Abstract: The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to germ free mice. The dysbiotic gut microbiota induces enteric neuropathy, reduces GLP-1 receptor and nNOS mRNA concentration, GLP-1-induced nitric oxide production for the control of insulin secretion and gastric emptying. The frequency of Lactobacilli in the ileum microbiota was tightly correlated with nMOS mRNA concentration, which is a mode of action of GLP-1, of the enteric nervous system opening a novel route for the improvement of GLP-1 based therapies in type 2 diabetic patients. In particular, the present invention relates to a method of enhancing the potency of an incretin-based drug administered to a diabetic subject as part of a treatment regimen.
Type:
Grant
Filed:
December 5, 2017
Date of Patent:
March 29, 2022
Assignees:
INSERM (Institut National de la Sante et de la Recherche Medicale), Université Paul Sabatier Toulouse III
Abstract: A method for producing a permanent or soft magnet including the following steps: a) providing: a solution containing a solvent in which are dispersed a set of objects which possess a permanent magnetic moment; a substrate on which are fixed to the surface or within a cavity that it may have, a 1st pad and a 2nd pad, said 1st pad includes a face facing and parallel to a face that the 2nd pad includes; b) the solution is deposited on the surface of the substrate or, as the case may be, within its cavity; c) the substrate is placed in a magnetic field so that the set of objects are grouped together between the face of the 1st pad and the face of the 2nd pad so as to form a permanent magnet.
Type:
Application
Filed:
December 12, 2019
Publication date:
February 24, 2022
Applicants:
INSTITUT NATIONAL DES SCIENCES APPLIQUÉES, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Lise-Marie LACROIX, Guillaume VIAU, Thierry LEICHLE, Pierre MORITZ
Abstract: The invention relates to a mineral compound, referred to as synthetic mica, with formula At(Six-Ge1x)4MzO10(OH)2, wherein: A designates at least one monovalent interfoliar cation of a metal element, A having the formula Liw(1)Naw(2)Kw(3)Rbw(4)Cssw(5), each instance of w(i) representing a real number in the interval [0; 1], such that the sum of the instances of w(i) is equal to 1; t is a real number in the interval [0.3; 1]; x is a real number in the interval [0; 1]; M designates at least one divalent metal having the formula Mgy(1)Coy(2)Zny(3)Cuy(4)Mny(5)Fey(6)Niy(7)Cr, each instance of y(i) representing a real number in the interval [0; 1], such as the formula (A); and z is a real number in the interval [2.50; 2.85]. The invention also relates to a composition comprising such a compound and a method for preparing such a compound.
Type:
Grant
Filed:
September 27, 2016
Date of Patent:
November 16, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
François Martin, Christophe Le Roux, Pierre Micoud, Marie Claverie, Cyril Aymonier
Abstract: The invention is a method for treating a heart failure patient with the steps of measuring the concentration of IGFBP2 in a blood, plasma or urine sample obtained from the heart failure patient and comparing the patient's IGFBP2 level to a threshold value derived from IGFBP2 measured in samples taken from a group of patients with heart failure selected from the group consisting of stage I, stage stage III and stage IV heart failure, according to New York Heart Association (NYHA) classification system. A patient with an IGFBP2 level that exceeds the threshold value is admitted or readmitted to a hospital and treated with at least one treatment selected from the group consisting of administration of a beta-blocker, an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker, an aldosterone antagonist, an implantable cardiac defibrillator, a cardiac resynchronization therapy, an implantable left ventricular assist device and a heart transplant.
Type:
Grant
Filed:
June 6, 2014
Date of Patent:
September 7, 2021
Assignees:
INSERM (INSTITUTE NATIONAL DE LAS SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVEERSITAIRE DE TOULOUSE
Inventors:
Philippe Rouet, Fatima Smith-Rouet, Franck Desmoulin, Michel Galinier
Abstract: The present invention relates to methods and pharmaceutical compositions for enhancing CD8+ T cell-dependent immune responses in subjects suffering from cancer. In particular, the present invention relates to a method of enhancing the CD8+ T cell-dependent immune response in a subject suffering from cancer comprising administering to the subject a therapeutically effective amount of an agent capable of increasing intra-tumoral ceramide content.
Type:
Grant
Filed:
February 1, 2017
Date of Patent:
August 3, 2021
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Thierry Levade, Bruno Segui, Florie Bertrand, Julia Rochotte, Anne Montfort, Nathalie Andrieu-Abadie, Celine Colacios Viatge, Nicolas Meyer
Abstract: Disclosed herein is a method for classifying a patient at risk for heart failure, wherein the method comprises the steps of (i) measuring the concentration of IGFBP2 in a sample obtained from the patient and (ii) comparing the concentration of IGFBP2 measured in step (i) to a control value derived from the concentration of IGFBP2 in samples from patients who are at particular stages of heart failure and/or to a control value derived from the concentration of IGFBP2 in blood samples from healthy patients.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
July 13, 2021
Assignees:
INSERM (INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Philippe Rouet, Fatima Smih-Rouet, Franck Desmoulin, Michel Galinier
Abstract: A method includes placing a fluid guide forming composition in contact with the optical source and with the optical fiber, injecting a first light in the guide forming composition from the optical source and/or from the optical fiber, to harden a central region of the optical guide, illuminating the guide forming composition with the second light to harden a peripheral region of the optical guide by photopolymerization initiated by the second photoinitiator system. The difference between the first peak wavelength and the second peak wavelength being more than 100 nm.
Type:
Grant
Filed:
December 16, 2016
Date of Patent:
July 6, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE HAUTE ALSACE, UNIVERSITE PAUL SABATIER TOULOUSE III
Abstract: Method for filtering a platinum bath by electrodialysis, including consecutive steps of extracting fluid from the platinum bat by an extraction current; filtering the fluid extracted during the extraction step, carried out by electrodialysis in a filtering device having an electrodialysis reactor; supplying the platinum bath with the fluid from the filtering step, by a filtered bath current; all of these steps being carried out in a continuous flow.
Type:
Application
Filed:
May 16, 2018
Publication date:
March 18, 2021
Applicants:
SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER - TOULOUSE III
Abstract: The present invention concerns a composition comprising at least one prophylactically or therapeutically active agent selected from the group consisting of attenuated Porphyromonas gingivalis, inactivated Porphyromonas gingivalis, a subunit of Porphyromonas gingivalis, a recombinant or isolated immunogenic polypeptide or peptide from Porphyromonas gingivalis or a c DNA from Porphyromonas gingivalis, for use as a vaccine for preventing or treating periodontitis, diabetes, obesity and/or complications thereof in a subject. The present invention also concerns an isolated antibody having specificity for Porphyromonas gingivalis for use for preventing or treating periodontitis, diabetes, obesity and/or complications thereof in a subject.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
February 23, 2021
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
Inventors:
Vincent Blasco-Baque, Lucile Garidou, Rémy Burcelin
Abstract: The present invention relates to methods and pharmaceutical composition for the treatment of cancer. In particular, the present invention relates to a method for enhancing the potency of an immune checkpoint inhibitor administered to a subject as part of a treatment regimen for cancer, the method comprising: administering a pharmaceutically effective amount of a TNF? blocking agent to a subject in combination with the immune checkpoint inhibitor.
Type:
Grant
Filed:
January 27, 2017
Date of Patent:
February 16, 2021
Assignees:
INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paul Sabatier Toulouse III, Centre Hospitalier Universitaire de Toulouse
Inventors:
Thierry Levade, Bruno Segui, Nicolas Meyer, Céline Colacios Viatgé, Nathalie Andrieu-Abadie, Florie Bertrand
Abstract: The present invention relates to the prevention or treatment of skeletal growth retardation disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FG-FR3), in particular by expression of a constitutively activated mutant of FGFR3. More particularly, the present invention relates to a soluble FGFR3 for use in the prevention or treatment of achondroplasia.
Type:
Application
Filed:
March 13, 2020
Publication date:
February 4, 2021
Applicants:
INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paul Sabatier Toulouse III
Abstract: The present invention relates to the prevention or treatment of skeletal growth retardation disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FG-FR3), in particular by expression of a prolonged activated mutant of FGFR3. More particularly, the present invention relates to a soluble FGFR3 for use in the prevention or treatment of achondroplasia.
Type:
Application
Filed:
June 19, 2020
Publication date:
February 4, 2021
Applicants:
Institut National de la Sante et de la Recherche Medicale, Université Paul Sabatier Toulouse III
Abstract: A method of fabricating an abradable coating of varying density, and such an abradable coating of varying density. According to the invention, the method comprises the following steps: providing a substrate (32) having a first portion with its surface situated at a first level (A), and a second portion with its surface situated at a second level (B) different from the first level; depositing a precursor material on the first and second portions of the substrate (32); compressing the precursor material between the substrate and a bearing surface; and sintering the precursor material as compressed in this way in order to obtain an abradable coating (36) having a first portion (36a) on the first portion of the substrate, and possessing a first density, and a second portion (36b) on the second portion of the substrate, and possessing a second density distinct from the first.
Type:
Grant
Filed:
December 13, 2016
Date of Patent:
December 22, 2020
Assignees:
SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER - TOULOUSE III
Inventors:
Philippe Charles Alain Le Biez, Geoffroy Chevallier, Romain Epherre, Claude Estournes, Jean-Baptiste Mottin, Serge Georges Vladimir Selezneff
Abstract: The present invention relates to methods for predicting pancreatic cancer treatment response.
Type:
Grant
Filed:
January 13, 2016
Date of Patent:
September 1, 2020
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Pierre Cordelier, Louis Buscail, Frédéric Lopez
Abstract: The present invention relates to the prevention or treatment of skeletal growth retardation disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FG-FR3), in particular by expression of a prolonged activated mutant of FGFR3. More particularly, the present invention relates to a soluble FGFR3 for use in the prevention or treatment of achondroplasia.
Type:
Grant
Filed:
January 16, 2014
Date of Patent:
July 28, 2020
Assignees:
Institut National de la Sante et de la Recherche Medicale, Université Paul Sabatier Toulouse III
Abstract: The present invention relates to ex vivo method for producing outer membrane vesicles (OMVs) by expression or overexpression of the hemolysin F gene (hlyF) in gram-negative bacterium.
Type:
Grant
Filed:
April 7, 2015
Date of Patent:
July 14, 2020
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITÉ PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Eric Oswald, Patricia Martin, Kazunori Murase
Abstract: Process for detecting and identifying micropeptides (miPEPs) encoded by a nucleotide sequence contained in the sequence of the primary transcript of a microRNA and use thereof for modulating gene expression.
Type:
Application
Filed:
October 8, 2019
Publication date:
April 30, 2020
Applicants:
UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention concerns an inhibitor of the expression of chemokine CCL7 or an inhibitor of the expression of the receptor CCR3 or an inhibitor of CCL7/CCR3 interaction for the use of same to prevent or treat the extension of prostate cancer outside the prostatic capsule in a subject. The invention also concerns a method for determining the degree of aggressiveness of a prostate cancer tumour in a subject suffering from prostate cancer, comprising a step of determining the concentration or level of expression of the receptor CCR3 in a sample of prostate tumour cells obtained from said subject.
Type:
Application
Filed:
July 15, 2019
Publication date:
March 12, 2020
Applicants:
Universite Paul Sabatier (Toulouse III), Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Toulouse, Institute National de la Sante et de la Recherche Medicale (INSRM)
Inventors:
Catherine Muller, Victor Laurent, Adrien Guerard, Philippe Valet, Bernard Malavaud