Abstract: The present invention concerns composite biomaterials comprising ceramic and a biodegradable polymer gel, with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
March 10, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITÉ PAUL SABATIER TOULOUSE III
Abstract: A composition comprising synthetic mineral particles, such as silicate or phyllosilicate mineral particles, is presented. The composition can be prepared by a process in which a hydrogel precursor of the synthetic mineral particles is produced by a coprecipitation reaction between at least one compound comprising silicon, such as sodium metasilicate, and at least one compound comprising at least one metal element, such as a dicarboxylate salt of the formula M(R1—COO)2, wherein R1 is H or an alkyl group having 1 to 4 carbon atoms. The coprecipitation reaction also takes place in the presence of at least one carboxylate salt of formula R2—COOM? wherein M? is Na or K, and R2 is H or an alkyl group having 1 to 4 carbon atoms.
Type:
Grant
Filed:
December 13, 2017
Date of Patent:
March 3, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER (TOULOUSE III)
Inventors:
Christophe Le Roux, Francois Martin, Pierre Micoud, Angela Dumas
Abstract: Process for detecting and identifying micropeptides (miPEPs) encoded by a nucleotide sequence contained in the sequence of the primary transcript of a microRNA and use thereof for modulating gene expression.
Type:
Application
Filed:
October 8, 2019
Publication date:
January 30, 2020
Applicants:
UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The present invention relates to a reactor and a process for photochemical degradation of ethylene that can be used with rooms for storing climacteric fruits and/or cut flowers.
Type:
Application
Filed:
March 28, 2019
Publication date:
October 3, 2019
Applicants:
ABSOGER, Institut National Polytechnique de Toulouse, Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique
Inventors:
Sylvain GERBAUD, Florence BENOIT-MARQUIE, Caroline ANDRIANTSIFERANA, Philippe DESTRAC, Karine LOUBIERE, Claire LAFOSSAS, Henri DELMAS, Marie-Hélène MANERO
Abstract: The invention relates to chemical compositions in the form of an organogel, comprising a gelled organic liquid, comprising or consisting of a volatile organic liquid, and at least one resin acid. The invention also relates to a method for producing same, and the use of same to reduce and control the evaporation of the contained volatile organic liquid.
Type:
Application
Filed:
July 11, 2017
Publication date:
September 26, 2019
Applicants:
Centre National de la Recherche Scientifique CNRS), Universite Paul Sabatier Toulouse III
Inventors:
Alexandra Ter-Halle, Emile Perez, Isabelle Giraud, Sophie Franceschi
Abstract: The invention concerns an inhibitor of the expression of chemokine CCL7 or an inhibitor of the expression of the receptor CCR3 or an inhibitor of CCL7/CCR3 interaction for the use of same to prevent or treat the extension of prostate cancer outside the prostatic capsule in a subject. The invention also concerns a method for determining the degree of aggressiveness of a prostate cancer tumor in a subject suffering from prostate cancer, comprising a step of determining the concentration or level of expression of the receptor CCR3 in a sample of prostate tumor cells obtained from said subject.
Type:
Grant
Filed:
June 16, 2015
Date of Patent:
September 3, 2019
Assignees:
Universite Paul Sabatier (Toulouse III), Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Toulouse, Institut National de la Sante et de la Recherche Medicale
Inventors:
Catherine Muller, Victor Laurent, Adrien Guerard, Philippe Valet, Bernard Malavaud
Abstract: A material, especially a glassy material of pyrophosphate type, corresponding to the general formula (I): {[(M2+)1?x(R+)2x]2[(P2O74?)1?y(PO43?)4y/3]} n(H2O) in which x and y are positive rational numbers each between 0 and 0.8, and n is such that the weight percentage of water in the material is greater than 0 and less than or equal to 95. M2+ represents a bivalent ion of a metal chosen from calcium, magnesium, strontium, copper, zinc, cobalt, manganese and nickel, or any mixture of such bivalent ions. R+ represents a monovalent ion of a metal selected from potassium, lithium, sodium, and silver, or any mixture of such monovalent ions. This material in particular can be used in manufacturing of bone replacements or prosthesis coatings.
Type:
Grant
Filed:
September 29, 2015
Date of Patent:
August 13, 2019
Assignees:
INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Jérémy Soulie, Christèle Combes, Christian Rey, Pierre Gras
Abstract: The invention relates to: —a protein having dextran-saccharase activity and the sequence SEQ ID NO: 1 for an amino acid sequence; —a protein having dextran-saccharase activity and the sequence SEQ ID NO: 2 for an amino acid sequence; —a complex containing a substrate and a protein with dextran-saccharase activity —a method for synthesizing dextrans; and —dextrans. The invention also relates to a method for synthesizing gluco-oligosaccharides and gluco-conjugates and to the resulting products.
Type:
Grant
Filed:
July 21, 2015
Date of Patent:
June 11, 2019
Assignees:
INSTITUT NATIONAL DES SCIENCES APPLIQUEES TOULOUSE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Marlène Vuillemin, Marion Claverie, Claire Moulis, Magali Remaud-Simeon, Pierre Monsan, Etienne Severac, Catherine Fontagne-Faucher
Abstract: A process for manufacturing a part provided with a lubricating surface coating (10), in which: a composition is prepared that includes at least one precursor having at least one organic group, the composition is deposited on the part, a heat treatment is carried out, wherein the heat treatment of the coating is carried out at a temperature above 220° C., so as to form a lubricating surface coating (10) formed of an at least partially inorganic solid network incorporating solid carbon in at least one lubricating allotropic form in the dispersed state and trapped within the solid network. A part, such as a foil of a foil bearing (1) obtained by the process, a turbomachine, such as a turbomachine for a fuel cell, including such a part, and an aircraft cabin air-conditioning system including at least one such turbomachine are also described.
Type:
Grant
Filed:
April 23, 2014
Date of Patent:
April 23, 2019
Assignees:
LIEBHERR-AEROSPACE TOULOUSE SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE PAUL SABATIER TOULOUSE III
Abstract: The invention relates to a method for manufacturing an abradable plate (32) for a turbomachine turbine shroud (24, 26), the method comprising preparing a mixture comprising a cobalt- or nickel-based metal powder and a powder based on a fluxing element, depositing a layer of the powder mixture in a mold, and making the abradable plate (32) by subjecting the powder mixture layer to a method of SPS sintering. The invention also provides a method of preparing a turbine shroud (24, 26) for a turbomachine.
Type:
Application
Filed:
March 10, 2017
Publication date:
March 14, 2019
Applicants:
SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER-TOULOUSE III
Abstract: A process for preparing phyllomineral synthetic particles formed from constituent chemical elements in stoichiometric proportions including at least one chemical element selected from the group formed from silicon and germanium, and at least one chemical element selected from the group formed from divalent metals and trivalent metals, by a continuous solvothermal treatment at a pressure above 1 MPa and at a temperature between 100° C. and 600° C., by making the reaction medium circulate continuously in a solvothermal treatment zone of a continuous reactor (15) with a residence time of the reaction medium in the solvothermal treatment zone that is suitable for continuously obtaining, at the outlet of the solvothermal treatment zone, a suspension including the phyllomineral synthetic particles.
Type:
Grant
Filed:
April 13, 2015
Date of Patent:
March 5, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Cyril Aymonier, Cedric Slostowski, Angela Dumas, Pierre Micoud, Christophe Le Roux, Francois Martin
Abstract: The invention relates to a method for manufacturing a turbine shroud (24) for a turbomachine, the method comprising manufacturing at least one turbine shroud sector (28), positioning the turbine shroud sector (26) in a bottom mold so that an outer surface of the turbine shroud sector is in contact at least in part with the bottom mold, and depositing a powder layer on an inner surface (28) of the turbine shroud sector (26). Thereafter, a top mold is positioned on the powder layer and an abradable layer (32) is made by subjecting the powder layer to a method of SPS sintering, the abradable layer (32) being for being disposed facing a turbine wheel.
Type:
Application
Filed:
March 10, 2017
Publication date:
February 21, 2019
Applicants:
SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER - TOULOUSE III
Abstract: The present invention concerns an in vitro method of diagnosis or prognosis of an atherosclerosis-related disorder by detecting a small Y RNA (s-RNY), as well as the use of an inhibitor of s-RNY as a medicament against atherosclerosis-related disorders. The invention also concerns a method for screening for a compound suitable for the treatment of an atherosclerosis-related disorder.
Type:
Grant
Filed:
October 20, 2014
Date of Patent:
February 19, 2019
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PAUL SABATIER TOULOUSE III, UNIVERSITE DE NICE SOPHIA ANTIPOLIS
Abstract: The present invention concerns ceramics having a modified surface with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
February 5, 2019
Assignees:
UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates to a method for enhancing the potency of an immune checkpoint inhibitor administered to a subject as part of a treatment regimen, the method comprising administering a pharmaceutically effective amount of a SK1 inhibitor to a subject in combination with the immune checkpoint inhibitor.
Type:
Application
Filed:
January 27, 2017
Publication date:
January 31, 2019
Applicants:
INSERM (Institut National De La Santé et de La Recherche Médicale, Université Paul Sabatier Toulouse III, Centre Hospitalier Universitaire de Toulouse
Inventors:
Thierry LEVADE, Nicolas MEYER, Céline COLACIOS VIATGÉ, Caroline IMBERT, Nathalie ANDRIEU-ABADIE, Bruno SEGUI
Abstract: The present invention concerns a CDC25A phosphatase inhibitor for use in the treatment of a drug resistant cancer and/or in prevention of tumor relapse in a patient suffering or having suffered from cancer.
Type:
Grant
Filed:
September 28, 2015
Date of Patent:
January 15, 2019
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Abstract: A method for producing a thermal barrier in a multilayered system for protecting a metal part made of superalloy, by producing a thermal treatment by flash sintering protection materials in layers superposed on the metal part in an SPS machine enclosure. The layers contain, on a superalloy substrate, at least two layers of zirconium-based refractory ceramics. A metal part is produced according to a SPS flash sintering method and contains a superalloy substrate, a metal sub-layer, a TGO oxide layer and the thermal barrier formed by the method. A first ceramic is an inner ceramic designed to have a substantially higher expansion coefficient. An outer ceramic is designed to have at least lower thermal conductivity, and at least one of a sintering temperature or maximum operating temperature that is substantially higher. The thermal barrier has a composition and porosity gradient from the metal sub-layer to the outer ceramic.
Type:
Grant
Filed:
March 7, 2012
Date of Patent:
December 25, 2018
Assignees:
SAFRAN AIRCRAFT ENGINES, Centre National De La Recherche Scientifique, Institut National Polytechnique de Toulouse, Université Paul-SABATIER Toulouse III
Inventors:
Juliette Hugot, Mathieu Boidot, Daniel Monceau, Djar Oquab, Claude Estournes
Abstract: A method of fabricating an abradable coating of varying density, and such an abradable coating of varying density. According to the invention, the method comprises the following steps: providing a substrate (32) having a first portion with its surface situated at a first level (A), and a second portion with its surface situated at a second level (B) different from the first level; depositing a precursor material on the first and second portions of the substrate (32); compressing the precursor material between the substrate and a bearing surface; and sintering the precursor material as compressed in this way in order to obtain an abradable coating (36) having a first portion (36a) on the first portion of the substrate, and possessing a first density, and a second portion (36b) on the second portion of the substrate, and possessing a second density distinct from the first.
Type:
Application
Filed:
December 13, 2016
Publication date:
December 20, 2018
Applicants:
SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER - TOULOUSE III
Inventors:
Philippe Charles Alain Le Biez, Geoffroy CHEVALLIER, Romain EPHERRE, Claude ESTOURNES, Jean-Baptiste MOTTIN, Serge Georges Vladimir SELEZNEFF
Abstract: The invention relates to a process for controlling the structure of a block copolymer by selective copolymerization, by ring opening, of cyclic carbonate and lactone monomers in the presence of a catalyst based on methanesulfonic acid, the said process comprising a sequence of stages carried out strictly in the following order: a) dissolving the cyclic carbonate monomer in a nonchlorinated aromatic solvent, b) adding, to the monomer solution, a bifunctional initiator chosen from diols or water, c) adding methanesulfonic acid (MSA) as catalyst of the polymerization reaction, d) when all the cyclic carbonate has been consumed, a telechelic polycarbonate capable of acting as macroinitiator of polymerization of the lactone is obtained, e) adding the lactone to the reaction medium in order to selectively obtain a block copolymer.
Type:
Application
Filed:
November 29, 2016
Publication date:
December 6, 2018
Applicants:
ARKEMA FRANCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER (TOULOUSE III)
Abstract: The present invention relates to a TNF? blocking agent for use in the treatment and prevention of melanoma in a subject in whom melanoma cells express MHCI and in whom stroma cells exhibit TNF expression.
Type:
Grant
Filed:
May 12, 2015
Date of Patent:
December 4, 2018
Assignees:
INSERM (Institut National de la Sante et de la Recherche Medicale), Centre Hospitalier Universitaire de Toulouse, Institut Claudius Regaud, Universite Paul Sabatier Toulouse III
Inventors:
Bruno Segui, Nathalie Andrieu-Abadie, Thierry Levade, Celine Colacios Viatge, Philippe Rochaix, Florie Bertrand, Herve Benoist, Julia Rochotte