a sense oligonucleotide in a chloroplastid gene of Arabidopsis thaliana or to an antisense oligonucleotide in a chloroplastid gene of Arabidopsis thaliana, the entire chloroplastid coding genome of Arabidopsis thaliana being represented on the microarray.

Abstract: The invention concerns an imaging system to monitor at least one surgical instrument in an operative site inside a volume of the body of an animal, comprising: at least one endoscopic camera to obtain endoscopic data on the operative site, at least one ultrasound imaging device to obtain ultrasound data on the operative site, a processing device to process the endoscopic and ultrasound data, characterized in that it further comprises at least three markers intended to be positioned in the operative site, said markers being mobile relative to the instrument, each marker being adapted to be detected both by the endoscopic camera and by the ultrasound imaging device, so as to permit cross-mapping of the endoscopic and ultrasound data by the processing means.